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Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health. The failure in drug discovery over the past decades has stressed the urgency and importance of seeking new perspectives. Recently, gut microbiome (GM), with the ability to communicate with the brain bidirectionally through the microbiome–gut–brain axis, has attracted much attention in AD-related studies, owing to their strong associations with amyloids, systematic and focal inflammation, impairment of vascular homeostasis and gut barrier, mitochondrial dysfunction, etc., making the regulation of GM, specifically supplementation of probiotics a promising candidate for AD treatment. This article aims to review the leading-edge knowledge concerning potential roles of GM in AD pathogenesis and of probiotics in its treatment and prevention.

C28H22CuN2O4, monoclinic, C2/c (no. 15), a = 17.2971(3) Å, b = 14.4409(3) Å, c = 9.5617(2) Å, β = 90.580(2)°, V = 2388.25(8) Å3, Z = 4, R gt(F) = 0.0536, wR ref(F 2) = 0.1406, T = 293 K.

C14H20CdCl2N4O4, monoclinic, P21/n (no. 14), a = 8.261(3) Å, b = 16.390(5) Å, c = 13.967(4) Å, β = 95.850(4)°, V = 1881.3(10) Å3, Z = 4, Rgt(F) = 0.0342, wRref(F2) = 0.0873, T = 296 K.

C11H16Br2N4O2Zn, monoclinic, Cc (no. 9), a = 15.534(7) Å, b = 7.956(4) Å, c = 14.589(7) Å, β = 119.094(8)°, V = 1575.5(13) Å3, Z = 4, Rgt(F) = 0.0296, wRref(F2) = 0.0703, T = 296 K.

Aiming at the problem that there is a large deviation of the spin-stabilized satellite using infrared benchmark for attitude controlling, the control theory of isoclinic angle is described firstly, the difference between the solar reference and infrared benchmark on attitude controlling is analyzed，the main cause leading to the large deviation using infrared benchmark is also explained. A method of execution angle compensation and correction is put forward finally. Verified by simulation, the control precision is improved effectively after execution angle correction.

The development of homemade computer system of measurement and controlling becomes quickly, but the research of software time on Kylin is still on an underway phase. This paper puts forward the software time project, and tests the performance. The test result shows that the performance of the software time accords with the technology criterion, and the software time project supports the technology instructor of system manufacture.

C14H20CdCl2N4O4, monoclinic, P21/n (no. 14), a = 8.261(3) Å, b = 16.390(5) Å, c = 13.967(4) Å, β = 95.850(4)°, V = 1881.3(10) Å3, Z = 4, Rgt(F) = 0.0342, wRref(F2) = 0.0873, T = 296 K. [ABSTRACT FROM AUTHOR]

C11H16Br2N4O2Zn, monoclinic, Cc (no. 9), a = 15.534(7) Å, b = 7.956(4) Å, c = 14.589(7) Å, β = 119.094(8)°, V = 1575.5(13) Å3, Z = 4, Rgt(F) = 0.0296, wRref(F2) = 0.0703, T = 296 K. [ABSTRACT FROM AUTHOR]

Expression of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer and the relationship between them and the clinicopathological parameters and prognosis were investigated. The clinical medical records of 132 patients with laryngeal cancer, who were admitted to Guangdong Second Provincial General Hospital from February 2009 to March 2014, were retrospectively analyzed and comprised the study group. The data of physical examinations of 56 healthy volunteers who took physical examinations in the same hospital comprised the control group. RT-qPCR was used to detect the expression levels of miRNA-145 and miRNA-218 in serum of the patients in the two groups. According to the relative expression levels of miRNA-145 and miRNA-218 in serum of the patients in the study group on the day when they left hospital, the study group was divided into the high expression group (n=73 patients) and the low expression group (n=59 patients). The patients received a 48-month follow-up visit and their survival condition was recorded and the Kaplan-Meier was used to carry out the survival analysis. The expression levels of miRNA-145 and miRNA-218 in serum of the patients in the study group were lower than those in the control group (P<0.05). The median survival time of the patients in the high expression group was 30 months while the median survival time of the patients in the low expression group was 26 months. The expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer decreased, the higher the expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer were, the better the prognosis was. miRNA-145 and miRNA-218 were used as indicators of assessing the prognosis of patients with laryngeal cancer. [ABSTRACT FROM AUTHOR]

A new series of paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties were synthesized and evaluated for their cytotoxicity in vitro against human non-small cell lung cancer NCI-H1299 cells and human cervical carcinoma HeLa cells. Among them, compared with that of paeonol, compounds 8-acetyl-4-{[(1-(5-chloro-2-nitrophenyl)-1 H -1,2,3-triazol-4-yl]methyl}-5-methoxy-2 H -1,4-benzoxazin-3(4 H)-one, 8-acetyl-4-[(1-mesityl-1 H -1,2,3-triazol-4-yl)methyl]-5-methoxy-2 H -1,4-benzoxazin-3(4 H)-one, and 8-acetyl-5-methoxy-4-{[(1-(naphthalen-1-yl)-1 H -1,2,3-triazol-4-yl]methyl}-2 H -1,4-benzoxazin-3(4 H)-one exhibited significant inhibitory activity toward the human non-small cell lung cancer NCI-H1299 cells (IC50 = 13.36 ± 0.003, 19.75 ± 0.3, 15.79 ± 0.05 μg mL−1). The last compound also exhibited significant inhibitory activity toward the human cervical carcinoma HeLa cells (IC50 = 19.73 ± 1.0 μg mL−1). [ABSTRACT FROM AUTHOR]

According to the requirement of quick response ability for air defense command system decision, this paper provides an architecture and function description, and proposes a general method of information fusion suitable for aerial information fusion. The proposed method and model algorithm formulize and digitize the complex process of air defense command system information fusion. Simulation results prove that the model is correct and effective. The model has already been applied in engineering. [ABSTRACT FROM AUTHOR]

The asymmetric binuclear copper(I) complex [Cu 2 (dppm) 2 (C 7 H 7 N)(μ-NO 3 )](NO 3 ) (dppm = Ph 2 PCH 2 PPh 2 , C 7 H 7 N = 4-vinylpyridine) has been prepared and characterized. The complex is photoluminescent at room temperature. Crystals are triclinic space group , with cell parameters a = 11.638(2), b = 12.621(3), c = 18.516(4) Å, α = 89.20(3), β = 83.11(3), γ = 76.04(3)°, V = 2619.5(9) Å 3 , D c = 1.426 g cm -3 , Z = 2, μ = 0.988 mm -1 , R = 0.0497 for 6574 independently observed reflections with I > 2σ( I ). The structure consists of [Cu 2 (dppm) 2 (C 7 H 7 N)(μ-NO 3 )] + cations and nitrate anions. Copper atoms show different coordination modes; Cu(2) has a distorted trigonal and Cu(1) a tetrahedral geometry. [ABSTRACT FROM AUTHOR]

The article discusses the synthesis and crystal structure of the title compound diaqua-(2,4-dihydroxybenzoato-κ2O,O')-(2,9-dimethyl-1,10-phenanthroline-κ2N,N') nickel(II) 2,4-dihydroxybenzoate (C28H26N2NiO10). Topics discussed include source of material, experimental data, and the use of 2,9-dimethyl-phenanthroline in coordination chemistry. Also provided is a table which shows information on data collection.

The article discusses the synthesis and crystal structure of the title compound diaqua-(2,4-dihydroxybenzoato-κ2O,O')-(2,9-dimethyl-1,10-phenanthroline-κ2N,N') nickel(II) 2,4-dihydroxybenzoate (C28H26N2NiO10). Topics discussed include source of material, experimental data, and the use of 2,9-dimethyl-phenanthroline in coordination chemistry. Also provided is a table which shows information on data collection.

C16H17N, orthorhombic, Pbca (no. 61), a = 10.3706(10) Å, b = 8.3879(7) Å, c = 29.555(3) Å, V = 2,570.9(4) Å3, Z = 8, R gt (F) = 0.0579, wR ref (F2) = 0.1327, T = 293(2) K. [ABSTRACT FROM AUTHOR]

C14H20CdCl2N4O4, monoclinic, P21/n (no. 14), a = 8.261(3) Å, b = 16.390(5) Å, c = 13.967(4) Å, β = 95.850(4)°, V = 1881.3(10) Å3, Z = 4, Rgt(F) = 0.0342, wRref(F2) = 0.0873, T = 296 K. [ABSTRACT FROM AUTHOR]

Background Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. Methods A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis. PSD status was evaluated by 24-item Hamilton Depression Rating Scale at 3 months after stroke. Results Two hundred and forty-one (40.30%) participants were considered as PSD. HCY and hs-CRP levels were not significantly different between PSD and non-PSD patients. Interesting, in a maximally adjusted model, the odds ratio (95% confidence interval) of PSD was 1.90 (1.18–3.06) for coexistence of HCY ≥ 14.65 μmol/l and hs-CRP ≥ 1.90 mg/l compared with the other levels (HCY < 14.65 μmol/l and/or hs-CRP < 1.90 mg/l). Adding combination of HCY and hs-CRP to a model containing conventional risk factors could significantly improve risk reclassification for PSD. Conclusions Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors. [ABSTRACT FROM AUTHOR]

The influence of alkylphenols to environment cannot be ignored, as they are common product from chemical industries and potential threat to human health. Some alkylphenols are listed as persistent toxic substances (PTS) by the United Nations Environment Programme (UNEP). In this study, the optimized magnetic reduced graphene oxide (MrGO) was synthesized by a facile solvothermal method, and investigated for adsorption of three typical alkylphenols. In neutral condition, MrGO showed extremely high adsorption capacity of three typical alkylphenols, 4-heptylphenol (4-HP), 4- tert -octylphenol (4-OP), and 4-nonylphenol (4-NP), which could reach 938.9 mg g−1 (40 °C), 987.8 mg g−1 (40 °C), and 989.7 mg g−1 (20 °C), respectively. This study revealed that the adsorption process was a heterogeneous multi-layer physical adsorption, and the adsorption rates were related to the number of unoccupied vacancies on the adsorbent surface. From batch experiments and density functional theory (DFT) calculations, the main adsorption interactions between MrGO and alkylphenols were deduced to be π–π, hydrogen-bond, and hydrophobic interactions. What's more, the different affinities of MrGO towards different targets were further distinguished and explained in detail. The wonderful stability and recyclability of MrGO made it a promising cost-effective remediation candidate. • Magnetic reduced graphene oxide exhibits excellent adsorption for target phenols. • Adsorption follows pseudo-second-order kinetics and Freundlich adsorption isotherm. • The strong adsorption was due to hydrogen-bond, π-π interaction and hydrophobicity. [ABSTRACT FROM AUTHOR]