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We describe a new statistical scorer for tandem mass spectrometry. The scorer is based on the probability that fragments with given chemical properties create measured intensity levels in the experimental spectrum. The scorer's parameters are computed using a fully automated procedure. Benchmarking the new scorer on a large set of experimental spectra, we show that it performs significantly better than the widely used cross-correlation scoring algorithm of Eng et al. (Eng, J. K.; McKormack, A. L; Yates, J. R. J. Am. Soc. Mass Spectrom 1994, 5, 976-989.).

Virtual reality (VR) and augmented reality (AR) head mounted displays project stereoscopic virtual images to the eyes to obtain a three‐dimensional illusion. The mismatch between the vergence and accommodation focus cues, known as the vergence‐accommodation conflict (VAC), can cause physical discomfort and limit the immersive experience of these systems. In AR systems, even monocular vision is affected by the focus mismatch, since the eye cannot focus simultaneously on a close real object and a close virtual object. We present a dynamic focus compensation approach to resolve VAC in which an electronically controlled dynamic lens is used to correct the focus of the virtual content. The dynamic lens is implemented using a pixel grid, enabling rapid lateral movement of the lens, thus increasing the lens quality and field of view. [ABSTRACT FROM AUTHOR]