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16 results on '"Hernández-Hernández, Vanesa"'

1. Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients

Author

Ferraz-Amaro, Iván, Genre, Fernanda, Blanco, Ricardo, Corrales, Alfonso, Mazón, Iñigo González, Portilla, Virginia, Aurrecoechea, Elena, Mata, Cristina, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez-Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, M. Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, Vivar, María Luz García, Galíndez-Agirregoikoa, Eva, Vegas-Revenga, Nuria, Urionagüena-Onaindia, Irati, Perez, Esther Montes, Díaz, Carlos Fernández, González-Gay, Miguel Ángel, and Rueda-Gotor, Javier

Published
2023
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2. Cardiovascular and disease-related features associated with extra-articular manifestations in axial spondyloarthritis. A multicenter study of 888 patients

Author

Rueda-Gotor, Javier, Ferraz-Amaro, Iván, Genre, Fernanda, González Mazón, Iñigo, Corrales, Alfonso, Portilla, Virginia, Llorca, Javier, Agudo-Bilbao, Mario, Aurrecoechea, Elena, Expósito, Rosa, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez-Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, M Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, Vivar, María Luz García, Galíndez-Agirregoikoa, Eva, Perez, Esther Montes, Fernández Díaz, Carlos, Blanco, Ricardo, and González-Gay, Miguel Ángel

Published
2022
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3. Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients

Author

Rueda-Gotor, Javier, Ferraz-Amaro, Iván, Genre, Fernanda, González-Mazón, Iñigo, Corrales, Alfonso, Calvo-Rio, Vanesa, Portilla, Virginia, Llorca, Javier, Expósito, Rosa, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez-Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, M Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, García-Vivar, María Luz, Galíndez-Agirregoikoa, Eva, Montes-Perez, Esther, Fernández-Díaz, Carlos, Blanco, Ricardo, and González-Gay, Miguel Ángel

Published
2022
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6. Subclinical atherosclerotic disease in ankylosing spondylitis and non-radiographic axial spondyloarthritis. A multicenter study on 806 patients

Author

González Mazón, Iñigo, Rueda-Gotor, Javier, Ferraz-Amaro, Iván, Genre, Fernanda, Corrales, Alfonso, Calvo Rio, Vanesa, Palmou Fontana, Natalia, Portilla, Virginia, Llorca, Javier, Mata, Cristina, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Lopez Medina, Clementina, Ladehesa-Pineda, María Lourdes, Castañeda, Santos, Vicente, Esther F., Fernández-Carballido, Cristina, Martínez-Vidal, María Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, García-Vivar, María Luz, Galíndez-Agirregoikoa, Eva, Montes Perez, Esther, Fernández Díaz, Carlos, Blanco, Ricardo, and González-Gay, Miguel Angel

Published
2021
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7. Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study

Author

Rueda-Gotor, Javier, López-Mejías, Raquel, Remuzgo-Martínez, Sara, Pulito-Cueto, Verónica, Corrales, Alfonso, Lera-Gómez, Leticia, Portilla, Virginia, González-Mazón, Íñigo, Blanco, Ricardo, Expósito, Rosa, Mata, Cristina, Llorca, Javier, Hernández-Hernández, Vanesa, Rodríguez-Lozano, Carlos, Barbarroja, Nuria, Castro, Rafaela Ortega, Vicente, Esther, Fernández-Carballido, Cristina, Martínez-Vidal, María Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Peiteado, Diana, Plasencia-Rodríguez, Chamaida, Galíndez-Agirregoikoa, Eva, García-Vivar, María Luz, Gualillo, Oreste, Quevedo-Abeledo, Juan Carlos, Castañeda, Santos, Ferraz-Amaro, Iván, González-Gay, Miguel Á., and Genre, Fernanda

Published
2021
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9. Sex-specific impact of inflammation on traditional cardiovascular risk factors and atherosclerosis in axial spondyloarthritis. A multicentre study of 913 patients.

Author

Ferraz-Amaro, Ivan, Genre, Fernanda, Blanco, Ricardo, Calvo-Rio, Vanesa, Corrales-Selaya, Cristina, Portilla, Virginia, Aurrecoechea, Elena, Batanero, Ricardo, Hernández-Hernández, Vanesa, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, López-Medina, Clementina, Ladehesa-Pineda, Lourdes, Castañeda, Santos, Vicente-Rabaneda, Esther F., Fernández-Carballido, Cristina, Vidal, María Paz Martínez, Corredor, David Castro, Fernández, Joaquín Anino, and Peiteado, Diana

Published
2024
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12. Irisin as a Novel Biomarker of Subclinical Atherosclerosis, Cardiovascular Risk and Severe Disease in Axial Spondyloarthritis.

Author

Remuzgo-Martínez, Sara, Rueda-Gotor, Javier, Pulito-Cueto, Verónica, López-Mejías, Raquel, Corrales, Alfonso, Lera-Gómez, Leticia, Pírez-Fernández, Raquel, Portilla, Virginia, lez-Mazón, I´ñigo Gonzá, Blanco, Ricardo, Expósito, Rosa, Mata, Cristina, Llorca, Javier, Hernández-Hernández, Vanesa, Rodrı´guez-Lozano, Carlos, Barbarroja, Nuria, Ortega-Castro, Rafaela, Vicente, Esther, Fernández-Carballido, Cristina, and Martínez-Vidal, María Paz

Subjects
CAROTID intima-media thickness, CARDIOVASCULAR diseases risk factors, IRISIN, SPONDYLOARTHROPATHIES, ANTIRHEUMATIC agents, ANKYLOSING spondylitis
Abstract

Introduction: Patients with axial spondyloarthritis (axSpA) have a high disease burden mainly due to the rheumatic disease itself, and also exhibit accelerated atherosclerosis, that leads to a higher incidence of cardiovascular (CV) disease. Accordingly, the identification of biomarkers of CV risk and inflammation in axSpA patients is clinically relevant. In this sense, given the beneficial functions exerted by the adipomyokine irisin in processes related to CV disease and inflammation, our aim was to assess, for the first time, the role of irisin as a genetic and serological biomarker of subclinical atherosclerosis, CV risk and disease severity in axSpA patients. Methods: A large cohort of 725 Spanish patients with axSpA was included. Subclinical atherosclerosis (presence of plaques and abnormal carotid intima-media thickness values) was evaluated by carotid ultrasound. Four irisin polymorphisms (rs16835198 G/ T, rs3480 A/G, rs726344 G/A, and rs1570569 G/T) were genotyped by TaqMan probes. Additionally, serum irisin levels were determined by ELISA. Results: Low irisin levels were linked to the presence of plaques (p=0.002) and atherogenic index values ≥4 (p=0.01). Serum irisin were positively correlated with Cpeptide levels (p<0.001) and negatively correlated with visual analogue scale and Bath Ankylosing Spondylitis Metrology Index (p<0.05 in all the cases). Moreover, lower irisin levels were observed in patients with sacroiliitis and in those with a negative HLA-B27 status (p<0.001 and p=0.006, respectively), as well as in those treated with non-steroidal anti-inflammatory drugs and conventional disease-modifying antirheumatic drugs (p<0.001 and p=0.002, respectively). Interestingly, the TT genotype and the T allele of rs16835198 were less frequent in axSpA patients with ASDAS >2.1 (Odds Ratio (OR): 0.48 [0.28-0.83] and OR: 0.73 [0.57-0.92], respectively, p=0.01 in both cases). Additionally, the frequency of rs1570569 T allele was higher in these patients (OR: 1.46 [1.08-1.97], p=0.01). Furthermore, the GGGT haplotype was more frequent in patients with ASDAS values >2.1 (OR: 1.73 [1.13-2.66], p=0.01). Conclusions: Our results indicate that low serum irisin levels could be indicators of the presence of subclinical atherosclerosis, high CV risk and more severe disease in axSpA patients. In addition, irisin may also constitute a genetic biomarker of disease activity in axSpA. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population

Author

Bossini-Castillo, Lara, Simeon, Carmen P., Beretta, Lorenzo, Vonk, Madelon C., Callejas-Rubio, José Luis, Espinosa, Gerard, Carreira, Patricia, Camps, María T., Rodríguez-Rodríguez, Luis, Rodríguez-Carballeira, Mónica, García-Hernández, Francisco J., López-Longo, Francisco J., Hernández-Hernández, Vanesa, Sáez-Comet, Luis, Egurbide, María Victoria, Hesselstrand, Roger, Nordin, Annika, Hoffmann-Vold, Anna-Maria, Vanthuyne, Marie, Smith, Vanessa, De Langhe, Ellen, Kreuter, Alexander, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Voskuyl, Alexandre E., Schuerwegh, Annemie J., Lunardi, Claudio, Airó, Paolo, Scorza, Raffaella, Shiels, Paul, van Laar, Jacob M., Fonseca, Carmen, Denton, Christopher, Herrick, Ariane, Worthington, Jane, Koeleman, Bobby P., Rueda, Blanca, Radstake, Timothy R. D. J., and Martin, Javier

Published
2011
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14. Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis.

Author

Genre, Fernanda, Rueda-Gotor, Javier, Remuzgo-Martínez, Sara, Pulito-Cueto, Verónica, Corrales, Alfonso, Mijares, Verónica, Lera-Gómez, Leticia, Portilla, Virginia, Expósito, Rosa, Mata, Cristina, Blanco, Ricardo, Llorca, Javier, Hernández-Hernández, Vanesa, Vicente, Esther, Fernández-Carballido, Cristina, Martínez-Vidal, María Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Rodríguez-Lozano, Carlos, and Gualillo, Oreste

Subjects
BIOMARKERS, CARDIOVASCULAR diseases risk factors, SPONDYLOARTHROPATHIES, ADIPOKINES, METABOLIC disorders
Abstract

Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA. [ABSTRACT FROM AUTHOR]

Published
2020
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16. Thematic stream: co-morbidity.

Author

Ferraz-Amaro, Ivan, Hernández-Hernández, Vanesa, Quevedo, Juan C, Muñiz, Juan, Franco, Andres, Arce-Franco, Maite, López-Fernández, Judith, and Díaz-González, Federico

Subjects
*RHEUMATOID arthritis, *COMORBIDITY, *TUMOR necrosis factors, *INFLAMMATION, *CARDIOVASCULAR diseases, *INSULIN resistance, *MAGNETIC resonance imaging, *PATIENTS
Abstract

Background: Tumor necrosis factor alpha (TNFα) may act as a link between inflammation and cardiovascular disease through several effects including the induction of insulin resistance (IR). The purpose of this study was to clarify if long-term modulation of inflammatory activity by TNFα inhibitors in RA patients has some influence on insulin sensitivity.Methods: Sixteen RA patients treated with anti-TNFα agents were followed during one year. Disease activity was assessed by DAS28, IR was determined by using Homeostatic Model Assessment-2, body composition was evaluated by impedance analysis, physical activity by accelerometry, abdominal fat distribution by magnetic resonance imaging, and serum level of key adipokines were quantified by ELISA.Results: Body mass indices were increased significantly after one year (25.71±3.20 vs 28.06±4.57 kg/m2, p=0.02) of treatment. Body composition interms of fat and fat-free mass had not changed except for a significant elevation of body cell mass (25.50±4.60 vs 26.60±3.17 kg, p=0.02). Values of visceral intraabdominal and subcutaneous abdominal adipose tissue were not modified. Levels of IR, beta cell production or insulin sensitivity did not change along the study. Basal levels of adiponectin, visfatin, leptin, ghrelin, resistin, and apelin did not change in response to anti-TNFα treatment; only retinol binding protein 4 showed a significant change (51.7±32.7 vs 64.9±28.4 μg/mL, p=0.03) at the end of the study.Conclusions: Insulin resistance, adiposity distribution, body composition, andserum levels of adipokines are not significantly affected by long-term inhibitionof TNFα in RA patients. Our findings question the suggested beneficial role ofanti-TNFα treatments in insulin resistance. [ABSTRACT FROM AUTHOR]

Published
2011
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