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Topical drug delivery is mostly preferred for dermatological action. Topical dosage form such as cream, ointments, gels etc. has certain drawbacks like stability problems, stickiness, poor absorption as well as permeability. It has limitations in terms of drug solubility, residence time, lipophilicity and permeability. To overcome this, a novel approach microemulsion based gel is formulated. Microemulgel is topical drug delivery system that incorporates the properties of both gel and microemulsion and shows dual release control system. The microemulgel is prepared by reducing the globule size of the emulsion (less than 200nm) so that the drug particles can easily penetrate through stratum corneum. In spite of penetration, microemulgel has several advantages like easily spreadable, non-grease, thixotropic, transparent, and bio-friendly. Currently many drugs of antimicrobial, antifungal and non-steroidal anti-inflammatory class are studied for topical delivery through microemulgel formulation. After the brief study, it can be concluded that the microemulgel appear better and effective delivery system as compared to other topical drug delivery system

Over the years researchers have been making an attempt to improve the potency of utilization of medicament for treatment of numerous diseases. During this endeavour, drug delivery systems have helped greatly by achieving reduced dose, reduced dosage frequency, improved patient compliance, improved bioavailability and maximum concentration of the drug at the target site. Recent years have seen an unprecedented growth in the use of nanotechnology in designing drug delivery systems. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, comparatively non-toxic, stable, economical and effective alternate to liposomes. This review is deepening and widening the interest of nNiosomes in several scientific disciplines and notably its application in drug delivery. This review additionally presents a summary of the types, methods of preparation, characterization and applications of Niosomes. [ABSTRACT FROM AUTHOR]

Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication may be improved. Mouth dissolving film has potential to improve onset of action lower the dosing and eliminate the fear of chocking. Formulation of mouth dissolving films involves both the visual and performance characteristics as plasticized hydrocolloids, API taste masking agents are being laminated by solvent casting and semisolid casting method. Solvent casting method being the most preferred method over other methods because it offers great uniformity of thickness and films prepared having fine glossy look and better physical properties. Mouth dissolving films are evaluated for its various parameters like thickness, physical property like folding endurance, disintegration and dissolution time. This review gives an idea about formulation techniques, evaluation parameters, overview on packaging and some available marketed products of mouth dissolving films. [ABSTRACT FROM AUTHOR]

Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. Oral bioavailability of Atorvastatin Calcium is low (14%) and shows extensive intestinal clearance and first-pass metabolism, which is the main cause for the low systemic availability. In the present work, orodispersible tablets of Atorvastatin calcium were prepared by direct compression method using Hibiscus rosa sinesis mucilage as natural superdisintegrant with a view to enhance patient compliance and to avoid hepatic first pass metabolism and to improve its bioavailability. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water-absorption ratio and in-vitro dispersion time. Short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro dispersion time. [ABSTRACT FROM AUTHOR]