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169 results on '"Hirose, Hiroshi"'

4. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author

Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmüller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Couto Alves, Alexessander, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliövaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kähönen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimäki, Terho, Letort, Sébastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melén, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O’Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Göran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlünssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valérie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, André G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widén, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L.

Published
2018
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6. A Functional Single Nucleotide Polymorphism in Mucin 1, at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer

Author

Saeki, Norihisa, Saito, Akira, Choi, Il Ju, Matsuo, Keitaro, Ohnami, Sumiko, Totsuka, Hirohiko, Chiku, Suenori, Kuchiba, Aya, Lee, Yeon–Su, Yoon, Kyong–Ah, Kook, Myeong–Cherl, Park, Sook Ryun, Kim, Young–Woo, Tanaka, Hideo, Tajima, Kazuo, Hirose, Hiroshi, Tanioka, Fumihiko, Matsuno, Yoshihiro, Sugimura, Haruhiko, Kato, Shunji, Nakamura, Tsuneya, Nishina, Tomohiro, Yasui, Wataru, Aoyagi, Kazuhiko, Sasaki, Hiroki, Yanagihara, Kazuyoshi, Katai, Hitoshi, Shimoda, Tadakazu, Yoshida, Teruhiko, Nakamura, Yusuke, Hirohashi, Setsuo, and Sakamoto, Hiromi

Published
2011
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19. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus

Author

Maeda, Shiro, Tsukada, Shuichi, Kanazawa, Akio, Sekine, Akihiro, Tsunoda, Tatsuhiko, Koya, Daisuke, Maegawa, Hiroshi, Kashiwagi, Atsunori, Babazono, Tetsuya, Matsuda, Masafumi, Tanaka, Yasushi, Fujioka, Tomoaki, Hirose, Hiroshi, Eguchi, Takashi, Ohno, Yoichi, Groves, Christopher J., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Kaku, Kohei, Iwamoto, Yasuhiko, Kawamori, Ryuzo, Kikkawa, Ryuichi, Kamatani, Naoyuki, McCarthy, Mark I., and Nakamura, Yusuke

Published
2005
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21. Genome-wide association study identifies three novel loci for type 2 diabetes

Author

Hara, Kazuo, Fujita, Hayato, Johnson, Todd A., Yamauchi, Toshimasa, Yasuda, Kazuki, Horikoshi, Momoko, Peng, Chen, Hu, Cheng, Ma, Ronald C. W., Imamura, Minako, Iwata, Minoru, Tsunoda, Tatsuhiko, Morizono, Takashi, Shojima, Nobuhiro, So, Wing Yee, Leung, Ting Fan, Kwan, Patrick, Zhang, Rong, Wang, Jie, Yu, Weihui, Maegawa, Hiroshi, Hirose, Hiroshi, Kaku, Kohei, Ito, Chikako, Watada, Hirotaka, Tanaka, Yasushi, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Jia, Weiping, Chan, Juliana C. N., Teo, Yik Ying, Shyong, Tai E., Kamatani, Naoyuki, Kubo, Michiaki, Maeda, Shiro, and Kadowaki, Takashi

Published
2014
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23. Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

Author

Saxena, Richa, Saleheen, Danish, Been, Latonya F., Garavito, Martha L., Braun, Timothy, Bjonnes, Andrew, Young, Robin, Ho, Weang Kee, Rasheed, Asif, Frossard, Philippe, Sim, Xueling, Hassanali, Neelam, Radha, Venkatesan, Chidambaram, Manickam, Liju, Samuel, Rees, Simon D., Ng, Daniel Peng-Keat, Wong, Tien-Yin, Yamauchi, Toshimasa, Hara, Kazuo, Tanaka, Yasushi, Hirose, Hiroshi, McCarthy, Mark I., Morris, Andrew P., Basit, Abdul, Barnett, Anthony H., Katulanda, Prasad, Matthews, David, Mohan, Viswanathan, Wander, Gurpreet S., Singh, Jai Rup, Mehra, Narinder K., Ralhan, Sarju, Kamboh, M. Ilyas, Mulvihill, John J., Maegawa, Hiroshi, Tobe, Kazuyuki, Maeda, Shiro, Cho, Yoon S., Tai, E. Shyong, Kelly, M. Ann, Chambers, John C., Kooner, Jaspal S., Kadowaki, Takashi, Deloukas, Panos, Rader, Daniel J., Danesh, John, and Sanghera, Dharambir K.

Published
2013
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24. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

Author

Imamura, Minako, Maeda, Shiro, Yamauchi, Toshimasa, Hara, Kazuo, Yasuda, Kazuki, Morizono, Takashi, Takahashi, Atsushi, Horikoshi, Momoko, Nakamura, Masahiro, Fujita, Hayato, Tsunoda, Tatsuhiko, Kubo, Michiaki, Watada, Hirotaka, Maegawa, Hiroshi, Okada-Iwabu, Miki, Iwabu, Masato, Shojima, Nobuhiro, Ohshige, Toshihiko, Omori, Shintaro, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Ito, Chikako, Tanaka, Yasushi, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Kasuga, Masato, Kamatani, Naoyuki, Nakamura, Yusuke, and Kadowaki, Takashi

Published
2012
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33. Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk

Author

Kohno, Takashi, Sakiyama, Tokuki, Kunitoh, Hideo, Goto, Koichi, Nishiwaki, Yutaka, Saito, Daizo, Hirose, Hiroshi, Eguchi, Takashi, Yanagitani, Noriko, Saito, Ryusei, Sasaki-Matsumura, Rumie, Mimaki, Sachiyo, Toyama, Kaoru, Yamamoto, Seiichiro, Kuchiba, Aya, Sobue, Tomotaka, Ohta, Tsutomu, Ohki, Misao, and Yokota, Jun

Published
2006

46. Intravitreal tPA Injection and Pneumatic Displacement for Submacular Hemorrhage in a 10-Year-Old Child

Author

Tsuyama, Takayuki, Hirose, Hiroshi, and Hattori, Tomohiro

Subjects
genetic structures, Article Subject, sense organs, eye diseases
Abstract

Background. Submacular hemorrhage can occur after blunt trauma to the eye. Intravitreal tissue plasminogen activator (tPA) and gas injection are often used for treatment and are effective for submacular hemorrhage caused by age-related macular degeneration. This report describes the clinical outcome in a child with submacular hemorrhage caused by traumatic choroidal rupture who underwent successful intravitreal tPA injection and pneumatic displacement. Case Presentation. A 10-year-old boy developed sudden decrease of vision and a central scotoma in his right eye after trauma. Submacular hemorrhage was found in the eye. Visual acuity was 20/70 OD. Tissue plasminogen activator (12.5 μg in 0.05 mL) and 0.3 mL of pure sulfur hexafluoride were injected into the vitreous cavity under general anesthesia. After surgery, the patient was instructed to maintain a prone position. Displacement of the submacular hemorrhage from the fovea revealed a choroidal rupture, presumed to be the cause of the hemorrhage. After 4 months of follow-up, visual acuity was restored and final visual acuity is 20/16. Conclusion. Intravitreal tPA and gas injection can be an effective treatment for children with submacular hemorrhage.

Published
2016
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49. Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese.

Author

Fujii, Chikako, Kawai, Toshihide, Azuma, Koichiro, Oguma, Yuko, Katsukawa, Fuminori, Hirose, Hiroshi, Tanaka, Kumiko, Meguro, Shu, Matsumoto, Hideo, and Itoh, Hiroshi

Subjects
INSULIN resistance, JAPANESE people, GLUCOSE tolerance tests, COMPUTED tomography, ORAL drug administration, DISEASES
Abstract

Objective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. Results. The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r=−0.411, p<0.0001), fasting glucose (r=−0.330, p<0.0001), HbA1c (r=−0.231, p=0.0146), and systolic blood pressure (r=−0.224, p=0.0184). Linoleic acid percentage was also significantly negatively correlated with HOMA-IR (r=−0.416, p<0.0001) by simple correlation. Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects. The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects. Conclusion. We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects. [ABSTRACT FROM AUTHOR]

Published
2017
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50. Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies.

Author

Matsuba, Ren, Imamura, Minako, Tanaka, Yasushi, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Maegawa, Hiroshi, Watada, Hirotaka, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, and Maeda, Shiro

Subjects
DISEASE susceptibility, PEOPLE with diabetes, META-analysis, JAPANESE people, LOCUS (Genetics), HEALTH
Abstract

Aim: We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and six susceptibility loci (TMEM154, SSR1, FAF1, POU5F1, ARL15, and MPHOSPH9) originally identified by a transethnic meta-analysis of genome-wide association studies (GWAS) in 2014. Methods: We genotyped 7,620 Japanese participants (5,817 type 2 diabetes patients and 1,803 controls) for each of the single nucleotide polymorphisms (SNPs) using a multiplex polymerase chain reaction invader assay. The association of each SNP locus with the disease was evaluated using logistic regression analysis. Results: Of the six SNPs examined in this study, four (rs6813195 near TMEM154, rs17106184 in FAF1, rs3130501 in POU5F1 and rs4275659 near MPHOSPH9) had the same direction of effect as in the original reports, but two (rs9505118 in SSR1 and rs702634 in ARL15) had the opposite direction of effect. Among these loci, rs3130501 and rs4275659 were nominally associated with type 2 diabetes (rs3130501; p = 0.017, odds ratio [OR] = 1.113, 95% confidence interval [CI] 1.019–1.215, rs4275659; p = 0.012, OR = 1.127, 95% CI 1.026–1.238, adjusted for sex, age and body mass index), but we did not observe a significant association with type 2 diabetes for any of the six evaluated SNP loci in our Japanese population. Conclusions: Our results indicate that effects of the six SNP loci identified in the transethnic GWAS meta-analysis are not major among the Japanese, although SNPs in POU5F1 and MPHOSPH9 loci may have some effect on susceptibility to type 2 diabetes in this population. [ABSTRACT FROM AUTHOR]

Published
2016
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