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2. Incidence and associated factors of cetuximab-induced hypersensitivity infusion reactions in 1392 cancer patients treated in four French areas: a possible association with Lyme disease?

Author

Dupont, M, Carlier, Claire, Gower-Rousseau, C, Barbier-Lider, P, Botsen, D, Brasseur, M, Burgevin, A, Chourbagi, C, D’Almeida, R, Hautefeuille, V, Hentzien, M, Lambert, A, Lamuraglia, M, Lavau-Denes, S, Lopez, A, Parent, D, Slimano, F, Brugel, M, and Bouché, O

Published
2022
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6. Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study

Author

Hochart, A, Gower-Rousseau, C, Sarter, H, Fumery, M, Ley, D, Spyckerelle, C, Peyrin-Biroulet, L, Laberenne, J-E, Vasseur, F, Savoye, G, Turck, D, Andre, JM, Antonietti, M, Aouakli, A, Armand, A, Aroichane, I, Assi, F, Aubet, JP, Auxenfants, E, Ayafi-Ramelot, F, Azzouzi, K, Bankovski, D, Barbry, B, Bardoux, N, Baron, P, Baudet, A, Bazin, B, Bebahani, A, Becqwort, JP, Benet, V, Benali, H, Benguigui, C, Ben Soussan, E, Bental, A, Berkelmans, I, Bernet, J, Bernou, K, Bernou-Dron, C, Bertot, P, Bertiaux-Vandaële, N, Bertrand, V, Billoud, E, Biron, N, Bismuth, B, Bleuet, M, Blondel, F, Blondin, V, Bohon, P, Boniface, E, Bonnière, P, Bonvarlet, E, Bonvarlet, P, Boruchowicz, A, Bostvironnois, R, Boualit, M, Bouche, B, Boudaillez, C, Bourgeaux, C, Bourgeois, M, Bourguet, A, Bourienne, A, Branche, J, Bray, G, Brazier, F, Breban, P, Bridenne, M, Brihier, H, Brung-Lefebvre, V, Bulois, P, Burgiere, P, Butel, J, Canva, JY, Canva-Delcambre, V, Capron, JP, Cardot, F, Carpentier, P, Cartier, E, Cassar, JF, Cassagnou, M, Castex, JF, Catala, P, Cattan, S, Catteau, S, Caujolle, B, Cayron, G, Chandelier, C, Chantre, M, Charles, J, Charneau, T, Chavance-Thelu, M, Chirita, D, Choteau, A, Claerbout, JF, Clergue, PY, Coevoet, H, Cohen, G, Collet, R, Colombel, JF, Coopman, S, Corvisart, J, Cortot, A, Couttenier, F, Crinquette, JF, Crombe, V, Dadamessi, I, Dapvril, V, Davion, T, Dautreme, S, Debas, J, Degrave, N, Dehont, F, Delatre, C, Delcenserie, R, Delette, O, Delgrange, T, Delhoustal, L, Delmotte, JS, Demmane, S, Deregnaucourt, G, Descombes, P, Desechalliers, JP, Desmet, P, Desreumaux, P, Desseaux, G, Desurmont, P, Devienne, A, Devouge, E, Devred, M, Devroux, A, Dewailly, A, Dharancy, S, Di Fiore, A, Djeddi, D, Djedir, R, Dreher-Duwat, ML, Dubois, R, Dubuque, C, Ducatillon, P, Duclay, J, Ducrocq, B, Ducrot, F, Ducrotte, P, Dufilho, A, Duhamel, C, Dujardin, D, Dumant-Forest, C, Dupas, JL, Dupont, F, Duranton, Y, Duriez, A, El Achkar, K, El Farisi, M, Elie, C, Elie-Legrand, MC, Elkhaki, A, Eoche, M, Evrard, D, Evrard, JP, Fatome, A, Filoche, B, Finet, L, Flahaut, M, Flamme, C, Foissey, D, Fournier, P, Foutrein-Comes, MC, Foutrein, P, Fremond, D, Frere, T, Gallet, P, Gamblin, C, Ganga, S, Gerard, R, Geslin, G, Gheyssens, Y, Ghossini, N, Ghrib, S, Gilbert, T, Gillet, B, Godard, D, Godard, P, Godchaux, JM, Godchaux, R, Goegebeur, G, Goria, O, Gottrand, F, Gower, P, Grandmaison, B, Groux, M, Guedon, C, Guillard, JF, Guillem, L, Guillemot, F, Guimberd, D, Haddouche, B, Hakim, S, Hanon, D, Hautefeuille, V, Heckestweiller, P, Hecquet, G, Hedde, JP, Hellal, H, Henneresse, PE, Heyman, B, Heraud, M, Herve, S, Hochain, P, Houssin-Bailly, L, Houcke, P, Huguenin, B, Iobagiu, S, Ivanovic, A, Iwanicki-Caron, I, Janicki, E, Jarry, M, Jeu, J, Joly, JP, Jonas, C, Katherin, F, Kerleveo, A, Khachfe, A, Kiriakos, A, Kiriakos, J, Klein, O, Kohut, M, Kornhauser, R, Koutsomanis, D, Laffineur, G, Lagarde, M, Lalanne, A, Lannoy, P, Lapchin, J, Laprand, M, Laude, D, Leblanc, R, Lecieux, P, Leclerc, N, Le Couteulx, C, Ledent, J, Lefebvre, J, Lefiliatre, P, Legrand, C, Le Grix, A, Lelong, P, Leluyer, B, Lenaerts, C, Lepileur, L, Leplat, A, Lepoutre-Dujardin, E, Leroi, H, Leroy, MY, Lesage, JP, Lesage, X, Lesage, J, Lescanne-Darchis, I, Lescut, J, Lescut, D, Leurent, B, Levy, P, Lhermie, M, Lion, A, Lisambert, B, Loire, F, Louf, S, Louvet, A, Luciani, M, Lucidarme, D, Lugand, J, Macaigne, O, Maetz, D, Maillard, D, Mancheron, H, Manolache, O, Marks-Brunel, AB, Marti, R, Martin, F, Martin, G, Marzloff, E, Mathurin, P, Mauillon, J, Maunoury, V, Maupas, JL, Mesnard, B, Metayer, P, Methari, L, Meurisse, B, Meurisse, F, Michaud, L, Mirmaran, X, Modaine, P, Monthe, A, Morel, L, Mortier, PE, Moulin, E, Mouterde, O, Mudry, J, Nachury, M, NʼGuyen Khac, E, Notteghem, B, Ollevier, V, Ostyn, A, Ouraghi, A, Ouvry, D, Paillot, B, Panien-Claudot, N, Paoletti, C, Papazian, A, Parent, B, Pariente, B, Paris, JC, Patrier, P, Paupart, L, Pauwels, B, Pauwels, M, Petit, R, Piat, M, Piotte, S, Plane, C, Plouvier, B, Pollet, E, Pommelet, P, Pop, D, Pordes, C, Pouchain, G, Prades, P, Prevost, A, Prevost, JC, Quesnel, B, Queuniet, AM, Quinton, JF, Rabache, A, Rabelle, P, Raclot, G, Ratajczyk, S, Rault, D, Razemon, V, Reix, N, Revillon, M, Richez, C, Robinson, P, Rodriguez, J, Roger, J, Roux, JM, Rudelli, A, Saber, A, Schlosseberg, P, Segrestin, M, Seguy, D, Serin, M, Seryer, A, Sevenet, F, Shekh, N, Silvie, J, Simon, V, Talbodec, N, Techy, A, Thelu, JL, Thevenin, A, Thiebault, H, Thomas, J, Thorel, JM, Tielman, G, Tode, M, Toisin, J, Tonnel, J, Touchais, JY, Touze, Y, Tranvouez, JL, Triplet, C, Uhlen, S, Vaillant, E, Valmage, C, Vanco, D, Vandamme, H, Vanderbecq, E, Vander Eecken, E, Vandermolen, P, Vandevenne, P, Vandeville, L, Vandewalle, A, Vandewalle, C, Vaneslander, P, Vanhoove, JP, Vanrenterghem, A, Varlet, P, Vasies, I, Verbiese, G, Vernier-Massouille, G, Vermelle, P, Verne, C, Vezilier-Cocq, P, Vigneron, B, Vincendet, M, Viot, J, Voiment, YM, Wacrenier, A, Waeghemaecker, L, Wallez, JY, Wantiez, M, Wartel, F, Weber, J, Willocquet, JL, Wizla, N, Wolschies, E, Zalar, A, Zaouri, B, Zellweger, A, and Ziade, C

Published
2017
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9. Opposite evolution in incidence of Crohn's disease and ulcerative colitis in Northern France (1988-1999)

Author

Molinie, F., Gower-Rousseau, C., Yzet, T., Merle, V., Grandbastien, B., Cortot, A., Salomez, J-L, Colombel, J-F, Dupas, J-L, Lerebours, E., and Marti, R.

Subjects
Ulcerative colitis -- Risk factors, Ulcerative colitis -- Care and treatment, Crohn's disease -- Risk factors, Crohn's disease -- Care and treatment, Health
Abstract

The trends in the incidence of inflammatory bowel disease (IBD) are examined over a period of 12 year from 1988 to 1999 in areas of Northern France. The incidence of Crohn's disease increased by 23 percent and the incidence of ulcerative colitis (UC) declined by 17 percent during the 12 years.

Published
2004

11. CARD4/NOD1 is not involved in inflammatory bowel disease. (Inflammatory Bowel Disease)

Author

Zouali, H., Lesage, S., Merlin, F., Cezard, J-P., Colombel, J-F., Belaiche, J., Almer, S., Tysk, C., O'Morain, C., Gassull, M., Christensen, S., Finkel, Y., Modigliani, R., Gower-Rousseau, C., Macry, J., Chamaillard, M., Thomas, G., and Hugot, J-P.

Subjects
Inflammatory bowel diseases -- Genetic aspects, Health
Abstract

Background and aims: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are complex genetic disorders. CARD15/NOD2, a member of the Ced4 super-family which includes Apaf-1 and [...]

Published
2003

14. Anticipation in familial Crohn's disease

Author

Grandbastien, B, Peeters, M, Franchimont, D, Gower-Rousseau, C, Speckel, D, Rutgeerts, P, Belaiche, J, Cortot, A, Vlietinck, R, and Colombel, J-F

Published
1998

15. Post‐operative complications in elderly onset inflammatory bowel disease: a population‐based study.

Author

Sacleux, S.‐C., Sarter, H., Fumery, M., Charpentier, C., Guillon‐Dellac, N., Coevoet, H., Pariente, B., Peyrin‐Biroulet, L., Gower‐Rousseau, C., Savoye, G., and the EPIMAD Group

Subjects
SURGICAL complications, INFLAMMATORY bowel diseases, INFLAMMATORY bowel disease treatment, GERIATRIC surgery, DISEASE incidence
Abstract

Summary: Background: IBD diagnosed after the age of 60 is increasing. Data on post‐operative complications in elderly onset IBD are scarce. Aim: To describe the incidence of and factors associated with post‐operative complications in elderly onset IBD, diagnosed after the age of 60. Methods: Using EPIMAD Cohort (1988‐2006), among 841 incident IBD patients, 139 (17%) underwent intestinal surgery, including 100 Crohn's disease (CD) and 39 ulcerative colitis (UC). Results: After a median post‐operative follow‐up of 6 years (2‐10), 50 (36%) patients experienced at least 1 complication with a total of 69. During the first 30 post‐operative days, the mortality rate was 4%. Thirty‐two early complications (<30 days) were observed in 23 patients (17%), with 15 infectious, without significant difference between CD and UC. More than half early post‐operative complications (n = 19, 59%) were severe (>grade 2) without significant difference between CD and UC (P = 0.28). Thirty‐seven long‐term adverse effects of surgical therapy (≥30 days) were observed in 33 patients (24%). Multivariate analysis found (1) acute severe colitis (OR = 7.84 [2.15‐28.52]) and emergency surgery (OR = 4.46 [1.75‐11.36]) were associated with early post‐operative complications, and (2) Female gender (HR = 2.10 [1.01‐4.37]) and delay before surgery >3 months (HR = 2.09 [1.01‐4.31]) with long‐term adverse effects of surgical therapy. Conclusions: One‐third of elderly IBD patients experienced at least 1 post‐operative complication. Half of the early complications were severe, and infectious. Emergency surgery was the key driver for post‐operative complication. [ABSTRACT FROM AUTHOR]

Published
2018
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17. Perinatal passive smoke exposure may be more important than childhood exposure in the risk of developing childhood IBD

Author

Russell, R.K., Farhadi, R., Wilson, M., Drummond, H., Satsangi, J., Wilson, D.C., Balde, M., Gower-Rousseau, C., Turck, D., and Colombel, J.F.

Subjects
Inflammatory bowel diseases -- Risk factors, Inflammatory bowel diseases -- Development and progression, Smoking in pregnancy -- Health aspects, Passive smoking -- Health aspects, Pediatric gastroenterology -- Research, Health
Published
2005

18. Incidence and Phenotype at Diagnosis of Very-early-onset Compared with Later-onset Paediatric Inflammatory Bowel Disease: A Population-based Study [1988–2011].

Author

Bequet, E., Sarter, H., Fumery, M., Vasseur, F., Armengol-Debeir, L., Pariente, B., Ley, D., Spyckerelle, C., Coevoet, H., Laberenne, J. E., Peyrin-Biroulet, L., Savoye, G., Turck, D., and Gower-Rousseau, C.

Abstract

Background and Aims:Very-early-onset inflammatory bowel disease [VEO-IBD] is a form of IBD that is distinct from that of children with an older onset. We compared changes over time in the incidence and phenotype at diagnosis between two groups according to age at IBD diagnosis: VEO-IBD diagnosed before the age of 6 years, and early-onset IBD [EO-IBD] diagnosed between 6 and 16 years of age.Methods:Data were obtained from a cohort enrolled in a prospective French population-based registry from 1988 to 2011.Results:Among the 1412 paediatric cases [< 17 years], 42 [3%] were VEO-IBD. In the VEO-IBD group, the incidence remained stable over the study period. In contrast, the incidence of EO-IBD increased from 4.4/105 in 1988–1990 to 9.5/105 in 2009–2011 [+116%; p < 10–4]. Crohn’s disease [CD] was the most common IBD, regardless of age, but ulcerative colitis [UC] and unclassified IBD were more common in VEO-IBD cases [40% vs 26%; p = 0.04]. VEO-IBD diagnosis was most often performed in hospital [69% vs 43%; p < 10–3]. Rectal bleeding and mucous stools were more common in patients with VEO-IBD, whereas weight loss and abdominal pain were more frequent in those with EO-IBD. Regarding CD, isolated colonic disease was more common in the VEO-IBD group [39% vs 14%; p = 0.003].Conclusions:In this large population-based cohort, the incidence of VEO-IBD was low and stable from 1988 to 2011, with a specific clinical presentation. These results suggest a probable genetic origin for VEO-IBD, whereas the increase in EO-IBD might be linked to environmental factors. [ABSTRACT FROM AUTHOR]

Published
2017
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23. Virus Serology in Familial Crohn Disease.

Author

van Kruiningen, H. J., Mayo, D. R., Vanopdenbosch, E., Gower-Rousseau, C., Cortot, A., and Colombel, J.-F.

Subjects
CROHN'S disease, VIRUS diseases, SEROLOGY, FAMILIAL diseases, DISEASE risk factors
Abstract

Background: Recent findings that early-in-life virus infections represent a risk factor for Crohn disease, that exacerbations of disease sometimes appear associated with common viral infections, and, in particular, suggestions that Crohn disease may be the result of persistent infection with measles virus prompted serologic studies for antibody to 19 common viruses, Chlamydia psittaci, and Mycoplasma pneumoniae. Methods: Sera from 14 affected members of 2 French families with a high frequency of Crohn disease and from age- and sex-matched controls, taken in 1990 and 1992, and from unaffected family members were tested. Complement fixation, enzyme immunoassay, and indirect immunofluorescent tests were used. Results: There were no significant differences between patients and controls or between affected and unaffected family members of family 2, with the exception that affected siblings carried higher antibody titers for mycoplasma one year and for varicella another year. There were no differences in measles IgM and IgG or mumps IgG antibody levels between patients and controls, or between patients and unaffected family members. Conclusions: Serology failed to find evidence of participation by 19 common viruses, C. psittaci, and M. pneumoniae in Crohn disease. The data do not support the hypothesis that persistent measles virus infection causes Crohn disease. [ABSTRACT FROM AUTHOR]

Published
2000
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24. Incidence of inflammatory bowel disease in northern France (1988-1990).

Author

Gower-Rousseau, C, Salomez, J L, Dupas, J L, Marti, R, Nuttens, M C, Votte, A, Lemahieu, M, Lemaire, B, Colombel, J F, and Cortot, A

Abstract

There were no data concerning the incidence of inflammatory bowel disease (IBD) in France. The aim of this study was to investigate the incidence of Crohn's disease and ulcerative colitis in northern France. This prospective population based study was realised through the gastroenterologists of the region Nord-Pas de Calais and the Somme Department. Each gastroenterologist referred patients consulting for the first time with clinical symptoms compatible with IBD. Data were collected by an interviewer practitioner present at the gastroenterologist's consulting room. Two independent expert gastroenterologists assessed each case in a blind manner and made a final diagnosis of Crohn's disease, ulcerative colitis, ulcerative proctitis, or unclassifiable chronic colitis. From 1988 to 1990, 1291 cases of IBD were recorded: 674 (52%) Crohn's disease, 466 (36%) ulcerative colitis including 162 proctitis (35%), and 151 (12%) unclassifiable chronic colitis. The mean annual incidence was 4.9 per 100,000 for Crohn's disease and 3.2 for ulcerative colitis. The sex ratio F/M was 1.3 for Crohn's disease and 0.8 for ulcerative colitis. The highest age specific incidence rate for Crohn's disease was between 20 and 29 years: 13.1 for women and 9.8 for men. The highest age specific incidence rate for ulcerative colitis was between 20 and 39 years: 5.5 for women and 6.5 for men. This first French prospective study has shown an incidence rate for Crohn's disease comparable with that seen in north European studies but lower than that seen for ulcerative colitis. These results could be related to the different environmental factors or the genetic background of the population studied, or both. [ABSTRACT FROM PUBLISHER]

Published
1994

25. Inflammatory bowel disease in married couples: 10 cases in Nord Pas de Calais region of France and Liège county of Belgium.

Author

Comes, M C, Gower-Rousseau, C, Colombel, J F, Belaïche, J, Van Kruiningen, H J, Nuttens, M C, and Cortot, A

Abstract

Ten pairs of husband-wife couples are reported with inflammatory bowel disease who were seen in the same geographical area in Nord Pas de Calais region of France and in Liège county (Belgium). Among these 10 couples, four were concordant for Crohn's disease, two for ulcerative colitis, and four were discordant. In nine of 10 couples neither spouse had symptoms before marriage but inflammatory bowel disease subsequently developed in both. In one couple, one spouse had Crohn's disease before marriage and the other partner experienced symptoms afterwards. Eighteen children were born to eight of 10 couples. Five of them developed Crohn's disease but four belong to the same family. In all cases the affected children were born to parents who both developed Crohn's disease after they had married and were conceived at a time when parents did not yet have symptoms. It is proposed that this pattern of emergence of inflammatory bowel disease suggests a role for an infectious agent yet to be identified. [ABSTRACT FROM PUBLISHER]

Published
1994
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26. The changing epidemiology of paediatric inflammatory bowel disease: authors' reply.

Author

Chouraki, V., Turck, D., Colombel, J.‐F., and Gower‐Rousseau, C.

Subjects
LETTERS to the editor, CROHN'S disease, DISEASE incidence
Abstract

A response by V. Chouraki and colleagues to a letter to the editor about their article "The changing pattern of Crohn's disease incidence in Northern France: A continuing increase in the 10 to 19-year-old age bracket (1988-2007)" in a 2011 issue is presented.

Published
2011
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50. Évaluation du recours aux médecines non conventionnelles par les enfants atteints de maladie inflammatoire chronique de l’intestin.

Author

Carette-Lherbier, S., Sarter, H., Spyckerelle, C., Devouge, E., Legrand, C., Couttenier, F., Coopman, S., Michaud, L., Guimber, D., Gottrand, F., Ganga-Zandzou, P.S., Gower-Rousseau, C., and Turck, D.

Abstract

Introduction Le recours aux médecines non conventionnelles (MNC) semble augmenter, surtout chez les patients ayant une maladie chronique. L’objectif de notre étude était d’estimer la fréquence du recours aux MNC au cours des maladies inflammatoires du tube digestif (MICI) pédiatriques. Les objectifs secondaires étaient de préciser les MNC les plus utilisées, étudier les facteurs favorisants et les raisons de leur utilisation ainsi que les bénéfices ressentis par les enfants et leurs parents. Méthodes Notre étude était une enquête, par auto-questionnaire nominatif, multicentrique menée dans les centres hospitaliers du Nord-Pas-de-Calais. Les enfants, âgés de moins de 18 ans révolus, suivis pour une MICI étaient inclus de manière prospective, de septembre à décembre 2013. Une étude dans les dossiers médicaux permettait de compléter le recueil de données. Résultats Cent dix questionnaires ont été distribués. Le taux de réponse était de 74 % ; 69 % des patients avaient une maladie de Crohn, 27 % une rectocolite hémorragique et 4 % une colite inclassée ; 32 % (IC : 22 %–42 %) des patients avaient eu recours aux MNC pour leur MICI et 39 % (IC : 29–50 %) pour une autre maladie. Au total, 53 % (IC : 41–63 %) des enfants avaient déjà eu recours à une MNC. Les MNC les plus utilisées étaient l’homéopathie (58 %), l’ostéopathie (27 %), la naturopathie et la kinésiologie (15 % chacun) ; 42 % des parents avaient discuté des MNC avec le pédiatre gastro-entérologue référent (56 % avant leur utilisation) ; 53 % des parents auraient aimé que le pédiatre leur parle de lui-même des MNC. Les principales raisons d’utilisation d’une MNC étaient : la volonté que l’enfant se sente mieux (88 %) ; la peur des effets secondaires des traitements (42 %) ; et l’impression que les MNC sont plus naturelles et moins dangereuses (42 %). En analyse multivariée, les facteurs favorisant l’utilisation des MNC étaient : âge du patient plus élevé ( p = 0,03) ; catégorie socioprofessionnelle de la mère élevée ( p = 0,04) ; utilisation des MNC par les parents ( p = 0,0002) ; traitement actuel par immunomodulateur ( p = 0,03) ; insatisfaction de la médecine conventionnelle ( p = 0,02). Parmi les patients ayant utilisé une MNC, 63 % ont ressenti un effet bénéfique et aucun un effet délétère. Conclusion Le recours aux MNC est fréquent chez les enfants suivis pour une MICI. Les pédiatres gastro-entérologues doivent s’informer sur ces pratiques et ouvrir le dialogue avec les familles, afin de pouvoir les guider dans leur choix, prévenir les effets potentiellement délétères des MNC et déterminer les sources d’insatisfaction motivant les familles à se tourner vers d’autres alternatives thérapeutiques. [ABSTRACT FROM AUTHOR]

Published
2016
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