1. A microparticle manipulation method facilitated via microfluidic chip based on swirling flow topology design and its application in sorting.
- Author
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Dang, Yanping, Zhang, Qin, Hu, Shuai, and Ou, Zhiming
- Subjects
SWIRLING flow ,MICROFLUIDICS ,TOPOLOGY ,FLOW velocity - Abstract
In this work, a new flow field structure is proposed for a 6-microchannel microfluidic chip, which has realized the active control of microparticles. The chip is capable of trapping, transferring, and enriching microparticles, thus it is applied for microparticles sorting. This work presents a pioneering flow field structure for swirl-based microfluidic chip, and provides a feasible scheme for sorting microparticles. It is a potential mean for bio-/chemical analysis and fluidic-directed assembly of multiple microparticles. [Display omitted] • A 6-microchannel microfluidic chip is proposed for manipulating microparticles. • Simulation and experiments are conducted to validate the functions of the proposed model. • Microparticles are successfully trapped, sorted by size, transferred, and enriched. • The manipulation of microparticles is facilitated by regulating velocities and flow topologies. • This microfluidic chip can be applied for fluidic-directed assembly and bio-/chemical analysis. Microfluidics technology is trustworthy for microparticle operation as it doesn't involve destructive contact. Our research endeavors have encompassed microparticles manipulation by generating swirling flow region (SFR). Now we try to utilize swirl and flow topology to promote microfluidic chip design because serial operation is still not well enabled. Herein, a new model is proposed for a 6-microchannel microfluidic chip, which has realized active control of microparticles. The chip is capable of trapping, transferring, and enriching microparticles, and is applied for microparticles sorting. Simulation is performed to substantiate the viability of generating SFRs, and experiments are conducted on 3D-printed chips to validate the envisioned functions of the proposed microfluidic chip. Encouragingly, our experiments yield convincing outcomes, wherein microparticles are successfully trapped, transferred, and enriched in separated SFRs. With the help of a self-developed vision algorithm, the size sorting of microparticles is facilitated. Significantly, the manipulation of different microparticles can be achieved by tuning the microchannel velocities and tailoring the flow topology. This work presents a pioneering flow field structure and provides a feasible scheme for sorting microparticles, which is a noteworthy advance in swirl-based microfluidic chip applications. It is a potential mean for bio-/chemical analysis and fluidic-directed assembly of multiple microparticles. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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