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Abstract In order to explore the mechanism of rockburst in coal seam with rock parting, a combination of on-site and numerical experiment is used to study the failure and instability process, crack propagation mechanism, and influencing factors. The following four points were addressed: (1) the instability is a process that roadway in coal seam with rock parting go through from stable locking in the initial stress unloading stage to slipping unlocking, and then to spatter ejection in slipping dynamic load disturbance stage. (2) The fracture development caused by unloading excavation of coal seam with rock parting will change from shear crack to tensile crack. In this process, coal-rock contact surface slip and coal-rock fracture are coupled with each other. (3) The greater the mining depth is, the greater the lateral pressure coefficient is, and the higher the rockburst risk is. On the contrary, the lower the risk of rockburst. (4) When choosing the support form of roadway in coal seam with rock parting, the two supporting forms of bolting (cable) and supplementary masonry support should be preferred. The results enrich the theory of the dynamics of surrounding rock fracture in coal mine, further clarify the potential dangers to mining-area roadways and working faces, and provide technical information to ensure the safe and efficient mining of bifurcated coal seam.

Unloading excavation can increase the possibility of rock burst, especially for coal seam with rock parting. In order to explore the evolution process of rock burst under lateral unloading, the combination of in situ measures and numerical experiments is used to study. The following four points were addressed: (1) the coal seam with rock parting easily causes the stick-slip and instability along the interface, and the process of stick-slip and instability has hysteresis characteristics; (2) the greater the degree of unloading or the smaller the interface friction angle of the Coal-Rock Parting-Coal Structure (CRCS), the more likely it is for stick-slip and instability to occur; (3) the abnormal increase of shear stress and slip dissipation energy can be used as the precursory information of the stick-slip and instability of CRCS; (4) the damage intensity of rock burst induced by stick-slip and instability of CRCS can be reduced by reducing the unloading speed or increasing the roughness of interface. The research results can be used for early warning and controlling of dynamic disaster induced by stick-slip instability in coal seam with rock parking.

Chen, Xu, et al. performed a population genetics analysis of the eight species in the Ovis genus to assess the evolutionary and demographic history of these wild species and its domesticated counterpart. The authors identified a number of introgression events at different time periods, likely associated with the domestication process as well as identify a number of possible genomic targets of domestication.

AbstractThe coal seam bifurcation area (CSBA) exists widely in coal measure strata, where the geological weak surface (GWS) slip in overburden structure is easy to induce coal burst. The coal mass of coal face shows overall instability failure and high-speed throwing characteristics during the coal burst, seriously threatening the safe and efficient coal mine production. In order to understand the GWS-induced coal burst caused by the slip in CSBA and find the main controlling factors of GWS slip, the GWS slip criterion in CSBA was established based on the coal burst case analysis of overburden structure in CSBA of 1305 coal face (1305CF) in Zhaolou Coal Mine. The case study showed that the angle and range of CSBA are the main controlling factors affecting GWS slip. The FLAC3D numerical model of CSBA was established to analyze the influence effect of main control factors. The results show that the increase of angle and range of CSBA will increase the influence scope and degree of coal face mining, improving coal face burst risk. However, the peak point region of abutment pressure will not be affected, gradually reaching its peak within 0 m ~10 m from the coal seam merging area. With the increase of the angle of CSBA, the integrity of the triangular wedged rock mass along the GWS slip will be enhanced, aggravating the dynamic disturbance to the coal mass. With the increase of the range of CSBA, the slip of triangular wedged rock mass along GWS gradually changes from integral slip to phased slip, which will intermittently disturb the coal mass of the coal face. The research results have certain theoretical significance and practical value for preventing and controlling coal bursts in CSBA.

Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis.

Purpose: To investigate the clinical effectiveness and safety of ultrasound (US)-guided percutaneous microwave ablation (MWA) for colorectal liver metastasis (CRLM) and evaluate the influencing factors of local efficacy. Methods: From January 2013 to January 2017, 137 CRLM patients accepting US-guided percutaneous MWA were included. The 2450-MHz microwave ablation system and a cooled-shaft antenna were used. All patients were regularly followed up for at least 6 months. Technical success, complete ablation, local tumor progression (LTP), complications and side effects were assessed. Logistic regression analysis was used to identify the independent prognostic factors for LTP. Results: In total, 411 lesions (mean diameter 15.4 ± 7.2 mm, range 5–67 mm) were treated. Complete ablation was achieved in 99.27% (408/411) of lesions and 97.81% (134/137) of patients. LTP occurred in 5.35% (22/411) of lesions and 16.06% (22/137) of patients. LTP was more likely to occur in lesions larger than 3 cm in diameter (OR: 14.71; p

To study fracture evolution and peak stress in burst risk coal samples (BRCSs) under true triaxial loading and unloading conditions, experimental and numerical research was applied to BRCSs under true triaxial stress paths entailing “x-direction displacement fixed, y-direction loading, z-direction unloading.” Both the experimental and the numerical results demonstrated that the peak stress borne by the BRCSs was not only affected by the initial stress but also had a negative exponential relationship with the ratio of the unloading rate and the loading rate (RURLR); therefore, peak stress equations of BRCSs under true triaxial loading and unloading conditions were established. The triaxial stress-time curves obtained by experiments and simulations exhibited an “elasticity-yield-destruction” phase, and the characteristics of the yield phase were determined by the RURLR. A typical BRCS was selected for velocity tomographic imaging to analyze the fracture evolution characteristics under true triaxial loading and unloading. The results showed that when the BRCS was subjected to a triaxial state of stress, the high- and low-velocity regions existed alternately due to the presence of the crack; during the elastic phase, the crack closed during loading in the previous phase was reopened upon unloading, so that the velocity of the sample decreased and a wide range of low-velocity regions could be formed; when entering the yield phase, the original crack continued to expand into a hole-through crack, leading to wider extreme values and ranges of these low- and high-velocity regions; at the breaking phase, multiple microcracks were generated around the hole-through cracks, decreasing the overall velocity, and showing point distributions characteristics of high- and low-velocity regions. Overall, many low-velocity regions with similar normal directions to the unloading direction were formed; these correlated well with macrofractures (postfailure).

Rockburst of deep roadway was induced by the superposition of mine earthquake disturbance and high static stress exceeding the limit strength of coal-rock mass. To study the roadway impact instability characteristics caused by mine earthquake disturbance and to propose an optimized support scheme, the discrete element model of the roadway structure was established based on the 1305 working face of the Zhaolou Coal Mine. The influence of mine earthquake amplitude and hypocenter location on the roadway was analyzed. The mesocrack evolution characteristics of the roadway were simulated and reproduced. Characteristics of stress field, crack field, displacement field, and energy field of the disturbed roadway with different support schemes were studied. The results showed that the greater the amplitude of the mine earthquake was, the severer the roadway impact failure was. The upper and left hypocenters had a significant influence on the roadway. The superposition of the high static stress and the dynamic stress due to the far-field mine earthquake resulted in the impact instability of coal-rock mass around the roadway, causing severe roof subsidence as well as rib and bottom heave. The evolution of tensile cracks caused the severe impact failure of roadway from a mesoscopic perspective. Using the flexible support to reinforce the roadway retarded the stress decline in roof and rib, improved the self-stability, reduced the number of near-field cracks, and decreased the displacement. Meanwhile, it allowed the roof and rib deformation, which was conducive to releasing elastic energy in surrounding rocks and reducing mine earthquake energy. The cracks and deformation in the floor were controlled by using the floor bolt. The optimal support scheme for a roadway to resist mine earthquake disturbance was proposed: “bolt-cable-mesh-steel strip-π-beam + floor bolt.” The research results have a specific guiding significance for the support of the coal mine roadway.

Slip and instability of coal-rock parting-coal structure (CRCS) subjected to excavation disturbance can easily induce coal-rock dynamic phenomena in deep coal mines. In this paper, the failure characteristics and influencing factors of CRCS slip and instability were investigated by theoretical analysis, numerical simulations, and field observations. The following main results are addressed: (1) the slip and instability of CRCS induced by excavation are due to stress release, and the damage of the rock parting is partitioned into three parts: shear failure zone, slipping zone, and splitting failure zone from inside to outside with slip; (2) the slip and instability process of CRCS is accompanied by initiation, expansion, and intersection of shear and tensile cracks. The development of the cracks is dominated by shear behaviour, while the tensile crack is the main factor affecting fracture and instability of CRCS; and (3) slip and instability of CRCS are characterized by stick-slip first and then stable slip, accompanied with high P-wave velocity and rockburst danger coefficient based on microseismic tomography.

Electromagnetic radiation (EMR) can reflect the stress state and deformation level of coal, yet its warning indexes correlated with coal properties and roof caving is poorly understood. The laboratory observations of EMR effects of coal samples bursting failure and in situ investigations in the process of roof caving are presented in this paper. EMR peak with increasing stress is discussed when the failure of coal samples happens, which provides an explanation to EMR signals positively correlated well with the stress loaded. The linearly increasing relation is also found between EMR intensity and the uniaxial compressive strength, and EMR maximum amplitudes and pulses behave a logarithmic accretion tendency with bursting energy indexes of coal. By in situ investigations, it is well found that EMR amplitude can effectively warn coal deformation and failure based on the critical value 120 mV proposed from experiments.

Using UDEC discrete element numerical simulation software and a cosine wave as vibration source, the whole process of rockburst failure and the propagation and attenuation characteristics of shock wave in coal-rock medium were investigated in detail based on the geological and mining conditions of 1111(1) working face at Zhuji coal mine. Simultaneously, by changing the thickness and strength of immediate roof overlying the mining coal seam, the whole process of rockburst failure of roadway and the attenuation properties of shock wave were understood clearly. The presented conclusions can provide some important references to prevent and control rockburst hazards triggered by shock wave interferences in deep coal mines.

Background and purpose: The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness. Methods: PubMed was searched for randomized, double-blinded, placebo-controlled trials that reported sleep changes during gabapentin treatment up to November 2015. Findings: This review included 26 studies involving 4,684 participants. Except for Composite Endpoint 3 [standardized mean difference (SMD) = 0.09, 95% confidence interval (CI): -0.05-0.22] compared with the placebo group, the gabapentin group showed superior outcomes on our endpoints: Composite Endpoint 1 (SMD = 0.50, 95% CI: 0.28-0.71), Composite Endpoint 2 (SMD = -0.53, 95% CI: -0.77 to -0.30), Composite Endpoint 4 (SMD = -0.38, 95% CI: -0.58 to -0.19), Composite Endpoint 5 [risk ratio (RR) = 1.79, 95% CI: 1.24-2.58], and Composite Endpoint 6 (RR = 0.48, 95% CI: 0.32-0.72). However, the patients in the gabapentin group showed worse tolerance than those in the placebo group (RR = 1.38, 95% CI: 1.08-1.76). Implications: This study is the first to systematically assess the clinical value of gabapentin for the treatment of sleep disorders. We found that regardless the type of sleep outcomes, gabapentin displayed stable treatment efficacy for sleep disturbance in patients with medical illness. However, when an average dose of approximately 1,800 mg/day was used, the risk of treatment discontinuation or drug withdrawal was relatively high. We recommend that further studies confirm these findings in patients with primary sleep disorders. [ABSTRACT FROM AUTHOR]

Preterm birth is the leading cause of mortality and morbidity in infants. Its etiology is multifactorial with genes and immune homeostasis. The authors investigated whether prostaglandin (PG) synthesis related single nucleotide polymorphisms (SNPs) PLA2G4C rs1366442 and PLA2G4D rs4924618 were associated with the risk of spontaneous preterm birth (SPTB) in a Chinese population of 114 cases of SPTB and 250 controls of term delivery. The risk associations were determined by odds ratios (ORs) and their 95% confidence intervals (CIs) calculated using multivariate logistic regression. Homology modeling was performed to elucidate potential mechanism of the SNP function. The maternal AT/ TT genotype of PLA2G4D rs4924618 was associated with a reduced risk of SPTB (OR, 0.61; 95% CI, 0.37‑0.99), while no significant association between PLA2G4C rs1366442 and SPTB risk was identified. Structure and sequence analysis revealed that the amino acid substitution introduced by this SNP located at the conserved central core of the catalytic domain of cytosolic phospholipase A2 δ and was close to the active site. These findings suggested that the polymorphism of PLA2G4D rs4924618 may have a protective influence on the SPTB susceptibility in a Chinese population, supporting a role for genetics in the association between PG synthesis and preterm birth. [ABSTRACT FROM AUTHOR]

Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8-9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of 5for 75 samples and ~42 for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10mm average annual precipitation) versus highly humid region (>600mm), and arid zone (<400mm) versus humid zone (>400mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energymetabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change. [ABSTRACT FROM AUTHOR]

The article discusses the efficacy of percutaneous thermal ablation in treating patients with medium and large hepatocellular carcinoma (HCC). The authors claim that radio frequency ablation (RFA) and microwave ablation (MWA) were effective in treating HCC smaller than 3 cm. Under the treatment, there were no treatment-related deaths reported and the major complication rate was 9.2%.

Background: Currently, some advanced treatments such as Levodopa-Carbidopa intestinal gel infusion (LCIG), deep-brain stimulation (DBS), and subcutaneous apomorphine infusion have become alternative strategies for advanced Parkinson's disease (PD). However, which treatment is better for individual patients remains unclear. This review aims to compare therapeutic effects of motor and/or non-motor symptoms of advanced PD patients between LCIG and DBS.Methods: We manually searched electronic databases (PubMed, Embase, Cochrane Library) and reference lists of included articles published until April 04, 2019 using related terms, without language restriction. We included case-controlled cohort studies and randomized-controlled trials, which directly compared differences between LCIG and DBS. The Newcastle-Ottawa scale (NOS), proposed by the Cochrane Collaboration, was utilized to assess the quality of the included studies. Two investigators independently extracted data from each trial. Pooled standard-mean differences (SMDs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated by meta-analysis. Outcomes were grouped according to the part III and part IV of the Unified Parkinson Disease Rating Scale (UPDRS) and adverse events. We also descriptively reviewed some data, which were unavailable for statistical analysis.Results: This review included five cohort trials of 257 patients for meta-analysis. There were no significant differences between LCIG and subthalamic nucleus deep-brain stimulation (STN-DBS) on UPDRS-III and adverse events comparisons: UPDRS-III (pooled SMDs = 0.200, 95% CI: −0.126–0.527, P = 0.230), total adverse events (pooled RRs = 1.279, 95% CI: 0.983–1.664, P = 0.067), serious adverse events (pooled RRs = 1.539, 95% CI: 0.664–3.566, P = 0.315). Notably, the improvement of UPDRS-IV was more significant in STN-DBS groups: pooled SMDs = 0.857, 95% CI: 0.130–1.584, P = 0.021. However, the heterogeneity was moderate for UPDRS-IV (I2 = 73.8%).Conclusion: LCIG has comparable effects to STN-DBS on motor function for advanced PD, with acceptable tolerability. More large, well-designed trials are needed to assess the comparability of LCIG and STN-DBS in the future.

Currently, no satisfactory treatment is available for sciatica caused by herniated discs and/or spinal stenosis. The objective of this study is to assess the value of tumor necrosis factor (TNF)-α inhibitors in the treatment of sciatica.Without language restrictions, we searched PubMed, OVID, EMBASE, the Web of Science, the Clinical Trials Registers, the Cochrane Central Register of Controlled Trials and the China Academic Library and Information System. We then performed a systematic review and meta-analysis on the enrolled trials that met the inclusion criteria.Nine prospective randomized controlled trials (RCTs) and two before-after controlled trials involving 531 patients met our inclusion criteria and were included in this study. Our systematic assessment and meta-analysis demonstrated that in terms of the natural course of the disease, compared with the control condition, TNF-α inhibitors neither significantly relieved lower back and leg pain (both p > 0.05) nor enhanced the proportion of patients who felt overall satisfaction (global perceived effect (satisfaction)) or were able to return to work (return to work) (combined endpoint; p > 0.05) at the short-term, medium-term and long-term follow-ups. In addition, compared with the control condition, TNF-α inhibitors could reduce the risk ratio (RR) of discectomy or radicular block (combined endpoint; RR = 0.51, 95% CI 0.26 to 1.00, p = 0.049) at medium-term follow-up, but did not decrease RR at the short-term (RR = 0.64, 95% CI 0.17 to 2.40, p = 0.508) and long-term follow-ups (RR = 0.64, 95% CI 0.40 to 1.03, p = 0.065).The currently available evidence demonstrated that other than reducing the RR of discectomy or radicular block (combined endpoint) at medium-term follow-up, TNF-α inhibitors showed limited clinical value in the treatment of sciatica caused by herniated discs and/or spinal stenosis.