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A novel immunologic method using antigen-antibody reactions and electrochemical measurement to monitor the oocyte maturation-inducing hormone 17, 20β-dihydroxy-4-pregnen-3-one (DHP) in fish was dev...

29th Annual Jackson Hole, Wyoming, Update in Clinical Immunology, Microbiology and Infectious DiseasesSalt Lake city, UT, USA, 9–13 July 2012The 29th Annual Jackson Hole, Wyoming, Update in Clinical Immunology, Microbiology and Infectious Diseases was held from 9 to 13 July 2012. This postgraduate, continuing medical education course of the University of Utah’s Department of Pathology (UT, USA) is designed for laboratorians, clinical pathologists, pathologists, clinicians, clinical immunology and infectious disease specialists and medical technologists, as well as residents and fellows training in immunology, microbiology or infectious diseases.

The effect of L-asparaginase (L-asp) therapy on circulating antithrombin-III (AT-III) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for AT-III by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum AT-III levels, followed by a protracted recovery beyond the period of L-asp exposure. One of the three patients developed a reversible venous thrombosis of the arm. The mechanism of the L-asparaginase effect may be related to peripheral degradation of AT-III or to inhibition of production.

Quantitative immunologic assay of the plasma of the proposita in a family with hereditary prothrombin deficiency demonstrated the defect to be due to an actual deficiency of the prothrombi...