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• Considering a competitive game for the problem of plasma collection in the context of the outbreak of COVID-19. • Providing the types of donors containing: healed donors, healed donors along with side diseases and healthy donors. • Considering various types of advertisements including social networks, TV ads, and banners to attract more donors. • Considering reserved donors and the possibility of donation during working and nonworking hours. • Suggesting a new mixed possibilistic-robust-fuzzy programming. This paper presents a bi-level blood supply chain network under uncertainty during the COVID-19 pandemic outbreak using a Stackelberg game theory technique. A new two-phase bi-level mixed-integer linear programming model is developed in which the total costs are minimized and the utility of donors is maximized. To cope with the uncertain nature of some of the input parameters, a novel mixed possibilistic-robust-fuzzy programming approach is developed. The data from a real case study is utilized to show the applicability and efficiency of the proposed model. Finally, some sensitivity analyses are performed on the important parameters and some managerial insights are suggested. [ABSTRACT FROM AUTHOR]

Disaster management is one of the most important actions to protect the property and lives of the victims. Failure to pay attention to logistical decisions of disaster can have irreversible consequences. Therefore, a multiechelon mathematical model for blood supply chain management in disaster situations is proposed in this research. The proposed supply chain includes supplier, central warehouse, reliable distributor, unreliable distributor, distributor, and affected areas. How the proposed model performs is explained as follows: blood is sent from the supplier to warehouses and distribution centers. Also, the capacity of suppliers is limited. The main objective of the mathematical model is to minimize supply chain costs while maximizing the level of satisfaction in order to meet the demand of the affected area. Hence, this research seeks to decide whether or not to establish a reliable distributor, unreliable distributor, and central warehouse. The amount of blood sent to the centers will also be calculated. One of the contributions of the proposed model is to consider the pre- and postdisaster modes simultaneously. Locating and investigating the flow between centers are also the other contributions of this study. Solving the proposed model using a robust optimization approach is another innovation taken into account in this research. The proposed model is solved using robust optimization, and finally, the results indicate the proper performance of the proposed model. [ABSTRACT FROM AUTHOR]

In this paper, a new production, allocation, location, inventory holding, distribution, and flow problems for a new sustainable-resilient health care network related to the COVID-19 pandemic under uncertainty is developed that also integrated sustainability aspects and resiliency concepts. Then, a multi-period, multi-product, multi-objective, and multi-echelon mixed-integer linear programming model for the current network is formulated and designed. Formulating a new MILP model to design a sustainable-resilience healthcare network during the COVID-19 pandemic and developing three hybrid meta-heuristic algorithms are among the most important contributions of this research. In order to estimate the values of the required demand for medicines, the simulation approach is employed. To cope with uncertain parameters, stochastic chance-constraint programming is proposed. This paper also proposed three meta-heuristic methods including Multi-Objective Teaching–learning-based optimization (TLBO), Particle Swarm Optimization (PSO), and Genetic Algorithm (GA) to find Pareto solutions. Since heuristic approaches are sensitive to input parameters, the Taguchi approach is suggested to control and tune the parameters. A comparison is performed by using eight assessment metrics to validate the quality of the obtained Pareto frontier by the heuristic methods on the experiment problems. To validate the current model, a set of sensitivity analysis on important parameters and a real case study in the United States are provided. Based on the empirical experimental results, computational time and eight assessment metrics proposed methodology seems to work well for the considered problems. The results show that by raising the transportation costs, the total cost and the environmental impacts of sustainability increased steadily and the trend of the social responsibility of staff rose gradually between − 20 and 0%, but, dropped suddenly from 0 to + 20%. Also in terms of the on-resiliency of the proposed network, the trends climbed slightly and steadily. Applications of this paper can be useful for hospitals, pharmacies, distributors, medicine manufacturers and the Ministry of Health. [ABSTRACT FROM AUTHOR]

Nowadays, a great deal of attention is paid to metaheuristic algorithms to reach the approximate solution in an acceptable computational time. As one of the recent-developed successful metaheuristics, Social Engineering Optimizer (SEO) algorithm is according to the inspiration of the rules of social engineering to solve approximate optimization problems. In this research, a Modified Social Engineering Optimizer algorithm (MSEO) by using an adjustment operator is proposed in which there are some assessment criteria for defender and attacker to determine and calculate the weight simultaneously for the first time. This enhancement comprises adding adjustment operators to improve the performance of SEO in terms of search accuracy and running time. Most notably, this operator is utilized to make a better new generation and improve the interaction between the search phases. The adjustment operator strategy is also applied to a novel division based on the best person. As an extensive comparison, the suggested algorithm is tested on fourteen standard benchmark functions and compared with ten well-established and recent optimization algorithms as well as the main version of the SEO algorithm. This algorithm is also tested for sensitivities on the parameters. In this regard, a set of engineering applications were provided to prove and validate the MSEO algorithm for the first time. The experimental outcomes show that the suggested algorithm produces very accurate results which are better than the SEO and other compared algorithms. Most notably, the MSEO provides a very competitive output and a high convergence rate. [ABSTRACT FROM AUTHOR]

• Determining the urban critical infrastructures in the event of an earthquake. • Designing Location-Routing-Inventory decisions in humanitarian relief chain. • Simulation of interaction of urban infrastructure in earthquake conditions. • Using a cooperative game to examine the manner of cooperation of disaster relief supply chain players. • Application of the model to a real-world disaster relief logistic case study. This paper describes a new simulation based mathematical model for locating distribution centres, vehicle routing, and inventory problems under earthquake conditions. In this paper, the proposed network includes affected areas, suppliers, distribution centres, and hospitals. Additionally, the basic infrastructures of the city, which are very fragile at the time of the earthquake, are identified. Then, the demand of each relief commodity is calculated depending on the different earthquake scenarios using simulation. The estimated demand is incorporated into the mathematical model as an uncertain parameter. The proposed methodology is designed as a two-stage model so that in the first stage the location and inventory of distribution centres are addressed. Thereafter, in the second stage the routing decisions are taken for the distribution of relief commodities from the distribution centres and suppliers to the affected areas. Due to the NP-hardness of the second stage model, this model is solved using multi-objective stochastic fractal search. This algorithm is one of the population-based and stochastic optimization techniques and inspired by the natural phenomenon of fractal growth. It should be noted that in the second stage, a cooperative game theory of coalition type is considered, which resulted in synergies that minimize the relief golden time. The kind of cooperation is the use of potential of co-operators' vehicle. In this stage, the possibility for the players to cooperate by sharing people and commodities transportation requests is considered. Also, to validate the model, a real case study is provided for a possible earthquake in Tehran. Finally, the comparison between the simulation results and the values obtained from the real system evaluates the performance of the implemented model. Considering normality and a 95% confidence interval, it can be concluded that the proposed model provides a precise representation of the real system's performance. [ABSTRACT FROM AUTHOR]

Highlights • An uncertain multi-objective multi-commodity multi-period multi-vehicle location-allocation model is proposed. • Two meta-heuristic method and one exact method are provided to solve the model. • Several types of injured people are considered in earthquake evacuation planning. • Failure rate of the centers are modeled using reliability and probability concepts. • The proposed model has been applied in a real case study in Tehran, Iran. Abstract In this paper, an uncertain multi-objective multi-commodity multi-period multi-vehicle location-allocation mixed-integer mathematical programing model is proposed for the response phase of the earthquake. The proposed model includes five echelons as affected areas, distribution centers, hospitals, temporary accommodation centers and temporary care centers. Two objective functions as minimizing the total cost of the location-allocation of facilities and minimizing the amount of the shortage of relief supplies, are considered. The uncertainty is modeled using a scenario-based probability approach. The main decisions made by the proposed model are locating of the temporary care and accommodation centers, allocation of the affected areas to the located centers and hospitals, as well as the allocation of the distribution centers to temporary accommodation centers. Several decisions associated with flow of injured people and commodities between facilities, and decisions associated with number of vehicles between facilities and shortage and inventory level at centers are also made by the proposed model. Several sets of constraints including demand and flow of relief commodities, capacity of centers, transportation of injured people, capacity of transportation vehicles for commodities and injured people, and back up centers are considered in multiple periods of planning in the proposed model. The proposed model is applied in a real case study in Tehran. The model is solved using modified multiple-objective particle swarm optimization (MMOPSO), Non-Dominated Sorting Genetic Algorithm-II (NSGA-II) and epsilon constraint method. The performance of the solution procedures is analyzed using multi-objective performance evaluation metrics. The results reveal the superiority of the MMOPSO over the other solution approaches. A preferred solution, from the set of non-dominated solutions generated by MMOPSO, has been selected, analyzed and described. Sensitivity analysis on main parameters of proposed model and the probabilities of the earthquake and failures of the facilities has also been accomplished. [ABSTRACT FROM AUTHOR]

This paper presents a new decentralized/distributed decision-making (DDM) supply chain planning model. A supply chain is called decentralized when various decisions are made in different companies trying to optimize their own objectives. The proposed approach is applied to plan a wood supply chain network called Puya Wood Company. The supply chain network design problem discussed in this paper is an integrated multi-echelon, multi-product problem considering total costs of purchasing raw materials/returned product, transportation of raw materials, and inventory holding of raw materials. A coordination mechanism is designed to share information between the retailer model and the manufacturer model called centralized planning. The main contributions of this paper are summarized as follows: (1) presenting a decentralized (distributed) approach in order to address the production and distribution problem in supply chain including manufacturer and retailers and (2) proposing a coordination mechanism in order to handle problems related to production and distribution in a two-echelon supply chain network through a decentralized approach. The proposed model is tested using real case study. Sensitivity analysis is accomplished to find the effects of changing the parameter on the results. The proposed coordination mechanism provides high-quality solutions in reasonable number of iterations for the case study. This coordination mechanism can be applied in other supply chains such as natural gas and oil, water resource management, and crisis and disaster planning. [ABSTRACT FROM AUTHOR]

Configuration of sustainable supply chains for agricultural products has been a well-known research field recently which is continuing to evolve and grow. It is a complex network design problem, and despite the abundant literature in the field, there are still few models offered to integrate social impacts and environmental effects to support network design decision-making to support the configuration of the citrus supply chain. In this work, the citrus supply chain design problem is investigated by integrating the production, distribution, inventory control, recycling and locational decisions in which the triple bottom lines of sustainability, as well as circularity strategy, are addressed. Accordingly, a novel multi-objective Mixed-Integer Linear Programming (MILP) model is proposed to formulate a multi-period multi-echelon problem to design the sustainable citrus Closed-Loop Supply Chain (CLSC) network. To solve the developed model, the ε-constraint approach is employed in small-sized problems. Furthermore, Strength Pareto Evolutionary Algorithm II (SPEA-II) and Pareto Envelope-based Selection Algorithm II (PESA-II) algorithms are used in medium- and large-sized problems. Taguchi design technique is then utilized to adjust the parameters of the algorithms efficiently. Three well-known assessment metrics and convergence analysis are regarded to test the efficiency of the suggested algorithms. The numerical results demonstrate that the SPEA-II algorithm has a superior efficiency over PESA-II. Moreover, to validate the applicability of the developed methodology, a real case study in Mazandaran/Iran is investigated with the help of a set of sensitivity analyses. • Developing a novel tri-objective MILP model for a citrus CLSC network design problem. • Addressing sustainable development and circular economy in the problem. • Applying four meta-heuristic methods to treat the problem complexity. • Investigating a real case study problem with a set of sensitivity analyses. [ABSTRACT FROM AUTHOR]

In this study, due to the importance of emergency centers and patient transport vehicles in epidemic conditions, the performance of emergency centers has been evaluated based on health protocols. The criteria were first divided into preventive and operational sections by collecting opinions, health experts, standard criteria, and the Delphi method. Preventive criteria for evaluating emergency centers and operating criteria for assessing vehicles in these centers are considered. The weighting of the determined criteria was done by the triangular fuzzy aggregation method. According to the standard criteria, the emergency centers have been evaluated for a 30-day period. The results have been assessed as a qualitative and quantitative matrix using the PROMETHEE method. The results showed better performance of Center A (63%) due to proper performance and better compliance with protocols in both criteria (preventive and operational). The reason for the superiority of this center over Center B can be considered the better performance of this center in terms of prevention indicators and better performance of the center's vehicles (Ambulance A-1 and Ambulance A-2) in the performance index by observing the standards. [ABSTRACT FROM AUTHOR]

In this study, a stochastic multi-objective mixed-integer mathematical programming is proposed for logistic distribution and evacuation planning during an earthquake. Decisions about the pre- and post-phases of the disaster are considered seamless. The decisions of the pre-disaster phase relate to the location of permanent relief distribution centers and the number of the commodities to be stored. The decisions of the second phase are to determine the optimal location for the establishment of temporary care centers to increase the speed of treating the injured people and the distribution of the commodities at the affected areas. Humanitarian and cost issues are considered in the proposed models through three objective functions. Several sets of constraints are also considered in the proposed model to make it flexible to handle real issues. Demands for food, blood, water, blanket, and tent are assumed to be probabilistic which are related to several complicated factors and modeled using a complicated network in this study. A simulation is setup to generate the probabilistic distribution of demands through several scenarios. The stochastic demands are assumed as inputs for the proposed stochastic multi-objective mixed integer mathematical programming model. The model is transformed to its deterministic equivalent using chance constraint programming approach. The equivalent deterministic model is solved using an efficient epsilon-constraint approach and an evolutionary algorithm, called non-dominated sorting genetic algorithm (NSGA-II). First several illustrative numerical examples are solved using both solution procedures. The performance of solution procedures is compared and the most efficient solution procedure, i.e., NSGA-II, is used to handle the case study of Tehran earthquake. The results are promising and show that the proposed model and the solution approach can handle the real case study in an efficient way. • Stochastic multi-objective optimization model is proposed for logistic distribution and evacuation planning. • Demands are assumed to be probabilistic and estimated using a simulation approach through several scenarios. • The stochastic optimization model is transformed to its deterministic equivalent using chance constraint programming. • The model is solved using an efficient epsilon-constraint approach and non-dominated sorting genetic algorithm (NSGA-II). • The proposed optimization model and solution approach are used to handle the case study of Tehran earthquake. [ABSTRACT FROM AUTHOR]

Cascade disasters can destroy urban infrastructures, kill thousands of people, and permanently displace millions of people. The paramount goal of disaster relief programs is to save lives, reduce financial loss, and accelerate the relief process. This study proposes a bi-level two-echelon mathematical model to minimize pre-disaster costs and maximize post-disaster relief coverage area. The model uses a geographic information system (GIS) to classify the disaster area and determine the optimal number and location of distribution centers while minimizing the relief supplies' inventory costs. A simulation model is used to estimate the demand for relief supplies. Initially, vulnerable urban infrastructures are identified, and then the interaction among them is investigated for cascade disasters. The aims of this study are threefold: (1) to identify vulnerable urban infrastructures in cascade disasters, (2) to prioritize urban areas based on the severity of cascade disasters using a GIS, and (3) to develop a bi-objective multi-echelon multi-supplies mathematical model for location, allocation, and distribution of relief supplies under uncertainty. The model is solved with an epsilon-constraint method for small and medium-scale problems and the invasive weed optimization algorithm for large-scale problems. A case study is presented to demonstrate the applicability and efficacy of the proposed method. The results confirm the difficulty of relief operations during the night as the cost of night-time relief operations is higher than daytime. In addition, the results show the coverage area increases as the demand surges. Therefore, establishing more distribution centers will increase operating costs and expand coverage are. [ABSTRACT FROM AUTHOR]

In Iran, location is usually done by temporary relief organizations without considering the necessary standards or conditions. The inappropriate and unscientific location may have led to another catastrophe, even far greater than the initial tragedy. In this study, the proposed locations of crisis management in the region and the optimal points proposed by the Geographic Information System (GIS), taking into account the opinions of experts and without the opinion of experts, were evaluated according to 18 criteria. First, the optimal areas have been evaluated according to standard criteria extracted by GIS and the intended locations of the region for accommodation in times of crisis. Then, the position of each place is calculated concerning each criterion. The resulting matrix of optimal options was qualitatively entered into the Preference Ranking Organization Method for Evaluation (PROMETHEE) for analysis. The triangular fuzzy aggregation method for weighting and standard classification of criteria for extracting optimal areas using GIS and integrating entropy and the Multiobjective Optimization Based on Ratio Analysis (MOORA) method for prioritizing places in the region are considered in this research. Finally, by applying constraints and using net input and output flows, optimal and efficient options are identified by PROMETHEE V. Among the research options, only four options were optimal and efficient. A case study of the Tehran metropolis is provided to show the ability of the proposed approach for selecting the points in three modes, with/without applying weights and applying crisis management. [ABSTRACT FROM AUTHOR]

In this paper, a new responsive-green-cold vaccine supply chain network during the COVID-19 pandemic is developed for the first time. According to the proposed network, a new multi-objective, multi-period, multi-echelon mathematical model for the distribution-allocation-location problem is designed. Another important novelty in this paper is that it considers an Internet-of-Things application in the COVID-19 condition in the suggested model to enhance the accuracy, speed, and justice of vaccine injection with existing priorities. Waste management, environmental effects, coverage demand, and delivery time of COVID-19 vaccine simultaneously are therefore considered for the first time. The LP-metric method and meta-heuristic algorithms called Gray Wolf Optimization (GWO), and Variable Neighborhood Search (VNS) algorithms are then used to solve the developed model. The other significant contribution, based on two presented meta-heuristic algorithms, is a new heuristic method called modified GWO (MGWO), and is developed for the first time to solve the model. Therefore, a set of test problems in different sizes is provided. Hence, to evaluate the proposed algorithms, assessment metrics including (1) percentage of domination, (2) the number of Pareto solutions, (3) data envelopment analysis, and (4) diversification metrics and the performance of the convergence are considered. Moreover, the Taguchi method is used to tune the algorithm's parameters. Accordingly, to illustrate the efficiency of the model developed, a real case study in Iran is suggested. Finally, the results of this research show MGO offers higher quality and better performance than other proposed algorithms based on assessment metrics, computational time, and convergence. [ABSTRACT FROM AUTHOR]

Bioethanol demands have increased during the last decade due to unexpected events worldwide. It is among the renewable energy sources that are utilized to replace fossil-fuel-based energy. Designing an efficient, Sustainable Bioethanol Supply Chain Network (SBSCN) is a critical task for the government and communities to manage the bioethanol demands appropriately. The contribution of this study is threefold. First, this study project the demand using three popular machine learning methods, including Random Forest (RF), Extreme Gradient Boosting (XGBoost), and Ensemble Learning (Adaboost) methods, to find the best one to be utilized as an input to the proposed mathematical to find optimal values for strategic, planning, and tactical decision variables. Second, the unemployment rate is considered an important parameter of the model to maximize the social effects. Third, since the proposed model of this study is NP-hard, to solve the problem, the CPLEX solver is applied for small size and two meta-heuristic algorithms, including Non-dominated Sorting Genetic Algorithm II (NSGA-II) and Multi-Objective Invasive Weed Optimization (MOIWO) are considered for medium and large size problems to find Pareto optimal solutions. Due to the sensitivity of two meta-heuristics algorithms, the Taguchi method, such as Max Spread (MS) and Mean Ideal Distance (MID), is utilized to control the parameters of those two applied algorithms. Since North Dakota (ND) is among the states with the most potential to produce bioethanol due to its vast land area, including marginal cropland and Conservation Research Program (CRP), the proposed model has been evaluated and validated based on the ND case study. The results show that the MOIWO algorithm outperforms NSGA-II based on the proposed model and the case study of this paper. Also, this algorithm is more reliable in terms of solution quality to tackle the problem. Finally, some research directions are discussed for future studies, and managerial insights are provided. • Bioethanol consumption experienced an increasing due to unexpected worldwide event. • Utilizing machine learning approaches to estimate the bioethanol demand in N.D. • Designing sustainable bioethanol supply chain by two meta-heuristic algorithms. • Optimal locations of biorefinery, pre-processing, distribution, and demand centers. • Gradual replacement of liquid fossil fuels with bioethanol to reduce air pollutions. [ABSTRACT FROM AUTHOR]

According to the increasing carbon dioxide released through vehicles and the shortage of water resources, decision-makers decided to combine the environmental and economic effects in the Agri-Food Supply Chain Network (AFSCN) in developing countries. This paper focuses on the citrus fruit supply chain network. The novelty of this study is the proposal of a mathematical model for a three-echelon AFSCN considering simultaneously CO2 emissions, coefficient water, and time window. Additionally, a bi-objective mixed-integer non-linear programming is formulated for production–distribution-inventory-allocation problem. The model seeks to minimise the total cost and CO+ emission simultaneously. To solve the multi-objective model in this paper, the Augmented Epsilon-constraint method is utilised for small- and medium-sized problems. The Augmented Epsilon-constraint method is not able to solve large-scale problems due to its high computational time. This method is a well-known approach to dealing with multi-objective problems. It allows for producing a set of Pareto solutions for multi-objective problems. Multi-Objective Ant Colony Optimisation, fast Pareto genetic algorithm, non-dominated sorting genetic algorithm II, and multi-objective simulated annealing are used to solve the model. Then, a hybrid meta-heuristic algorithm called Hybrid multi-objective Ant Colony Optimisation with multi-objective Simulated Annealing (HACO-SA) is developed to solve the model. In the HACO-SA algorithm, an initial temperature and temperature reduction rate is utilised to ensure a faster convergence rate and to optimise the ability of exploitation and exploration as input data of the SA algorithm. The computational results show the superiority of the Augmented Epsilon-constraint method in small-sized problems, while HACO-SA indicates that is better than the suggested original algorithms in the medium- and large-sized problems. [ABSTRACT FROM AUTHOR]

In this study, we present a novel fuzzy control strategy that considers the influence of lead times on nonlinear supply chain management (SCM) systems. The authors have constructed a fuzzy control model for an SCM model based on nonlinear phenomena with lead times, drawing inspiration from Takagi-Sugeno's (T-S) fuzzy control system. Additionally, the authors have designed a fuzzy H ∞ control approach to mitigate the effects of lead times, switch between sub-models, and address customers' stochastic requests, all while considering the concept of maximal overlapped rules groups. The control of nonlinear supply chain management is implemented in a manner that ensures asymptotic stability and facilitates smooth transitions from one subsystem to another. The introduction of the membership function into the fuzzy system results in reduced fluctuations in the system's variables. The key contributions of the research include the design of a fuzzy H ∞ control approach, leveraging maximal overlapping-rules group (MRRG) to ensure stability through localized definite positive matrices identification. This strategy achieves two primary objectives: asymptotic stability of the supply chain system and smooth switching between nonlinear SCM elements. The authors demonstrate the effectiveness of their proposed method through comprehensive comparisons with the fuzzy H ∞ control technique. The study provides a valuable insight into managing lead times in SCM through dynamic and stable control methodologies. Finally, a comprehensive comparison is provided between the suggested H ∞ management approach and the fuzzy H ∞ control strategy. This comparison is demonstrated through two-stage nonlinear numerical simulations, keeping SCM lead times in mind. Movement results are presented to illustrate the effectiveness of our suggested algorithm. • A fuzzy control for mitigating the effects of lead times. • Considering stochastic demands from customers. • MRRG in T-S fuzzy system linked to control ensures stability. • Proposed control ensures smooth switching in nonlinear supply chain elements. • Linked to fuzzy H_∞ control, our method is paralleled for effective demonstration. [ABSTRACT FROM AUTHOR]

Three-dimensional printing (3DP) is an evolutionary solution for making customize items for all sectors, but it has become more prominent in the healthcare sector. In this field, some solutions have to be adapted to patients. This is especially true for dentistry, where all the patients have their own unique mouth and tooth structure. It is now possible to provide an accurate model of the patient's mouth and teeth with solutions that are perfectly compatible with them, leading to the provision of a dental service with a high success rate. Even if there is a problem, it is enough to change the three-dimensional design. Therefore, it is a time-saving method, too. The purpose of this study is to investigate the role of 3DP in dentistry and to identify the processes and procedures resulting from the use of this technology. To do so, with the help of a case study, a 3DP-based dental clinic that provides implant, orthodontics, restoration and dentures services is simulated in Arena software. The current state of the system is assessed by defining appropriate evaluation criteria including net profit, utilization, waiting time, patients makespan and laboratory makespan. The simulation model is then developed with innovations such as adding an inventory control policy, creating rest time for resources and controlling the policy of sending products from laboratory to the clinic. After an extensive sensitivity analysis, improving the performance of the system is on the agenda of this paper by examining various scenarios. Results show that scenarios such as reducing some resources of the system or considering rest time in exchange for increasing the duration of the work shift can have a significant impact on clinic performance. [ABSTRACT FROM AUTHOR]

This study develops a novel mathematical model to design a sustainable mask Closed-Loop Supply Chain Network (CLSCN) during the COVID-19 outbreak for the first time. A multi-objective Mixed-Integer Linear Programming (MILP) model is proposed to address the locational, supply, production, distribution, collection, quarantine, recycling, reuse, and disposal decisions within a multi-period multi-echelon multi-product supply chain. Additionally, sustainable development is studied in terms of minimizing the total cost, total pollution and total human risk at the same time. Since the CLSCN design is an NP-hard problem, Multi-Objective Grey Wolf Optimization (MOGWO) algorithm and Non-Dominated Sorting Genetic Algorithm II (NSGA-II) are implemented to solve the proposed model and to find Pareto optimal solutions. Since Meta-heuristic algorithms are sensitive to their input parameters, the Taguchi design method is applied to tune and control the parameters. Then, a comparison is performed using four assessment metrics including Max-Spread, Spread of Non-Dominance Solution (SNS), Number of Pareto Solutions (NPS), and Mean Ideal Distance (MID). Additionally, a statistical test is employed to evaluate the quality of the obtained Pareto frontier by the presented algorithms. The obtained results reveal that the MOGWO algorithm is more reliable to tackle the problem such that it is about 25% superior to NSGA-II in terms of the dispersion of Pareto solutions and about 2% superior in terms of the solution quality. To validate the proposed mathematical model and testing its applicability, a real case study in Tehran/Iran is investigated as well as a set of sensitivity analyses on important parameters. Finally, the practical implications are discussed and useful managerial insights are given. [ABSTRACT FROM AUTHOR]

Recently, sustainable supply chains have emerged to emphasize the importance of social and environmental concerns along with economic factors in supply chain management. In this context, there is a necessity for mathematical models that indicate environmental aspects and the social effects of the supply chain network. In the present study, a new multi-product production, distribution, and transportation, in which the economic, environmental, and social effects under CO2 emission to fill this gap are presented. Additionally, service technology under various criteria in the social aspects and time window for the earliest and latest arrival time of products to main distribution centers are provided. Also, other novelties of this paper, the environmental effects to open main and local distribution centers, warehouses, and pharmacies are considered as environmental effects. So, the main contributions of this paper are to develop a multi objective, dynamic production and distribution planning using time windows in service technology of sustainable pharmaceutical supply Chain Network. In this regard, the mathematical model is formulated as a mixed-integer linear programming model. Moreover, a Benders decomposition approach is appropriately extended to solve the presented model. In the proposed approach, the problem is decomposed into two models of sub-problem and a master. The master problem is developed by means of preprocessing and valid inequalities. The general and relative efficiency of the model and approach is experimentally assessed. The pharmaceutical production and distribution system of France is considered as a real case study in this paper. Eventually, the results indicate that the proposed approach considerably outperforms, and the efficiency of the developed model is verified through a set of sensitivity analyses. [ABSTRACT FROM AUTHOR]

Nowadays, in the pharmaceutical industry, a growing concern with sustainability has become a strict consideration during the COVID-19 pandemic. There is a lack of good mathematical models in the field. In this research, a production–distribution–inventory–allocation–location problem in the sustainable medical supply chain network is designed to fill this gap. Also, the distribution of medicines related to COVID-19 patients and the periods of production and delivery of medicine according to the perishability of some medicines are considered. In the model, a multi-objective, multi-level, multi-product, and multi-period problem for a sustainable medical supply chain network is designed. Three hybrid meta-heuristic algorithms, namely, ant colony optimization, fish swarm algorithm, and firefly algorithm are suggested, hybridized with variable neighborhood search to solve the sustainable medical supply chain network model. Response surface method is used to tune the parameters since meta-heuristic algorithms are sensitive to input parameters. Six assessment metrics were used to assess the quality of the obtained Pareto frontier by the meta-heuristic algorithms on the considered problems. A real case study is used and empirical results indicate the superiority of the hybrid fish swarm algorithm with variable neighborhood search. [ABSTRACT FROM AUTHOR]

The main need of people during natural disasters, such as earthquakes, is to have a safe shelter. Since it is not possible to provide suitable places immediately after the occurrence of crises, such as earthquakes, it is necessary to identify safe places for accommodation before such crises occur. Failure to identify effective criteria in locating aid centers and failure to evaluate the effect of each criterion in selecting optimal centers will pose new and irreparable challenges to crisis management in crisis situations. In this research, 18 criteria were collected and evaluated by experts to assess relief centers. Thirty locations, considered by crisis management, were evaluated using geographic information systems. After creating information layers and a matrix of paired comparisons resulting from the evaluation of relief centers in relation to the problem's criteria, the research criteria were weighted. Then, using the fuzzy cognitive mapping method and after analyzing the correlation of the criteria, the effectiveness and influence of each location criterion in the occurrence of a crisis were evaluated, and the weight of each criterion was determined. By applying the weights obtained from the two methods, the relief centers were ranked separately in each stage using the PROMETHEE method. Distance from the fault (17%), distance from worn-out tissue (12%), and distance from educational centers (1%) had the highest and least impact on the ranking of the options, respectively. In addition, criteria such as distance to the river, population, and distance to medical centers have been the most effective criteria compared to others for locating relief centers. Finally, the Borda and Copeland methods were used to combine the ranking results and determine the final priority of options, and the results indicated both similar and different performances of some options in the final ranking. The use of the fuzzy mapping method to calculate the weight of the criteria for ranking relief centers and determining effective and efficient criteria in locating relief centers is one of the contributions of this research. Furthermore, evaluating the effectiveness and value of location criteria in the event of an earthquake crisis is another innovation of this research. [ABSTRACT FROM AUTHOR]

With the discovery of the COVID-19 vaccine, what has always been worrying the decision-makers is related to the distribution management, the vaccination centers' location, and the inventory control of all types of vaccines. As the COVID-19 vaccine is highly demanded, planning for its fair distribution is a must. University is one of the most densely populated areas in a city, so it is critical to vaccinate university students so that the spread of this virus is curbed. As a result, in the present study, a new stochastic multi-objective, multi-period, and multi-commodity simulation-optimization model has been developed for the COVID-19 vaccine's production, distribution, location, allocation, and inventory control decisions. In this study, the proposed supply chain network includes four echelons of manufacturers, hospitals, vaccination centers, and volunteer vaccine students. Vaccine manufacturers send the vaccines to the vaccination centers and hospitals after production. The students with a history of special diseases such as heart disease, corticosteroids, blood clots, etc. are vaccinated in hospitals because of accessing more medical care, and the rest of the students are vaccinated in the vaccination centers. Then, a system dynamic structure of the prevalence of COVID -19 in universities is developed and the vaccine demand is estimated using simulation, in which the demand enters the mathematical model as a given stochastic parameter. Thus, the model pursues some goals, namely, to minimize supply chain costs, maximize student desirability for vaccination, and maximize justice in vaccine distribution. To solve the proposed model, Variable Neighborhood Search (VNS) and Whale Optimization Algorithm (WOA) algorithms are used. In terms of novelties, the most important novelties in the simulation model are considering the virtual education and exerted quarantine effect on estimating the number of the vaccines. In terms of the mathematical model, one of the remarkable contributions is paying attention to social distancing while receiving the injection and the possibility of the injection during working and non-working hours, and regarding the novelties in the solution methodology, a new heuristic method based on a meta-heuristic algorithm called Modified WOA with VNS (MVWOA) is developed. In terms of the performance metrics and the CPU time, the MOWOA is discovered with a superior performance than other given algorithms. Moreover, regarding the data, a case study related to the COVID-19 pandemic period in Tehran/Iran is provided to validate the proposed algorithm. The outcomes indicate that with the demand increase, the costs increase sharply while the vaccination desirability for students decreases with a slight slope. • Designing a system dynamic structure of the prevalence of COVID -19 in universities. • Decision making about COVID-19 vaccine's production, distribution, location, allocation, and inventory. • Developing a new stochastic multi-objective, multi-period, and multi-commodity simulation-optimization model. • Minimizing supply chain costs, maximizing student desirability of vaccination, and maximizing vaccine distributive justice. • Developing Whale Optimization Algorithm, Variable Neighborhood Search algorithm and a Modified WOA with VNS. [ABSTRACT FROM AUTHOR]