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Abstract: Global competition leads to a need for a fast time to market and increased resource efficiency. Continuous processing, module‐based plant design, and multipurpose equipment are recently discussed approaches for the fine‐chemical industry. As a representative, the downstream process of amino acid production is discussed herein. A conventional batch procedure was transferred to a continuous process and realized in a modular miniplant, which comprised of evaporation in a wiped‐film evaporator, seeded cooling crystallization in a coiled tubular crystallizer, and solid/liquid separation on a vacuum belt filter. The operations were realized on‐skid with individual automation systems and integrated sensors. L‐Alanine was successfully processed in steady‐state operation. [ABSTRACT FROM AUTHOR]

MAP6 proteins were first described as microtubule-stabilizing agents, whose properties were thought to be essential for neuronal development and maintenance of complex neuronal networks. However, deletion of all MAP6 isoforms in MAP6 KO mice does not lead to dramatic morphological aberrations of the brain but rather to alterations in multiple neurotransmissions and severe behavioural impairments. A search for protein partners of MAP6 proteins identified Tctex1 - a dynein light chain with multiple non-microtubule-related functions. The involvement of Tctex1 in calcium signalling led to investigate it in MAP6 KO neurons. In this study, we show that functional Cav2.2/N-type calcium channels are deficient in MAP6 KO neurons, due to improper location. We also show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Cav2.2/N-type calcium channels. A balance of these two interactions seems to be crucial for MAP6 to modulate calcium signalling in neurons. [ABSTRACT FROM AUTHOR]