175 results on '"Crouch Peter J"'
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2. Microglial ferroptotic stress causes non-cell autonomous neuronal death
3. Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis
4. C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
5. Transdermal Application of Soluble CuII(atsm) Increases Brain and Spinal Cord Uptake Compared to Gavage with an Insoluble Suspension
6. Quantification of metallothionein-III in brain tissues using liquid chromatography tandem mass spectrometry
7. Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND
8. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
9. Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain
10. CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background
11. The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1
12. Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in amyotrophic lateral sclerosis.
13. Evidence for disrupted copper availability in human spinal cord supports CuII(atsm) as a treatment option for sporadic cases of ALS.
14. Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture
15. Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex
16. Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD
17. Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice.
18. ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism
19. Fundamental Neurochemistry Review: Copper availability as a potential therapeutic target in progressive supranuclear palsy: Insight from other neurodegenerative diseases.
20. Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease
21. Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells
22. Prion protein “gamma-cleavage”: characterizing a novel endoproteolytic processing event
23. An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II
24. Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates
25. Increasing Cu Bioavailability Inhibits Aβ Oligomers and Tau Phosphorylation
26. Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model
27. A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5
28. Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice
29. Zinc induces depletion and aggregation of endogenous TDP-43
30. Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43
31. Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.
32. Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease
33. Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex
34. Clioquinol Promotes Cancer Cell Toxicity through Tumor Necrosis Factor α Release from Macrophages
35. Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease
36. Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide
37. Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity
38. Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation
39. Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies
40. Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntingtonʼs disease affected brain
41. Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord.
42. The role of metals in modulating metalloprotease activity in the AD brain
43. Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy.
44. Linker Histone H1 Binds to Disease Associated Amyloid-like Fibrils
45. The Alzheimerʼs therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity
46. Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation
47. Membrane-targeted strategies for modulating APP and Aβ-mediated toxicity
48. The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimerʼs disease
49. Copper-dependent inhibition of cytochrome c oxidase by Aβ1−42 requires reduced methionine at residue 35 of the Aβ peptide
50. CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background.
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