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Are SARS-CoV-2 IgA antibodies in paediatric patients with chilblain-like lesions indicative of COVID-19 asymptomatic or paucisymptomatic infection? Dear Editor, Acral chilblain-like lesions in young patients are one of the commonest skin manifestations reported during COVID-19 pandemic.1-3 Despite the temporal and spatial correlation between the outbreak of pernio-like and the pandemic, the relationship with COVID-19 remains uncertain. Three patients of group B reported flu-like symptoms 3-4 weeks before skin lesion onset, and a single patient developed chilblain after proving positive to SARS-CoV-2. [Extracted from the article]

The article presents a case study of a 3-month-old male infant with the epidermolysis bullosa (EB). His immunofluorescence examination of a skin biopsy revealed a patchy, reticular labelling extending from the cutaneous basement membrane zone (BMZ) to the papillary dermis. The article discusses the Kindler syndrome (KS) with skin atrophy.

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unknown aetiology. Clinical manifestations of PG are characterized by destructive, necrotizing, and noninfective ulceration of the skin. 20-30% of cases are initiated and aggravated by minor trauma or surgery, a phenomenon named pathergy. PG is related to several autoimmune diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, and monoclonal gammopathy. The association with Takayasu's arteritis (TA), a chronic inflammatory and stenotic disease of large and medium-sized arteries, is instead less common. We report a case of PG associated with TA that was induced by an accident with folgoration of the skin; in this case the folgoration can be considered as an exemple of Pathergy, that is, a characteristic feature of PG. [ABSTRACT FROM AUTHOR]