Search

Advanced equipment is an important material foundation of the school teaching and scientific research, is the core of key laboratories of scientific research. Management level of geodetic advanced equipment can indicate whether or not the resource of university is used effectively, and it is also important index for evaluating the situation of teaching and laboratory management. Based on analyzing characters of geodetic advanced equipment, management system is investigated. At the end, sharing management of surveying equipment is discussed and some significant practice experiences are attained. [ABSTRACT FROM AUTHOR]

Background. Avian influenza A virus H5N1 has the potential to cause a pandemic. Adjuvants and wholevirion vaccines are regarded as antigen sparing for pandemic vaccines. Methods. A double-blind, randomized trial was performed from 28 August to 22 December 2007 in 402 adults; 301 adults were randomly assigned to receive 2 doses of an inactivated, aluminum-adjuvanted, whole-virion H5N1 vaccine containing 5, 10, or 15 μg of hemagglutinin per dose 28 days apart, and 101 of them received 2 doses of 10 μg of vaccine 14 days apart. The vaccine was manufactured from the recombinant A/Vietman/1194/2004 (NIBRG14) strain. Blood samples were collected for hemagglutination inhibition and microneutralization assays. Results. All formulations were well tolerated, with no serious adverse events. Most local and systemic reactions were mild or moderate. Immune responses were induced after 1 dose in all vaccination groups. The highest immune response was seen after 2 doses of 15 μg of vaccine, with 90% and 100% seroconversion rates and 90% and 100% of participants having a titer of ⩾1:40 for hemagglutination inhibition and microneutralization assays, respectively. Both the 10-and 15-μg doses met or exceeded European Union licensure criteria. Generally, higher immune responses were elicited in participants vaccinated 28 days apart than those vaccinated 14 days apart. Cross-reaction assays showed that after 2 doses of 10 μg of vaccine, 98% and 87% of participants had a microneutralization titer of ⩾1:40 against heterologous Indonesia and Anhui strains, respectively. Conclusions. The inactivated, aluminum-adjuvanted, whole-virion H5N1 vaccine not only showed good immunogenicity and safety but also elicited significant cross-reactivity against heterologous H5N1 strains in clade 2. [ABSTRACT FROM AUTHOR]

An inactivated, alum-adjuvanted, whole-virion H5N1 vaccine had been evaluated previously. Hemagglutination inhibition (HI) assays showed that the antibody levels declined significantly, with 4.8%-20.8% and 0%-18.8% of participants retaining seroprotection (HI titer ⩾ 1:40) 6 and 12 months after the second dose, respectively. A third dose of the same vaccine given 12 months after the second dose significantly boosted immune responses. Thirty days after the third dose in the 1.25-, 2.5-, 5-, and 10-μg dose groups, 29.4%, 31.3%, 78.6%, and 90.0% of participants had HI titers ⩾1:40,and 52.9%, 81.2%, 92.9%, and 100% of participants had microneutralization titers ⩾1:40, respectively. Both the 5-μg and 10-μg doses met European Union criteria. (ClinicalTrials.gov identifier: NCT00660257.) [ABSTRACT FROM AUTHOR]