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Your search keyword '"Harrison, Justin R."' showing total 19 results
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19 results on '"Harrison, Justin R."'

2. Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.

Author

Smith, Alasdair, Wall, Richard J., Patterson, Stephen, Rowan, Tim, Rico Vidal, Eva, Stojanovski, Laste, Huggett, Margaret, Hampton, Shahienaz E., Thomas, Michael G., Corpas Lopez, Victoriano, Gillingwater, Kirsten, Duke, Jeff, Napier, Grant, Peter, Rose, Vitouley, Hervé S., Harrison, Justin R., Milne, Rachel, Jeacock, Laura, Baker, Nicola, and Davis, Susan H.

Published
2022
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5. A concise synthesis of the octalactins

Author

O'Sullivan, Paul T., Buhr, Wilm, Fuhry, Mary Ann M., Harrison, Justin R., Davies, John E., Feeder, Neil, Marshall, David R., Burton, Jonathan W., and Holmes, Andrew B.

Subjects
Rearrangements (Chemistry) -- Analysis, Carbonates -- Research, Carbonates -- Chemical properties, Methylation -- Analysis, Chemistry
Abstract

The total synthesis of octalactins A and B is achieved in 15 steps and 10% overall yield from commercially available materials. Key steps include the Paterson-Aldol reaction for the rapid assembly of the carbonate, methylenation of cyclic carbonate and subsequent Claisen rearrangement of the corresponding alkenyl-substituted cyclic ketene acetal to provide the core unsaturated medium-ring lactone and the use of enzyme-mediated acetate deprotection in the presence of a medium-ring lactone.

Published
2004

6. A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors.

Author

Harrison, Justin R., Brand, Stephen, Smith, Victoria, Robinson, David A., Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S., Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G., Gilbert, Ian H., and Read, Kevin D.

Published
2018
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7. Lead Optimization of a PyrazoleSulfonamide Seriesof Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluationof CNS Penetrant Compounds as Potential Treatments for Stage 2 HumanAfrican Trypanosomiasis.

Author

Brand, Stephen, Norcross, Neil R., Thompson, Stephen, Harrison, Justin R., Smith, Victoria C., Robinson, David A., Torrie, Leah S., McElroy, Stuart P., Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C., van Aalten, Daan, Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Wyatt, Paul G., and Gilbert, Ian H.

Published
2014
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9. The Horner–Wadsworth–Emmons reaction in the synthesis of macrocyclic peptides: the Trp-His-Gly-Arg derived macrocycle of moroidin

Author

Harrison, Justin R. and Moody, Christopher J.

Subjects
*MACROCYCLIC compounds, *CHEMICAL reactions
Abstract

The Trp-His-Gly-Arg derived macrocycle 4 of moroidin 1 containing the unusual tryptophan C-2 histidine N-1 link has been synthesised in protected form. The key steps are displacement of a 2-chloroindole with a histidine derived nucleophile, a Horner–Wadsworth–Emmons reaction followed by asymmetric hydrogenation to establish the tryptophan side chain, and incorporation of the Gly-Arg dipeptide by peptide coupling. [Copyright &y& Elsevier]

Published
2003
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