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1. Left ventricular diastolic dysfunction in systemic sclerosis: Clinical, immunological and survival differences in the Spanish RESCLE registry

Author

González García, Andrés, Fabregate, Martin, Manzano, Luis, Guillén del Castillo, Alfredo, Rubio Rivas, Manuel, Argibay, Ana, Marín Ballvé, Adela, Rodríguez Pintó, Ignasi, Pla Salas, Xavier, Marí-Alfonso, Begoña, Callejas Moraga, Eduardo, Colunga Argüelles, Dolores, Sáez Comet, Luis, González-Echávarri, Cristina, Ortego-Centeno, Norberto, Vargas Hitos, José Antonio, Todolí Parra, José Antonio, Trapiella Martínez, Luis, Herranz Marín, María Teresa, Freire, Mayka, Chamorro, Antonio-J, Perales Fraile, Isabel, Madroñero Vuelta, Ana Belén, Sánchez Trigo, Sabela, Tolosa Vilella, Carles, Fonollosa Pla, Vicent, and Simeón Aznar, Carmen Pilar

Published
2022
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2. Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension

Author

Guillén-Del-Castillo, Alfredo, Meseguer, Manuel López, Fonollosa-Pla, Vicent, Giménez, Berta Sáez, Colunga-Argüelles, Dolores, Revilla-López, Eva, Rubio-Rivas, Manuel, Ropero, Maria Jose Cristo, Argibay, Ana, Barberá, Joan Albert, Salas, Xavier Pla, Meñaca, Amaya Martínez, Vuelta, Ana Belén Madroñero, Padrón, Antonio Lara, Comet, Luis Sáez, Morera, Juan Antonio Domingo, González-Echávarri, Cristina, Mombiela, Teresa, Ortego-Centeno, Norberto, González, Manuela Marín, Tolosa-Vilella, Carles, Blanco, Isabel, Subías, Pilar Escribano, and Simeón-Aznar, Carmen Pilar

Published
2022
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3. Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation

Author

Rubio-Rivas, Manuel, Corbella, Xavier, Guillén-del-Castillo, Alfredo, Tolosa Vilella, Carles, Colunga Argüelles, Dolores, Argibay, Ana, Vargas Hitos, José Antonio, Todolí Parra, José Antonio, González-Echávarri, Cristina, Ortego-Centeno, Norberto, Trapiella Martínez, Luis, Rodríguez Carballeira, Mónica, Marín Ballvé, Adela, Pla Salas, Xavier, Perales Fraile, Isabel, Chamorro, Antonio-J, Madroñero Vuelta, Ana Belén, Freire, Mayka, Ruiz Muñoz, Manuel, González García, Andrés, Pons Martín del Campo, Isaac, Sánchez García, María Esther, Bernal Bello, David, Espinosa, Gerard, García Hernández, Francisco José, Sáez Comet, Luis, Ríos Blanco, Juan José, Fernández de la Puebla Giménez, Rafael Ángel, Sánchez Trigo, Sabela, Fonollosa Pla, Vicent, and Simeón Aznar, Carmen Pilar

Published
2020
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4. Hepatobiliary involvement in systemic sclerosis and the cutaneous subsets: Characteristics and survival of patients from the Spanish RESCLE Registry

Author

Marí-Alfonso, Begoña, Simeón-Aznar, Carmen Pilar, Guillén-Del Castillo, Alfredo, Rubio-Rivas, Manuel, Trapiella-Martínez, Luis, Todolí-Parra, José Antonio, Rodríguez Carballeira, Mónica, Marín-Ballvé, Adela, Iniesta-Arandia, Nerea, Colunga-Argüelles, Dolores, Castillo-Palma, María Jesús, Sáez-Comet, Luis, Egurbide-Arberas, María Victoria, Ortego-Centeno, Norberto, Freire, Mayka, Vargas Hitos, José Antonio, Chamorro, Antonio-J, Madroñero-Vuelta, Ana Belen, Perales-Fraile, Isabel, Pla-Salas, Xavier, Fernández-De-La-Puebla, Rafael A., Fonollosa-Pla, Vicent, and Tolosa-Vilella, Carles

Published
2018
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5. Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort

Author

Trapiella-Martínez, Luis, Díaz-López, José Bernardino, Caminal-Montero, Luis, Tolosa-Vilella, Carles, Guillén-Del Castillo, Alfredo, Colunga-Argüelles, Dolores, Rubio-Rivas, Manuel, Iniesta-Arandia, Nerea, Castillo-Palma, María Jesús, Sáez-Comet, Luis, Egurbide-Arberas, María Victoria, Ortego-Centeno, Norberto, Freire, Mayka, Vargas-Hitos, Jose Antonio, Ríos-Blanco, Juan José, Todolí-Parra, Jose Antonio, Rodríguez-Carballeira, Mónica, Marín-Ballvé, Adela, Chamorro-Fernández, Antonio Javier, Pla-Salas, Xavier, Madroñero-Vuelta, Ana Belén, Ruiz-Muñóz, Manuel, Fonollosa-Pla, Vicent, and Simeón-Aznar, Carmen Pilar

Published
2017
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6. First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study

Author

Rubio-Rivas, Manuel, Corbella, Xavier, Pestaña-Fernández, Melany, Tolosa-Vilella, Carles, Guillen-del Castillo, Alfredo, Colunga-Argüelles, Dolores, Trapiella-Martínez, Luis, Iniesta-Arandia, Nerea, Castillo-Palma, María Jesús, Sáez-Comet, Luis, Egurbide-Arberas, María Victoria, Ortego-Centeno, Norberto, Freire, Mayka, Vargas-Hitos, Jose Antonio, Ríos-Blanco, Juan José, Todolí-Parra, Jose Antonio, Rodríguez-Carballeira, Mónica, Marín-Ballvé, Adela, Segovia-Alonso, Pablo, Pla-Salas, Xavier, Madroñero-Vuelta, Ana Belén, Ruiz-Muñoz, Manuel, Fonollosa-Pla, Vicent, Simeón-Aznar, Carmen Pilar, on behalf of RESCLE investigators, Autoimmune Diseases Study Group (GEAS), Callejas Moraga, E, Calvo, E., Carbonell, C., Castillo, M. J., Chamorro, A. J., Colunga, D., Corbella, X., Egurbide, M. V., Espinosa, G., Fonollosa, V., Freire, M., García Hernández, F. J., González León, R., Guillén del Castillo, A., Iniesta, N., Lorenzo, R., Madroñero, A. B., Marí, B., Marín, A., Ortego-Centeno, N., Pérez Conesa, M., Pestaña, M., Pla, X., Ríos Blanco, J. J., Rodríguez Carballeira, M., Rubio Rivas, M., Ruiz Muñoz, M., Sáez Comet, L., Segovia, P., Simeón, C. P., Soto, A., Tarí, E., Todolí, J. A., Tolosa, C., Trapiella, L., Vargas Hitos, J. A., and Verdejo, G.

Published
2018
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8. Anti-Polymyositis/Scl Antibodies in Systemic Sclerosis: Clinical Associations in a Multicentric Spanish Cohort and Review of the Literature.

Author

Iniesta Arandia, Nerea, Espinosa, Gerard, Guillén del Castillo, Alfredo, Tolosa-Vilella, Carles, Colunga-Argüelles, Dolores, González de Echávarri Pérez de Heredia, Cristina, Lledó, Gema M., Comet, Luis Sáez, Ortego-Centeno, Norberto, Vargas Hito, José Antonio, Rubio-Rivas, Manuel, Freire, Mayka, Ríos-Blanco, Juan José, Rodríguez-Carballeira, Mónica, Trapiella-Martínez, Luis, Fonollosa-Pla, Vicent, and Simeón-Aznar, Carmen Pilar

Published
2022
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9. The incidence rate of pulmonary arterial hypertension and scleroderma renal crisis in systemic sclerosis patients with digital ulcers on endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i).

Author

Pestaña-Fernández, Melani, Rubio-Rivas, Manuel, Tolosa-Vilella, Carles, Guillén-Del-Castillo, Alfredo, Colunga-Argüelles, Dolores, Argibay, Ana, Marí-Alfonso, Begoña, Marín-Ballvé, Adela, Pla-Salas, Xavier, Chamorro, Antonio-J, Castro-Salomó, Antoni, Madroñero-Vuelta, Ana Belén, Sánchez-García, María Esther, Sáez-Comet, Luis, González-Echávarri, Cristina, Ortego-Centeno, Norberto, Vargas-Hitos, José Antonio, Todolí-Parra, José Antonio, Trapiella-Martínez, Luis, and Lledó, Gema María

Subjects
KIDNEY disease diagnosis, CELL receptors, CONFIDENCE intervals, REPORTING of diseases, ENDOTHELINS, FINGERS, KIDNEY diseases, LONGITUDINAL method, MEDICAL records, PULMONARY hypertension, SYSTEMIC scleroderma, TIME, DISEASE incidence, DISEASE prevalence, RETROSPECTIVE studies, PHOSPHODIESTERASE inhibitors, DESCRIPTIVE statistics, ACQUISITION of data methodology, SKIN ulcers, CHEMICAL inhibitors, DISEASE complications
Abstract

Introduction Endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i) are beneficial in pulmonary arterial hypertension (PAH) and digital ulcers (DU) and prevent from DU recurrences. Our study aimed to determine the difference in the incidence rate of PAH and scleroderma renal crisis (SRC) in patients with SSc and DU (SSc-DU) under ERAs/PDE5i or without treatment. Methods We conducted a retrospective cohort study including SSc-DU patients from the Spanish Scleroderma Registry (RESCLE). The primary outcome was the incidence rate of PAH and SRC in patients under ERAs/PDE5i or not. Results Some 544 patients out of 1817 (29.9%) in the RESCLE database had DU, 221 (40.6%) under ERAs/PDE5i and 323 (59.4%) not. The incidence rate (95% CI) difference between patients under treatment or not under did not reach statistical significance in PAH [−0.1 (−4.8, 4.69), P  = 0.988] or in SRC [0.7 (−2.2, 3.7), P  = 0.620]. However, the time from the first DU to the diagnosis of SRC was delayed in treated patients [mean (s. d.) 7.6 (5.8) years vs 2.9  (5.3); P  = 0.021]. The dcSSc subset was more prevalent in the treatment group (36 vs 26%; P  = 0.018), along with anti-topoisomerase I antibodies (34 vs 18%; P  < 0.001) and tendon friction rubs (12 vs 6%; P  = 0.038), whereas the lcSSc subset was more prevalent in the no-treatment group (57 vs 66%; P  = 0.031) along with ACA (37 vs 46%; P  = 0.031). Conclusion There was no difference in the incidence rate of PAH and SRC between groups. However, treatment with ERAs and/or PDE5i appeared to delay the occurrence of SRC. [ABSTRACT FROM AUTHOR]

Published
2021
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10. Enfermedad de neuro-Behçet en el Hospital Universitario Central de Asturias.

Author

Charca-Benavente, Lilyan C., Gómez de la Torre, Ricardo, Caminal-Montero, Luis, Coto-Hernández, Rubén, and Colunga-Argüelles, Dolores

Subjects
MAGNETIC resonance imaging, CEREBRAL embolism & thrombosis, VENOUS thrombosis, BIOMARKERS, CEREBROSPINAL fluid
Abstract

Describir frecuencia y perfil de pacientes con neuro-Behçet (NB) del Hospital Universitario Central de Asturias desde 1981 hasta junio del 2018. Estudio retrospectivo que incluye características: epidemiológicas, clínicas, neuroimagen, estudio de líquido cefalorraquídeo (LCR), histopatología, tratamiento y evolución. Se diferencian características clínicas entre pacientes con Behçet sin afectación neurológica y NB. Se describen 10 casos de NB (25,6%). La edad media al diagnóstico, 29,7 años, siendo más frecuente en varones. El 60% tienen afectación parenquimatosa. En la afectación no parenquimatosa se incluyen un caso con trombosis venosa cerebral y dos con meningitis aséptica aislada. Se encontraron hallazgos de vasculitis en la resonancia magnética cerebral y alteración en la bioquímica del LCR. Un paciente presentó discapacidad motora llamativa. La afectación ocular ha sido mayor en el grupo de los pacientes sin afectación neurológica (p = 0,009). El NB es relativamente frecuente, sobre todo en varones y en la forma parenquimatosa. No se encuentra un marcador clínico propio de la afectación neurológica. To describe the frequency and profile of patients with neuro-Behçet's disease (NBD) at the Central University Hospital of Asturias between 1981 and June 2018. Retrospective study including epidemiological, clinical, neuroimaging, cerebrospinal fluid (CSF) study, histopathology, treatment and evolution characteristics. Clinical characteristics are differentiated between patients with Behçet without neurological affectation and NBD. We found 10 cases of NBD (25.6%). The mean age was 29.7 years, and it was more frequent in males. Sixty percent had parenchymal involvement. The non-parenchymal involvement included a case with cerebral venous thrombosis and two cases with isolated aseptic meningitis. Findings of vasculitis were found on cerebral magnetic resonance imaging, and alteration in the biochemistry of the CSF. One patient presented a striking motor disability. Ocular involvement was greater in the group of patients without neurological involvement (P = 0.009). NBD is a relatively frequent presentation, especially in males and in the parenchymal form. We did not find a systemic clinical marker of neurological involvement. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis-associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study.

Author

Pestaña-Fernández, Melani, Rubio-Rivas, Manuel, Tolosa-Vilella, Carles, Guillén-Del-Castillo, Alfredo, Freire, Mayka, Vargas-Hitos, Jose Antonio, Todolí-Parra, Jose Antonio, Rodríguez-Carballeira, Mónica, Marín-Ballvé, Adela, Espinosa, Gerard, Colunga-Argüelles, Dolores, Ortego-Centeno, Norberto, Trapiella-Martínez, Luis, Carbonell-Muñoz, Cristina, Pla-Salas, Xavier, Perales-Fraile, Isabel, Corbella, Xavier, Fonollosa-Pla, Vicent, Simeón-Azna, Carmen Pilar, and Simeón-Aznar, Carmen Pilar

Published
2020
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12. Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry.

Author

García-Hernández, Francisco J., Castillo-Palma, María J., Tolosa-Vilella, Carles, Guillén-del Castillo, Alfredo, Rubio-Rivas, Manuel, Freire, Mayka, Vargas-Hitos, José A., Todolí-Parra, José A., Rodríguez-Carballeira, Mónica, Espinosa-Garriga, Gerard, Colunga-Argüelles, Dolores, Ortego-Centeno, Norberto, Trapiella-Martínez, Luis, Rodero-Roldán, María M., Pla-Salas, Xavier, Perales-Fraile, Isabel, Pons-Martín del Campo, Isaac, Chamorro, Antonio J., Fernández-de la Puebla Giménez, Rafael A., and Madroñero-Vuelta, Ana B.

Subjects
SYSTEMIC scleroderma, PULMONARY hypertension, INTERSTITIAL lung diseases, PULMONARY artery, HEART diseases
Abstract

Introduction: Our objective was to evaluate the pulmonary hypertension (PH) data for Spanish patients with systemic sclerosis (SSc), define the PH types and determine the associated factors.Method: Descriptive study of PH-related data from the multicentre RESCLE registry. Estimated systolic pulmonary artery pressure (esPAP), measured via echocardiogram was considered elevated if ≥ 35 mmHg. Left heart disease (LHD) and interstitial lung disease (ILD) were identified. When performed, data from right heart catheterisation (RHC) were collected.Results: esPAP was elevated in 350 of 808 patients (43.3%). One hundred and forty-four patients (17.8%) were considered to have PH (88 via RHC and the rest due to elevated esPAP along with evidence of significant LHD or ILD): PAH 3.7%, secondary to ILD 8.3%, secondary to LHD 2.8% and unclassified 3%. Prevalence of elevated esPAP was greater in diffuse SSc (dSSc) than in limited scleroderma (lSSc) (50.5 vs. 42.2%, p 0.046). In the group with elevated esPAP, a lower prevalence of anti-centromere antibodies (41.9% vs. 52.3%, p 0.006) and a greater prevalence of anti-topoisomerase-1 antibodies (ATA) (25.1% vs. 18.6%, p 0.04) were observed compared to the group with normal esPAP. Patients with elevated esPAP had a lower rate of digital ulcers (50.6% vs. 60.2%, p 0.007) and esophageal involvement (83.6% vs. 88.7%, p 0.07) and higher rate of renal crisis (4.6% vs. 1.8%, p 0.066).Conclusions: Prevalence of PAH was lower than expected (3.7%). Probability of having elevated esPAP was higher among patients with dSSc and among those with ATA. [ABSTRACT FROM AUTHOR]

Published
2019
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13. Applying the ACR/EULAR Systemic Sclerosis Classification Criteria to the Spanish Scleroderma Registry Cohort.

Author

Sáez-Comet, Luis, Pilar Simeón-Aznar, Carmen, Pérez-Conesa, Mercedes, Vallejo-Rodríguez, Carmen, Tolosa-Vilella, Carles, Iniesta-Arandia, Nerea, Colunga-Argüelles, Dolores, Victoria Egurbide-Arberas, Maria, Ortego-Centeno, Norberto, Antonio Vargas-Hitos, José, Freire-Dapena, Mayka, Rubio-Rivas, Manuel, José Ríos-Blanco, Juan, Trapiella-Martínez, Luis, Fonollosa-Pla, Vicent, Simeón-Aznar, Carmen Pilar, Egurbide-Arberas, Maria Victoria, Vargas-Hitos, José Antonio, Ríos-Blanco, Juan José, and RESCLE Investigators

Published
2015
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15. Corrigendum to 'Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation' [AUTREV 19-5 (2020) 102507].

Author

Rubio-Rivas, Manuel, Corbella, Xavier, Guillén-del-Castillo, Alfredo, Tolosa Vilella, Carles, Colunga Argüelles, Dolores, Argibay, Ana, Vargas Hitos, José Antonio, Todolí Parra, José Antonio, González-Echávarri, Cristina, Ortego-Centeno, Norberto, Trapiella Martínez, Luis, Rodríguez Carballeira, Mónica, Marín Ballvé, Adela, Pla Salas, Xavier, Perales Fraile, Isabel, Chamorro, Antonio-J, Madroñero Vuelta, Ana Belén, Freire, Mayka, Ruiz Muñoz, Manuel, and González García, Andrés

Subjects
*DIAGNOSIS, *MORTALITY, *FORECASTING, *TIME, *PATIENTS, *SCLERODERMA (Disease)
Published
2021
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