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Pemphigus is a group of autoimmune mucocutaneous bullous disorders characterized by acantholysis resulting from autoantibodies targeting epithelial cell surface antigens. Studies reflect the presence of nail manifestations in some patients and suggest a potential correlation with clinical severity. This study examines the overall prevalence and characterizes the diverse manifestations of nail changes in pemphigus. We searched Cochrane, MEDLINE, EMBASE, and LILACS from 1990 to June 26, 2023 for studies reporting different nail changes in pemphigus patients. Data were collected and pooled to obtain proportions of the prevalence of nail changes in patients with pemphigus and subgroup analysis for pemphigus foliaceous and pemphigus vulgaris. The risk of bias was assessed with the Joanna Briggs Institute Checklist. Of 321 studies screened, 14 studies with 1,208 patients were included. Paronychia (n = 185) and Beau's lines (n = 104) were the most common nail changes identified. The pooled prevalence of nail disease in pemphigus patients was 0.389 (number of studies; [95% CI]: n = 9; [0.160–0.680], with high heterogeneity between studies (I2 = 95.0%, P < 0.001). Subgroup analysis revealed the highest prevalence in pemphigus foliaceous at 0.342 (n = 3; [0.109–0.688]) and pemphigus vulgaris at 0.396 (n = 5; [0.114–0.769]). Nail changes exhibited varied temporal relationships with disease onset and flares, preceding, concurrent, or following these events. Correlation with disease severity was noted, although discrepancies between studies were reported. Nail changes in pemphigus, particularly pemphigus vulgaris and pemphigus foliaceous, may be underrecognized. Observations regarding temporal associations and potential correlations with disease severity highlight the diagnostic and prognostic implications of nail changes in pemphigus. The limitations of this study include study heterogeneity and possible bias. Further research to establish the correlation of the presence and severity of nail changes on the overall disease course would be helpful. [ABSTRACT FROM AUTHOR]

Background: Erythroderma is an inflammatory skin condition that causes extensive erythema and skin scaling amounting ≥90% of the body surface area. This retrospective cohort study describes the prevalence of malignancy‐associated erythroderma in a single centre where there was concerted effort to systematically offer malignancy screens to all adult erythroderma patients above the age of 65 years. Methods: Clinical charts were reviewed for all adult inpatients and outpatients with erythroderma who attended the National University Hospital (NUH) from 1 July 2019 to 31 December 2021. Data collected included patient demographics, clinical findings, laboratory investigations, disease‐specific investigations such as endoscopic procedures and biopsies, follow‐up duration and mortality data. Results: Seventy‐four patients were analysed. The median age of the patients was 73 years old (interquartile range: 59–81 years old). An underlying dermatosis was the most common cause of erythroderma—63 patients having atopic dermatitis/asteatotic eczema or psoriasis. Three patients had erythroderma from drug eruptions, and 1 patient had chronic actinic dermatitis. Four patients had associated malignancies (5.4%). Half of our patients completed further evaluation for malignancy (52.7%). The rest had either declined or were eventually unable to complete the investigations. There was a higher prevalence of associated malignancy (7.8%) in elderly patients above 65 years old. Conclusion: When compared to existing literature, our cohort reflects a higher observed occurrence of malignancy in association with erythroderma. As delays in evaluation for underlying malignancy could result in potentially deleterious outcomes, it is prudent to consider systematic screening for malignancy in high‐risk populations such as elderly erythroderma patients. [ABSTRACT FROM AUTHOR]

There is a growing concern amongst patients about topical corticosteroid (TCS) side effects, with increasing discussion of topical steroid addiction (TSA) and topical steroid withdrawal (TSW) particularly on social media platforms. However, the acceptance of TSA/TSW as a distinct condition remains controversial within the dermatological community. We conducted a literature search using PubMed, MEDLINE, Cochrane Library, Google Scholar, Embase and Web of Science to identify original articles addressing TSA/TSW. We described the definition and reported clinical features of TSA/TSW including its classification into erythemato-edematous and papulopustular subtype. To assess the validity of TSA/TSW, we summarised and objectively appraised the postulated mechanisms for this condition, including tachyphylaxis, dysregulation of glucocorticoid receptors, rebound vasodilation and impaired skin barrier leading to a cytokine cascade. Understanding the evidence including its limitations and uncertainties highlights areas for future research and helps medical practitioners better counsel and provide care to patients who may be experiencing or who have concerns about TSA/TSW. [ABSTRACT FROM AUTHOR]

Supportive oncodermatology is an interdisciplinary field, emerging due to increasing dermatological morbidity in patients with cancer and the recognition of the need for greater collaborative and integrated care to improve patient outcomes. These two unique fields (Oncology and Dermatology) may be integrated in various ways, such as through specialised combined clinics, protocols for expedited access, multidisciplinary groups and meetings, and the development of best practices guidelines. This narrative review consolidates the small but growing literature surrounding supportive oncodermatology; discusses the potential benefit and disadvantages, and areas for future research; and suggests a framework for implementation. [ABSTRACT FROM AUTHOR]

Detection of Merkel cell polyoma virus and beta human papillomavirus in multiple eccrine poromas in a patient with acute leukemia treated with stem cell transplant. He underwent a shave biopsy of two growths over the left abdomen and right heel in 2016 and two further biopsies for a right back and right abdominal lump in 2017. Other authors have suggested a possible role of viruses in poroma tumorigenesis.1,2 Human papillomavirus (HPV) DNA and Merkel cell polyomavirus were detected in a patient with eccrine poromatosis after allogenic stem cell transplant for acute myeloid leukemia,2 and HPV DNA was detected in another patient with eccrine poromatosis after allogenic stem cell transplant for mantle cell lymphoma.1 However, the presence of viral DNA in these lesions does not itself prove a direct causal role in the formation of eccrine poromas. [Extracted from the article]

We examined the prevalence and impact of hair loss, treatment-seeking behaviour and expectations of treatment in patients with self-reported hair loss. This study highlights the health-seeking behaviours in hair loss, expectations of treatment, and factors associated with impaired QoL and willingness to pay. [Extracted from the article]

Social media platforms such as Twitter, Facebook, and Instagram serve as useful educational tools for dermatological trainees and patients. In this piece, we discuss how dermatologists can embrace social media to improve self-learning, outreach, and patient care. Dear Editor, Social media encompasses various online platforms that facilitate information delivery and exchange through audio, image, text, and videographic means. [Extracted from the article]

It was approved on March 28, 2017 by US Food and Drug Administration (FDA) for treatment of moderate to severe atopic dermatitis (AD). Herein, we report the treatment response and changes in skin using RSOM imaging and CRS in a 67-year-old Chinese male with moderate AD treated with dupilumab. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. [Extracted from the article]