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1. Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.

Author

Fodero-Tavoletti MT, Villemagne VL, Paterson BM, White AR, Li QX, Camakaris J, O'Keefe G, Cappai R, Barnham KJ, Donnelly PS, Fodero-Tavoletti, Michelle T, Villemagne, Victor L, Paterson, Brett M, White, Anthony R, Li, Qiao-Xin, Camakaris, James, O'Keefe, Graeme, Cappai, Roberto, Barnham, Kevin J, and Donnelly, Paul S

Abstract

A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden. [ABSTRACT FROM AUTHOR]

Published
2010
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