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【Objective】To improve the linear fit between the reflected spectral center wavelength and external environmental variables in Fiber Bragg Grating (FBG) sensing system, this paper proposes to use particle swarm optimization of Gaussian process regression model to the field of FBG stress sensing.【Methods】For the reflectance spectral characteristics of the FBG, the paper studies the impact of the linear fit in the spectral fitting of FBG sensing system. The particle swarm algorithm is used to search for the optimal hyperparameters in the Gaussian process regression model in order to enhance the predictive performance of the reflectance spectral wavelength of the center. A FBG stress sensing experimental platform was built, and the FBG was laid on the strength beam. Different weights were applied to one end of the equal strength beam to produce axial strain on the FBG, and the reflectance spectral data were collected by the spectrometer and analyzed by linear fitting with the studied model. The results obtained by the unoptimized Gaussian process regression model, the maximum value method, the Gaussian fitting method, and the center of mass method were used as the control group.【Results】The results show that under the conditions of erbium-doped fiber amplifier output power of 10 dBm, transmission fiber distance of 50 m, and the number of sampling points of the spectrometer of 501, the linear fit between the reflected spectral center wavelength and the mass of the weights is better than that of the control group. The linear fit of the studied model can reach up to 0.951 9, which is improved compared with that of the control group. Under the conditions of 501, 251, 167 and 126 spectral sampling points, the studied model can improve the linear fit of the system to 0.990 0, which is a maximum improvement of 0.258 7 compared with the maximum value method.【Conclusion】The analysis results show that the Gaussian process regression model optimized by the particle swarm is able to effectively improve the linear fit of the FBG stress sensing system.

Abstract The E‐proteinoid 3 receptor (PTGER3), a member of the prostaglandin E2 (PGE2) subtype receptor, belongs to the G‐protein‐coupled superfamily of receptors. Animal studies have demonstrated its involvement in salt sensitivity by regulating sodium reabsorption. This study aimed to investigate the association between genetic variants of PTGER3 and salt sensitivity, longitudinal blood pressure (BP) changes, and the incidence of hypertension in Chinese adults. A chronic salt intake intervention was conducted involving 514 adults from 124 families in the 2004 Baoji Salt‐Sensitivity Study Cohort in northern China. These participants followed a 3‐day regular baseline diet, followed by a 7‐day low‐salt diet (3.0 g/d) and a 7‐day high‐salt diet (18 g/d), and were subsequently followed for 14 years. The findings revealed a significant relationship between the single nucleotide polymorphism (SNP) rs17482751 of PTGER3 and diastolic blood pressure (DBP) response to high salt intervention. Additionally, SNPs rs11209733, rs3765894, and rs2268062 were significantly associated with longitudinal changes in systolic blood pressure (SBP), DBP, and mean arterial pressure (MAP) during the 14‐year follow‐up period. SNP rs6424414 was significantly associated with longitudinal changes in DBP over 14 years. Finally, SNP rs17482751 showed a significant correlation with the incidence of hypertension over 14 years. These results emphasize the significant role of PTGER3 gene polymorphism in salt sensitivity, longitudinal BP changes, and the development of hypertension in the Chinese population.

DL/T 684—2012 Guide of Calculating Settings of Relay Protection for Large Generator Transformer （hereinafter referred to as the “2012 Guide”） has played a significant role in improving the correct operation rate of relay protection devices for generator transformers and ensuring the safe operation of electrical equipment in power plants. However， with the increase in capacity of individual generator units in China and the emergence of new faults， the “2012 Guide” has proved inadequate， requiring revision to better guide engineering practice. Therefore， this paper analyzes the problems in the “2012 Guide” and puts forward specific revision suggestions to address problems such as misoperation of generator differential protection under sympathetic inrush current， misoperation of false power-on protection under poor synchronous conditions， and tripping of gap zero-sequence current protection of main transformer before reclosing in the case of transient single-phase ground faults on the line. The suggestions can provide reference for the revision of the “2012 Guide”.

Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain unclear. Therefore, further investigation is necessary. Methods We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis, social behavioural tests, hippocampal electrophysiology, immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and iGABASnFR. Additionally, we utilized optogenetics and administered ursolic acid (UA) via oral gavage to examine the effects of these agents on social memory in mice. Results The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1 (vCA1) under both physiological conditions and AD-like tau pathology. As tau progressively accumulated, vCA1, especially its excitatory and parvalbumin (PV) neurons, were fully filled with mislocated and phosphorylated tau (p-Tau). This finding was not observed for dorsal hippocampal CA1 (dCA1). The overexpression of human tau (hTau) in excitatory and PV neurons mimicked AD-like tau accumulation, significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within vCA1. Photoactivating excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social memory. Notably, 1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB (TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social memory. Conclusion This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau accumulation. Notably, our novel findings regarding the efficacy of UA in reducing tau load and targeting the vCA1 microcircuit may provide a promising strategy for treating AD in the future.

Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia and inflammation underlies joint destruction. Delaying or even blocking synovial angiogenesis has emerged as an important target of RA treatment. Natural medicines has a long history of treating RA, and numerous reports have suggested that natural medicines have a strong inhibitory activity on synovial angiogenesis, thereby improving the progression of RA. Natural medicines could regulate the following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs pathway, NF-κB pathway, PPARγ pathway, JAK2/STAT3 pathway, etc., thereby inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, and total glucoside of Paeonia lactiflora Pall. Are currently the most representative of all natural products worthy of development and utilization. In this paper, the main factors affecting angiogenesis were discussed and different types of natural medicines that inhibit angiogenesis were systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming to provide new perspective and options for the management of RA by targeting angiogenesis.

Abstract Three‐dimensional (3D) echocardiography is an emerging technique for assessing right ventricular (RV) volume and function, but 3D‐RV normal values from a large Chinese population are still lacking. The aim of the present study was to establish normal values of 3D‐RV volume and function in healthy Chinese volunteers. A total of 1117 Han Chinese volunteers from 28 laboratories in 20 provinces of China were enrolled, and 3D‐RV images of 747 volunteers with optimal image quality were ultimately analyzed by a core laboratory. Both vendor‐dependent and vendor‐independent software platforms were used to analyze the 3D‐RV images. We found that men had larger RV volumes than women did in the whole population, even after indexing to body surface area, and older individuals had smaller RV volumes. The normal RV volume was significantly smaller than that recommended by the American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines in both sexes. There were significant differences in 3D‐RV measurements between the two vendor ultrasound systems and the different software platforms. The echocardiographic measurements in normal Chinese adults II study revealed normal 3D‐RV volume and function in a large Chinese population, and there were significant differences between the sexes, ages, races, and vendor groups. Thus, normal 3D‐RV values should be stratified by sex, age, race, and vendor.

Abstract An excellent single-atomic photocatalyst, Ti@C4N3, is theoretically found to effectively convert CO2 to C2H6 by density functional theory (DFT) calculations and non-adiabatic molecular dynamics (NAMD) simulations. The Ti@C4N3 photocatalyst has remarkable stability both thermally, chemically, and mechanically. Electronically, it has strong absorption properties (λ = 327.77 and 529.61 nm), suitable band positions, and a long photogenerated electron lifetime (τ e = 38.21 ps), allowing photogenerated electrons to migrate to the surface. Notably, the high-valence active site effectively activates two CO2 through dual activation: Under light irradiation, the weakly adsorbed CO2 undergoes photo-induced activation by the photoelectron of conduction band minimum (CBM); without light, the high Lewis acidity of the Ti site induces CO2 activation through back-donating π-bond. Contrast simulation results uncovered that dual activation of CO2 is attributed to the thermal and photonic synergy. Furthermore, two activated CO2 species under light easily couple to form oxalate with the barrier of 0.19 eV, and further reduced to C2H6 with a low activation energy of 1.09 eV.

Abstract Normoalbuminuria has recently been associated with increased cardiovascular risk, and vascular aging is proposed as the early manifestation of cardiovascular disease. Here, the authors aimed to examine the association of high‐normal albuminuria and vascular aging in a Chinese cohort. From our previously established cohort, 1942 participants with estimated glomerular filtration rate ≥60 mL/min/1.73 m2 or urinary albumin‐creatinine ratio (UACR)

Magnetic property (e.g. spin order) of support is of great importance in the rational design of heterogeneous catalysts. Herein, we have taken the Ni-supported ferromagnetic (FM) CrBr3 support (Nix/CrBr3) to thoroughly investigate the effect of spin-order on electrocatalytic oxygen reduction reaction (ORR) via spin-polarized density functional theory calculations. Specifically, Ni loading induces anti-FM coupling in Ni–Cr, leading to a transition from FM-to-ferrimagnetic (FIM) properties, while Ni–Ni metallic bonds create a robust FM direct exchange, benefiting the improvement of the phase transition temperature. Interestingly, with the increase in Ni loading, the easy magnetic axis changes from out-of-plane (2D-Heisenberg) to in-plane (2D-XY). The adsorption properties of Nix/CrBr3, involving O2 adsorption energy and configuration, are not governed by the d-band center but strongly correlate with magnetic anisotropy. It is noteworthy that the applied potential and electrolyte acidity triggers spin-order transition phenomena during the ORR and induces the catalytic pathway change from 4e− ORR to 2e− ORR with the excellent onset potential of 0.93 V/reversible hydrogen electrode, comparable to the existing most excellent noble-metal catalysts. Generally, these findings offer new avenues to understand and design heterogeneous catalysts with magnetic support. [ABSTRACT FROM AUTHOR]