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Metabolic disease is an epidemic phenomenon that affects both men and women from various ages, ethnic, and socio-economic groups. The term metabolic disease itself is an umbrella term that includes, among others: hypertension, type 2 diabetes mellitus, hyperlipidemia, obesity, and non-alcoholic fatty liver disease. Lifestyles such as poor nutrition, physical activity, and habits are risk factors that can increase the incidence of metabolic disease. Therefore, prevention of metabolic diseases is necessary, including for ordinary people. Metabolic disease, namely hypertension, is in 3rd place and diabetes is in 10th place, the most common disease suffered by residents of Singotrunan Village, Banyuwangi. In this regard, it is important to make efforts to prevent metabolic disease and even death due to complications from metabolic disease. This community service program is designed to create a fit village as a sustainable healthy lifestyle, initiated through health checks for screening, exercise training, education and discussions as encouragement to do regular exercise. The participants' pre-test and post-test results showed a significant increase in their level of knowledge (p=0.01). The results of the participant satisfaction test showed that 80.9% of participants said they were very satisfied and the rest (19.1%) said they were satisfied. It is hoped that the PKM activity to initiate a fit village in Singotrunan Village, Banyuwangi will provide motivation for residents to exercise regularly and can become a model village for residents of other areas.

Highlights: 1. The ongoing advancement of dietary research has significant importance in the exploration of strategies to optimize the impact of nutrition on performance during resistance training. 2. This study provides a prompt for future research to explore the effectiveness of incorporating an additional dietary strategy that may enhance resistance training performance. Abstract: Poor diet with a purpose to lose a certain body weight or body fat can impair muscle protein synthesis. This results in muscle loss and poor performance in physical training, particularly resistance training. This study aimed to determine the short-term effect of extra carbohydrates, specifically in the form of maltodextrin, during a diet break on the resistance training performanced by rats. This study was an experimental laboratory study with a randomized posttest-only control group design. Twenty-seven male rats, aged 3 months with a weight range of 140–165 g, were randomly and equally assigned into three groups: KN (standard diet), KP (75% calorie intake), and K1 (65% calorie intake with a diet break and extra maltodextrin every week). These diets were administered for four weeks, during which the rats had ad libitum feeding. Additionally, the rats underwent ladder-climbing training three times a week. The body weight was measured pre- and post-treatment, while the performance in resistance training was evaluated post-intervention using a ladder climbing platform. There was no significant difference in the weight before and after treatment, with p>0.05 for the increments (∆) among KN (14.00±9.89 g), KP (13±9.5 g), and K1 (20.89±14.77 g). According to the posttest assessment results, only 17 out of 27 rats succeeded in the maximum weightlifting test. This study showed that a short-term high-carbohydrate diet break does not improve the resistance training performance of rats. Further research is necessary to ascertain the outcomes of the treatment implemented over an extended period of time.

Introductions: During the COVID-19 epidemic, college students were expected to adjust to varied daily routines, resulting in pressure and bad emotional sensations in each individual. This situation necessitates college students’ attempts to better their survival through coping. Religion is one coping mechanism that may be used to help pupils reduce stress. The presence of resilience is another characteristic that can overcome any challenges. Coping is used to deal with stress caused by challenges, and spirituality is regarded as one part of developing excellent resilience. Objectives: Researchers decided to undertake a study to see whether there is a relationship between religious coping and resilience in the Faculty of Medicine, Universitas Airlangga students class of 2020 during a pandemic. Methods: This cross-sectional observational analytic study collects primary data using two questionnaire instruments, BRIEF RCOPE and Growth-Focused Resilience. Non-random sampling was used to collect samples from 208 Faculty of Medicine, Airlangga University students class of 2020. The Chi-Square Test was used to examine the data using the SPSS version 21 tool. Results: The p-value (sig) was 0.000 (0.05), indicating a significant connection between religious coping characteristics and resilience variables. Religious coping has been shown to be one of the variables affecting and associated with resilience; effective coping will lead to good growth and vice versa. Conclusions: It is possible to infer a substantial association between religious coping and resilience among the Faculty of Medicine, Universitas Airlangga students class of 2020.

Introduction: Habit of consuming excess calories and sedentary lifestyle can cause oxidative stress which is known to be involved in the pathophysiological process of various diseases including diseases of the gastrointestinal mucosa. Increased Reactive Oxygen Species (ROS) due to a high-calorie diet can damage lipids, proteins, and DNA oxidation of the mucosa and lead to inflammation, apoptosis, damage of mucosal and its barrier. Moderate-intensity physical exercise is known to have health benefits, improve quality of life, reduce the risk of death, and prevent the occurrence of diseases related to oxidative stress. The aim of this study was to analyze the effect of high-calorie diet and moderate-intensity physical exercise on gastric histopathological features of mice. Methods: This research was a true experimental study with posttest only control group design. Female Balb/C strain were randomly assigned into three groups, the control group/K1 (n=12), high-calorie diet group/K2 (n=12), and high-calorie diet and moderate-intensity physical exercise group/K3 (n=9). High-calorie diet in the form of dextrose (D40) was given ad libitum using sonde in a dose of 3-5% of calories or 0.0325 mL/gBW. The moderate-intensity physical exercise was carried out by swimming three times a week for 15 minutes using 6% gBW loading. After 4 weeks of treatment, the mice were sacrificed and their stomach were sampled and prepared for microscopic analysis. Results: The histopathological examination of the gastric mucosa showed the average number of inflammatory cells was 11.60 for K1, 11.25 for K2, and 14.5222 for K3. The Shapiro-Wilk test revealed that the data on inflammatory cells infiltrations were not normally distributed (p0.05, which means no significant difference was found between the three study groups. Conclusion: There was no effect of a high-calorie diet and moderate-intensity physical exercise on the gastric histopathological features of mice (Mus musculus) in this study

The aging process can be slowed by reducing the calorie intake consumed by the body by calorie restriction or fasting. This study aimed to analyze the effect of calorie restriction on adipose tissue in mice. The experimental research design uses 12 months old Rattus Novergicus Strain Wistar, weighing 250–300 grams. The intervention was carried out for 14 days, then the average weight of subcutaneous and visceral fat was measured using Kruskal Wallis analysis and ANOVA. Based on the four treatment groups, the mice fasting and given a high-calorie diet (group 4) had the highest average fat weight value of 4.02 grams in the subcutaneous and 3.55 grams in the visceral area. Meanwhile, in group 1, mice that were not fasting and did not get a high-calorie diet had the lowest average fat weight values, namely 2.14 grams in the subcutaneous area and 2.72 grams in the visceral area. Based on the test results, it was found that there was no difference between subcutaneous (p=0.121) and visceral (p=0.443) fat tissue in all groups. Calorie restriction is beneficial for delaying aging and increasing mammal life span, but intermittent calorie restriction does not affect adipose tissue.

Background: Skin aging is a physiological process that involves changes in skin cells and tissues due to abnormal mechanisms and decreased tissue function caused by both intrinsic and extrinsic factors. Skin aging has different clinical manifestations in each individual, which were classified using Glogau's photoaging classification. Purpose: The objective of this descriptive observational study is to evaluate the profile of skin aging patients at Dr. Soetomo General Hospital Surabaya from January – December 2019. Methods: This study utilized a total sampling technique from data obtained from the patients' medical records, which included age, gender, occupation, anamnesis, physical examination, diagnosis, and treatment received by patients. This research has been reviewed by the Ethics Committee at Dr. Soetomo General Hospital Surabaya (0438/KEPK/XII/2021). Result: Based on data obtained from medical records, 415 samples of skin aging patients were collected. The highest number of cases occurred among patients aged 45 - < 60 years. Most patients were female, and the majority of patients’ occupations were private employees. History taking findings include the most common complaint, namely dull skin, with the most precipitating factors discovered in patients, namely exposure to sunlight and pollution. Wrinkles were the most common physical examination finding in patients, with Glogau's photoaging III being the most common diagnosis. Most patients were treated with photoprotection in the form of sunscreen. Conclusion: With the increase of public awareness about appearance, as well as human health and quality of life, skin aging is receiving adequate attention nowadays, with sun exposure being the most common precipitating factor.

Introduction: Hormonal changes affecting a child's growth occur in deep sleep phase of preschoolers. Nowadays, obesity is still a world health problem. In 2014, Indonesia had three growth problems, one of them was overweight in preschoolers. This study aimed to analyze the association between sleep disturbance with weight-for-height and body mass index (BMI) in preschoolers. Methods: This was a cross-sectional study by analyzing the tendency with boxplot charts and the association was measured by Mann-Whitney test and independent t-test. Data of 86 preschoolers aged 3-5 years old were obtained from three kindergartens in Kalijudan, Surabaya from March to September 2018. Z-score values and the categories of weight-for-height Z-score (WHZ) and BMI-for-age Z-score (BAZ) refer to WHO Standards 2006 and sleep disturbances were measured by sleep disturbance scale for children (SDSC) questionnaire. Results: 65.12% of preschoolers had sleep disturbance and 66.28% of them had normal WHZ and BAZ. The average WHZ and BAZ value in preschoolers who had sleep disturbance (M = -0.2730; -0.2207) were higher than preschoolers who had no sleep disturbance (M = -0.6083; -0, 5920). Results from Mann-Whitney test showed the same significance value between WHZ and BAZ, p = 0.226. Independent t-test showed a significance value of p = 0.524 and p = 0.490, meaning that there was no statistically significant association. Conclusion: There was no statistically significant association between sleep disturbance with WHZ and BAZ in preschoolers aged 3-5 years old, however descriptively, the values of WHZ and BAZ in the group of preschoolers who had sleep disturbance tended to be higher.

Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity. Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse. Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days. Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse. Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.

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