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Corinna Bolloni, Paola Badas, Giorgio Corona, Marco Diana Laboratory of Cognitive Neuroscience, G Minardi Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy Abstract: There is a common consensus in considering substance-use disorders (SUDs) a devastating chronic illness with social and psychological impact. Despite significant progress in understanding the neurobiology of SUDs, therapeutic advances have proceeded at a slower pace, in particular for cocaine-use disorder (CUD). Transcranial magnetic stimulation (TMS) is gaining support as a safe and cost-effective tool in the treatment of SUDs. In this review, we consider human studies that have investigated the efficacy of TMS in achieving therapeutic benefits in treating CUD. All studies conducted to date that have evaluated the therapeutic effect of TMS in CUD are included. We focus on the protocol of stimulation applied, emphasizing the neurophysiological effects of coils employed related to outcomes. Moreover, we examine the subjective and objective measurements used to assess the therapeutic effects along the timeline considered. The revision of scientific literatures underscores the therapeutic potential of TMS in treating CUD. However, the variability in stimulation protocols applied and the lack of methodological control do not allow us to draw firm conclusions, and further studies are warranted to examine the interaction between TMS patterns of stimulation relative to clinical outcomes in depth. Keywords: TMS, cocaine-use disorder, PfCx, craving, intake, dopamine

Mauro Gacci,1 Matteo Salvi,1 Arcangelo Sebastianelli,1 Linda Vignozzi,2 Giovanni Corona,3 Kevin T McVary,4 Steven A Kaplan,5 Mario Maggi,2 Marco Carini,1 Matthias Oelke6 1Department of Urology, University of Florence, Florence, 2Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, 3Endocrinology Unit, Maggiore-Bellaria Hospital, Bologna, Italy; 4Division of Urology, Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL, 5Department of Urology, Weill Cornell Medical College, Cornell University, New York, NY, USA; 6Department of Urology, Hannover Medical School, Hannover, Germany Abstract: A strong and independent association between lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) and erectile dysfunction (ED) has been widely evidenced in several clinical epidemiologic studies. Preclinical animal models have provided a great deal of information on potential common pathogenic mechanisms underlying these two clinical identities. Although the efficacy of the most commonly used treatments for LUTS/BPH is well defined, the negative impact of these treatments on sexual function – in particular, on ED – has triggered the search for new treatment options. In this regard, a new role for phosphodiesterase type 5 inhibitors in the treatment of LUTS/BPH and ED has been claimed. Tadalafil is one of the most extensively investigated phosphodiesterase type 5 inhibitors for this new indication. All evidence reported to date suggests that tadalafil 5 mg once daily is a safe and effective treatment option for both LUTS/BPH and ED. Keywords: phosphodiesterase type 5 inhibitor, LUTS/BPH, ED, sexual function, Cialis

The purpose of this study was to implement the neutrosophic logic in order to identify the most favorable corporate social responsibility strategies to be applied in the short and medium term in a small and medium-sized food company located in the city of Santo Domingo. To achieve this objective, the COPRAS method approach was expanded by incorporating single-valued neutrosophic sets as an essential part of the decision-making process related to the aforementioned area of study. The adoption of the neutrosophic COPRAS method provided an effective framework for evaluating and prioritizing the various facets of corporate social responsibility, empowering the organization to make more informed and ethical decisions. As a result, it was confirmed that the application of neutrosophic logic proved to be a valuable tool for addressing the inherent uncertainty present in decision-making focused on corporate social responsibility.

Emotional intelligence has received considerable attention in recent research. Although it emerged as a topic in the 1990s, the majority of investigations have only surfaced in recent decades. Although it emerged as a topic in the 1990s, the majority of investigations have only surfaced in recent decades. Studies have suggested that individuals with higher emotional intelligence possess greater control over their abilities, and mental wellness, and are better equipped to find quick solutions to the issues they encounter. This study introduces a method of measuring emotional intelligence levels in people based on neutrosophy. The study identifies the primary challenges found in the components of emotional intelligence among citizens from Ecuador and outlines the necessary steps for addressing them.

The analysis of Corporate Social Responsibility (CSR) practices in Ecuadorian companies is a relevant topic due to the indeterminacies existing in their implementation. The general objective of this analysis is to evaluate CSR practices in companies, considering aspects such as environmental sustainability, responsibility to employees, business ethics, and financial performance. To achieve this, the criteria and comprehensive solutions were evaluated through the modeling of the neutrosophic ELECTRE method. The results of the analysis indicate that the implementation of CSR practices can have multiple benefits, and comprehensive solutions with higher scores were identified, such as the implementation of ethics and transparency policies and the implementation of training and professional development programs. To enhance these comprehensive solutions, it is significant to establish clear and transparent policies, train the personnel, and communicate effectively with the community, and other relevant stakeholders. This ensures that CSR practices in Ecuadorian companies have a positive impact on the community.

The present study aimed to conduct a neutrosophic analysis of internal and external ethical factors affecting the supply chain of a painting company in the city of Quito. To achieve this, the SWOT method was applied, coupled with the neutrosophic AHP method for prioritizing and weighting the most influential factors. The results obtained allowed for the identification of the factors that had the greatest impact on the system, as per the opinions of the consulted experts. The combination of the neutrosophic AHP and SWOT analysis methods has proven to be a powerful tool for addressing ethical challenges in business decision-making, and the results obtained can serve as a guide for implementing effective ethical strategies in the supply chain.