1. Difference in imaging biomarkers of neurodegeneration between early and late-onset amnestic Alzheimer's disease
- Author
-
Anne-Laure Aziz, Jean-Philippe Ranjeva, Eric Guedj, José Boucraut, Lejla Koric, Lauréline Duprat, Olivier Felician, Sven Joubert, Bernard Giusiano, Mathieu Ceccaldi, Mira Didic, Claude Gueriot, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche de l'Institut universitaire de gériatrie, Université de Montréal (UdeM), Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC), Service de neurologie et de neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire d'Immunologie [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION)-Centre National de la Recherche Scientifique (CNRS), Fondation FondaMental [Créteil], Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre de Mémoire de Ressources et de Recherche [Hôpital La Timone, Marseille], Hôpital de la Timone [CHU - APHM] (TIMONE)-CHU Marseille, Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Neurobiologie intégrative et adaptative (NIA), Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Service Central de Biophysique et de Médecine Nucléaire, Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Mémoire de Ressources et de Recherche, CHU Marseille, and Guedj, Eric
- Subjects
Male ,0301 basic medicine ,Aging ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Disease ,Neuroimaging biomarkers ,Severity of Illness Index ,Cognition ,0302 clinical medicine ,Semantic memory ,Early-onset Alzheimer's disease ,Age of Onset ,Aged, 80 and over ,General Neuroscience ,Neurodegeneration ,Brain ,Middle Aged ,Alzheimer's disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Cardiology ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Psychology ,Amyloid ,medicine.medical_specialty ,Temporoparietal junction ,Neuroimaging ,03 medical and health sciences ,Atrophy ,Alzheimer Disease ,Memory ,Internal medicine ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,medicine ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,snc ,Positron emission tomography imaging ,Aged ,medicine.disease ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Glucose ,030104 developmental biology ,Positron-Emission Tomography ,Posterior cingulate ,Nerve Degeneration ,Neurology (clinical) ,Geriatrics and Gerontology ,Age of onset ,Neuroscience ,Biomarkers ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
International audience; Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown. This study aimed at investigating changes in neuroimaging biomarkers, according to the age of onset of the disease, in mild amnestic Alzheimer's disease patients with positive amyloid biomarkers in cerebrospinal fluid. Both patient groups were impaired on tasks assessing verbal and visual recognition memory. EOAD patients showed greater executive and linguistic deficits, while LOAD patients showed greater semantic memory impairment. In EOAD and LOAD, hypometabolism involved the bilateral temporoparietal junction and the posterior cingulate cortex. In EOAD, atrophy was widespread, including frontotemporoparietal areas, whereas it was limited to temporal regions in LOAD. Atrophic volumes were greater in EOAD than in LOAD. Hypometabolic volumes were similar in the 2 groups. Greater extent of atrophy in EOAD, despite similar extent of hypometabolism, could reflect different underlying pathophysiological processes, different glucose-based compensatory mechanisms or distinct level of premorbid atrophic lesions.
- Published
- 2017
- Full Text
- View/download PDF