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Intravascular papillary endothelial hyperplasia (Masson's vegetated hemangioendothelioma) is a rare condition affecting the neuroaxis. In the literature, only eight cases of this lesion involving the vertebral canal with spinal cord compression has been reported. We present a 37-year-old man with thoracic location mimicking schwannoma. Differential diagnosis, management, and review of literature are discussed in this short report. [ABSTRACT FROM AUTHOR]

Intravascular papillary endothelial hyperplasia (IPEH) is an uncommon reactive lesion that shares some features with, and thus can be misdiagnosed as, hemangiosarcoma. Most are associated with a thrombus. Oral cases are rare, only 105 being reported through 2020, and only one has been reported in the hard palate. The stroma of the papillary structures has been described as fibrous, hyalinized, or hypocellular and hyalinized. Presented here is a case of IPEH of the hard palate with no associated thrombus and a myxoid stroma of the papillary structures and wall. The significance of the myxoid stroma is that it has the potential to confound the diagnosis and, by analogy to odontogenic and other myxomas, for concern regarding a tendency to recur.

Background: Cavernous sinus hemangiomas are benign vascular tumors of the cavernous sinus. Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson's angioma is a rare, aberrant thrombus organization occurring independently or in pre-existent lesions, and information on its occurrence in the intracranial region, or its management is sparse. Objective: We aim to describe a case of IPEH occurring in a pre-existing cavernous sinus hemangioma, treated with surgical excision and radiation therapy, providing insight into the appropriate treatment of these tumors and their response to therapy. Materials and Methods: We describe a right cavernous sinus hemangioma, recurring after initial radiation therapy and requiring surgical excision, at which point the presence of IPEH was noted. A sellar recurrence following partial excision was treated with hypofractionated Stereotactic radiotherapy (SRT), and this provided an excellent long-term outcome. Conclusions: Cavernous sinus hemangiomas are treated with surgical excision or primary radiation therapy. IPEH must be looked for in all excised specimens, as there are no radiological features that indicate its presence, and it may resemble the original lesion histologically. When detected, adjuvant radiation must be administered as the IPEH responds well to the use of radiation therapy. [ABSTRACT FROM AUTHOR]

Masson's tumor, also known as intravascular papillary endothelial hyperplasia (IPEH), is a rare and benign vascular disease in which there is a reactive hyperplasia of intravascular endothelial cells. This tumor is most commonly found in soft tissues in the head, neck and upper extremities. We report a rare case of IPEH on the vulva. A Hispanic woman in her mid-thirties presented with a painful and pruritic left vulvar mass. On physical examination, a pedunculated mass was visualized on the left labia majora. Under pathologic examination, it was concluded the lesion was IPEH and it was surgically excised. This is a rare case of IPEH located on the vulva. However, despite this rarity, a simple local excision could be used to manage IPEH.

• Masson's tumor or IPEH is a rare benign tumor composed of reactive endothelial cells in a thrombus. • Angiosarcoma may mimick Masson's tumor, thus ruling it out is imperative. • Surgical resection conveys excellent outcome and prognosis, with handful of recurrence cases. Masson's tumor or IPEH represents a rare exuberant endothelial proliferation within a thrombus through an uncomprehended phenomenon. Being reported for the 1st time in Saudi Arabia, plastic surgeons should keep it in the list of differential diagnosis. We report a case of 17-year-old-girl who presented with a 6-month-old, painful mass on the volar side of her left 4th MCP. Radiology was inconclusive. Histopathology reported Masson's tumor following surgical excision with good functional outcome and no recurrence. Comprising 2%–4% of overall skin vascular tumor and with no identifying clinical or radiological feature, IPEH poses as a diagnostic challenge. The literature reports similar tumors in the hand with different locations and presentations. Surgical excision remains the cornerstone of management, yet the role of radiotherapy remains undefined. Incomplete excision may result in recurrence, which requires a consensus on the extend of marginal excision. Rare cases of recurrence were reported. Histopathology is the only reliable method of diagnosis. We present the 1st reported case of IPEH involving the hand in Saudi Arabia. Plastic surgeons should be aware of such rare conditions and be able to differentiate them from relatively identical yet more sinister tumors, especially angiosarcoma. [ABSTRACT FROM AUTHOR]

Intravascular papillary endothelial hyperplasia (IPEH) is a benign vascular lesion that is uncommon in the central nervous system. To our knowledge, there has been only one previous report of occurrence in the pineal region. We present a second case and a review of the literature. A 28-year-old woman presented with 1 month of headaches and visual auras. Brain magnetic resonance imaging scan demonstrated a 2.6- × 1.8- × 1.3-cm nonenhancing T1-hypointense, T2-/fluid-attenuated inversion recovery–hyperintense pineal region mass with cerebral aqueduct obstruction and hydrocephalus. She underwent placement of a right extraventricular drain followed by complete surgical resection. Histologic analysis was consistent with IPEH. Although rare, IPEH is an entity that should be considered in the differential diagnosis for intracranial masses with radiographic features characteristic of vascular lesions. Tissue sampling is imperative for distinction from more malignant entities. Complete resection is curative and is the standard of care when feasible. Given the risk of local progression and neurologic compromise with subtotal resection of central nervous system lesions, further study regarding adjuvant treatment options is warranted. [ABSTRACT FROM AUTHOR]

A 66‐year‐old woman had a new left breast mass with a prior history of a stage IIIC left breast cancer. She had excision of the mass. The pathology noted intravascular papillary endothelial hyperplasia (IPEH) also known as Masson's tumor. Although a benign lesion, this remains in the differential of breast lesions with vascular morphology. IPEH has been described at multiple sites throughout the body. It must be distinguished from angiosarcoma. Although Masson's tumor has been previously documented in the breast, prior treatment for breast cancer presents a diagnostic dilemma. Treatment for the breast cancer may be a contributing event for Masson's tumor. [ABSTRACT FROM AUTHOR]

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Summary: Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson''s tumor, is a rare, generally considered a non neoplastic vascular lesion, caused by an abnormal endovascular proliferation of endothelial cells. We describe, as far as we know, the first case of this lesion, localized at the origin of the internal carotid artery, which was responsible for an ischemic stroke. Although this entity is very rare, it is important for the clinician to become familiar with this lesion, since the complete removal of the lesion is the only treatment of choice. A partial removal may lead to further clinical events. [Copyright &y& Elsevier]