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Your search keyword '"Forcina, Alessandra"' showing total 10 results
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10 results on '"Forcina, Alessandra"'

2. Nanosphere’s Verigene® Blood Culture Assay to Detect Multidrug-Resistant Gram-Negative Bacterial Outbreak: A Prospective Study on 79 Hematological Patients in a Country with High Prevalence of Antimicrobial Resistance

Author

Greco, Raffaella, Barbanti, Maria Chiara, Mancini, Nicasio, Infurnari, Laura, Pasciuta, Renée, Forcina, Alessandra, Oltolini, Chiara, Casirati, Gabriele, Mannina, Daniele, Giglio, Fabio, Messina, Carlo, Morelli, Mara, Lorentino, Francesca, Mastaglio, Sara, Perini, Tommaso, Vago, Luca, Scarpellini, Paolo, Carrabba, Matteo Giovanni, Stanghellini, Maria Teresa Lupo, Marktel, Sarah, Assanelli, Andrea, Bernardi, Massimo, Corti, Consuelo, Peccatori, Jacopo, Clementi, Massimo, and Ciceri, Fabio

Published
2019
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4. Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome

Author

Greco, Raffaella, Crucitti, Lara, Noviello, Maddalena, Racca, Sara, Mannina, Daniele, Forcina, Alessandra, Lorentino, Francesca, Valtolina, Veronica, Rolla, Serena, Dvir, Roee, Morelli, Mara, Giglio, Fabio, Barbanti, Maria Chiara, Lupo Stanghellini, Maria Teresa, Oltolini, Chiara, Vago, Luca, Scarpellini, Paolo, Assanelli, Andrea, Carrabba, Matteo G., Marktel, Sarah, Bernardi, Massimo, Corti, Consuelo, Clementi, Massimo, Peccatori, Jacopo, Bonini, Chiara, and Ciceri, Fabio

Published
2016
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5. Adjuvant role of SeptiFast to improve the diagnosis of sepsis in a large cohort of hematological patients

Author

Greco, Raffaella, Barbanti, Maria Chiara, Mancini, Nicasio, Crucitti, Lara, Oltolini, Chiara, Forcina, Alessandra, Lorentino, Francesca, Vago, Luca, Messina, Carlo, Clerici, Daniela, Morelli, Mara, Giglio, Fabio, Lupo Stanghellini, Maria Teresa, Infurnari, Laura, Carrabba, Matteo G., Marktel, Sarah, Assanelli, Andrea, Scarpellini, Paolo, Bernardi, Massimo, Peccatori, Jacopo, Corti, Consuelo, Clementi, Massimo, and Ciceri, Fabio

Published
2018
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6. Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients

Author

Mancini, Nicasio, Greco, Raffaella, Pasciuta, Renée, Barbanti, Maria Chiara, Pini, Giacomo, Morrow, Olivia Beatrice, Morelli, Mara, Vago, Luca, Clementi, Nicola, Giglio, Fabio, Lupo Stanghellini, Maria Teresa, Forcina, Alessandra, Infurnari, Laura, Marktel, Sarah, Assanelli, Andrea, Carrabba, Matteo, Bernardi, Massimo, Corti, Consuelo, Burioni, Roberto, Peccatori, Jacopo, Sormani, Maria Pia, Banfi, Giuseppe, Ciceri, Fabio, and Clementi, Massimo

Published
2017
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10. Integrating a prospective pilot trial and patient-derived xenografts to trace metabolic changes associated with acute myeloid leukemia.

Author

Carrabba, Matteo G., Tavel, Laurette, Oliveira, Giacomo, Forcina, Alessandra, Quilici, Giacomo, Nardelli, Francesca, Tresoldi, Cristina, Ambrosi, Alessandro, Ciceri, Fabio, Bernardi, Massimo, and Vago, Luca

Subjects
ACUTE myeloid leukemia, METABOLISM, XENOGRAFTS, MOLECULAR oncology, IMMUNOCOMPROMISED patients
Abstract

Despite the considerable progress in understanding the molecular bases of acute myeloid leukemia (AML), new tools to link disease biology to the unpredictable patient clinical course are still needed. Herein, high-throughput metabolomics, combined with the other "-omics" disciplines, holds promise in identifying disease-specific and clinically relevant features. In this study, we took advantage of nuclear magnetic resonance (NMR) to trace AML-associated metabolic trajectory employing two complementary strategies. On the one hand, we performed a prospective observational clinical trial to identify metabolic changes associated with blast clearance during the first two cycles of intensive chemotherapy in nine adult patients. On the other hand, to reduce the intrinsic variability associated with human samples and AML genetic heterogeneity, we analyzed the metabolic changes in the plasma of immunocompromised mice upon engraftment of primary human AML blasts. Combining the two longitudinal approaches, we narrowed our screen to seven common metabolites, for which we observed a mirror-like trajectory in mice and humans, tracing AML progression and remission, respectively. We interpreted this set of metabolites as a dynamic fingerprint of AML evolution. Overall, these NMR-based metabolomic data, to be consolidated in larger cohorts and integrated in more comprehensive system biology approaches, hold promise for providing valuable and non-redundant information on the systemic effects of leukemia. [ABSTRACT FROM AUTHOR]

Published
2016
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