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1. Synthesis, Properties, and Applications of Oligonucleotides Containing an RNA Dinucleotide Phosphorothiolate Linkage.

Author

Nan-Sheng Li, John K. Frederiksen, and Joseph A. Piccirilli

Subjects
*OLIGONUCLEOTIDES, *RNA, *LINKAGE (Genetics), *CHEMICAL synthesis, *CHEMICAL properties, *GENE expression, *RNA modification & restriction
Abstract

RNA represents a prominent class of biomolecules. Present in all living systems, RNA plays many essential roles in gene expression, regulation, and development. Accordingly, many biological processes depend on the accurate enzymatic processing, modification, and cleavage of RNA. Understanding the catalytic mechanisms of these enzymes therefore represents an important goal in defining living systems at the molecular level. [ABSTRACT FROM AUTHOR]

Published
2011
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