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2. Direct Aortic Versus Supra-Aortic Arterial Cannulation During Surgery for Acute Type A Aortic Dissection

Author

Juvonen, Tatu, Jormalainen, Mikko, Mustonen, Caius, Demal, Till, Fiore, Antonio, Perrotti, Andrea, Hervé, Amélie, Mazzaro, Enzo, Gatti, Giuseppe, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Nappi, Francesco, Conradi, Lenard, Pinto, Angel G., Rodriguez Lega, Javier, Pol, Marek, Kacer, Petr, Dell’Aquila, Angelo M., Rukosujew, Andreas, Wisniewski, Konrad, Vendramin, Igor, Piani, Daniela, Ferrante, Luisa, Rinaldi, Mauro, Quintana, Eduard, Pruna-Guillen, Robert, Gerelli, Sebastien, Di Perna, Dario, Folliguet, Thierry, Acharya, Metesh, Field, Mark, Kuduvalli, Manoj, Onorati, Francesco, Rossetti, Cecilia, Mäkikallio, Timo, Raivio, Peter, Mariscalco, Giovanni, and Biancari, Fausto

Published
2023
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3. Nature of Neurological Complications and Outcome After Surgery for Type A Aortic Dissection

Author

Biancari, Fausto, Onorati, Francesco, Peterss, Sven, Buech, Joscha, Mariscalco, Giovanni, Lega, Javier Rodriguez, Pinto, Angel G., Fiore, Antonio, Perrotti, Andrea, Hérve, Amelié, Rukosujew, Andreas, Demal, Till, Conradi, Lenard, Wisniewski, Konrad, Pol, Marek, Kacer, Petr, Gatti, Giuseppe, Mazzaro, Enzo, Vendramin, Igor, Piani, Daniela, Rinaldi, Mauro, Ferrante, Luisa, Pruna-Guillen, Robert, Di Perna, Dario, Gerelli, Sebastien, El-Dean, Zein, Nappi, Francesco, Field, Mark, Kuduvalli, Manoj, Pettinari, Matteo, Francica, Alessandra, Jormalainen, Mikko, Dell'Aquila, Angelo M., Mäkikallio, Timo, Juvonen, Tatu, and Quintana, Eduard

Published
2024
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4. Classification of the Urgency of the Procedure and Outcome of Acute Type A Aortic Dissection

Author

Biancari, Fausto, Dell'Aquila, Angelo M., Onorati, Francesco, Rossetti, Cecilia, Demal, Till, Rukosujew, Andreas, Peterss, Sven, Buech, Joscha, Fiore, Antonio, Folliguet, Thierry, Perrotti, Andrea, Hervé, Amélie, Nappi, Francesco, Conradi, Lenard, Pinto, Angel G., Lega, Javier Rodriguez, Pol, Marek, Kacer, Petr, Wisniewski, Konrad, Mazzaro, Enzo, Gatti, Giuseppe, Vendramin, Igor, Piani, Daniela, Ferrante, Luisa, Rinaldi, Mauro, Quintana, Eduard, Pruna-Guillen, Robert, Gerelli, Sebastien, Di Perna, Dario, Acharya, Metesh, Mariscalco, Giovanni, Field, Mark, Kuduvalli, Manoj, Pettinari, Matteo, Rosato, Stefano, Mustonen, Caius, Kiviniemi, Tuomas, Roberts, Charles S., Mäkikallio, Timo, and Juvonen, Tatu

Published
2024
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5. Interinstitutional analysis of the outcome after surgery for type A aortic dissection

Author

Biancari, Fausto, Dell’Aquila, Angelo M., Gatti, Giuseppe, Perrotti, Andrea, Hervé, Amélie, Touma, Joseph, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Wisniewski, Konrad, Juvonen, Tatu, Jormalainen, Mikko, Mustonen, Caius, Rukosujew, Andreas, Demal, Till, Conradi, Lenard, Pol, Marek, Kacer, Petr, Onorati, Francesco, Rossetti, Cecilia, Vendramin, Igor, Piani, Daniela, Rinaldi, Mauro, Ferrante, Luisa, Quintana, Eduard, Pruna-Guillen, Robert, Lega, Javier Rodriguez, Pinto, Angel G., Acharya, Metesh, El-Dean, Zein, Field, Mark, Harky, Amer, Kuduvalli, Manoj, Nappi, Francesco, Gerelli, Sebastien, Di Perna, Dario, Mazzaro, Enzo, Rosato, Stefano, Fiore, Antonio, and Mariscalco, Giovanni

Published
2023
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6. Malperfusion syndrome in patients undergoing repair for acute type A aortic dissection: Presentation, mortality, and utility of the Penn classification

Author

Dell’Aquila, Angelo M., Wisniewski, Konrad, Georgevici, Adrian-Iustin, Szabó, Gábor, Onorati, Francesco, Rossetti, Cecilia, Conradi, Lenard, Demal, Till, Rukosujew, Andreas, Peterss, Sven, Caroline, Radner, Buech, Joscha, Fiore, Antonio, Folliguet, Thierry, Perrotti, Andrea, Hervé, Amélie, Nappi, Francesco, Pinto, Angel G., Lega, Javier Rodriguez, Pol, Marek, Kacer, Petr, Mazzaro, Enzo, Gatti, Giuseppe, Vendramin, Igor, Piani, Daniela, Ferrante, Luisa, Rinaldi, Mauro, Quintana, Eduard, Pruna-Guillen, Robert, Gerelli, Sebastien, Di Perna, Dario, Acharya, Metesh, Sherzad, Hiwa, Mariscalco, Giovanni, Field, Mark, Harky, Amer, Kuduvalli, Manoj, Pettinari, Matteo, Rosato, Stefano, Juvonen, Tatu, Mikko, Jormalainen, Mäkikallio, Timo, Mustonen, Caius, and Biancari, Fausto

Published
2024
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7. Preoperative arterial lactate and outcome after surgery for type A aortic dissection: The ERTAAD multicenter study

Author

Biancari, Fausto, Nappi, Francesco, Gatti, Giuseppe, Perrotti, Andrea, Hervé, Amélie, Rosato, Stefano, D'Errigo, Paola, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Juvonen, Tatu, Jormalainen, Mikko, Mustonen, Caius, Demal, Till, Conradi, Lenard, Pol, Marek, Kacer, Petr, Dell’Aquila, Angelo M., Wisniewski, Konrad, Vendramin, Igor, Piani, Daniela, Ferrante, Luisa, Mäkikallio, Timo, Quintana, Eduard, Pruna-Guillen, Robert, Fiore, Antonio, Folliguet, Thierry, Mariscalco, Giovanni, Acharya, Metesh, Field, Mark, Kuduvalli, Manoj, Onorati, Francesco, Rossetti, Cecilia, Gerelli, Sebastien, Di Perna, Dario, Mazzaro, Enzo, Pinto, Angel G., Lega, Javier Rodriguez, and Rinaldi, Mauro

Published
2023
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8. The Efficacy and Safety of Hybrid Ablations for Atrial Fibrillation

Author

Osmancik, Pavel, Herman, Dalibor, Kacer, Petr, Rizov, Vitalii, Vesela, Jana, Rakova, Radka, Karch, Jakub, Susankova, Marketa, Znojilova, Lucie, Fojt, Richard, Prodanov, Petko, Kremenova, Karin, Malikova, Hana, Peisker, Tomas, Stros, Petr, Curila, Karol, Javurkova, Alena, Raudenska, Jaroslava, and Budera, Petr

Published
2021
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9. The David Versus the Bentall Procedure for Acute Type A Aortic Dissection.

Author

Biancari, Fausto, Mastroiacovo, Giorgio, Rinaldi, Mauro, Ferrante, Luisa, Mäkikallio, Timo, Juvonen, Tatu, Mariscalco, Giovanni, El-Dean, Zein, Pettinari, Matteo, Rodriguez Lega, Javier, Pinto, Angel G., Perrotti, Andrea, Onorati, Francesco, Wisniewski, Konrad, Demal, Till, Kacer, Petr, Rocek, Jan, Di Perna, Dario, Vendramin, Igor, and Piani, Daniela

Published
2024
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10. Survival after surgery for acute type A aortic dissection in octogenarians.

Author

Fiore, Antonio, Lega, Javier Rodriguez, Buech, Joscha, Mariscalco, Giovanni, Perrotti, Andrea, Wisniewski, Konrad, Pinto, Angel G., Demal, Till, Rocek, Jan, Kacer, Petr, Gatti, Giuseppe, Vendramin, Igor, Rinaldi, Mauro, Quintana, Eduard, Di Perna, Dario, Nappi, Francesco, Field, Mark, Harky, Amer, Pettinari, Matteo, and Dell’Aquila, Angelo M.

Subjects
AORTIC dissection, OCTOGENARIANS, RETROSPECTIVE studies, HOSPITAL mortality, RESEARCH, OVERALL survival
Abstract

Objective To evaluate the benefits of surgical repair acute type A aortic dissection (ATAAD) on survival of octogenarians. Methods Patients who underwent surgery for acute ATAAD from the multicenter European Registry of Type A Aortic Dissection (ERTAAD) were the subjects of the present analysis. Results 326 (8.4%) patients were aged ≥ 80 years. Among 280 propensity score matched pairs, in-hospital mortality was 30.0% in patients aged ≥ 80 years and 20.0% in younger patients (P = 0.006), while 10-year mortality were 93.2% and 48.0%, respectively (P < 0.001). The hazard of mortality was higher among octogenarians up to two years after surgery, but it became comparable to that of younger patients up to 5 years. Among patients who survived 3 months after surgery, 10-year relative survival was 0.77 in patients aged < 80 years, and 0.46 in patients aged ≥ 80 years. Relative survival of octogenarians decreased markedly 5 years after surgery. Age ≥ 85 years, glomerular filtration rate, preoperative invasive ventilation, preoperative mesenteric mal-perfusion and aortic root replacement were independent predictors of in-hospital mortality among octogenarians (AUC = 0.792; E:O ratio = 0.991; CITL = 0.016; slope = 1.096). An additive score was developed. A risk score ≤ 1 was observed in 68.4% of patients, and their in-hospital mortality was 20.9%. Conclusions Provided a thoughtful patient selection, surgery may provide a survival benefit in patients aged ≥ 80 years with ATAAD that, when compared to younger patients and the general population, may last up to 5 years after the procedure. These findings have significant epidemiologic and clinical relevance because of the increasing longevity of the population of the Western countries. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Predictors, prognosis and costs of prolonged intensive care unit stay after surgery for type A aortic dissection.

Author

BIANCARI, Fausto, HÉRVE, Amelié, PETERSS, Sven, RADNER, Caroline, BUECH, Joscha, PETTINARI, Matteo, LEGA, Javier RODRIGUEZ, PINTO, Angel G., FIORE, Antonio, ONORATI, Francesco, FRANCICA, Alessandra, WISNIEWSKI, Konrad, DEMAL, Till, CONRADI, Lenard, ROCEK, Jan, KACER, Petr, GATTI, Giuseppe, VENDRAMIN, Igor, RINALDI, Mauro, and FERRANTE, Luisa

Published
2024
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13. Femoral arterial cannulation for surgical repair of stanford type A aortic dissection.

Author

Juvonen, Tatu, Vendramin, Igor, Mariscalco, Giovanni, Jormalainen, Mikko, Perrotti, Andrea, Hervé, Amélie, Mazzaro, Enzo, Gatti, Giuseppe, Pettinari, Matteo, Peterss, Sven, Buech, Joscha, Nappi, Francesco, Pinto, Angel G., Rodriguez Lega, Javier, Pol, Marek, Rocek, Jan, Kacer, Petr, Rukosujew, Andreas, Wisniewski, Konrad, and Piani, Daniela

Subjects
AORTIC dissection, DISSECTION, AXILLARY artery, CATHETERIZATION, FEMORAL artery, HOSPITAL mortality
Abstract

Background: The benefits and harms associated with femoral artery cannulation over other sites of arterial cannulation for surgical repair of acute Stanford type A aortic dissection (TAAD) are not conclusively established. Methods: We evaluated the outcomes after surgery for TAAD using femoral artery cannulation, supra‐aortic arterial cannulation (i.e., innominate/subclavian/axillary artery cannulation), and direct aortic cannulation. Results: 3751 (96.1%) patients were eligible for this analysis. In‐hospital mortality using supra‐aortic arterial cannulation was comparable to femoral artery cannulation (17.8% vs. 18.4%; adjusted OR 0.846, 95% CI 0.799–1.202). This finding was confirmed in 1028 propensity score‐matched pairs of patients with supra‐aortic arterial cannulation or femoral artery cannulation (17.5% vs. 17.0%, p = 0.770). In‐hospital mortality after direct aortic cannulation was lower compared to femoral artery cannulation (14.0% vs. 18.4%, adjusted OR 0.703, 95% CI 0.529–0.934). Among 583 propensity score‐matched pairs of patients, direct aortic cannulation was associated with lower rates of in‐hospital mortality (13.4% vs. 19.6%, p = 0.004) compared to femoral artery cannulation. Switching of the primary site of arterial cannulation was associated with increased rate of in‐hospital mortality (36.5% vs. 17.0%; adjusted OR 2.730, 95% CI 1.564–4.765). Ten‐year mortality was similar in the study cohorts. Conclusions: In this study, the outcomes of surgery for TAAD using femoral arterial cannulation were comparable to those using supra‐aortic arterial cannulation. However, femoral arterial cannulation was associated with higher in‐hospital mortality than direct aortic cannulation. Trial registration: ClinicalTrials.gov registration code: NCT04831073. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Role of gender in short- and long-term outcomes after surgery for type A aortic dissection: analysis of a multicentre European registry.

Author

Onorati, Francesco, Francica, Alessandra, Demal, Till, Nappi, Francesco, Peterss, Sven, Buech, Joscha, Fiore, Antonio, Folliguet, Thierry, Perrotti, Andrea, Hervé, Amélie, Conradi, Lenard, Dell'Aquila, Angelo M, Rukosujew, Andreas, Pinto, Angel G, Lega, Javier Rodriguez, Pol, Marek, Rocek, Jan, Kacer, Petr, Wisniewski, Konrad, and Mazzaro, Enzo

Subjects
AORTIC dissection, GENDER, PROPENSITY score matching, OPERATIVE surgery, LOG-rank test
Abstract

OBJECTIVES Gender difference in the outcome after type A aortic dissection (TAAD) surgery remains an issue of ongoing debate. In this study, we aimed to evaluate the impact of gender on the short- and long-term outcome after surgery for TAAD. METHODS A multicentre European registry retrospectively included all consecutive TAAD surgery patients between 2005 and 2021 from 18 hospitals across 8 European countries. Early and late mortality, and cumulative incidence of aortic reoperation were compared between genders. RESULTS A total of 3902 patients underwent TAAD surgery, with 1185 (30.4%) being females. After propensity score matching, 766 pairs of males and females were compared. No statistical differences were detected in the early postoperative outcome between genders. Ten-year survival was comparable between genders (47.8% vs 47.1%; log-rank test, P  = 0.679), as well as cumulative incidences of distal or proximal aortic reoperations. Ten-year relative survival compared to country-, year-, age- and sex-matched general population was higher among males (0.65) compared to females (0.58). The time-period subanalysis revealed advancements in surgical techniques in both genders over the years. However, an increase in stroke was observed over time for both populations, particularly among females. CONCLUSIONS The past 16 years have witnessed marked advancements in surgical techniques for TAAD in both males and females, achieving comparable early and late mortality rates. Despite these findings, late relative survival was still in favour of males. [ABSTRACT FROM AUTHOR]

Published
2024
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24. The nociceptive response during adult cardiac surgery measured by the qNOX index: A feasibility study.

Author

Rogozov, Vladislav, Vanek, Tomas, Maly, Marek, Rocek, Jan, and Kacer, Petr

Abstract

Background. Monitoring nociception during general anaesthesia remains a substantial challenge. The Conox monitor uses two EEG indices, the qCon and the qNox. The qNox refers to the probability that a nociceptive stimulation triggers a movement of the patient and the response probability of reaction to nociceptive stimulation. We decided to test the feasibility of monitoring the qNOX index during adult cardiac surgery and to investigate whether this index correlates with hemodynamic and hormonal signs of nociceptive stimulation. Method. We enrolled 19 patients undergoing elective cardiac surgery. These were randomised to 2 groups receiving different doses of sufentanil via target controlled infusion: group A (n=9) 0.25 ng/mL and group B (n=10) 0.75 ng/mL. All patients were maintained at the same depth of anaesthesia. We recorded the Conox monitor indices (qNOX, qCON, electromyographic), hemodynamic variables and plasmatic levels of cortisol and noradrenaline. Results. There was significantly higher blood pressure (P=0.013) and plasmatic cortisol (P=0.003) in group A and a significant increase in plasmatic noradrenaline with increasing intensity of surgical stimulation in both groups: A (P=0.001), B (P=0.008). We found no significant corresponding changes in the qNOX index. There was a positive correlation between qNOX and hemodynamic signs of stimulation (P=0.012) and between the qNOX and EMG indices (P=0.013) after endotracheal intubation, but not later after EMG index dropped. Conclusion. Our results do not support the assumption that signs of nociceptive stimulation during adult cardiac surgery will be reflected by the qNOX index. This may be related to compounding of qNOX processing and use of muscle relaxants. Further investigation on this field is needed. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study.

Author

Biancari, Fausto, Demal, Till, Nappi, Francesco, Onorati, Francesco, Francica, Alessandra, Peterss, Sven, Buech, Joscha, Fiore, Antonio, Folliguet, Thierry, Perrotti, Andrea, Hervé, Amélie, Conradi, Lenard, Rukosujew, Andreas, Pinto, Angel G., Lega, Javier Rodriguez, Pol, Marek, Rocek, Jan, Kacer, Petr, Wisniewski, Konrad, and Mazzaro, Enzo

Published
2024
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40. Outcome after Surgery for Iatrogenic Acute Type A Aortic Dissection.

Author

Biancari, Fausto, Pettinari, Matteo, Mariscalco, Giovanni, Mustonen, Caius, Nappi, Francesco, Buech, Joscha, Hagl, Christian, Fiore, Antonio, Touma, Joseph, Dell'Aquila, Angelo M., Wisniewski, Konrad, Rukosujew, Andreas, Perrotti, Andrea, Hervé, Amélie, Demal, Till, Conradi, Lenard, Pol, Marek, Kacer, Petr, Onorati, Francesco, and Rossetti, Cecilia

Subjects
AORTIC dissection, HEART valve prosthesis implantation, CEREBRAL angiography, PERCUTANEOUS coronary intervention, IATROGENIC diseases, TREATMENT effectiveness, CORONARY angiography
Abstract

(1) Background: Acute Stanford type A aortic dissection (TAAD) may complicate the outcome of cardiovascular procedures. Data on the outcome after surgery for iatrogenic acute TAAD is scarce. (2) Methods: The European Registry of Type A Aortic Dissection (ERTAAD) is a multicenter, retrospective study including patients who underwent surgery for acute TAAD at 18 hospitals from eight European countries. The primary outcomes were in-hospital mortality and 5-year mortality. Twenty-seven secondary outcomes were evaluated. (3) Results: Out of 3902 consecutive patients who underwent surgery for acute TAAD, 103 (2.6%) had iatrogenic TAAD. Cardiac surgery (37.8%) and percutaneous coronary intervention (36.9%) were the most frequent causes leading to iatrogenic TAAD, followed by diagnostic coronary angiography (13.6%), transcatheter aortic valve replacement (10.7%) and peripheral endovascular procedure (1.0%). In hospital mortality was 20.5% after cardiac surgery, 31.6% after percutaneous coronary intervention, 42.9% after diagnostic coronary angiography, 45.5% after transcatheter aortic valve replacement and nihil after peripheral endovascular procedure (p = 0.092), with similar 5-year mortality between different subgroups of iatrogenic TAAD (p = 0.710). Among 102 propensity score matched pairs, in-hospital mortality was significantly higher among patients with iatrogenic TAAD (30.4% vs. 15.7%, p = 0.013) compared to those with spontaneous TAAD. This finding was likely related to higher risk of postoperative heart failure (35.3% vs. 10.8%, p < 0.0001) among iatrogenic TAAD patients. Five-year mortality was comparable between patients with iatrogenic and spontaneous TAAD (46.2% vs. 39.4%, p = 0.163). (4) Conclusions: Iatrogenic origin of acute TAAD is quite uncommon but carries a significantly increased risk of in-hospital mortality compared to spontaneous TAAD. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Protein‐losing enteropathy in an adult with non‐ischaemic cardiomyopathy: complete reversal by heart transplantation

Author

Melenovsky, Vojtech, Kubanek, Milos, and Kacer, Petr

Subjects
Cardiac transplantation, Case Report, Heart failure, Protein‐losing enteropathy
Abstract

Protein‐losing enteropathy (PLE) due to leakage of lymph into the gut sometimes occurs in young patients after Fontan palliation but is very rarely reported with other aetiologies of chronic heart failure (HF). PLE leads to severe hypoalbuminemia and immunodeficiency and is associated with poor prognosis. The mechanisms and the predispositions to PLE are poorly understood. Here, we report an adult patient with advanced HF due to non‐ischaemic non‐dilated hypocontractile cardiomyopathy who developed severe PLE, probably owing to increased ventricular stiffness and constraint by atypically placed epicardial electrode encircling both ventricles. Importantly, both PLE and immunodeficiency completely resolved after heart transplantation.

Published
2018

42. Thin-film SnO2 and ZnO detectors of hydrogen peroxide vapors

Author

Aroutiounian, Vladimir, Arakelyan, Valeri, Aleksanyan, Mikayel, Shahnazaryan, Gohar, Kacer, Petr, Picha, Pavel, Kovarik, Jiri, Pekarek, Jakub, and Joost, Berndt

Subjects
inorganic chemicals, lcsh:T, technology, industry, and agriculture, food and beverages, lcsh:Technology
Abstract

Thin-film hydrogen peroxide vapor sensors made from Co-doped SnO2 and La-doped ZnO were manufactured using the high-frequency magnetron sputtering method. Thicknesses of deposited doped metal oxide films were measured and their morphology was investigated. The gas sensing characteristics of the prepared sensors were measured at different concentrations of hydrogen peroxide vapors and different operating temperatures of the sensor. It was found that both sensors made from doped metal oxides SnO2 and ZnO exhibit a sufficient response to 10 ppm of hydrogen peroxide vapors at the 200 and 220 ∘C operating temperature, respectively. It was established that the dependencies of the response on hydrogen peroxide vapor concentration have a linear character for prepared structures at the 150 ∘C operating temperature and can be used for determination of hydrogen peroxide vapor concentration.

Published
2018

50. Post-infarction left ventricular free wall rupture: 12-years experience from the Cardiac Centre of the Institute of Clinical and Experimental Medicine in Prague, Czech Republic.

Author

Kacer, Petr, Adamkova, Vera, Hubacek, Jaroslav Alois, Cervinkova, Tereza, Adamek, Vaclav, Lesna, Ivana Kralova, Lanska, Vera, and Pirk, Jan

Abstract

Background. Post-infarction left ventricular free wall rupture (LVFWR) is a feared and catastrophic complication of myocardial infarction that carries a high surgical and hospital mortality. Due to the rarity of this complication, little information exists on surgical treatment and outcomes. Goal and Methods. The goal of this study was to present our experience with LVFWR. We present a retrospective cohort of 19 consecutive patients who were surgically treated in the Cardiac Centre of the Institute of Clinical and Experimental Medicine in Prague between January 2006 and December 2017. Results. Thirty-day mortality was 26%. Five patients died. Four patients died in the operating theatre and one patient on the ninth postoperative day following re-rupture. Seventy-four percent of the patient cohort survived and were discharged from hospital. The median length of follow-up was 45 months (range 0.75-150). No patient died during follow-up. Median postoperative ejection fraction was 45% (range 25-65%). Angina pectoris and dyspnea were investigated during follow-up and graded according to the Canadian cardiology society (CCS) and the New York Heart Association (NYHA) classifications. Fourteen patients had CCS class I, eight patients had NYHA class I dyspnea and six patients had NYHA class II. Re-rupture occurred after hospital discharge in one patient one month after the original surgery. The patient was treated successfully by urgent surgical intervention. Conclusion. LVFWR is a catastrophic and challenging complication of myocardial infarction. Good outcomes can be achieved by rapid diagnosis and urgent surgical intervention as shown by our results. [ABSTRACT FROM AUTHOR]

Published
2021
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