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3. Third Report of the Japan Diabetes Society (JDS)/Japanese Cancer Association (JCA) Joint Committee on diabetes and cancer: summary of the results of a questionnaire survey of oncologists and diabetologists—secondary publication

Author

Goto, Atsushi, Ohashi, Ken, Noda, Mitsuhiko, Noto, Hiroshi, Ueki, Kohjiro, Inoue, Manami, Nishimura, Rimei, Takahashi, Shin, Ioka, Tatsuya, Oshima, Masanobu, Fujibayashi, Kazutoshi, Tsuji, Akihito, Kodaira, Makoto, Tamakoshi, Akiko, Mimori, Koshi, Tanabe, Yuko, Hara, Eiji, Matsuo, Keitaro, Murakami, Yoshinori, and Watada, Hirotaka

Published
2024
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9. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

Author

Hanyuda, Akiko, Goto, Atsushi, Katagiri, Ryoko, Koyanagi, Yuriko N., Nakatochi, Masahiro, Sutoh, Yoichi, Nakano, Shiori, Oze, Isao, Ito, Hidemi, Yamaji, Taiki, Sawada, Norie, Iwagami, Masao, Kadota, Aya, Koyama, Teruhide, Katsuura-Kamano, Sakurako, Ikezaki, Hiroaki, Tanaka, Keitaro, Takezaki, Toshiro, Imoto, Issei, Suzuki, Midori, Momozawa, Yukihide, Takeuchi, Kenji, Narita, Akira, Hozawa, Atsushi, Kinoshita, Kengo, Shimizu, Atsushi, Tanno, Kozo, Matsuo, Keitaro, Tsugane, Shoichiro, Wakai, Kenji, Sasaki, Makoto, Yamamoto, Masayuki, and Iwasaki, Motoki

Published
2023
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11. Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach

Author

Katagiri, Ryoko, Goto, Atsushi, Nakano, Shiori, Nakatochi, Masahiro, Koyanagi, Yuriko N., Iwagami, Masao, Hanyuda, Akiko, Yamaji, Taiki, Sawada, Norie, Nakamura, Yohko, Nakamura, Sho, Kuriki, Kiyonori, Suzuki, Sadao, Imoto, Issei, Momozawa, Yukihide, Oze, Isao, Ito, Hidemi, Tsugane, Shoichiro, Wakai, Kenji, Matsuo, Keitaro, and Iwasaki, Motoki

Published
2023
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17. Low HbA1c levels and all-cause or cardiovascular mortality among people without diabetes: the US National Health and Nutrition Examination Survey 1999-2015.

Author

Inoue, Kosuke, Nianogo, Roch, Telesca, Donatello, Goto, Atsushi, Khachadourian, Vahe, Tsugawa, Yusuke, Sugiyama, Takehiro, Mayeda, Elizabeth Rose, and Ritz, Beate

Subjects
Humans, Cardiovascular Diseases, Diabetes Mellitus, Nutrition Surveys, Risk Factors, Adult, Glycated Hemoglobin, Low HbA1c, NHANES, cardiovascular, machine learning, mortality, parametric g-formula, Diabetes, Cardiovascular, Nutrition, Prevention, Good Health and Well Being, Glycated Hemoglobin A, Statistics, Public Health and Health Services, Epidemiology
Abstract

ObjectiveIt is unclear whether relatively low glycated haemoglobin (HbA1c) levels are beneficial or harmful for the long-term health outcomes among people without diabetes. We aimed to investigate the association between low HbA1c levels and mortality among the US general population.MethodsThis study includes a nationally representative sample of 39 453 US adults from the National Health and Nutrition Examination Surveys 1999-2014, linked to mortality data through 2015. We employed the parametric g-formula with pooled logistic regression models and the ensemble machine learning algorithms to estimate the time-varying risk of all-cause and cardiovascular mortality by HbA1c categories (low, 4.0 to

Published
2021

28. Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population

Author

Hanyuda, Akiko, Goto, Atsushi, Nakatochi, Masahiro, Sutoh, Yoichi, Narita, Akira, Nakano, Shiori, Katagiri, Ryoko, Wakai, Kenji, Takashima, Naoyuki, Koyama, Teruhide, Arisawa, Kokichi, Imoto, Issei, Momozawa, Yukihide, Tanno, Kozo, Shimizu, Atsushi, Hozawa, Atsushi, Kinoshita, Kengo, Yamaji, Taiki, Sawada, Norie, Iwagami, Masao, Yuki, Kenya, Tsubota, Kazuo, Negishi, Kazuno, Matsuo, Keitaro, Yamamoto, Masayuki, Sasaki, Makoto, Tsugane, Shoichiro, and Iwasaki, Motoki

Published
2023
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37. Interface-sensitive nuclear magnetic resonance at a semiconductor heterojunction using hyperpolarization

Author

Goto, Atsushi, Hashi, Kenjiro, Ohki, Shinobu, and Shimizu, Tadashi

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

We demonstrate an interface-sensitive NMR in a semiconducting nanostructure, where an NMR signal from the minute heterojunction region of a model heterojunction structure (In$_{0.48}$Ga$_{0.52}$P/GaAs) is detected by using nuclear hyperpolarization created by optical pumping. The key to the detection is the use of minute lattice distortions occurring at the heterojunction due to the lattice mismatch, which enables us to create and localize hyperpolarization at the heterojunction and distinguish it from the other parts. In particular, the suppression of nuclear spin diffusion by the spatial variation in the strain and the resultant unexpectedly stable hyperpolarization at the heterojunction are the keys to successful detection., Comment: 15 pages, 4 figures

Published
2017
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43. Hyperfine couplings between the paramagnetic moment and nuclei in the metallic phase of low silica X zeolite loaded with potassium.

Author

Igarashi, Mutsuo, Shimizu, Tadashi, Goto, Atsushi, Hashi, Kenjiro, Yamamichi, Keiko, and Nakano, Takehito

Subjects
COUPLING constants, SILICA, POTASSIUM, ZEOLITES, HYPERFINE coupling, HYPERFINE interactions, MAGNETISM, ATOMS
Abstract

Temperature dependences of NMR spectra have been observed for 23Na and 27Al in the metallic phase of Na–K form low silica X (LSX) zeolite loaded with potassium, where the condition of saturation is achieved with a loading level of 9.0 atoms per supercage and the paramagnetic moment contributes to the magnetism of the system beyond simple isolated spin. Two separated peaks have been recognized for 23Na, where the shift values show a quite linear relationship with susceptibility, and the so-called K–χ plot works quite well to give values of 0.32 kOe μB−1 and 0.40 kOe μB−1 for hyperfine coupling constants. Although no separated peak is seen in the 27Al NMR spectrum, the spectral centroid deviates to the positive side. The shoulder of the spectrum scales to susceptibility and the K–χ plot also works well to give a value of 0.15 kOe μB−1 for the hyperfine coupling constant. The orbital of potassium-originated electrons confined in the cage of LSX is understood as seeping out over the framework of zeolite, which is wider than that of the sodium-originated case. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Usual source and better quality of primary care are associated with lower loneliness scores: a cross-sectional study.

Author

Kaneko, Makoto, Shinoda, Satoru, Nakayama, Izumi, Xu, Juan, Yagome, Susumu, and Goto, Atsushi

Subjects
PRIMARY care, LONELINESS, INCOME, CROSS-sectional method, PATIENT-centered care
Abstract

Background Loneliness is a global issue, and primary care physicians play an important role in assessing and intervening with loneliness. This study aimed to examine the association between having a usual source of care (USC) or a good quality of primary care, and loneliness. Methods This cross-sectional study was conducted in Japan in 2022. A total of 6,000 residents were randomly sampled from the general population, aged 20–74 years. The outcome was the total score of the University of California, Los Angeles (UCLA) 3-item loneliness scale. The exposure included USC and the Person-Centered Primary Care Measure (PCPCM), which assesses the quality of primary care. We conducted a linear regression analysis to adjust for age, sex, educational status, annual household income, self-rated health, living status (whether alone or not), and the existence of physical health problems. Results Of the 6,000 residents, 1,277 responded to the survey. The median score of the UCLA 3-item loneliness scale was 6.0 and the mean total score of the PCPCM was 2.62. Of the 1,277 individuals, 713 (55.8%) had USC. Having USC was significantly associated with lower scores on the UCLA 3-item loneliness scale; the coefficient was −0.34 (95% confidence interval (CI): −0.57 to −0.12). Also, the total PCPCM score was significantly associated with lower loneliness scores; the coefficient was −0.56 (P < 0.001, 95% CI: −0.78 to −0.35). Conclusions Having USC and a better quality primary care were associated with a lower loneliness score. The quality of primary care could be a factor to mitigate patient loneliness. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Genetic variants in sex hormone pathways and the risk of type 2 diabetes among African American, Hispanic American, and European American postmenopausal women in the US.

Author

Goto, Atsushi, Chen, Brian, Chan, Kei-Hang, Lee, Cathy, Nelson, Sarah, Crenshaw, Andrew, Bookman, Ebony, Margolis, Karen, Sale, Michèle, Ng, Maggie, Reiner, Alexander, and Liu, Simin

Subjects
diabetes risk, sex hormone pathways, single nucleotide polymorphisms, 单核苷酸多态性, 性激素途径, 糖尿病风险, Black or African American, Aged, Biomarkers, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Genome-Wide Association Study, Hispanic or Latino, Humans, Middle Aged, Polymorphism, Single Nucleotide, Postmenopause, Prognosis, Receptors, Progesterone, White People
Abstract

BACKGROUND: Sex hormones are implicated in the development of diabetes. However, whether genetic variations in sex hormone pathways (SHPs) contribute to the risk of type 2 diabetes mellitus (T2DM) remains to be determined. This study investigated associations between genetic variations in all candidate genes in SHPs and T2DM risk among a cohort of women participating in the Womens Health Initiative (WHI). METHODS: Single nucleotide polymorphisms (SNPs) located within 30 kb upstream and downstream of SHP genes were comprehensively examined in 8180 African American, 3498 Hispanic American, and 3147 European American women in the WHI. In addition, whether significant SNPs would be replicated in independent populations was examined. RESULTS: After adjusting for age, region, and ancestry estimates and correcting for multiple testing, seven SNPs were significantly associated with the risk of T2DM among Hispanic American women were identified in the progesterone receptor (PGR) gene, with rs948516 showing the greatest significance (odds ratio 0.67; 95% confidence interval 0.57-0.78; P = 8.8 × 10-7 ; false discovery rate, Q = 7.8 × 10-4 ). These findings were not replicated in other ethnic groups in the WHI or in sex-combined analyses in replication studies. CONCLUSION: Significant signals were identified implicating the PGR gene in T2DM development in Hispanic American women in the WHI, which are consistent with genome-wide association studies findings linking PGR to glucose homeostasis. Nevertheless, the PGR SNPs-T2DM association was not statistically significant in other ethnic populations. Further studies, especially sex-specific analyses, are needed to confirm the findings and clarify the role of SHPs in T2DM.

Published
2018

48. Third Report of the Japan Diabetes Society/Japanese Cancer Association Joint Committee on Diabetes and Cancer: Summary of the results of a questionnaire survey of oncologists and diabetologists—Secondary publication

Author

Goto, Atsushi, primary, Ohashi, Ken, additional, Noda, Mitsuhiko, additional, Noto, Hiroshi, additional, Ueki, Kohjiro, additional, Inoue, Manami, additional, Nishimura, Rimei, additional, Takahashi, Shin, additional, Ioka, Tatsuya, additional, Oshima, Masanobu, additional, Fujibayashi, Kazutoshi, additional, Tsuji, Akihito, additional, Kodaira, Makoto, additional, Tamakoshi, Akiko, additional, Mimori, Koshi, additional, Tanabe, Yuko, additional, Hara, Eiji, additional, Matsuo, Keitaro, additional, Murakami, Yoshinori, additional, and Watada, Hirotaka, additional

Published
2024
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49. Validity of self-reported Helicobacter pylori eradication treatment from questionnaire and interview surveys of the JPHC-NEXT study: comparison with prescription history from insurance claims data

Author

Kihara, Tomomi, primary, Yamagishi, Kazumasa, additional, Imatoh, Takuya, additional, Ihira, Hikaru, additional, Goto, Atsushi, additional, Iso, Hiroyasu, additional, Sawada, Norie, additional, Tsugane, Shoichiro, additional, and Inoue, Manami, additional

Published
2024
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