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Simple Summary: The current prognostic index for chronic lymphocytic leukemia does not account for the dynamic changes in the B-cell clone over time. This study aims to investigate the association between the tumor microenvironment and the kinetics of clonal B-cells in early-stage CLL patients. By categorizing patients based on the rate of clonal B-cell increase, we identified significant differences in immune cell profiles and clinical outcomes. Patients with rapidly increasing clones exhibited poorer prognosis and shorter time to treatment, but notably, lower Tαβ CD4+CD8lo cell counts, altered B-cell subsets, and higher plasma cell counts were associated with highly proliferative clones. Multivariate analysis confirmed that the number of clonal B-cells, Tαβ CD4+CD8lo cells, and the IGHV mutational status were independent predictors of clonal expansion. These findings suggest that the interplay between CLL cells and the immune microenvironment might play a relevant role in disease progression, potentially leading to the development of novel prognostic markers. Background/Objectives: Despite the current international prognostic index for chronic lymphocytic leukemia (CLL) being widely accepted and broadly used, it does not consider the kinetics of the B-cell clone over time. Here, we investigated the potential association between distinct features of leukemic cells and other immune cells in blood and the kinetics of clonal B-cells in CLL stage Binet A/Rai 0 (A/0) patients; Methods: Based on the leukemia cell kinetics, 69 CLL A/0 cases followed for a median of 105 months were classified as carrying stable (n = 53) vs. rapidly increasing in size (n = 16) CLL clones; Results: Patients with increasing CLL clones had a significantly higher risk of disease progression and shortened time to first therapy vs. those carrying stable B-cell clones (p ≤ 0.001). Strikingly, the distribution of various immune-cell populations in blood at diagnosis also differed significantly between the two groups, with lower Tαβ CD4+CD8lo cell counts (p = 0.03), a greater switched/unswitched memory B-cell ratio (p = 0.01), and higher plasma cell counts (p = 0.05) in CLL with increasing vs. stable clones. Multivariate analysis revealed that the number of circulating clonal B-cells (≥15 × 109/L) and Tαβ CD4+CD8lo cells (≤35 cells/µL), together with an IGHV unmutated gene status at diagnosis, were independent predictors of an increasing CLL clone; Conclusions: Altogether, these data suggest that the expansion of the CLL clone in stage A/0 patients may depend on both the intrinsic characteristics of CLL cells and the surrounding immune microenvironment. [ABSTRACT FROM AUTHOR]

The number of foreign owners in football clubs has recently increased in Europe and especially in England. This study aims to analyze whether clubs owned by foreign investors show different parameters of sporting and managerial efficiency. We use data on expected performance (from betting odds), wage costs, and the results of football clubs in the English Premier League (EPL) and English Football League Championship (EFL) over 13 seasons. We estimate different measures of efficiency using three alternative methods: expected vs. actual performance index, nonparametric conditional data envelopment analysis (DEA), and stochastic frontier, while considering foreign ownership as an exogenous factor. Our results suggest that there are not significant differences between domestic- and foreign-owned clubs. [ABSTRACT FROM AUTHOR]

A rich literature shows that ethnic discrimination is an omnipresent and highly persistent phenomenon. Little is known, however, about how to reduce discrimination. This study reports the results of a large-scale field experiment we ran together with the Norwegian Football Federation. The federation sent an email to a random selection of about 500 amateur soccer coaches, pointing towards the important role that soccer can play in promoting inclusivity and reducing racism in society and calling on the coaches to be open to all interested applicants. Two weeks later, we sent fictitious applications to join an amateur club, using either a native-sounding or a foreign-sounding name, to the same coaches and to a random selection of about 500 coaches who form the control group. In line with earlier research, we find that applications from people with a native-sounding name receive significantly more positive responses than applications from people with a foreign-sounding name. Surprisingly and unintentionally, the email from the federation substantially increased rather than decreased this gap. Our study underlines the importance of running field experiments to check whether well-intended initiatives are effective in reducing discrimination. [ABSTRACT FROM AUTHOR]

Empirical studies show that first- and second-generation immigrants are less likely to be members of sports clubs than their non-immigrant peers. Common explanations are cultural differences and socioeconomic disadvantages. However, lower participation rates in amateur sport could be at least partly due to ethnic discrimination. Are minority ethnic groups granted the same right to belong as their non-immigrant peers? To answer this question, this paper uses publicly available data from a field experiment in which mock applications were sent out to over 1,600 football clubs in Germany. Having a foreign-sounding name significantly reduces the likelihood of being invited to participate. The paper concludes that amateur football clubs are not as permeable as they are often perceived to be. It claims that traditional explanations for lower participation rates of immigrants need to be revisited. [ABSTRACT FROM AUTHOR]

This article describes the content published in the Journal of Sports Economics (JSE) for its 20th anniversary. The analysis focuses on the most relevant topics and captures the characteristics of authors, institutions, and types of collaborations over a 20-year period. In total, the sample includes 663 research articles (published from February 2000 to December 2019) and 856 authors from 490 institutions. The 20-year period offers an insightful picture of sports economics research. The article discusses additional features and trends and reflects on expected directions for future research in the journal. [ABSTRACT FROM AUTHOR]

Abstract Background Event-related potentials (ERPs) may be used as a highly sensitive way of detecting subtle degrees of cognitive dysfunction. On the other hand, impairment of cognitive skills is increasingly recognised as a hallmark of patients suffering from multiple sclerosis (MS). We sought to determine the psychophysiological pattern of information processing among MS patients with the relapsing-remitting form of the disease and low physical disability considered as two subtypes: 'typical relapsing-remitting' (RRMS) and 'benign MS' (BMS). Furthermore, we subjected our data to a cluster analysis to determine whether MS patients and healthy controls could be differentiated in terms of their psychophysiological profile. Methods We investigated MS patients with RRMS and BMS subtypes using event-related potentials (ERPs) acquired in the context of a Posner visual-spatial cueing paradigm. Specifically, our study aimed to assess ERP brain activity in response preparation (contingent negative variation -CNV) and stimuli processing in MS patients. Latency and amplitude of different ERP components (P1, eN1, N1, P2, N2, P3 and late negativity -LN) as well as behavioural responses (reaction time -RT; correct responses -CRs; and number of errors) were analyzed and then subjected to cluster analysis. Results Both MS groups showed delayed behavioural responses and enhanced latency for long-latency ERP components (P2, N2, P3) as well as relatively preserved ERP amplitude, but BMS patients obtained more important performance deficits (lower CRs and higher RTs) and abnormalities related to the latency (N1, P3) and amplitude of ERPs (eCNV, eN1, LN). However, RRMS patients also demonstrated abnormally high amplitudes related to the preparation performance period of CNV (cCNV) and post-processing phase (LN). Cluster analyses revealed that RRMS patients appear to make up a relatively homogeneous group with moderate deficits mainly related to ERP latencies, whereas BMS patients appear to make up a rather more heterogeneous group with more severe information processing and attentional deficits. Conclusions Our findings are suggestive of a slowing of information processing for MS patients that may be a consequence of demyelination and axonal degeneration, which also seems to occur in MS patients that show little or no progression in the physical severity of the disease over time.

This study aims to analyse the tenure of head coaches in college women's soccer in the USA and puts the focus on the influence of race and gender. The analysis includes individual characteristics of coaches (educational and professional background), team performance, institutional characteristics, and geographical differences (at the state level) from 1977 until 2015. The main results show that African American coaches and women have a significantly shorter tenure in these college institutions. Other factors related to the background of coaches and the characteristics of institutions also play a significant role. The findings are relevant for coaches from minority groups and athletic departments, who are interested in equity in sport. Future research may use an alternative approach to investigate the causes of tenure disparity in college women's soccer. [ABSTRACT FROM AUTHOR]

In this paper, we examine if a slight behavioural modification has an influence on discrimination. Specifically, we use a field experiment based on emails to observe if persistence increases the chances of joining a social group. We find that native- or foreign-sounding names are equally successful when being persistent. However, non-persistent individuals with foreign-sounding names suffer from discrimination. The results show that persistent individuals can be especially interesting in the context of field experiments. [ABSTRACT FROM AUTHOR]

Decisions often reflect implicit biases. Ethnic, racial, and gender traits are associated with stereotypes that may influence the decision-making process. Previous research shows that referees' decisions in men's professional sports are often biased in favor of racial and nationalistic in-groups. This study examined if similar biases exist in women's professional sports. Additionally, this study analyzed the potential influence of the gender composition of referee teams on rapid decisions. We gathered data on referee foul calls in women's professional basketball in Spain, 2014–2019 and defined important decisions (fifth fouls) and stressful situations (one-possession matches). The main finding is that out-groups based on racial (i.e., Black players) and nationalistic (i.e., foreign players) criteria did not differ in number of foul calls received. In stressful situations, foreign players actually received fewer fouls than Spanish players. Similarly, there was no evidence of bias due to the gender composition of referee teams: foul calls did not differ between all-male and mixed teams. Implications for race and nationality as dynamic social constructs within ethnocentric and social identity theories are discussed. [ABSTRACT FROM AUTHOR]

Objective: The ranking of countries in the Olympic Games generates a great deal of interest among analysts, academics, and fans. This article proposes an innovative approach to provide Olympic medals (gold, silver, and bronze) with different weights based on metrics of popularity and media visibility and create an alternative historical ranking. Methods: The analysis uses "Google Trends" and "MERIT" appraisals to capture content and news articles on the Internet that relate to the different types of metals. Figures on weekly relative search intensity in Google and content in the Internet registered monthly are used to track changes over time and thus to control for differences between Summer and Winter Olympic Games. Results: The results show that gold medals gather far more attention than silver and bronze medals. By applying the estimated multiplying factors, we create an alternative historical ranking of countries that shows some relevant changes. Conclusion: The use of weights based on popularity and visibility has managerial implications and opens new avenues for future research. [ABSTRACT FROM AUTHOR]

Direct imaging of exoplanets is a challenging task as it requires to reach a high contrast at very close separation to the star. Today, the main limitation in the high-contrast images is the quasi-static speckles that are created by residual instrumental aberrations. They have the same angular size as planetary companions and are often brighter, hence hindering our capability to detect exoplanets. Dedicated observation strategies and signal processing techniques are necessary to disentangle these speckles from planetary signals. The output of these methods is a detection map in which the value of each pixel is related to a probability of presence of a planetary signal. The detection map found in the literature relies on the assumption that the residual noise is Gaussian. However, this is known to lead to higher false positive rates, especially close to the star. In this paper, we re-visit the notion of detection map by analysing the speckle noise distribution, namely the Modified Rician distribution. We use non-asymptotic analysis of the sum of random variables to show that the tail of the distribution of the residual noise decays as an exponential distribution, hence explaining the high false detection rate obtained with the Gaussian assumption. From this analysis, we introduce a novel time domain detection map and we demonstrate its capabilities and the relevance of our approach through experiments on real data. We also provide an empirical rule to determine detection threshold providing a good trade-off between true positive and false positive rates for exoplanet detection. [ABSTRACT FROM AUTHOR]

Sports betting is an important industry that generates billions of euros of revenue in Europe, and attracts the attention of sports economists. The recent entry of new companies could influence the market regarding the prices (overround), and hence, cross-bookmaker arbitrage opportunities. This paper investigates the movements of major betting companies in European football during the period from 2000-2001 to 2016-2017 with respect to these two issues. The results show a continuous decrease in the prices of the odds, which is especially noticeable in the top five leagues. In this line, the number of surebets have increased among major bookmakers in recent years, which offers bettors more possibilities of making a profit. [ABSTRACT FROM AUTHOR]

Studying the performance and efficiency of countries participating in the Olympic Games is a topic of interest in the area of economics and operations research. Commonly, efficiency in this area has been analyzed using outputs like number of medals, the number of medals weighted by category, and the number of diplomas, while the most common inputs are gross domestic product (GDP) and population. This paper contributes to the literature by analyzing the countries' efficiencies in the Rio 2016 Summer Olympics with stochastic frontier models. Moreover, this study aims to fill three research gaps in the literature. On the one hand, given that the athletes' qualification for the Games is a great achievement itself for many countries, the analysis uses the number of participants as the output. On the other hand, the analysis weights the number of medals in relation to the number of participants in each competition (i.e., two in tennis doubles, 14 in handball). Finally, this paper develops a measure to calculate the inefficiency of countries with zero medals, since traditional frontier methods do not consider them. [ABSTRACT FROM AUTHOR]

Background: Event-related potentials (ERPs) may be used as a highly sensitive way of detecting subtle degrees of cognitive dysfunction. On the other hand, impairment of cognitive skills is increasingly recognised as a hallmark of patients suffering from multiple sclerosis (MS). We sought to determine the psychophysiological pattern of information processing among MS patients with the relapsing-remitting form of the disease and low physical disability considered as two subtypes: 'typical relapsing-remitting' (RRMS) and 'benign MS' (BMS). Furthermore, we subjected our data to a cluster analysis to determine whether MS patients and healthy controls could be differentiated in terms of their psychophysiological profile. Methods: We investigated MS patients with RRMS and BMS subtypes using event-related potentials (ERPs) acquired in the context of a Posner visual-spatial cueing paradigm. Specifically, our study aimed to assess ERP brain activity in response preparation (contingent negative variation -CNV) and stimuli processing in MS patients. Latency and amplitude of different ERP components (P1, eN1, N1, P2, N2, P3 and late negativity -LN) as well as behavioural responses (reaction time -RT; correct responses -CRs; and number of errors) were analyzed and then subjected to cluster analysis. Results: Both MS groups showed delayed behavioural responses and enhanced latency for long-latency ERP components (P2, N2, P3) as well as relatively preserved ERP amplitude, but BMS patients obtained more important performance deficits (lower CRs and higher RTs) and abnormalities related to the latency (N1, P3) and amplitude of ERPs (eCNV, eN1, LN). However, RRMS patients also demonstrated abnormally high amplitudes related to the preparation performance period of CNV (cCNV) and post-processing phase (LN). Cluster analyses revealed that RRMS patients appear to make up a relatively homogeneous group with moderate deficits mainly related to ERP latencies, whereas BMS patients appear to make up a rather more heterogeneous group with more severe information processing and attentional deficits. Conclusions: Our findings are suggestive of a slowing of information processing for MS patients that may be a consequence of demyelination and axonal degeneration, which also seems to occur in MS patients that show little or no progression in the physical severity of the disease over time. [ABSTRACT FROM AUTHOR]

The formation of massive stars remains one of the most intriguing questions in astrophysics today. The main limitations result from the difficulty to obtain direct observational constraints on the formation process itself. In this context, the Carina High-contrast Imaging Project of massive Stars (CHIPS) aims to observe all 80+ O stars in the Carina nebula using the new VLT 2nd-generation extreme-AO instrument SPHERE. This instrument offers unprecedented imaging contrast allowing us to detect the faintest companions around massive stars. These novel observational constraints will help to discriminate between the different formation scenarios by comparing their predictions for companion statistics and properties. [ABSTRACT FROM AUTHOR]