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Unavoidably, the expansion of industry causes the release of numerous heavy metals, radionuclides, and organic pollutants into the environment. Due to these pollutants, the extremely toxic, highly carcinogenic chemicals provide a serious risk to people and aquatic life. Wastewater pollutants must be removed to safeguard the ecology. A huge specific surface area, multiple binding sites, a plethora of functional groups, variable pore size, and simplicity of surface modification are just a few advantages of porous materials. They are considered viable candidate materials for the efficient and selective removal of contaminants from aqueous solutions in a range of difficult circumstances due to their benefits. This work reviews the characteristics, methods of functionalization, and ways of modification of many novel porous materials in recent years. The use of these porous materials in the treatment of wastewater was examined. The development potential of porous materials is finally summed up.

BackgroundPsychiatric diseases are a serious threat to human health. Studies have shown an association between ambient air pollution and psychiatric diseases, yet the results are inconsistent. ObjectiveTo explore the potential effects of air pollution exposure on psychiatric diseases using Zhengzhou City as an example. MethodsOutpatient consultation data of the Clinical Psychology Clinic at The First Affiliated Hospital of Henan University of Traditional Chinese Medicine as well as air quality data between 28 October 2013 and 28 August 2019 were collected. The exposure-lag effect between air pollutant exposure and daily outpatient visits was assessed using a distribution lag nonlinear model (DLNM), and subgroup analyses were conducted including sex (male and female), age (59 years), season (spring, summer, autumn, and winter), and types of diseases (depression and anxiety). ResultsA total of 112986 valid confirmed outpatient visit records for psychiatric diseases were collected. The largest proportions of visits in each subgroup were females, 18-59 years old, spring, and depression. The results of one-day lagged risk of total outpatient visits showed that PM2.5, PM10, SO2, and NO2 all significantly associated with an increased risk of psychiatric outpatient visits. The one-day lagged risk peaks were: PM2.5 (RR=1.0016, 95%CI: 1.0011, 1.0022), PM10 (RR=1.0012, 95%CI: 1.0001, 1.0022), SO2 (RR=1.0060, 95%CI: 1.0002, 1.0117), and NO2 (RR=1.0144, 95%CI: 1.0100, 1.0187). The cumulative lagged risk peaks were: PM2.5 (CumRR=1.0274, 95%CI: 1.0158, 1.0392), PM10 (CumRR=1.0124, 95%CI: 1.0044, 1.0205), SO2 (CumRR=1.0214, 95%CI: 1.0009, 1.0423), and NO2 (CumRR=1.0613, 95%CI: 1.0460, 1.0770). The results of subgroup analysis showed more significant impacts of air pollution exposure on females and people aged 18-59 years, and in winter. To be specific, PM2.5 (RR=1.0022, 95%CI: 1.0006, 1.0037), PM10 (RR=1.0015, 95%CI: 1.0003, 1.0027), SO2 (RR=1.0082, 95%CI: 1.0016, 1.0148), and NO2 (RR=1.0156, 95%CI: 1.0106, 1.0206) exposures associated with an increased risk of outpatient visits for psychiatric disorders in women; PM2.5 (RR=1.0018, 95%CI: 1.0011, 1.0024), PM10 (RR=1.0012, 95%CI: 1.0001, 1.0023), and NO2 (RR=1.0142, 95%CI: 1.0095, 1.0189) associated with an increased risk of visits in those 18-59 years of age; PM2.5 (RR= 1.0043, 95%CI: 1.0001, 1.0085), PM10 (RR= 1.0038, 95%CI: 1.0007, 1.0069), and NO2 (RR= 1.0215, 95%CI: 1.0117, 1.0313) in winter months significantly associated with an increased risk of psychiatric outpatient visits. In addition, the risk of depression and anxiety visits varied depending on the concentration of air pollutants and the duration of exposure. The risk of visits for depression were more affected by CO, NO2, and SO2, and the risk of visits for anxiety were more affected by PM2.5, PM10, and O3. ConclusionExposure to air pollution is associated with an increased risk of psychiatric outpatient visits. The effects vary by air pollutants as well as by sex, age, type of psychiatric illness, and season.

Abstract Due to wavelength‐selective characteristics, the InGaN‐based photodetectors show bright prospects in visible light communication and fast imaging system. However, the application of InGaN photodetectors with simple structures is limited in the above field owing to the slow response speed. Herein, an ultrafast photodetector based on axial InN/InGaN nanorod array (NRA) heterojunction is prepared through a self‐catalytic high (930 °C) and low (400 °C) temperature two‐step growth method by molecular beam epitaxy (MBE). The performance of photodetectors is analyzed by semiconductor device analyzer, wavelength response system (consists with a xenon lamp and monochromator), and time response system (combined by an optical chopper, a laser, and a digital oscilloscope). The photodetectors present a fast response speed with a rise/full time of 18.2/24.7 µs. Further analyses reveal a responsivity of 9.27 A W−1 and a specific detectivity of 3.54 × 1010 Jones under −1 V bias. As a result, the axial NRA heterojunction photodetectors exhibit great potential for application in ultrafast photoelectric conversion systems and provide valuable guidance for realizing ultrafast photodetectors.

Abstract Backgrounds Long non-coding RNA is a novel group of non-protein coding transcripts over 200 nt in length. Recent studies have found that they are widely involved in many pathological and physiological processes. In our previous study, we found that lnc-GULP1–2:1 was significantly down-regulated in the ovarian cortical tissue of patients with primary ovarian insufficiency and predicted that lnc-GULP1–2:1 has a regulatory effect on COL3A1. Results In this study, we found that lnc-GULP1–2:1 was mainly localized in the cytoplasm of luteinized granulosa cells. The expression of lnc-GULP1–2:1 was lower in patients with diminished ovarian reserve but substantially elevated in patients with polycystic ovary syndrome. Overexpression of lnc-GULP1–2:1 in KGN cells significantly inhibited cell proliferation, likely through cell cycle related genes CCND2 and p16. Moreover, lnc-GULP1–2:1 expression was positively correlated with the level of COL3A in luteinized granulosa cells from patients with different ovarian functions as well as in multiple cell lines. Overexpression of lnc-GULP1–2:1 in KGN cells promoted the expression of COL3A1 and its translocation into the nucleus. Consistently, silencing COL3A1 in KGN cells also significantly inhibited cell proliferation. Conclusions Lnc-GULP1–2:1 affects the proliferation of granulosa cells by regulating the expression and localization of COL3A1 protein, and may participate in the regulation of ovarian follicle development. This study will provide new insight into molecular mechanisms underlying ovarian follicular development, which will help generate novel diagnostic and therapeutic strategies for diseases related to ovarian follicular development disorders.

A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is an extracellular matrix metalloproteinase that plays an important role in the process of ovulation. According to previous studies, the expression level of ADAMTS1 in the granulosa cells of polycystic ovarian syndrome (PCOS) patients and the mechanism for regulating oocyte quality and embryonic development potential are still unclear. Our research clarified that ADAMTS1 was significantly increased in granulosa cells of PCOS patients as compared to ovulatory controls. After silencing ADAMTS1 in granulosa cells, cell proliferation and E2 secretion were significantly inhibited, which may be related to the down-regulation of B-cell lymphoma 2 (Bcl2) family genes and key genes involved in E2 synthesis. Through retrospective analysis of the clinical data, it was found that the expression level of ADAMTS1 was significantly positively correlated to the oocyte maturation rate and good-quality embryo rate in PCOS patients. The downregulation of ADAMTS1 in primary granulosa cells lead to the changes in the expression of marker genes for oocyte and embryonic quality. By using immunofluorescence staining, it was found ADAMTS1 was expressed in various stages of pre-implantation embryo but its expression level gradually decreases with the development of the embryo. In addition, the silence of ADAMTS1 in 3PN zygotes significantly prolonged the development time of the zygote to the morula stage. This is, to our knowledge, the first time to explored the mechanism by which ADAMST1 is involved in affecting the quality of oocytes and embryonic development potential, which will provide new evidence for further understanding of the follicular microenvironment and embryo development.

This systematic review and meta-analysis aimed to explore the association between atopic dermatitis (AD) and alopecia areata (AA). A comprehensive search was conducted in PubMed, Embase, Cochrane, and Web of Science from the inception of each database to November 10, 2022 for relevant studies. As there is a potential bilateral association between the 2 diseases, we assessed the prevalence/incidence of AA in patients with AD and the prevalence/incidence of AD in patients with AA. A total of 29 studies involving 11,233,448 participants were included in this analysis. AA was the exposure factor in 23 studies, AD in 7 studies, and both in 1 study. Themeta-analysis revealed that the prevalence of AD was 11.2%(7.7%-15.1%) in patients with AA, and the prevalence of AA was 3.2%(95% confidence interval [CI]: 0.0%-11.5%) in patients with AD. The incidence of AD in AA patients was found to vary with age (P = 0.07). Based on 7 studies, there was a significant association between AD and AA when AA was the exposure factor [odds ratio, OR, = 4.537 (95% CI: 2.409-8.544)]; based on 10 studies, there was also a significant association between AD and AA when AD was the exposure factor [OR = 2.643 (95% CI: 1.737-3.995)]. In conclusion, this meta-analysis demonstrated the 2-way association between AD and AA, providing a clinical reference for disease prevention and control. [ABSTRACT FROM AUTHOR]