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3. In vitro antiplasmodial activity of Central American medicinal plants.

Author

Jenett-Siems, Kristina, Mockenhaupt, Frank P., Bienzle, Ulrich, Gupta, Mahabir P., Eich, Eckart, Jenett-Siems, K, Mockenhaupt, F P, Bienzle, U, Gupta, M P, and Eich, E

Subjects
MEDICINAL plants, TRADITIONAL medicine, MALARIA treatment, PHYTOTHERAPY, ANIMAL experimentation, ANTIMALARIALS, COMPARATIVE studies, HERBAL medicine, RESEARCH methodology, MEDICAL cooperation, PROTOZOA, RESEARCH, EVALUATION research, IN vitro studies, PHARMACODYNAMICS
Abstract

The in vitro antiplasmodial activities of 14 plant species traditionally used in Central America for the treatment of malaria or fever were evaluated. Lipophilic extracts of Piper hispidum, Siparuna andina, S. pauciflora, S. tonduziana, and Xylopia cf. frutescens, proved to be active against both a chloroquine-sensitive and a resistant strain of Plasmodium falciparum. IC50 values ranged between 3.0 microg/ml and 21.9 microg/ml; however, moderate cytotoxicity of active extracts was observed. Bioactivity-guided fractionation of Piper hispidum yielded 2',4, 6'-trihydroxy-4'-methoxydihydrochalcone (asebogenin) as an active compound. [ABSTRACT FROM AUTHOR]

Published
1999
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9. Cytotoxicity of plants used in traditional medicine in Yemen

Author

Al-Fatimi, M., Friedrich, U., and Jenett-Siems, K.

Subjects
*EUCALYPTUS, *ALTERNATIVE medicine, *TRADITIONAL medicine
Abstract

Abstract: Twenty-five extracts obtained from 14 plant species used in the traditional medicine in Yemen have been screened for cytotoxic activity against human ECV-304 cells. Extracts of Dracaena cinnabari, Eucalyptus camaldulensis, Euclea divinorum, Euphorbia cactus, Pulicaria crispa, and Withania somnifera displayed a remarkable activity. [Copyright &y& Elsevier]

Published
2005
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