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Objective: The enteric nervous system is a system made up of neurons that form the "brain of the intestines" and function independently of the central nervous system. Neurexin is a presynaptic neuronal cell adhesion protein, and they bind with neuroligin, the postsynaptic protein. 'Stress' is defined as a condition that threatens body self-balance. The enteric nervous system provides regulatory control over a large number of gastrointestinal functions. Therefore, changes in the enteric nervous system function can lead to deep clinical symptoms in stress-related gastrointestinal disorders. In our study, we aimed to investigate the effects of perinatal stress on neuroligin-1 and neurexin Ha in the enteric nervous system of rats on different embryonic/neonatal days. Methods: 36 female Wistar albino rats were mated. Embryos taken at embryonic days El 6, El 8, E20. and experimental animals bom normally (up to postnatal 21st day?) were used. There are 8 groups in which prenatal and/or postnatal stress protocols were applied. Western blot analysis were performed to determine the protein levels of Neuroligin-1 and Neuroxin Ila on the whole intestinal tissue. Results: Statistically; prenatal stress on embryonic days E16, El8, E20 caused 20%, 10%, and 27% decrease in Neuroligin-1 protein levels in the collected embryonic intestinal tissues, and a 46%, 37%, 28% decrease in Neurexin Ila protein levels, respectively. Postnatal or perinatal stress caused a decrease in Neuroligin-1 and Neurexin Ila protein levels in all intestinal sections, but the highest reductions were observed in duodenal tissue in group 8 with Neuroligin-1 by 64% and in colon tissue in group 8 with Neurexin Eta with 55%. Conclusion: General and regional decreases in protein levels in stress groups compared to control groups are remarkable. It is concluded that perinatal stress negatively affects the enteric nervous system by showing regional differences. The study was supported byTübitak 3001 project numbered SBAG 118S031. [ABSTRACT FROM AUTHOR]

Objective: The relationship between enteric nervous system, gastrointestinal function and stress is very important in clinical and pathophysiological aspects. Neuroligin and neuroxins are synaptic cell adhesion molecules that play a key role in synaptic functions. In recent studies, it is thought that neurologin and neuroxins play an important role in the detection of various cognitive diseases. The bidirectional communication between the brain and the gut, including neuronal, immune and endocrine pathways, is called the brain-gut axis. This axis is affected by various stress factors. In our study, we aimed to investigate the effects of perinatal stress on neuroligin-1 and neuroxin IIa in the enteric nervous system of different intestinal parts of rats at different embryonic / neonatal days. Methods: In our study, 36 female Wistar albino rats were mated. The experimental animals born with the embryos taken at embryonic days E16, E18, E20. of pregnant rats and raised with their mothers until they were weaned (up to postnatal 21st day) were used. There are 8 groups in total in the experiment. Prenatal and/or postnatal stress protocols were applied to the experimental groups. Immunepressions of neuroligin-1 and neuroxin IIa in myenteric plexuses were evaluated of duodenum, jejunum, ileum and colon tissues. Results: When evaluated statistically, the decrease in the percentages of immunoreactivity density and cell positive numbers of neuroligin-1 and neuroxin II- in the myenteric plexuses in the stress groups compared to the control groups is remarkable (p<0.05). Conclusion: Perinatal stress affected the neuroligin-1 and neuroxin IIa immunoreactivities in the enteric nervous system. [ABSTRACT FROM AUTHOR]