Search

Your search keyword '"Dharia, Chhaya"' showing total 7 results
Start Over Author "Dharia, Chhaya" Search Limiters Peer Reviewed
7 results on '"Dharia, Chhaya"'

5. Structural basis of BLyS receptor recognition.

Author

Oren, Deena A., Li, Yuling, Volovik, Yulia, Morris, Tina S., Dharia, Chhaya, Das, Kalyan, Galperina, Olga, Gentz, Reiner, and Arnold, Eddy

Subjects
TUMOR necrosis factors, LYMPHOCYTES, BINDING sites, PROTEOLYTIC enzymes
Abstract

B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 Å resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a β-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity. [ABSTRACT FROM AUTHOR]

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results