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190 results on '"Hara, Daisuke"'

24. Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry

Author

Fujiwara, Toshifumi, Kondo, Masakazu, Yamada, Hisakata, Haraguchi, Akihisa, Fujimura, Kenjiro, Sakuraba, Koji, Kamura, Satoshi, Fukushi, Jun-ichi, Miyahara, Hisaaki, Inoue, Yasushi, Tsuru, Tomomi, Shuto, Toshihide, Yoshizawa, Seiji, Suematsu, Eiichi, Miyamura, Tomoya, Ayano, Masahiro, Mitoma, Hiroki, Arinobu, Yojiro, Niiro, Hiroaki, Ohishi, Masanobu, Hirata, Akie, Tokunaga, Shoji, Takada, Atsushi, Hara, Daisuke, Tsushima, Hidetoshi, Akasaki, Yukio, Ikemura, Satoshi, Sueishi, Takuya, Toya, Masakazu, Sakuragi, Takahide, Tsutsui, Tomoko, Kai, Kazuhiro, Arisumi, Shinkichi, and Nakashima, Yasuharu

Published
2022
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25. PP2A negatively regulates NK cell T-bet expression and anti-tumor effector function.

Author

Shinzawa, Yui, Hara, Daisuke, Shinguryo, Yuki, Yokoyama, Satoru, Kawada, Manabu, and Hayakawa, Yoshihiro

Subjects
*KILLER cells, *IMMUNE response, *MTOR protein, *PHOSPHOPROTEIN phosphatases, *RIBOSOMAL proteins
Abstract

The transcription factor T-bet is essential for the anti-tumor effector function of natural killer (NK) cells, but the mechanism regulating its expression in NK cells remains unclear. In this study, we aimed to identify an NK cell-intrinsic regulator that controls T-bet expression. Using T-bet-luciferase reporter assay screening, we identified a protein phosphatase inhibitor as a potential activator of T-bet expression. A series of protein phosphatase 2A (PP2A)-specific inhibitors (PP2Ai) or PP2A siRNA induced the expression of T-bet. In PP2Ai-treated mice, the expression of T-bet and its downstream effector molecules, granzyme B and IFN-γ, was also upregulated in NK cells. Mechanistically, PP2Ai increased the phosphorylation of mTOR and ribosomal protein S6 in NK cells, and mTOR inhibitor canceled the effects of PP2Ai in NK cells. Importantly, NK cells isolated from PP2Ai-treated mice showed higher cytotoxicity and IFN-γ production; therefore, they increased the anti-tumor effector function of NK cells. Accordingly, PP2Ai treatment inhibited lung metastasis of B16 melanoma by NK cell- and mTOR-dependent mechanisms. These results suggest that PP2A negatively regulates NK cell T-bet expression and effector function by an mTOR-dependent mechanism. [ABSTRACT FROM AUTHOR]

Published
2025
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28. Perilymphatic enhancement and endolymphatic hydrops: MRI findings and clinical associations.

Author

Kobayashi, Masumi, Yoshida, Tadao, Fukunaga, Yukari, Hara, Daisuke, Naganawa, Shinji, and Sone, Michihiko

Subjects
MENIERE'S disease, SENSORINEURAL hearing loss, EAR diseases, MAGNETIC resonance imaging, HEARING levels, INNER ear, EAR
Abstract

Objective: In this study, we aimed to summarize magnetic resonance imaging (MRI) findings of perilymphatic enhancement (PE) and endolymphatic hydrops (EH) of the inner ear, which are associated with vestibular and cochlear symptoms. Methods: We analyzed data on ears with definite Meniere's disease (MD), sensorineural hearing loss (SNHL), vertigo, and listening difficulties (LiD) from 508 ears of 254 patients who underwent contrast‐enhanced 3‐Tesla MRI between April 2021 and March 2023. We evaluated the degree of endolymphatic hydrops (EH), signal intensity ratios (SIRs) between the basal turns of the cochlea and cerebellum, and hearing levels for all ears. Ears with definite MD were also assessed for changes in vestibular and cochlear symptoms within 6 months. Results: Ears with definite MD exhibited significantly higher percentages of EH in both the vestibule and cochlea compared with ears with other diseases. Furthermore, ears with MD or sensorineural hearing loss (SNHL) had significantly higher SIRs of PE compared with ears with other diseases or asymptomatic ears. Among patients with definite MD, those experiencing hearing fluctuations or vertigo attacks within the last 6 months had significantly higher SIRs of PE compared with those who did not experience any symptoms. Conclusion: Significant EH in the vestibule and cochlea was a major finding for the imaging diagnosis of definite MD. A high SIR of PE was a good indicator for assessing MD activity, reflecting vestibular and cochlear symptoms and fluctuations. Level of Evidence: 4. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Synovial-tissue resident macrophages play proinflammatory functions in the pathogenesis of RA while maintaining the phenotypes in the steady state.

Author

Kai, Kazuhiro, Yamada, Hisakata, Tsurui, Ryosuke, Sakuraba, Koji, Fujimura, Kenjiro, Kawahara, Shinya, Akasaki, Yukio, Tsushima, Hidetoshi, Fujiwara, Toshifumi, Hara, Daisuke, Fukushi, Jun-ichi, Sawa, Shinichiro, and Nakashima, Yasuharu

Subjects
MACROPHAGES, PHENOTYPES, RHEUMATOID arthritis, GENE expression, INFLAMMATORY mediators, FIBROBLASTS
Abstract

Synovial tissue-resident macrophages (STRMs) maintain normal joint homeostasis in a steady state. However, it is unclear whether STRMs still play homeostatic roles or change the functions in the joint of rheumatoid arthritis (RA), where infiltrating peripheral blood monocyte-derived macrophages (PBMoMs) play proinflammatory roles. In the present study, we examined changes in the phenotypes and functions of STRMs in response to RA-related stimuli in vitro. STRMs were prepared from non-inflammatory osteoarthritis (OA) joint synovium, which is histologically indistinguishable from normal joint synovium. PBMoMs were prepared and used for comparison. After stimulation with plate-bound IgG, which mimics anti-citrullinated protein antibody immunocomplex formed in RA joints, or with combinations of RA-related inflammatory mediators, namely tumor necrosis factor-α (TNF-α) and prostaglandin E2 or interferon-γ, PBMoMs downregulated surface markers and genes associated with anti-inflammatory macrophages, and upregulated cytokine and marker genes of proinflammatory macrophages in RA. On the other hand, STRMs hardly changed the expression of surface molecules and marker genes but altered the pattern of cytokine gene expression after stimulation like PBMoMs. Furthermore, in vitro stimulated STRMs promote proinflammatory functions of cocultured synovial fibroblasts. Thus, STRMs might play proinflammatory roles in RA joints, while maintaining their phenotypes in the steady state. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Improvement of vertigo symptoms and acoustic power absorbance in cases with endolymphatic hydrops.

Author

Kobayashi, Masumi, Yoshida, Tadao, Fukunaga, Yukari, Hara, Daisuke, Sugimoto, Satofumi, Naganawa, Shinji, and Sone, Michihiko

Subjects
MENIERE'S disease, VERTIGO, EAR, LIGHT absorbance, MIDDLE ear, HEARING levels
Abstract

Objective: The pathophysiology and symptoms underlying Meniere's disease (MD) manifest as endolymphatic hydrops (EH), potentially impacting acoustic power absorbance in vestibular EH. The longitudinal effects of middle ear pressure therapy (MEPT) and conservative therapies for EH by magnetic resonance imaging (MRI) and on acoustic power absorbance on wideband acoustic immittance (WAI) were evaluated, and their changes were compared with clinical symptoms. Methods: Eleven patients with definite MD or delayed endolymphatic hydrops (DEH), resistant to conservative therapies and who continued MEPT for 1 year, were included. Vertigo scores, hearing levels, acoustic power absorbance on WAI, and degrees of EH on 3‐T MRI were evaluated and compared before and after the treatments. Results: One year after the start of MEPT, all cases showed symptomatic improvement in vertigo score; however, the degrees of EH showed no improvements except in one case. In the affected ears with EH, their absorbances on WAI improved, particularly at 1580–1905 or 2400–2953 Hz (p <.05). Conclusion: Alleviation of vestibular symptoms with the therapy of MD was not necessarily associated with improved EH. Vestibular symptoms could be related to the change in the impedance of inner ear pressure, which was proven by the normalization of acoustic power absorbance. Assessments of acoustic power absorbance may provide useful information for physiological conditions and causative factors of vertigo in ears with EH. Level of evidence: 4 [ABSTRACT FROM AUTHOR]

Published
2024
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44. Computed tomography attenuation predicts the growth of pure ground-glass nodules

Author

Eguchi, Takashi, Kondo, Ryoichi, Kawakami, Satoshi, Matsushita, Mina, Yoshizawa, Akihiko, Hara, Daisuke, Matsuoka, Shunichiro, Takeda, Tetsu, Miura, Kentaro, Agatsuma, Hiroyuki, Sakaizawa, Takao, Tominaga, Yoshiaki, Saito, Gaku, Toishi, Masayuki, Hamanaka, Kazutoshi, Hashizume, Masahiro, Shiina, Takayuki, Amano, Jun, Koizumi, Tomonobu, and Yoshida, Kazuo

Published
2014
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46. Contralateral Hip Abductor Muscle Strength Associated with Comfort of Getting into and out of the Car after Total Hip Arthroplasty.

Author

Harada, Tetsunari, Hamai, Satoshi, Hara, Daisuke, Fujita, Tsutomu, Fujiyoshi, Daisuke, Kawahara, Shinya, Yamaguchi, Ryosuke, Kawaguchi, Kenichi, and Nakashima, Yasuharu

Subjects
TOTAL hip replacement, MUSCLE strength, EXTENSOR muscles, KNEE muscles, OPHTHALMIC surgery
Abstract

There are no studies that have investigated the characteristics of car use across THA patients, including those who do not drive. This study aimed to evaluate, in THA patients, (1) postoperative car usage, (2) comfort while entering and exiting a car, and (3) whether lower limb muscle strength affects action comfort. One hundred seventy-two post-THA patients completed the questionnaire in 2020, along with assessments of hip abductor and knee extensor muscle strength before surgery and at discharge. Patients whose overall comfort level was judged as comfortable were defined as the comfort group; others were placed in the discomfort group. Of the 172 patients, 161 reported car usage at a mean of 5.6 years after THA. Of these, 114 and 47 patients were placed in the comfort and discomfort groups, respectively. Patients in the discomfort group were three times more likely to experience discomfort using the contralateral side door than the surgical side door, and about twice as many patients experienced discomfort when entering as when exiting. Lower preoperative contralateral hip abductor muscle strength was the only independent predictor for discomfort. The take-home messages were that prevention of contralateral-side weakness may improve comfort during the action after THA. [ABSTRACT FROM AUTHOR]

Published
2023
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