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2. PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial

Author

Weiss, Scott L, Balamuth, Fran, Long, Elliot, Thompson, Graham C, Hayes, Katie L, Katcoff, Hannah, Cook, Marlena, Tsemberis, Elena, Hickey, Christopher P, Williams, Amanda, Williamson-Urquhart, Sarah, Borland, Meredith L, Dalziel, Stuart R, Gelbart, Ben, Freedman, Stephen B, Babl, Franz E, Huang, Jing, and Kuppermann, Nathan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Kidney Disease, Pediatric, Infectious Diseases, Sepsis, Hematology, Patient Safety, Clinical Trials and Supportive Activities, Comparative Effectiveness Research, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Renal and urogenital, Child, Crystalloid Solutions, Fluid Therapy, Humans, Randomized Controlled Trials as Topic, Saline Solution, Shock, Septic, Septic shock, Intravenous fluid, Crystalloid, Saline, Renal failure, Pragmatic trial, Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) Investigators of the PECARN, PERC, and PREDICT Networks, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Epidemiology, Health services and systems
Abstract

Background/aimsDespite evidence that preferential use of balanced/buffered fluids may improve outcomes compared with chloride-rich 0.9% saline, saline remains the most commonly used fluid for children with septic shock. We aim to determine if resuscitation with balanced/buffered fluids as part of usual care will improve outcomes, in part through reduced kidney injury and without an increase in adverse effects, compared to 0.9% saline for children with septic shock.MethodsThe Pragmatic Pediatric Trial of Balanced versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) study is an international, open-label pragmatic interventional trial being conducted at > 40 sites in the USA, Canada, and Australia/New Zealand starting on August 25, 2020, and continuing for 5 years. Children > 6 months to

Published
2021

4. Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

Author

van der Horst, Jennifer, Manville, Rian W, Hayes, Katie, Thomsen, Morten B, Abbott, Geoffrey W, and Jepps, Thomas A

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Acetaminophen, Animals, Benzoquinones, Blood Pressure, Hypotension, Imines, KCNQ Potassium Channels, Male, Membrane Potentials, Mesenteric Arteries, Rats, Wistar, Signal Transduction, Vasodilation, Xenopus laevis, acetaminophen, hypotension, linopirdine, potassium channels, vasodilation, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectiveIntravenous acetaminophen/paracetamol (APAP) is well documented to cause hypotension. Since the patients receiving intravenous APAP are usually critically ill, any severe hemodynamic changes, as with those associated with APAP, can be life-threatening. The mechanism underlying this dangerous iatrogenic effect of APAP was unknown. Approach and Results: Here, we show that intravenous APAP caused transient hypotension in rats, which was attenuated by the Kv7 channel blocker, linopirdine. APAP metabolite N-acetyl-p-benzoquinone imine caused vasodilatation of rat mesenteric arteries ex vivo. This vasodilatation was sensitive to linopirdine and also the calcitonin gene-related peptide antagonist, BIBN 4096. Further investigation revealed N-acetyl-p-benzoquinone imine stimulates calcitonin gene-related peptide release from perivascular nerves, causing a cAMP-dependent activation of Kv7 channels. We also show that N-acetyl-p-benzoquinone imine enhances Kv7.4 and Kv7.5 channels overexpressed in oocytes, suggesting that it can activate Kv7.4 and Kv7.5 channels directly, to elicit vasodilatation.ConclusionsDirect and indirect activation of Kv7 channels by the APAP metabolite N-acetyl-p-benzoquinone imine decreases arterial tone, which can lead to a drop in blood pressure. Our findings provide a molecular mechanism and potential preventive intervention for the clinical phenomenon of intravenous APAP-dependent transient hypotension.

Published
2020

6. Smart City Edmonton

Author

Hayes, Katie, Ghosh, Soumya, Gnenz, Wendy, Annett, Janice, Bryne, Mary Beth, Augusto, Juan Carlos, Section editor, and Augusto, Juan Carlos, editor

Published
2021
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13. Epidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments

Author

Alpern, Elizabeth R., Hayes, Katie L., Lee, Brian R., Lumb, Catherine E., Mitchell, Christine E., Peaper, David R., Rooholamini, Sahar N., Shin, Sarah J., Williams, Derek J., Woll, Christopher, Neuman, Mark I., Pruitt, Christopher M., Wang, Marie E., Shapiro, Eugene D., Shah, Samir S., McCulloh, Russell J., Nigrovic, Lise E., Desai, Sanyukta, DePorre, Adrienne G., Leazer, Rianna C., Marble, Richard D., Balamuth, Fran, Feldman, Elana A., Sartori, Laura F., Browning, Whitney L., and Aronson, Paul L.

Published
2018
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14. Extreme Weather and Climate Change: Population Health and Health System Implications

Author

Ebi, Kristie L, Vanos, Jennifer, Baldwin, Jane W, Bell, Jesse E, Hondula, David M, Errett, Nicole A, Hayes, Katie, Reid, Colleen E, Saha, Shubhayu, Spector, June, and Berry, Peter

Subjects
Epidemiology, Public Health, Health Sciences, Global Warming Climate Change, Climate-Related Exposures and Conditions, Mental Health, Patient Safety, Climate Change, Climate Action, Good Health and Well Being, Delivery of Health Care, Extreme Weather, Global Health, Humans, Population Health, climate change, climate variability, extreme events, health systems, population health, Public Health and Health Services, Public health
Abstract

Extreme weather and climate events, such as heat waves, cyclones, and floods, are an expression of climate variability. These events and events influenced by climate change, such as wildfires, continue to cause significant human morbidity and mortality and adversely affect mental health and well-being. Although adverse health impacts from extreme events declined over the past few decades, climate change and more people moving into harm's way could alter this trend. Long-term changes to Earth's energy balance are increasing the frequency and intensity of many extreme events and the probability of compound events, with trends projected to accelerate under certain greenhouse gas emissions scenarios. While most of these events cannot be completely avoided, many of the health risks could be prevented through building climate-resilient health systems with improved risk reduction, preparation, response, and recovery. Conducting vulnerability and adaptation assessments and developing health system adaptation plans can identify priority actions to effectively reduce risks, such as disaster risk management and more resilient infrastructure. The risks are urgent, so action is needed now.

Published
2021

15. Smart City Edmonton

Author

Hayes, Katie, primary, Ghosh, Soumya, additional, Gnenz, Wendy, additional, Annett, Janice, additional, and Bryne, Mary Beth, additional

Published
2020
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24. Prevalence of and Associations With Avascular Necrosis After Pediatric Sepsis: A Single-Center Retrospective Study

Author

Periasamy, Uvaraj, Chilutti, Marianne, Kaplan, Summer L., Hickey, Christopher P., Hayes, Katie, Pennington, Jeffrey W., Balamuth, Fran, Fitzgerald, Julie C., and Weiss, Scott L.

Subjects
Adult, Risk Factors, Sepsis, Pediatrics, Perinatology and Child Health, Odds Ratio, Osteonecrosis, Prevalence, Humans, Child, Critical Care and Intensive Care Medicine, Article, Retrospective Studies
Abstract

OBJECTIVE: Avascular necrosis (AVN) is a rare, but serious, complication after sepsis in adults. We sought to determine if sepsis is associated with post-illness diagnosis of AVN, as well as potential associated risk factors for AVN in children with sepsis. DESIGN: Retrospective observational study. SETTING: Single academic children’s hospital. PATIENTS: Patients

Published
2022

26. Association between Clinical Outcomes and Hospital Guidelines for Cerebrospinal Fluid Testing in Febrile Infants Aged 29-56 Days

Author

Thurm, Cary, Williams, Derek J., Browning, Whitney L., Nigrovic, Lise E., Alpern, Elizabeth R., Tieder, Joel S., Feldman, Elana A., Shah, Samir S., Schondelmeyer, Amanda C., Alessandrini, Evaline A., McCulloh, Russell J., Myers, Angela L., Balamuth, Fran, Hayes, Katie L., Chua, Kao-Ping, Neuman, Mark I., McWilliams, J. Michael, and Aronson, Paul L.

Published
2015
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42. Temperature Trajectory Sub-phenotypes and the Immuno-Inflammatory Response in Pediatric Sepsis

Author

Yehya, Nadir, primary, Fitzgerald, Julie C., additional, Hayes, Katie, additional, Zhang, Donglan, additional, Bush, Jenny, additional, Koterba, Natalka, additional, Chen, Fang, additional, Tuluc, Florin, additional, Teachey, David T., additional, Balamuth, Fran, additional, Lacey, Simon F., additional, Melenhorst, Jan Joseph, additional, and Weiss, Scott L., additional

Published
2022
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45. 1440: TEMPERATURE TRAJECTORY SUBPHENOTYPES AND THE IMMUNOINFLAMMATORY RESPONSE IN PEDIATRIC SEPSIS

Author

Yehya, Nadir, primary, Fitzgerald, Julie, additional, Hayes, Katie, additional, Zhang, Donglan, additional, Bush, Jenny, additional, Koterba, Natalka, additional, Chen, Fang, additional, Tuluc, Florin, additional, Teachey, David, additional, Balamuth, Fran, additional, Lacey, Simon, additional, Melenhorst, Joseph, additional, and Weiss, Scott, additional

Published
2021
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50. Meet a member

Author

Hayes, Katie and Luke, Jarryd

Published
2016

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