Search

Lidvine Godaert,1 Camille Nicolon,2 Fatiha Najioullah,3 Lukshe Kanagaratnam,4 Raymond Césaire,3,5 Moustapha Dramé5,6 1Department of Geriatrics, General Hospital of Valenciennes, Valenciennes, France; 2Department of Geriatrics, Hospital of Marennes, Marennes, France; 3Department of Virology, University Hospitals of Martinique, Fort-de-France, Martinique; 4Department of Research and Public Health, University Hospitals of Reims, Reims, France; 5Faculty of Medicine, University of French West Indies, Fort-de-France, Martinique; 6Department of Research and Innovation, University Hospitals of Martinique, Fort-de-France, MartiniqueCorrespondence: Moustapha DraméDepartment of Research and Innovation - CS 90632, University Hospitals of Martinique - Pierre Zobda-Quitman Hospital, Fort-de-France 97261, MartiniqueTel +596 596 559769Email moustapha.drame@chu-martinique.frPurpose: The aim of this study was to investigate whether Chikungunya virus infection (CVI) was an independent risk factor for 2-year mortality in Afro-Caribbean subjects aged 65 years or older.Patients and methods: A retrospective cohort study was performed from January 2014 to December 2016 in the University Hospital of Martinique. Subjects aged ≥ 65 years admitted to the hospital were included. Baseline characteristics and concurrent manifestations at admission were collected. Subjects were followed up by phone for 2 years.Results: A total of 687 old Afro-Caribbean subjects (80.4± 8.0 years) were included: 467 positive for CVI (Chik+) and 220 negative for CVI (Chik-). During the follow-up, 180 (26.2%) died. The proportion of deaths was higher among Chik- (40.9%) than among Chik+ subjects (21.6%) (p< 0.0001). By multivariable analysis, when adjusted for age polyarthralgia, neurological troubles, cardiovascular disorders, absence of neutrophilia, thrombocytopenia, hypernatremia, and hospital stay, Chik+ subjects had significantly higher survival rates (HR: 0.58; 95% CI: 0.40– 0.85) than Chik- ones.Conclusion: Within the two years following hospital admission of subjects aged ≥ 65 years or older, Chik+ subjects had significantly higher survival rates than Chik- ones.Keywords: Chikungunya, survival, elderly people, hospital admission

Only 14.3% of the population with a confirmed diagnosis of CHIKV (n=24/168) and 3.5% of those with confirmed biological diagnosis of dengue (n=16/452) were aged 65 years or older. 1 T. Bonifay, G. Vesin, B. Bidaud, C. Bonnefoy, M. Dueymes, M. Nacher, Clinical characteristics and predictive score of dengue vs. chikungunya virus infections, Med Mal Infect, 2018. [Extracted from the article]