1. A review of the importance of immune responses in luminal B breast cancer.
- Author
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Nelson, Delia J., Clark, Briony, Munyard, Kylie, Williams, Vincent, Groth, David, Gill, Jespal, Preston, Henry, and Chan, Arlene
- Subjects
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IMMUNE response , *BREAST cancer , *HER2 gene - Abstract
Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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