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5. Randomized trial of diaspirin cross-linked hemoglobin solution as an alternative to blood transfusion after cardiac surgery. The DCLHb Cardiac Surgery Trial Collaborative Group.

Author

Lamy, Maurice L., Daily, Elaine K., Brichant, Jean-François, Larbuisson, Robert P., Demeyere, Roland H., Vandermeersch, Eugene A., Lehot, Jean-Jacques, Parsloe, Malcolm R., Berridge, John C., Sinclair, Colin J., Baron, Jean-François, Przybelski, Robert J., Lamy, M L, Daily, E K, Brichant, J F, Larbuisson, R P, Demeyere, R H, Vandermeersch, E A, Lehot, J J, and Parsloe, M R

Published
2000

6. The use of midazolam versus propofol for short-term sedation following coronary artery bypass grafting.

Author

Snellen, F., Lauwers, P., Derneyere, R., Byttebier, G., Aken, H., Demeyere, R, and Van Aken, H

Subjects
ARTIFICIAL respiration, COMPARATIVE studies, CORONARY artery bypass, HEMODYNAMICS, INTRAVENOUS therapy, RESEARCH methodology, MEDICAL cooperation, MIDAZOLAM, POSTOPERATIVE pain, RESEARCH, MECHANICAL ventilators, EVALUATION research, RANDOMIZED controlled trials, PHARMACODYNAMICS, PROPOFOL, THERAPEUTICS
Abstract

Midazolam and propofol were compared in an open randomized study for postoperative sedation during 12 h of mechanical ventilation in 40 patients following coronary artery bypass grafting. After an intravenous loading dose of midazolam (50 micrograms.kg-1) or propofol (500 micrograms.kg-1), a titrated continuous infusion was administered of midazolam (mean dose 38.1 micrograms.kg-1.h-1 (SEM 2.6)) or propofol (mean dose 909 micrograms.kg-1.h-1 (SEM 100)) together with a narcotic analgesic infusion. During mechanical ventilation midazolam and propofol produced a similar quality of sedation, but recovery (midazolam 66 min (SEM 16); propofol 24 min (SEM 7)) and weaning from the ventilator (midazolam 243 min (SEM 44); propofol 154 min (SEM 33)) where faster with propofol. In the 2 groups administration of an intravenous loading dose caused a significant decrease in mean arterial pressure but hemodynamic tolerance during maintenance infusion was good. [ABSTRACT FROM AUTHOR]

Published
1990
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