41 results on '"FORNARI, CARLA"'
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2. Heterogeneous impact of Sighs on mortality in patients with acute hypoxemic respiratory failure: insights from the PROTECTION study
- Author
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Rezoagli, Emanuele, Fornari, Carla, Fumagalli, Roberto, Grasselli, Giacomo, Volta, Carlo Alberto, Navalesi, Paolo, Knafelj, Rihard, Brochard, Laurent, Pesenti, Antonio, Mauri, Tommaso, and Foti, Giuseppe
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- 2024
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3. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
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Schumacher, Austin E, Kyu, Hmwe Hmwe, Aali, Amirali, Abbafati, Cristiana, Abbas, Jaffar, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abdurehman, Ame Mehadi, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abhilash, E S, Abiodun, Olugbenga Olusola, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abrigo, Michael R M, Abtahi, Dariush, Abu Rumeileh, Samir, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Acuna, Juan Manuel, Adair, Tim, Addo, Isaac Yeboah, Adebayo, Oladimeji M, Adegboye, Oyelola A, Adekanmbi, Victor, Aden, Bashir, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adeyeoluwa, Temitayo Esther, Adeyomoye, Olorunsola Israel, Adha, Rishan, Adibi, Amin, Adikusuma, Wirawan, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afework, Abel, Afolabi, Aanuoluwapo Adeyimika, Afraz, Ali, Afyouni, Shadi, Afzal, Saira, Agasthi, Pradyumna, Aghamiri, Shahin, Agodi, Antonella, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadzade, Amir Mahmoud, Ahmadzade, Mohadese, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Ajumobi, Olufemi, Akalu, Gizachew Taddesse, Akara, Essona Matatom, Akinosoglou, Karolina, Akkala, Sreelatha, Akyirem, Samuel, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Al Homsi, Ammar, Al Qadire, Mohammad, Ala, Moein, Aladelusi, Timothy Olukunle, AL-Ahdal, Tareq Mohammed Ali, Alalalmeh, Samer O, Al-Aly, Ziyad, Alam, Khurshid, Alam, Manjurul, Alam, Zufishan, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Albashtawy, Mohammed, AlBataineh, Mohammad T, Aldridge, Robert W, Alemi, Sharifullah, Al-Eyadhy, Ayman, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhalaiqa, Fadwa Alhalaiqa Naji, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Akhtar, Ali, Beriwan Abdulqadir, Ali, Hassam, Ali, Mohammed Usman, Ali, Rafat, Ali, Syed Shujait Shujait, Ali, Zahid, Alian Samakkhah, Shohreh, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Aligol, Mohammad, Alimi, Rasoul, Aliyi, Ahmednur Adem, Al-Jumaily, Adel, Aljunid, Syed Mohamed, Almahmeed, Wael, Al-Marwani, Sabah, Al-Maweri, Sadeq Ali Ali, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Omar, Alomari, Mahmoud A, Alonso, Nivaldo, Alqahtani, Jaber S, Alqutaibi, Ahmed Yaseen, Al-Sabah, Salman Khalifah, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Alvi, Farrukh Jawad, Alwafi, Hassan, Al-Worafi, Yaser Mohammed, Aly, Hany, Alzoubi, Karem H, Amare, Azmeraw T, Ameyaw, Edward Kwabena, Amhare, Abebe Feyissa, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Aminian Dehkordi, Javad, Amiri, Sohrab, Amu, Hubert, Amugsi, Dickson A, Amzat, 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Behboudi, Emad, Behnoush, Amir Hossein, Beiranvand, Maryam, Bejarano Ramirez, Diana Fernanda, Belgaumi, Uzma Iqbal, Bell, Michelle L, Bello, Aminu K, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bendak, Salaheddine, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Berezvai, Zombor, Berman, Adam E, Bermudez, Amiel Nazer C, Bettencourt, Paulo J G, Beyene, Habtamu B, Beyene, Kebede A, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhalla, Ashish, Bhandari, Dinesh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhardwaj, Prarthna V, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhutta, Zulfiqar A, Bikbov, Boris, Binmadi, Nada, Bintoro, Bagas Suryo, Biondi, Antonio, Bisignano, Catherine, Bisulli, Francesca, Biswas, Atanu, Biswas, Raaj Kishore, Bitaraf, Saeid, Bjørge, Tone, Bleyer, Archie, Boampong, Mary Sefa, Bodolica, Virginia, Bodunrin, Aadam Olalekan, 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R, Cembranel, Francieli, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Cevik, Muge, Chacón-Uscamaita, Pamela R Uscamaita, Chahine, Yaacoub, Chakraborty, Chiranjib, Chan, Jeffrey Shi Kai, Chang, Chin-Kuo, Charalampous, Periklis, Charan, Jaykaran, Chattu, Vijay Kumar, Chatzimavridou-Grigoriadou, Victoria, Chavula, Malizgani Paul, Cheema, Huzaifa Ahmad, Chen, An-Tian, Chen, Haowei, Chen, Lingxiao, Chen, Meng Xuan, Chen, Simiao, Cherbuin, Nicolas, Chew, Derek S, Chi, Gerald, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, So Mi Jemma, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Choudhary, Rahul, Chowdhury, Rajiv, Chu, Dinh-Toi, Chukwu, Isaac Sunday, Chung, Eric, Chung, Eunice, Chung, Sheng-Chia, Cini, Karly I, Clark, Cain C T, Coberly, Kaleb, Columbus, Alyssa, Comfort, Haley, Conde, Joao, Conti, Sara, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G, Criqui, Michael H, Cruz-Martins, Natália, Culbreth, Garland T, Cullen, Patricia, Cunningham, Matthew, da Silva e Silva, Daniel, Dadana, Sriharsha, Dadras, Omid, Dai, Zhaoli, Dalal, Koustuv, Dalli, Lachlan L, Damiani, Giovanni, D'Amico, Emanuele, Daneshvar, Sara, Darwesh, Aso Mohammad, Das, Jai K, Das, Saswati, Dash, Nihar Ranjan, Dashti, Mohsen, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davletov, Kairat, De Leo, Diego, Debele, Aklilu Tamire, Degenhardt, Louisa, Dehbandi, Reza, Deitesfeld, Lee, Delgado-Enciso, Ivan, Delgado-Ortiz, Laura, Demant, Daniel, Demessa, Berecha Hundessa, Demetriades, Andreas K, Deng, Xinlei, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Des Jarlais, Don C, Desai, Hardik Dineshbhai, Desai, Rupak, Deuba, Keshab, Devanbu, Vinoth Gnana Chellaiyan, Dey, Sourav, Dhali, Arkadeep, Dhama, Kuldeep, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Dhingra, Sameer, Dias da Silva, Diana, Diaz, Daniel, Dima, Adriana, Ding, Delaney D, Dirac, M Ashworth, Dixit, Abhinav, Dixit, Shilpi Gupta, Do, Thanh Chi, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Dodangeh, Masoud, Dokova, Klara Georgieva, Dolecek, Christiane, Dorsey, E Ray, dos Santos, Wendel Mombaque, Doshi, Rajkumar, Doshmangir, Leila, Douiri, Abdel, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Haneil Larson, Dube, John, Dumith, Samuel C, Dunachie, Susanna J, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dutta, Sulagna, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, Ebenezer, Oluwakemi, Eboreime, Ejemai, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Ed-Dra, Abdelaziz, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Defi, Efendi, Ferry, Eghdami, Shayan, Eikemo, Terje Andreas, Eini, Ebrahim, Ekholuenetale, Michael, Ekpor, Emmanuel, Ekundayo, Temitope Cyrus, El Arab, Rabie Adel, El Morsi, Doaa Abdel Wahab, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elbarazi, Iffat, Elemam, Noha Mousaad, Elgar, Frank J, Elgendy, Islam Y, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, Elmeligy, Omar Abdelsadek Abdou, Elshaer, Mohammed, Elsohaby, Ibrahim, Emami Zeydi, Amir, Emamverdi, Mehdi, Emeto, Theophilus I, Engelbert Bain, Luchuo, Erkhembayar, Ryenchindorj, Eshetie, Tesfahun C, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Estep, Kara, Etaee, Farshid, Eze, Ugochukwu Anthony, Fabin, Natalia, Fadaka, Adewale Oluwaseun, Fagbamigbe, Adeniyi Francis, Fahimi, Saman, Falzone, Luca, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Farjoud Kouhanjani, Mohsen, Faro, Andre, Farrokhpour, Hossein, Fatehizadeh, Ali, Fattahi, Hamed, Fauk, Nelsensius Klau, Fazeli, Pooria, Feigin, Valery L, Fekadu, Ginenus, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrante, Daniela, Ferrara, Pietro, Ferreira, Nuno, Fetensa, Getahun, Filip, Irina, Fischer, Florian, Flavel, Joanne, Flaxman, Abraham D, Flor, Luisa S, Florin, Bobirca Teodor, Folayan, Morenike Oluwatoyin, Foley, Kristen Marie, Fomenkov, Artem Alekseevich, Force, Lisa M, Fornari, Carla, Foroutan, Behzad, Foschi, Matteo, Francis, Kate Louise, Franklin, Richard Charles, Freitas, Alberto, Friedman, Joseph, Friedman, Sara D, Fukumoto, Takeshi, Fuller, John E, Gaal, Peter Andras, Gadanya, Muktar A, Gaihre, Santosh, Gaipov, Abduzhappar, Gakidou, Emmanuela, Galali, Yaseen, Galehdar, Nasrin, Gallus, Silvano, Gan, Quan, Gandhi, Aravind P, Ganesan, Balasankar, Garg, Jalaj, Gau, Shuo-Yan, Gautam, Prem, Gautam, Rupesh K, Gazzelloni, Federica, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremariam, Tesfay Brhane, Gerema, Urge, Getachew, Motuma Erena, Getachew, Tamirat, Gething, Peter W, Ghafourifard, Mansour, Ghahramani, Sulmaz, Ghailan, Khalid Yaser, Ghajar, Alireza, Ghanbarnia, Mohammad Javad, Ghasemi, MohammadReza, Ghasemzadeh, Afsaneh, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Ghimire, Sailaja, Gholamian, Asadollah, Gholamrezanezhad, Ali, Ghorbani Vajargah, Pooyan, Ghozali, Ghozali, Ghozy, Sherief, Ghuge, Arun Digambarrao, Gialluisi, Alessandro, Gibson, Ruth Margaret, Gil, Artyom Urievich, Gill, Paramjit Singh, Gill, Tiffany K, Gillum, Richard F, Ginindza, Themba G, Girmay, Alem, Glasbey, James C, Gnedovskaya, Elena V, Göbölös, Laszlo, Goel, Amit, Goldust, Mohamad, Golechha, Mahaveer, Goleij, Pouya, Golestanfar, Arefeh, Golinelli, Davide, Gona, Philimon N, Goudarzi, Houman, Goudarzian, Amir Hossein, Goyal, Anmol, Greenhalgh, Scott, Grivna, Michal, Guarducci, Giovanni, Gubari, Mohammed Ibrahim Mohialdeen, Gudeta, Mesay Dechasa, Guha, Avirup, Guicciardi, Stefano, Gunawardane, Damitha Asanga, Gunturu, Sasidhar, Guo, Cui, Gupta, Anish Kumar, Gupta, Bhawna, Gupta, Indarchand Ratanlal, Gupta, Rajat Das, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vijai Kumar, Gupta, Vivek Kumar, Gutiérrez, Reyna Alma, Habibzadeh, Farrokh, Habibzadeh, Parham, Hachinski, Vladimir, Haddadi, Mohammad, Haddadi, Rasool, Haep, Nils, Hajj Ali, Adel, Halboub, Esam S, Halim, Sobia Ahsan, Hall, Brian J, Haller, Sebastian, Halwani, Rabih, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Hamidi, Samer, Hamiduzzaman, Mohammad, Hammoud, Ahmad, Hanifi, Nasrin, Hankey, Graeme J, Hannan, Md Abdul, Haque, Md Nuruzzaman, Harapan, Harapan, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Faizul, Hasan, Ikramul, Hasan, M Tasdik, Hasani, Hamidreza, Hasanian, Mohammad, Hasanpour- Dehkordi, Ali, Hassan, Abbas M, Hassan, Amr, Hassanian-Moghaddam, Hossein, Hassanipour, Soheil, Haubold, Johannes, Havmoeller, Rasmus J, Hay, Simon I, Hbid, Youssef, Hebert, Jeffrey J, Hegazi, Omar E, Heidari, Golnaz, Heidari, Mohammad, Heidari-Foroozan, Mahsa, Heidari-Soureshjani, Reza, Helfer, Bartosz, Herteliu, Claudiu, Hesami, Hamed, Hettiarachchi, Dineshani, Heyi, Demisu Zenbaba, Hezam, Kamal, Hiraike, Yuta, Hoffman, Howard J, Holla, Ramesh, Horita, Nobuyuki, Hossain, Md Belal, Hossain, Md Mahbub, Hossain, Sahadat, Hosseini, Mohammad-Salar, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hsairi, Mohamed, Hsieh, Vivian Chia-rong, Hu, Chengxi, Huang, Junjie, Huda, Md Nazmul, Hugo, Fernando N, Hultström, Michael, Hussain, Javid, Hussain, Salman, Hussein, Nawfal R, Huy, Le Duc, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Idowu, Oluwatope Olaniyi, Ijo, Desta, Ikuta, Kevin S, Ilaghi, Mehran, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Inbaraj, Leeberk Raja, Iradukunda, Arnaud, Iravanpour, Farideh, Iregbu, Kenneth Chukwuemeka, Islam, Md Rabiul, Islam, Mohammad Mainul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Ismail, Nahlah Elkudssiah, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iwu-Jaja, Chinwe Juliana, Iyer, Mahalaxmi, J, Linda Merin, Jaafari, Jalil, Jacob, Louis, Jacobsen, Kathryn H, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jaggi, Khushleen, Jahankhani, Kasra, Jahanmehr, Nader, Jahrami, Haitham, Jain, Akhil, Jain, Nityanand, Jairoun, Ammar Abdulrahman, Jakovljevic, Mihajlo, Jalilzadeh Yengejeh, Reza, Jamshidi, Elham, Jani, Chinmay T, Janko, Mark M, Jatau, Abubakar Ibrahim, Jayapal, Sathish Kumar, Jayaram, Shubha, Jeganathan, Jayakumar, Jema, Alelign Tasew, Jemere, Digisie Mequanint, Jeong, Wonjeong, Jha, Anil K, Jha, Ravi Prakash, Ji, John S, Jiang, Heng, Jin, Yingzhao, Jin, Yinzi, Johnson, Olatunji, Jomehzadeh, Nabi, Jones, Darwin Phan, Joo, Tamas, Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kaambwa, Billingsley, Kabir, Ali, Kabir, Hannaneh, Kabir, Zubair, Kadashetti, Vidya, Kahe, Farima, Kakodkar, Pradnya Vishal, Kalani, Rizwan, Kalankesh, Leila R, Kaliyadan, Feroze, Kalra, Sanjay, Kamath, Ashwin, Kamireddy, Arun, Kanagasabai, Thanigaivelan, Kandel, Himal, Kanmiki, Edmund Wedam, Kanmodi, Kehinde Kazeem, Kantar, Rami S, Kapoor, Neeti, Karajizadeh, Mehrdad, Karami Matin, Behzad, Karanth, Shama D, Karaye, Ibraheem M, Karim, Asima, Karimi, Hanie, Karimi, Salah Eddin, Karimi Behnagh, Arman, Karkhah, Samad, Karna, Ajit K, Kashoo, Faizan Zaffar, Kasraei, Hengameh, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Kassel, Molly B, Katamreddy, Adarsh, Katikireddi, Srinivasa Vittal, Katoto, Patrick DMC, Kauppila, Joonas H, Kaur, Navjot, Kaydi, Neda, Kayibanda, Jeanne Françoise, Kayode, Gbenga A, Kazemi, Foad, Kazemian, Sina, Kazeminia, sara, Keikavoosi-Arani, Leila, Keller, Cathleen, Kempen, John H, Kerr, Jessica A, Kesse-Guyot, Emmanuelle, Keykhaei, Mohammad, Khadembashiri, Mohamad Mehdi, Khadembashiri, Mohammad Amin, Khafaie, Morteza Abdullatif, Khajuria, Himanshu, Khalafi, Mohammad, Khalaji, Amirmohammad, Khalid, Nauman, Khalil, Ibrahim A, Khamesipour, Faham, Khan, Asaduzzaman, Khan, Gulfaraz, Khan, Ikramullah, Khan, Imteyaz A, Khan, Maseer, Khan, Moien AB, Khan, Taimoor, Khan suheb, Mahammed Ziauddin, Khanmohammadi, Shaghayegh, Khatab, Khaled, Khatami, Fatemeh, Khavandegar, Armin, Khayat Kashani, Hamid Reza, Kheirallah, Khalid A, Khidri, Feriha Fatima, Khodadoust, Elaheh, Khormali, Moein, Khosrowjerdi, Mahmood, Khubchandani, Jagdish, Khusun, Helda, Kifle, Zemene Demelash, Kim, Grace, Kim, Jihee, Kimokoti, Ruth W, Kinzel, Kasey E, Kiross, Girmay Tsegay, Kisa, Adnan, Kisa, Sezer, Kiss, Juniper Boroka, Kivimäki, Mika, Klu, Desmond, Knudsen, Ann Kristin Skrindo, Kolahi, Ali-Asghar, Kompani, Farzad, Koren, Gerbrand, Kosen, Soewarta, Kostev, Karel, Kotnis, Ashwin Laxmikant, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krishna, Hare, Krishnamoorthy, Vijay, Krishnamoorthy, Yuvaraj, Krohn, Kris J, Kuate Defo, Barthelemy, Kubeisy, Connor M, Kucuk Bicer, Burcu, Kuddus, Md Abdul, Kuddus, Mohammed, Kuitunen, Ilari, Kujan, Omar, Kulimbet, Mukhtar, Kulkarni, Vishnutheertha, Kumar, Ashish, Kumar, Harish, Kumar, Nithin, Kumar, Rahul, Kumar, Shiv, Kumari, Madhulata, Kurmanova, Almagul, Kurmi, Om P, Kusnali, Asep, Kusuma, Dian, Kutluk, Tezer, Kuttikkattu, Ambily, Kyei, Evans F, Kyriopoulos, Ilias, La Vecchia, Carlo, Ladan, Muhammad Awwal, Laflamme, Lucie, Lahariya, Chandrakant, Lahmar, Abdelilah, Lai, Daphne Teck Ching, Laksono, Tri, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lám, Judit, Lamnisos, Demetris, Lan, Tuo, Lanfranchi, Francesco, Langguth, Berthold, Lansingh, Van Charles, Laplante-Lévesque, Ariane, Larijani, Bagher, Larsson, Anders O, Lasrado, Savita, Latief, Kamaluddin, Latif, Mahrukh, Latifinaibin, Kaveh, Lauriola, Paolo, Le, Long Khanh Dao, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Le, Trang Diep Thanh, Lee, Munjae, Lee, Paul H, Lee, Sang-woong, Lee, Seung Won, Lee, Wei-Chen, Lee, Yo Han, Legesse, Samson Mideksa, Leigh, James, Lenzi, Jacopo, Leong, Elvynna, Lerango, Temesgen L, Li, Ming-Chieh, Li, Wei, Li, Xiaopan, Li, Yichong, Li, Zhihui, Libra, Massimo, Ligade, Virendra S, Likaka, Andrew Tiyamike Makhiringa, Lim, Lee-Ling, Lin, Ro-Ting, Lin, Shuzhi, Lioutas, Vasileios-Arsenios, Listl, Stefan, Liu, Jue, Liu, Simin, Liu, Xiaofeng, Livingstone, Katherine M, Llanaj, Erand, Lo, Chun-Han, Loreche, Arianna Maever, Lorenzovici, László, Lotfi, Mojgan, Lotfizadeh, Masoud, Lozano, Rafael, Lubinda, Jailos, Lucchetti, Giancarlo, 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Lin, Yano, Yuichiro, Yao, Yao, Ye, Pengpeng, Yesera, Gesila Endashaw, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zahedi, Mohammad, Zahid, Muhammad Nauman, Zahir, Mazyar, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Burhan Abdullah, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zandi, Milad, Zandieh, Ghazal G Z, Zanghì, Aurora, Zare, Iman, Zastrozhin, Mikhail Sergeevich, Zeariya, Mohammed G M, Zeng, Youjie, Zhai, Chunxia, Zhang, Chen, Zhang, Haijun, Zhang, Hongwei, Zhang, Yunquan, Zhang, Zhaofeng, Zhang, Zhenyu, Zhao, Hanqing, Zhao, Yang, Zhao, Yong, Zheng, Peng, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Zhaohua, Ziaeefar, Pardis, Zielińska, Magdalena, Zou, Zhiyong, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Lim, Stephen S, and Murray, Christopher J L
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- 2024
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4. A Cross-Indication Budget Impact Model of Secukinumab for the Treatment of Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis in Italy
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Cortesi, Paolo Angelo, Fornari, Carla, Gisondi, Paolo, Iannone, Florenzo, Antonazzo, Ippazio Cosimo, Aloisi, Elisabetta, Fiocchi, Martina, Ritrovato, Daniela, and Mantovani, Lorenzo Giovanni
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- 2023
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5. Clinical risk factors for increased respiratory drive in intubated hypoxemic patients
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Spinelli, Elena, Pesenti, Antonio, Slobod, Douglas, Fornari, Carla, Fumagalli, Roberto, Grasselli, Giacomo, Volta, Carlo Alberto, Foti, Giuseppe, Navalesi, Paolo, Knafelj, Rihard, Pelosi, Paolo, Mancebo, Jordi, Brochard, Laurent, and Mauri, Tommaso
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- 2023
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6. Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019
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Cortesi, Paolo Angelo, Fornari, Carla, Conti, Sara, Antonazzo, Ippazio Cosimo, Ferrara, Pietro, Ahmed, Ayman, Andrei, Catalina Liliana, Andrei, Tudorel, Artamonov, Anton A, Banach, Maciej, Baravelli, Carl Michael, Bärnighausen, Till Winfried, Bhagavathula, Akshaya Srikanth, Briko, Nikolay Ivanovich, Calina, Daniela, Carreras, Giulia, Chung, Sheng-Chia, Dianatinasab, Mostafa, Dubljanin, Eleonora, Durojaiye, Oyewole Christopher, Ezeonwumelu, Ifeanyi Jude, Fagbamigbe, Adeniyi Francis, Fischer, Florian, Gallus, Silvano, Glushkova, Ekaterina Vladimirovna, Golinelli, Davide, Gorini, Giuseppe, Hassan, Shoaib, Hay, Simon I, Hostiuc, Mihaela, Ilic, Irena M, Ilic, Milena D, Jakovljevic, Mihajlo, Jamshidi, Elham, Jozwiak, Jacek Jerzy, Kabir, Zubair, Kauppila, Joonas H, Khalilov, Rovshan, Khan, Moien AB, Khatab, Khaled, Koyanagi, Ai, La Vecchia, Carlo, Lazarus, Jeffrey V, Ledda, Caterina, Levi, Miriam, Lopukhov, Platon D, Loureiro, Joana A, Matthews, Philippa C, Mentis, Alexios-Fotios A, Mestrovic, Tomislav, Moazen, Babak, Mohammed, Shafiu, Monasta, Lorenzo, Mulita, Francesk, Murray, Christopher J L, Negoi, Ionut, Oancea, Bogdan, Palladino, Claudia, Patel, Jay, Petcu, Ionela-Roxana, Postma, Maarten J, Rawaf, David Laith, Rawaf, Salman, Romero-Rodríguez, Esperanza, Santric-Milicevic, Milena M, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Tabarés-Seisdedos, Rafael, Tampa, Mircea, Taveira, Nuno, Thiyagarajan, Arulmani, Tovani-Palone, Marcos Roberto, Westerman, Ronny, Zastrozhin, Mikhail Sergeevich, Mazzaglia, Giampiero, and Mantovani, Lorenzo Giovanni
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- 2023
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7. Azithromycin use and outcomes in patients with COVID-19: an observational real-world study
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Antonazzo, Ippazio Cosimo, Fornari, Carla, Rozza, Davide, Conti, Sara, di Pasquale, Raffaella, Cortesi, Paolo, Kaleci, Shaniko, Ferrara, Pietro, Zucchi, Alberto, Maifredi, Giovanni, Silenzi, Andrea, Cesana, Giancarlo, Mantovani, Lorenzo Giovanni, and Mazzaglia, Giampiero
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- 2022
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8. Multiple Sclerosis Progressive Courses: A Clinical Cohort Long-Term Disability Progression Study
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Cortesi, Paolo A., Fornari, Carla, Capra, Ruggero, Cozzolino, Paolo, Patti, Francesco, and Mantovani, Lorenzo G.
- Published
- 2022
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9. Italy's health performance, 1990–2017: findings from the Global Burden of Disease Study 2017
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Monasta, Lorenzo, Abbafati, Cristiana, Logroscino, Giancarlo, Remuzzi, Giuseppe, Perico, Norberto, Bikbov, Boris, Tamburlini, Giorgio, Beghi, Ettore, Traini, Eugenio, Redford, Sofia Boston, Ariani, Filippo, Borzì, Antonio M, Bosetti, Cristina, Carreras, Giulia, Caso, Valeria, Castelpietra, Giulio, Cirillo, Massimo, Conti, Sara, Cortesi, Paolo Angelo, Damiani, Giovanni, D'Angiolella, Lucia Sara, Fanzo, Jessica, Fornari, Carla, Gallus, Silvano, Giussani, Giorgia, Gorini, Giuseppe, Grosso, Giuseppe, Guido, Davide, La Vecchia, Carlo, Lauriola, Paolo, Leonardi, Matilde, Levi, Miriam, Madotto, Fabiana, Mondello, Stefania, Naldi, Luigi, Olgiati, Stefano, Palladino, Raffaele, Piccinelli, Cristiano, Piccininni, Marco, Pupillo, Elisabetta, Raggi, Alberto, Rubino, Salvatore, Santalucia, Paola, Vacante, Marco, Vidale, Simone, Violante, Francesco S, Naghavi, Mohsen, and Ronfani, Luca
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- 2019
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10. Time-Trends in Air Pollution Impact on Health in Italy, 1990-2019: An Analysis From the Global Burden of Disease Study 2019.
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Conti, Sara, Fornari, Carla, Ferrara, Pietro, Antonazzo, Ippazio C., Madotto, Fabiana, Traini, Eugenio, Levi, Miriam, Cernigliaro, Achille, Armocida, Benedetta, Bragazzi, Nicola L., Cadum, Ennio, Carugno, Michele, Crotti, Giacomo, Deandrea, Silvia, Cortesi, Paolo A., Guido, Davide, Iavicoli, Ivo, Iavicoli, Sergio, La Vecchia, Carlo, and Lauriola, Paolo
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GLOBAL burden of disease ,AIR pollution ,PARTICULATE matter ,EPISTEMIC uncertainty ,AIR quality - Abstract
Objectives: We explored temporal variations In disease burden of ambient particulate matter 2.5 pm or less in diameter (PM
2.5 ) and ozone in Italy using estimates from the Global Burden of Disease Study 2019. Methods: We compared temporal changes and percent variations (95% Uncertainty Intervals [95% UI]) in rates of disability adjusted life years (DALYs), years of life lost, years lived with disability and mortality from 1990 to 2019, and variations in pollutant-attributable burden with those in the overall burden of each PM2.5 - and ozone-related disease. Results: In 2019, 467,000 DALYs (95% UI: 371,000, 570,000) were attributable to PM2.5 and 39,600 (95% UI: 18,300, 61,500) to ozone. The crude DALY rate attributable to PM2.5 decreased by 47.9% (95% UI: 10.3, 65.4) from 1990 to 2019. For ozone, it declined by 37.0% (95% UI: 28.9, 44.5) during 1990-2010, but it increased by 44.8% (95% UI: 35.5, 56.3) during 2010-2019. Age-standardized rates declined more than crude ones. Conclusion: In Italy, the burden of ambient PM2.5 (but not of ozone) significantly decreased, even in concurrence with population ageing. Results suggest a positive impact of air quality regulations, fostering further regulatory efforts. [ABSTRACT FROM AUTHOR]- Published
- 2024
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11. Transthoracic impedance variability to assess quality of chest compression in out‐of‐hospital cardiac arrest.
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Magliocca, Aurora, Castagna, Valentina, Fornari, Carla, Zimei, Gabriele, Merigo, Giulia, Penna, Alessio, Carlson, Jonas, Fumagalli, Francesca, Stirparo, Giuseppe, Migliari, Maurizio, Coppo, Anna, Sechi, Giuseppe Maria, Grasselli, Giacomo, Hardig, Bjarne Madsen, and Ristagno, Giuseppe
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CHEST compressions ,CARDIAC arrest ,RETURN of spontaneous circulation ,ODDS ratio - Abstract
Background: Chest compression is a lifesaving intervention in out‐of‐hospital cardiac arrest (OHCA), but the optimal metrics to assess its quality have yet to be identified. The objective of this study was to investigate whether a new parameter, that is, the variability of the chest compression‐generated transthoracic impedance (TTI), namely ImpCC, which measures the consistency of the chest compression maneuver, relates to resuscitation outcome. Methods: This multicenter observational, retrospective study included OHCAs with shockable rhythm. ImpCC variability was evaluated with the power spectral density analysis of the TTI. Multivariate regression model was used to examine the impact of ImpCC variability on defibrillation success. Secondary outcome measures were return of spontaneous circulation and survival. Results: Among 835 treated OHCAs, 680 met inclusion criteria and 565 matched long‐term outcomes. ImpCC was significantly higher in patients with unsuccessful defibrillation compared to those with successful defibrillation (p =.0002). Lower ImpCC variability was associated with successful defibrillation with an odds ratio (OR) of 0.993 (95% confidence interval [95% CI], 0.989–0.998, p =.003), while the standard chest compression fraction (CCF) was not associated (OR 1.008 [95 % CI, 0.992–1.026, p =.33]). Neither ImpCC nor CCF was associated with long‐term outcomes. Conclusions: In this population, consistency of chest compression maneuver, measured by variability in TTI, was an independent predictor of defibrillation outcome. ImpCC may be a useful novel metrics for improving quality of care in OHCA. [ABSTRACT FROM AUTHOR]
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- 2024
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12. The value‐based healthcare approach to haemophilia: Development of outcome measures for the evaluation of care of people with haemophilia.
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Cortesi, Paolo Angelo, Fornari, Carla, Conti, Sara, Pollio, Berardino, Boccalandro, Elena, Buzzi, Andrea, Carulli, Christian, Coppola, Antonio, De Cristofaro, Raimondo, Di Minno, Matteo Nicola Dario, Dolan, Gerard, Ferri Grazzi, Enrico, Fornari, Arianna, Gualtierotti, Roberta, Hermans, Cedric, Jiménez‐Juste, Victor, Kenet, Gili, Lupi, Angelo, Martinoli, Carlo, and Mansueto, Maria Francesca
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VALUE-based healthcare , *HEMOPHILIA , *HEMOPHILIA treatment , *CARE of people , *PATIENT reported outcome measures - Abstract
Introduction: Considering the advances in haemophilia management and treatment observed in the last decades, a new set of value‐based outcome indicators is needed to assess the quality of care and the impact of these medical innovations. Aim: The Value‐Based Healthcare in Haemophilia project aimed to define a set of clinical outcome indicators (COIs) and patient‐reported outcome indicators (PROIs) to assess quality of care in haemophilia in high‐income countries with a value‐based approach to inform and guide the decision‐making process. Methods: A Value‐based healthcare approach based on the available literature, current guidelines and the involvement of a multidisciplinary group of experts was applied to generate a set of indicators to assess the quality of care of haemophilia. Results: A final list of three COIs and five PROIs was created and validated. The identified COIs focus on two domains: musculoskeletal health and function, and safety. The identified PROIs cover five domains: bleeding frequency, pain, mobility and physical activities, Health‐Related Quality of Life and satisfaction. Finally, two composite outcomes, one based on COIs, and one based on PROIs, were proposed as synthetic outcome indicators of quality of care. Conclusion: The presented standard set of health outcome indicators provides the basis for harmonised longitudinal and cross‐sectional monitoring and comparison. The implementation of this value‐based approach would enable a more robust assessment of quality of care in haemophilia, within a framework of continuous treatment improvements with potential added value for patients. Moreover, proposed COIs and PROIs should be reviewed and updated routinely. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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13. Treatment patterns in essential tremor: Real‐world evidence from a United Kingdom and France primary care database.
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Antonazzo, Ippazio Cosimo, Rozza, Davide, Conti, Sara, Fornari, Carla, Cortesi, Paolo Angelo, Eteve‐Pitsaer, Caroline, Paris, Claire, Gantzer, Laurène, Valentine, Dennis, Mantovani, Lorenzo Giovanni, and Mazzaglia, Giampiero
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TREMOR ,DATABASES ,ESSENTIAL tremor ,PRIMARY care ,DRUG therapy ,DEMOGRAPHIC characteristics ,LOGISTIC regression analysis - Abstract
Background and purpose: Essential tremor (ET) is one of the most common neurological disorders, but information on treatment pattern is still scant. The aim of this study was to describe the demographic and clinical characteristics, treatment patterns, and determinants of drug use in patients with newly diagnosed ET in France and the United Kingdom. Methods: Incident cases of ET diagnosed between January 1, 2015 and December 31, 2018 with 2 years of follow‐up were identified by using The Health Improvement Network (THIN®) general practice database. During the follow‐up, we assessed the daily prevalence of use and potential switches from first‐line to second‐line treatment or other lines of treatment. Logistic regression models were conducted to assess the effect of demographic and clinical characteristics on the likelihood of receiving ET treatment. Results: A total of 2957 and 3249 patients were selected in the United Kingdom and France, respectively. Among ET patients, drug use increased from 12 months to 1 month prior the date of index diagnosis (ID). After ID, nearly 40% of patients received at least one ET treatment, but during follow‐up drug use decreased and at the end of the follow‐up approximately 20% of patients were still on treatment. Among treated patients, ≤10% maintained the same treatment throughout the entire follow‐up, nearly 20% switched, and 40%–75% interrupted any treatment. Results from the multivariate analysis revealed that, both in France and the United Kingdom, patients receiving multiple concomitant therapies and affected by psychiatric conditions were more likely to receive an ET medication. Conclusion: This study shows that ET is an undertreated disease with a lower‐than‐expected number of patients receiving and maintaining pharmacological treatment. Misclassification of ET diagnosis should be acknowledged; thus, results require cautious interpretation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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14. Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial
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Mauri, Tommaso, Foti, Giuseppe, Fornari, Carla, Constantin, Jean-Michel, Guerin, Claude, Pelosi, Paolo, Ranieri, Marco, Conti, Sara, Tubiolo, Daniela, Rondelli, Egle, Lovisari, Federica, Fossali, Tommaso, Spadaro, Savino, Grieco, Domenico Luca, Navalesi, Paolo, Calamai, Italo, Becher, Tobias, Roca, Oriol, Wang, Yu-Mei, Knafelj, Rihard, Cortegiani, Andrea, Mancebo, Jordi, Brochard, Laurent, Pesenti, Antonio, and for the Protection Study Group
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- 2018
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15. The effect of revascularization procedures on myocardial infarction incidence rates and time trends: The MONICA-Brianza and CAMUNI MI registries in Northern Italy
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Veronesi, Giovanni, Ferrario, Marco M., Chambless, Lloyd E., Borsani, Andrea, Fornari, Carla, and Cesana, Giancarlo
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- 2012
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16. The contribution of major risk factors and job strain to occupational class differences in coronary heart disease incidence: the MONICA Brianza and PAMELA population-based cohorts
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Ferrario, Marco M, Veronesi, Giovanni, Chambless, Lloyd E, Sega, Roberto, Fornari, Carla, Bonzini, Matteo, and Cesana, Giancarlo
- Published
- 2011
17. Using real-world healthcare data for pharmacovigilance signal detection – the experience of the EU-ADR project
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Patadia, Vaishali K, Coloma, Preciosa, Schuemie, Martijn J, Herings, Ron, Gini, Rosa, Mazzaglia, Giampiero, Picelli, Gino, Fornari, Carla, Pedersen, Lars, van der Lei, Johan, Sturkenboom, Miriam, and Trifirò, Gianluca
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- 2015
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18. Cardiorespiratory treatments as modifiers of the relationship between particulate matter and health: A case-only analysis on hospitalized patients in Italy
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Conti, Sara, Lafranconi, Alessandra, Zanobetti, Antonella, Fornari, Carla, Madotto, Fabiana, Schwartz, Joel, and Cesana, Giancarlo
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- 2015
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19. Statins Use in Patients with Cardiovascular Diseases and COVID-19 Outcomes: An Italian Population-Based Cohort Study.
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Antonazzo, Ippazio Cosimo, Fornari, Carla, Rozza, Davide, Conti, Sara, Di Pasquale, Raffaella, Cortesi, Paolo Angelo, Kaleci, Shaniko, Ferrara, Pietro, Zucchi, Alberto, Maifredi, Giovanni, Silenzi, Andrea, Cesana, Giancarlo, Mantovani, Lorenzo Giovanni, and Mazzaglia, Giampiero
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COVID-19 , *COHORT analysis , *INTENSIVE care units , *CARDIOVASCULAR diseases , *STATINS (Cardiovascular agents) , *ARTIFICIAL respiration - Abstract
Background: The role of statins among patients with established cardiovascular diseases (CVDs) who are hospitalized with COVID-19 is still debated. This study aimed at assessing whether the prior use of statins was associated with a less severe COVID-19 prognosis. Methods: Subjects with CVDs infected with SARS-CoV-2 and hospitalized between 20 February 2020 and 31 December 2020 were selected. These were classified into two mutually exclusive groups: statins-users and non-users of lipid-lowering therapies (non-LLT users). The relationship between statins exposure and the risk of Mechanical Ventilation (MV), Intensive Care Unit (ICU) access and death were evaluated by using logistic and Cox regressions models. Results: Of 1127 selected patients, 571 were statins-users whereas 556 were non-LLT users. The previous use of statins was not associated with a variation in the risk of need of MV (Odds Ratio [OR]: 1.00; 95% Confidence Intervals [CI]: 0.38–2.67), ICU access (OR: 0.54; 95% CI: 0.22–1.32) and mortality at 14 days (Hazard Ratio [HR]: 0.42; 95% CI: 0.16–1.10). However, a decreased risk of mortality at 30 days (HR: 0.39; 95% CI: 0.18–0.85) was observed in statins-users compared with non-LLT users. Conclusions: These findings support the clinical advice for patients CVDs to continue their treatment with statins during SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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20. Time trends in the incidence of essential tremor: Evidences from UK and France primary care data.
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Antonazzo, Ippazio Cosimo, Conti, Sara, Rozza, Davide, Fornari, Carla, Eteve-Pitsaer, Caroline, Paris, Claire, Gantzer, Laurène, Valentine, Dennis, Mantovani, Lorenzo Giovanni, and Mazzaglia, Giampiero
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PRIMARY care ,MOVEMENT disorders ,ESSENTIAL tremor ,REGRESSION analysis ,PREVENTIVE medicine ,HEALTH care networks - Abstract
Introduction: Although essential tremor (ET) is considered a common adult movement disorder, evidence on its incidence is still scant. This study aims at estimating ET incidence in two European countries, namely, the UK and France. Methods: Incident cases of ET were identified within the Health Improvement Network (THIN®) database between 1st January 2014 and 31 December 2019. Yearly crude and standardized incidence rates (IR) were estimated across the study period for both countries. Poisson regressionmodels were built to assess temporal trends in IRs and differences between sexes and age classes. Results: In total, 4,970 and 4,905 incident cases of ET were identified in the UK and France, respectively. The yearly average crude IR (per 100,000 person- years) was 18.20 (95%CI: 15.09-21.32) in UK and 21.42 (17.83-25.00) in France, whereas standardized ones were 19.51 (18.97-20.01) and 19.50 (18.97-20.05). Regression analyses showed slightly increasing trends in both countries, higher incidence among males, and a significant increase with age. Yearly average IR increased from 3.96 (0.95-6.97) and 5.28 (1.12-9.44) in subjects aged <20 years to 49.27 (26.29-72.24) and 51.52 (30.19-72.86) in those aged >80 year in UK and France. Conclusions: Standardized ET incidence was comparable in the UK and France, showing a slight increase in both countries, reporting a higher value among people aged 60 years and older. This study outlines the need to conduct future studies to estimate the burden of ET in terms of disease control and healthcare resource utilization. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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21. Persistence with oral and transdermal hormone replacement therapy and hospitalisation for cardiovascular outcomes
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Corrao, Giovanni, Zambon, Antonella, Nicotra, Federica, Fornari, Carla, La Vecchia, Carlo, Mezzanzanica, Mario, Nappi, Rossella E., Merlino, Luca, and Cesana, Giancarlo
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- 2007
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22. Harmonization process for the identification of medical events in eight European healthcare databases: the experience from the EU-ADR project
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Avillach, Paul, Coloma, Preciosa M, Gini, Rosa, Schuemie, Martijn, Mougin, Fleur, Dufour, Jean-Charles, Mazzaglia, Giampiero, Giaquinto, Carlo, Fornari, Carla, Herings, Ron, Molokhia, Mariam, Pedersen, Lars, Fourrier-Réglat, Annie, Fieschi, Marius, Sturkenboom, Miriam, van der Lei, Johan, Pariente, Antoine, and Trifirò, Gianluca
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- 2013
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23. Gender differences in the association between education and the incidence of cardiovascular events in Northern Italy
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Veronesi, Giovanni, Ferrario, Marco M., Chambless, Lloyd E., Sega, Roberto, Mancia, Giuseppe, Corrao, Giovanni, Fornari, Carla, and Cesana, Giancarlo
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- 2011
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24. COVID-19 Outbreak Impact on Anticoagulants Utilization: An Interrupted Time-Series Analysis Using Health Care Administrative Databases.
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Antonazzo, Ippazio Cosimo, Fornari, Carla, Paoletti, Olga, Bartolini, Claudia, Conti, Sara, Cortesi, Paolo Angelo, Mantovani, Lorenzo Giovanni, Gini, Rosa, and Mazzaglia, Giampiero
- Published
- 2021
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25. Social status and cardiovascular disease: a Mediterranean case. Results from the Italian Progetto CUORE cohort study
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Pilotto Lorenza, Ferrario Marco M, Vanuzzo Diego, Panico Salvatore, Palmieri Luigi, Riva Michele A, Donfrancesco Chiara, Fornari Carla, Giampaoli Simona, and Cesana Giancarlo
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Social factors could offer useful information for planning prevention strategy for cardiovascular diseases. This analysis aims to explore the relationship between education, marital status and major cardiovascular risk factors and to evaluate the role of social status indicators in predicting cardiovascular events and deaths in several Italian cohorts. Methods The population is representative of Italy, where the incidence of the disease is low. Data from the Progetto CUORE, a prospective study of cohorts enrolled between 1983-1997, were used; 7520 men and 13127 women aged 35-69 years free of previous cardiovascular events and followed for an average of 11 years. Educational level and marital status were used as the main indicators of social status. Results About 70% of the studied population had a low or medium level of education (less than high school) and more than 80% was married or cohabitating. There was an inverse relationship between educational level and major cardiovascular risk factors in both genders. Significantly higher major cardiovascular risk factors were detected in married or cohabitating women, with the exception of smoking. Cardiovascular risk score was lower in married or cohabitating men. No relationship between incidence of cardiac events and the two social status indicators was observed. Cardiovascular case-fatality was significantly higher in men who were not married and not cohabitating (HR 3.20, 95%CI: 2.21-4.64). The higher cardiovascular risk observed in those with a low level of education deserves careful attention even if during the follow-up it did not seem to determine an increase of cardiac events. Conclusions Preventive interventions on cardiovascular risk should be addressed mostly to people with less education. Cardiovascular risk score and case-fatality resulted higher in men living alone while cardiovascular factors were higher in women married or cohabitating. Such gender differences seem peculiar of our population and require further research on unexpected cultural and behavioural influences.
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- 2010
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26. Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS: The PROTECTION Pilot Randomized Clinical Trial.
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Mauri, Tommaso, Foti, Giuseppe, Fornari, Carla, Grasselli, Giacomo, Pinciroli, Riccardo, Lovisari, Federica, Tubiolo, Daniela, Volta, Carlo Alberto, Spadaro, Savino, Rona, Roberto, Rondelli, Egle, Navalesi, Paolo, Garofalo, Eugenio, Knafelj, Rihard, Gorjup, Vojka, Colombo, Riccardo, Cortegiani, Andrea, Zhou, Jian-Xin, D'Andrea, Rocco, and Calamai, Italo
- Subjects
ADULT respiratory distress syndrome ,CLINICAL trials ,POSITIVE end-expiratory pressure - Abstract
Background: Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant.Research Question: Is the clinical application of sigh during pressure support ventilation (PSV) feasible?Study Design and Methods: We conducted a multicenter noninferiority randomized clinical trial on adult intubated patients with acute hypoxemic respiratory failure or ARDS undergoing PSV. Patients were randomized to the no-sigh group and treated by PSV alone, or to the sigh group, treated by PSV plus sigh (increase in airway pressure to 30 cm H2O for 3 s once per minute) until day 28 or death or successful spontaneous breathing trial. The primary end point of the study was feasibility, assessed as noninferiority (5% tolerance) in the proportion of patients failing assisted ventilation. Secondary outcomes included safety, physiologic parameters in the first week from randomization, 28-day mortality, and ventilator-free days.Results: Two-hundred and fifty-eight patients (31% women; median age, 65 [54-75] years) were enrolled. In the sigh group, 23% of patients failed to remain on assisted ventilation vs 30% in the no-sigh group (absolute difference, -7%; 95% CI, -18% to 4%; P = .015 for noninferiority). Adverse events occurred in 12% vs 13% in the sigh vs no-sigh group (P = .852). Oxygenation was improved whereas tidal volume, respiratory rate, and corrected minute ventilation were lower over the first 7 days from randomization in the sigh vs no-sigh group. There was no significant difference in terms of mortality (16% vs 21%; P = .337) and ventilator-free days (22 [7-26] vs 22 [3-25] days; P = .300) for the sigh vs no-sigh group.Interpretation: Among hypoxemic intubated ICU patients, application of sigh was feasible and without increased risk.Trial Registry: ClinicalTrials.gov; No.: NCT03201263; URL: www.clinicaltrials.gov. [ABSTRACT FROM AUTHOR]- Published
- 2021
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27. Management of pregnancy blood pressure increase in the emergency room: role of PlGF-based biochemical markers and relative economic impact.
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Giardini, Valentina, Allievi, Sara, Fornari, Carla, Rovelli, Roberta, Cesana, Giancarlo, Lafranconi, Alessandra, and Vergani, Patrizia
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BLOOD pressure ,BIOMARKERS ,ECONOMIC impact ,HOSPITAL emergency services ,FETAL growth retardation ,PREECLAMPSIA ,PREECLAMPSIA diagnosis ,RETROSPECTIVE studies ,PLACENTA - Abstract
Introduction: To evaluate the clinical and economic impact of healthcare management of pregnant women with blood pressure increase (BPI) accessing emergency room (ER) and the utility of the introduction of a PlGF-based test in clinical practice.Materials and Methods: This retrospective cohort study included women with single pregnancies who performed at least 1 ER access for BPI after the 20th gestational week in 2016. BPI was subsequently classified as significant if associated with preeclampsia (PE) or Fetal Growth Restriction (FGR) and not significant otherwise. Two experts evaluated potential changes in patients' management with the introduction of a PlGF-based test. The direct healthcare cost was estimated.Results: We enrolled 107 patients, of which 30% showed significant BPI (17 PE cases, 13 FGR, and 2 both pathologies). Anamnestic, clinical, and laboratory evaluations were not effective in differentiating between significant and not significant BPI (p-values: .8320, .2856, and .2297, respectively). The introduction of a PlGF-based test would have reduced overtreatment and undertreatment. The test would have avoided 18% of all hospitalizations, 35% of hospitalizations for BPI, 43% of outpatient referrals, and 13% of ER accesses. The number of avoidable accesses was higher in women with not significant BPI. Overall, the mean total cost (from first ER access until delivery) was €2634 per woman and €401 would have been avoidable.Conclusion: The clinical integration of PlGF-based tests is advantageous in diagnostic, prognostic and economic terms, as an objective marker of placental dysfunction. [ABSTRACT FROM AUTHOR]- Published
- 2021
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28. Trends in cardiovascular diseases burden and vascular risk factors in Italy: The Global Burden of Disease study 1990-2017.
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Cortesi, Paolo A., Fornari, Carla, Madotto, Fabiana, Conti, Sara, Naghavi, Mohsen, Bikbov, Boris, Briant, Paul S., Caso, Valeria, Crotti, Giacomo, Johnson, Catherine, Nguyen, Minh, Palmieri, Luigi, Perico, Norberto, Profili, Francesco, Remuzzi, Giuseppe, Roth, Gregory A., Traini, Eugenio, Voller, Fabio, Yadgir, Simon, and Mazzaglia, Giampiero
- Published
- 2021
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29. Spontaneous Breathing Patterns During Maximum Extracorporeal CO2 Removal in SubjectsWith Early Severe ARDS.
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Spinelli, Elena, Mauri, Tommaso, Lissoni, Alfredo, Crotti, Stefania, Langer, Thomas, Albanese, Marco, Volta, Carlo Alberto, Fornari, Carla, Tagliabue, Paola, Grasselli, Giacomo, and Pesenti, Antonio
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CHI-squared test ,EXTRACORPOREAL membrane oxygenation ,FISHER exact test ,LONGITUDINAL method ,RESPIRATION ,ADULT respiratory distress syndrome ,STATISTICS ,DATA analysis ,CONTINUING education units ,EXTRACORPOREAL carbon dioxide removal ,DESCRIPTIVE statistics ,KRUSKAL-Wallis Test - Abstract
BACKGROUND: Switching patients affected by early severe ARDS and undergoing extracorporeal membrane oxygenation (ECMO) from controlled ventilation to spontaneous breathing can be either beneficial or harmful, depending on how effectively the breathing pattern is controlled with ECMO. Identifying the factors associated with ineffective control of spontaneous breathing with ECMO may advance our pathophysiologic understanding of this syndrome. METHODS: We conducted a prospective study in subjects with severe ARDS who were on ECMO support ≤ 7 d. Subjects were switched to minimal sedation and pressure-support ventilation while extracorporeal CO
2 removal was increased to approximate the subject's total CO2 production (VCO2 ). We calculated the rapid shallow breathing index (RSBI) as breathing frequency divided by tidal volume. We explored the correlation between certain characteristics recorded during pretest controlled ventilation and the development of apnea (ie, expiratory pause lasting > 10 s; n = 3), normal breathing pattern (ie, apnea to RSBI ≤ 105 breaths/min/L; n = 6), and rapid shallow breathing (RSBI > 105 breaths/min/L; n = 6) that occurred during the test study. RESULTS: The ratio of extracorporeal CO2 removal to the subjects' VCO2 was >90% in all 15 subjects, and arterial blood gases remained within normal ranges. Baseline pretest Sequential Organ Failure Assessment score, total VCO2 and ventilatory ratio increased steadily, whereas PaO2 /FIO2 was higher in subjects with apnea compared to intermediate RSBI >105 breaths/min/L and elevated RSBI >105 breaths/min/L. In subjects with rapid shallow breathing, baseline lung weight measured with quantitative computed tomography scored higher, as well. CONCLUSIONS: In early severe ARDS, the factors associated with rapid shallow breathing despite maximum extracorporeal CO2 extraction include less efficient CO2 and O2 exchange by the natural lung, higher severity of organ failure, and greater magnitude of lung edema. [ABSTRACT FROM AUTHOR]- Published
- 2020
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30. Clinical outcome indicators in chronic hepatitis B and C: A primer for value‐based medicine in hepatology.
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Strazzabosco, Mario, Cortesi, Paolo A., Conti, Sara, Okolicsanyi, Stefano, Rota, Matteo, Ciaccio, Antonio, Cozzolino, Paolo, Fornari, Carla, Gemma, Marta, Scalone, Luciana, Cesana, Giancarlo, Fabris, Luca, Colledan, Michele, Fagiuoli, Stefano, Ideo, Gaetano, Zavaglia, Claudio, Perricone, Giovanni, Munari, Luca M., Mantovani, Lorenzo G., and Belli, Luca S.
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CHRONIC hepatitis B ,DELPHI method ,LIVER diseases - Abstract
Background & Aims: Chronic liver diseases (CLDs) are major health problems that require complex and costly treatments. Liver‐specific clinical outcome indicators (COIs) able to assist both clinicians and administrators in improving the value of care are presently lacking. The Value‐Based Medicine in Hepatology (VBMH) study aims to fill this gap, devising and testing a set of COIs for CLD, that could be easily collected during clinical practice. Here we report the COIs generated and recorded for patients with HBV or HCV infection at different stages of the disease. Methods / Results: In the first phase of VBMH study, COIs were identified, based on current international guidelines and literature, using a modified Delphi method and a RAND 9‐point appropriateness scale. In the second phase, COIs were tested in an observational, longitudinal, prospective, multicentre study based in Lombardy, Italy. Eighteen COIs were identified for HBV and HCV patients. Patients with CLD secondary to HBV (547) or HCV (1391) were enrolled over an 18‐month period and followed for a median of 4 years. The estimation of the proposed COIs was feasible in the real‐word clinical practice and COI values compared well with literature data. Further, the COIs were able to capture the impact of new effective treatments like direct‐acting antivirals (DAAs) in the clinical practice. Conclusions: The COIs efficiently measured clinical outcomes at different stages of CLDs. While specific clinical practice settings and related healthcare systems may modify their implementation, these indicators will represent an important component of the tools for a value‐based approach in hepatology and will positively affect care delivery. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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31. Amplitude spectrum area to guide defibrillation: a validation on 1617 patients with ventricular fibrillation.
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Ristagno, Giuseppe, Mauri, Tommaso, Cesana, Giancarlo, Li, Yongqin, Finzi, Andrea, Fumagalli, Francesca, Rossi, Gianpiera, Grieco, Niccolò, Migliori, Maurizio, Andreassi, Aida, Latini, Roberto, Fornari, Carla, Pesenti, Antonio, and Azienda Regionale Emergenza Urgenza (AREU) Research Group*
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- 2015
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32. 462 Amplitude Spectrum Area predicts True Shock-Refractory Ventricular Fibrillation in Out-of-Hospital Cardiac Arrest.
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Magliocca, Aurora, Fumagalli, Francesca, Fornari, Carla, Merigo, Giulia, Stirparo, Giuseppe, and Ristagno, Giuseppe
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- *
VENTRICULAR fibrillation , *CARDIAC arrest , *FORECASTING - Published
- 2024
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33. Burden of Diabetes Mellitus Estimated with a Longitudinal Population-Based Study Using Administrative Databases.
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Scalone, Luciana, Cesana, Giancarlo, Furneri, Gianluca, Ciampichini, Roberta, Beck-Peccoz, Paolo, Chiodini, Virginio, Mangioni, Silvia, Orsi, Emanuela, Fornari, Carla, and Mantovani, Lorenzo Giovanni
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DIABETES ,ESTIMATION theory ,LONGITUDINAL method ,MEDICAL databases ,DATA warehousing - Abstract
Objective: To assess the epidemiologic and economic burden of diabetes mellitus (DM) from a longitudinal population-based study. Research Design and Methods: Lombardy Region includes 9.9 million individuals. Its DM population was identified through a data warehouse (DENALI), which matches with a probabilistic linkage demographic, clinical and economic data of different Healthcare Administrative databases. All individuals, who, during the year 2000 had an hospital discharge with a IDC-9 CM code 250.XX, and/or two consecutive prescriptions of drugs for diabetes (ATC code A10XXXX) within one year, and/or an exemption from co-payment healthcare costs specific for DM, were selected and followed up to 9 years. We calculated prevalence, mortality and healthcare costs (hospitalizations, drugs and outpatient examinations/visits) from the National Health Service’s perspective. Results: We identified 312,223 eligible subjects. The study population (51% male) had a mean age of 66 (from 0.03 to 105.12) years at the index date. Prevalence ranged from 0.4% among subjects aged ≤45 years to 10.1% among those >85 years old. Overall 43.4 deaths per 1,000 patients per year were estimated, significantly (p<0.001) higher in men than women. Overall, 3,315€/patient-year were spent on average: hospitalizations were the cost driver (54.2% of total cost). Drugs contributed to 31.5%, outpatient claims represented 14.3% of total costs. Thirty-five percent of hospital costs were attributable to cerebro−/cardiovascular reasons, 6% to other complications of DM, and 4% to DM as a main diagnosis. Cardiovascular drugs contributed to 33.5% of total drug costs, 21.8% was attributable to class A (16.7% to class A10) and 4.3% to class B (2.4% to class B01) drugs. Conclusions: Merging different administrative databases can provide with many data from large populations observed for long time periods. DENALI shows to be an efficient instrument to obtain accurate estimates of burden of diseases such as diabetes mellitus. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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34. The Clinical and Economic Impact of Exacerbations of Chronic Obstructive Pulmonary Disease: A Cohort of Hospitalized Patients.
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Blasi, Francesco, Cesana, Giancarlo, Conti, Sara, Chiodini, Virginio, Aliberti, Stefano, Fornari, Carla, and Mantovani, Lorenzo Giovanni
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ECONOMIC impact ,COHORT analysis ,HOSPITAL patients ,OBSTRUCTIVE lung diseases ,MEDICAL care costs - Abstract
Background: Chronic Obstructive Pulmonary Disease (COPD) is a common disease with significant health and economic consequences. This study assesses the burden of COPD in the general population, and the influence of exacerbations (E-COPD) on disease progression and costs. Methods: This is a secondary data analysis of healthcare administrative databases of the region of Lombardy, in northern Italy. The study included ≥ 40 year-old patients hospitalized for a severe E-COPD (index event) during 2006. Patients were classified in relation to the number and type of E-COPD experienced in a three-year pre-index period. Subjects were followed up until December 31
st , 2009, collecting data on healthcare resource use and vital status. Results: 15857 patients were enrolled –9911 males, mean age: 76 years (SD 10). Over a mean follow-up time of 2.4 years (1.36), 81% of patients had at least one E-COPD with an annual rate of 3.2 exacerbations per person-year and an all-cause mortality of 47%. A history of exacerbation influenced the occurrence of new E-COPD and mortality after discharge for an E-COPD. On average, the healthcare system spent 6725€ per year per person (95%CI 6590–6863). Occurrence and type of exacerbations drove the direct healthcare cost. Less than one quarter of patients presented claims for pulmonary function tests. Conclusions: COPD imposes a substantial burden on healthcare systems, mainly attributable to the type and occurrence of E-COPD, or in other words, to the exacerbator phenotypes. A more tailored approach to the management of COPD patients is required. [ABSTRACT FROM AUTHOR]- Published
- 2014
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35. Design and evaluation of a semantic approach for the homogeneous identification of events in eight patient databases: a contribution to the European EU-ADR project.
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Safran, C., Reti, S., Marin, H.F., Avillach, Paul, Joubert, Michel, Thiessard, Frantz, Trifirò, Gianluca, Dufour, Jean-Charles, Pariente, Antoine, Mougin, Fleur, Polimeni, Giovanni, Catania, Maria Antonietta, Giaquinto, Carlo, Mazzaglia, Giampiero, Fornari, Carla, Herings, Ron, Gini, Rosa, Hippisley-Cox, Julia, Molokhia, Mariam, and Pedersen, Lars
- Abstract
The overall objective of the EU-ADR project is the design, development, and validation of a computerised system that exploits data from electronic health records and biomedical databases for the early detection of adverse drug reactions. Eight different databases, containing health records of more than 30 million European citizens, are involved in the project. Unique queries cannot be performed across different databases because of their heterogeneity: Medical record and Claims databases, four different terminologies for coding diagnoses, and two languages for the information described in free text. The aim of our study was to provide database owners with a common basis for the construction of their queries. Using the UMLS, we provided a list of medical concepts, with their corresponding terms and codes in the four terminologies, which should be considered to retrieve the relevant information for the events of interest from the databases. [ABSTRACT FROM AUTHOR]
- Published
- 2010
36. Social status and cardiovascular disease: a Mediterranean case. Results from the Italian Progetto CUORE cohort study.
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Fornari, Carla, Donfrancesco, Chiara, Riva, Michele A., Palmieri, Luigi, Panico, Salvatore, Vanuzzo, Diego, Ferrario, Marco M., Pilotto, Lorenza, Giampaoli, Simona, and Cesana, Giancarlo
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- *
CARDIOVASCULAR diseases , *CARDIOVASCULAR agents , *PUBLIC health , *WOMEN ,SEX differences (Biology) - Abstract
Background: Social factors could offer useful information for planning prevention strategy for cardiovascular diseases. This analysis aims to explore the relationship between education, marital status and major cardiovascular risk factors and to evaluate the role of social status indicators in predicting cardiovascular events and deaths in several Italian cohorts. Methods: The population is representative of Italy, where the incidence of the disease is low. Data from the Progetto CUORE, a prospective study of cohorts enrolled between 1983-1997, were used; 7520 men and 13127 women aged 35-69 years free of previous cardiovascular events and followed for an average of 11 years. Educational level and marital status were used as the main indicators of social status. Results: About 70% of the studied population had a low or medium level of education (less than high school) and more than 80% was married or cohabitating. There was an inverse relationship between educational level and major cardiovascular risk factors in both genders. Significantly higher major cardiovascular risk factors were detected in married or cohabitating women, with the exception of smoking. Cardiovascular risk score was lower in married or cohabitating men. No relationship between incidence of cardiac events and the two social status indicators was observed. Cardiovascular case-fatality was significantly higher in men who were not married and not cohabitating (HR 3.20, 95%CI: 2.21-4.64). The higher cardiovascular risk observed in those with a low level of education deserves careful attention even if during the follow-up it did not seem to determine an increase of cardiac events. Conclusions: Preventive interventions on cardiovascular risk should be addressed mostly to people with less education. Cardiovascular risk score and case-fatality resulted higher in men living alone while cardiovascular factors were higher in women married or cohabitating. Such gender differences seem peculiar of our population and require further research on unexpected cultural and behavioural influences. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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37. Antidepressants Drug Use during COVID-19 Waves in the Tuscan General Population: An Interrupted Time-Series Analysis.
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Antonazzo, Ippazio Cosimo, Fornari, Carla, Maumus-Robert, Sandy, Cei, Eleonora, Paoletti, Olga, Ferrara, Pietro, Conti, Sara, Cortesi, Paolo Angelo, Mantovani, Lorenzo Giovanni, Gini, Rosa, and Mazzaglia, Giampiero
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- *
DRUG utilization , *STAY-at-home orders , *ANTIDEPRESSANTS , *COVID-19 , *TIME series analysis , *PHARMACOEPIDEMIOLOGY , *MEDICAL care cost statistics - Abstract
In Italy, during the COVID-19 waves two lockdowns were implemented to prevent virus diffusion in the general population. Data on antidepressant (AD) use in these periods are still scarce. This study aimed at exploring the impact of COVID-19 lockdowns on prevalence and incidence of antidepressant drug use in the general population. A population-based study using the healthcare administrative database of Tuscany was performed. We selected a dynamic cohort of subjects with at least one ADs dispensing from 1 January 2018 to 27 December 2020. The weekly prevalence and incidence of drug use were estimated across different segments: pre-lockdown (1 January 2018–8 March 2020), first lockdown (9 March 2020–15 June 2020), post-first lockdown (16 June 2020–15 November 2020) and second lockdown (16 November 2020–27 December 2020). An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. Compared to the pre-lockdown we observed an abrupt reduction of ADs incidence (Incidence-Ratio: 0.82; 95% Confidence-Intervals: 0.74–0.91) and a slight weekly decrease of prevalence (Prevalence-Ratio: 0.997; 0.996–0.999). During the post-first lockdown AD use increased, with higher incidence- and similar prevalence values compared with those expected in the absence of the outbreak. This pandemic has impacted AD drug use in the general population with potential rebound effects during the period between waves. This calls for future studies aimed at exploring the mid–long term effects of this phenomenon. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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38. Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis.
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Antonazzo, Ippazio Cosimo, Fornari, Carla, Maumus-Robert, Sandy, Cei, Eleonora, Paoletti, Olga, Conti, Sara, Cortesi, Paolo Angelo, Mantovani, Lorenzo Giovanni, Gini, Rosa, and Mazzaglia, Giampiero
- Published
- 2021
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39. Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia: a threshold-finding prospective observational study
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Mauri, Tommaso, Coppadoro, Andrea, Bombino, Michela, Bellani, Giacomo, Zambelli, Vanessa, Fornari, Carla, Berra, Lorenzo, Bittner, Edward A, Schmidt, Ulrich, Sironi, Marina, Bottazzi, Barbara, Brambilla, Paolo, Mantovani, Alberto, and Pesenti, Antonio
- Abstract
Introduction: Timely diagnosis of pneumonia in intubated critically ill patients is rather challenging. Pentraxin 3 (PTX3) is an acute-phase mediator produced by various cell types in the lungs. Animal studies have shown that, during pneumonia, PTX3 participates in fine-tuning of inflammation (for example, microbial clearance and recruitment of neutrophils). We previously described an association between alveolar PTX3 and lung infection in a small group of intubated patients. The aim of the present study was to determine a threshold level of alveolar PTX3 with elevated sensitivity and specificity for microbiologically confirmed pneumonia. Methods: We recruited 82 intubated patients from two intensive care units (San Gerardo Hospital, Monza, Italy, and Massachusetts General Hospital, Boston, MA, USA) undergoing bronchoalveolar lavage (BAL) as per clinical decision. We collected BAL fluid and plasma samples, together with relevant clinical and microbiological data. We assayed PTX3 and soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in BAL fluid and PTX3, sTREM-1, C-reactive protein (CRP) and procalcitonin (PCT) in plasma. Two blinded independent physicians reviewed patient data to confirm pneumonia. We determined the PTX3 threshold in BAL fluid for pneumonia and compared it to other biomarkers. Results: Microbiologically confirmed pneumonia of bacterial (n =12), viral (n =4) or fungal (n =8) etiology was diagnosed in 24 patients (29%). PTX3 levels in BAL fluid predicted pneumonia with an area under the receiving operator curve of 0.815 (95% CI =0.710 to 0.921, P <0.0001), whereas none of the other biomarkers were effective. In particular, PTX3 levels ≥1 ng/ml in BAL fluid predicted pneumonia in univariate analysis (β =2.784, SE =0.792, P <0.001) with elevated sensitivity (92%), specificity (60%) and negative predictive value (95%). Net reclassification index PTX3 values ≥1 ng/ml in BAL fluid for pneumonia indicated gain in sensitivity and/or specificity vs. all other mediators. These results did not change when we limited our analyses only to confirmed cases of bacterial pneumonia. Moreover, when we considered only the 70 patients who fulfilled the clinical criteria for the diagnosis of pneumonia at BAL fluid sampling, the diagnostic accuracy of PTX levels was confirmed in univariate and ROC curve analysis. Conclusions: In this hypothesis-generating convenience sample, a PTX3 level ≥1 ng/ml in BAL fluid was discriminative of microbiologically confirmed pneumonia in mechanically ventilated patients. Electronic supplementary material The online version of this article (doi:10.1186/s13054-014-0562-5) contains supplementary material, which is available to authorized users.
- Published
- 2014
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40. Burden of acute myocardial infarction
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Mantovani, Lorenzo G., Fornari, Carla, Madotto, Fabiana, Riva, Michele A., Merlino, Luca, Ferrario, Marco M., Chiodini, Virginio, Zocchetti, Alberto, Corrao, Giovanni, and Cesana, Giancarlo
- Published
- 2011
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41. The short-term effect of particulate matter on cardiorespiratory drug prescription, as a proxy of mild adverse events.
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Conti, Sara, Lafranconi, Alessandra, Zanobetti, Antonella, Cesana, Giancarlo, Madotto, Fabiana, and Fornari, Carla
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- *
PARTICULATE matter , *CARDIOPULMONARY system , *DISEASES , *INDUSTRIALIZATION & the environment , *AIR pollution , *AIR pollutants - Abstract
Introduction and aims The association between particulate matter < 10 µm in aerodynamic diameter (PM 10 ) and mild disease episodes, not leading to hospitalization or death, has been rarely investigated. We studied the short-term effect of PM 10 on purchases of specific cardiorespiratory medications, as proxies of mild episodes, in 7 small- and medium-sized cities of Northern Italy, during 2005–2006. Materials and methods We extracted information on purchased prescriptions from healthcare administrative databases, and we obtained daily PM 10 concentrations from fixed monitoring stations. We applied a time-stratified case-crossover design, using the time-series of antidiabetic drugs purchases to control for confounding due to irregularities in daily purchase frequencies. Results During the warm season, we estimated a delayed (lags 2–6) increased risk of buying glucocorticoid (4.53%, 95% Confidence Interval (CI): 2.62, 6.48) and adrenergic inhalants (1.66%, 95% CI: 0.10, 3.24), following an increment (10 μg/m 3 ) in PM 10 concentration. During the cold season, we observed an immediate (lags 0–1) increased risk of purchasing antiarrhythmics (0.76%; 95% CI: 0.16, 1.36) and vasodilators (0.72%; 95% CI: 0.30, 1.13), followed by a risk reduction (lags 2–6), probably due to harvesting. Conclusions Focusing on drug purchases, we reached sufficient statistical power to study PM 10 effect outside large urban areas and conclude that short-term increments in PM 10 concentrations might cause mild cardiorespiratory disease episodes. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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