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9 results on '"Kammler R"'

1. Multiplexed high-throughput immune cell imaging in patients with high-risk triple negative early breast cancer: Analysis from the International Breast Cancer Study Group (IBCSG) Trial 22-00

Author

Rusakiewicz, S., Tyekucheva, S., Tissot-Renaud, S., Chaba, K., Imbimbo, M., Benedetti, F., Kammler, R., Hornfeld, J., Munzone, E., Gianni, L., Thurlimann, B., Láng, I., Pruneri, G., Gray, K.P., Regan, M.R., Loi, S., Colleoni, M., Viale, G., Kandalaft, L., Coukos, G., and Curigliano, Giuseppe

Published
2024
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2. Genomic characterisation of hormone receptor-positive breast cancer arising in very young women

Author

Luen, S.J., Viale, G., Nik-Zainal, S., Savas, P., Kammler, R., Dell’Orto, P., Biasi, O., Degasperi, A., Brown, L.C., Láng, I., MacGrogan, G., Tondini, C., Bellet, M., Villa, F., Bernardo, A., Ciruelos, E., Karlsson, P., Neven, P., Climent, M., Müller, B., Jochum, W., Bonnefoi, H., Martino, S., Davidson, N.E., Geyer, C., Chia, S.K., Ingle, J.N., Coleman, R., Solbach, C., Thürlimann, B., Colleoni, M., Coates, A.S., Goldhirsch, A., Fleming, G.F., Francis, P.A., Speed, T.P., Regan, M.M., and Loi, S.

Published
2023
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3. Consolidation nivolumab and ipilimumab versus observation in limited-disease small-cell lung cancer after chemo-radiotherapy – results from the randomised phase II ETOP/IFCT 4-12 STIMULI trial

Author

Stahel, R., Hiltbrunner, A., Pardo-Contreras, M., Gasca-Ruchti, A., Giacomelli, N., Kammler, R., Marti, N., Pfister, R., Piguet, A.C., Roux, S., Troesch, S., Schneider, M., Schweri, R., Zigomo, I., Tsourti, Z., Zygoura, P., Tsouprou, S., Kassapian, M., Vervita, K., Dimopoulou, G., Andriakopoulou, C., Morin, F., Amour, E., Mariaule, G., Archirel, N., Fernandez, M., Pereira, E., Benito, L., Lopez, K., Hernández, A., Chinchen, S., Jurkovic, H., Livingstone, A., Mitchell, J., Walker, M., Mitchell, P., Ng, S., Steer, C., Briscoe, K., Saqib, A., Abdi, E., Houghton, B., O’Byrne, K., Chittajallu, B.R., Hughes, B.G., Black, A., Nackaerts, K., Werner, H., Gervais, R., Zalcman, G., Vaylet, F., Merle, P., Monnet, I., Moro-Sibilot, D., Molinier, O., Girard, N., Souquet, P.-J., Barlesi, F., Debieuvre, D., Senellart, H., Poudenx, M., Dixmier, A., Pouessel, D., Cadranel, J., Lena, H., Quoix, E., Friard, S., Audigier-Valette, C., Mazieres, J., Pichon, E., Faehling, M., Kokowski, K., Kirchen, H., Griesinger, F., Tufman, A., De-Colle, C., de Langen, J., González Larriba, J.L., Insa, A., Majem, M., Massutí, B., Pulla, M.P., Aix, S.P., Villanueva, N., Vivanco, G.L., Andrade, J., Curioni-Fontecedro, A., Franks, K., Califano, R., Peters, S., Pujol, J.-L., Dafni, U., Dómine, M., Popat, S., Reck, M., Becker, A., Insa Mollá, A., López Vivanco, G., Madelaine, J., Provencio Pulla, M., Roschitzki-Voser, H., Ruepp, B., Stahel, R.A., Le Pechoux, C., and De Ruysscher, D.

Published
2022
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5. Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: results from the ETOP Lungscape Project

Author

Kerr, K.M., Dafni, U., Schulze, K., Thunnissen, E., Bubendorf, L., Hager, H., Finn, S., Biernat, W., Vliegen, L., Losa, J.H., Marchetti, A., Cheney, R., Warth, A., Speel, E.-J., Blackhall, F., Monkhorst, K., Jantus Lewintre, E., Tischler, V., Clark, C., Bertran-Alamillo, J., Meldgaard, P., Gately, K., Wrona, A., Vandenberghe, P., Felip, E., De Luca, G., Savic, S., Muley, T., Smit, E.F., Dingemans, A.-M.C., Priest, L., Baas, P., Camps, C., Weder, W., Polydoropoulou, V., Geiger, T.R., Kammler, R., Sumiyoshi, T., Molina, M.A., Shames, D.S., Stahel, R.A., and Peters, S.

Published
2018
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9. Predictive value of a proliferation score (MS) in postmenopausal women with endocrine-responsive breast cancer: results from International Breast Cancer Study Group (IBCSG) Trial IX.

Author

Sninsky, J., Wang, A., Gray, K., Lagier, R., Christopherson, C., Rowland, C., Chang, M., Kammler, R., Viale, G., Kwok, S., Regan, M., and Leyland-Jones, B.

Subjects
*BREAST cancer research, *POSTMENOPAUSE, *TAMOXIFEN, *DRUG therapy, *HER2 gene
Abstract

Background: While representing the largest fraction of women diagnosed with primary breast cancer, older postmenopausal women with ER+, HER2-- tumors are less responsive to chemoendocrine therapy than younger women and have been underrepresented in molecular profiling of randomized trials. IBCSG Trial IX, a randomized controlled trial in postmenopausal women, median age 61y, with node negative disease, failed to demonstrate the benefit of preceding tamoxifen (T) by 3 cycles of CMF for ER+ tumors. We sought to determine if MS, a proliferation score, could identify a subset of women who differentially benefit from addition of chemotherapy to T in this trial. Methods: From 1988-1999, 1669 eligible patients (1040 with ER+, HER2-- tumors) were randomized to CMF ->T vs T. Disease-free survival (DFS) was the primary trial endpoint; breast cancer-free interval (BCFI) which excludes second (non-breast) malignancies and censors deaths without prior cancer event was also evaluated. Analysis was limited to the first 7 years of follow-up. From 671 (ER+, HER2--) available subjects, 568 were successfully profiled by RT-PCR. The mRNA expression levels of 14 equally-weighted proliferation genes and 3 normalization genes were used to generate MS; predetermined binary categorization of MS was used. Analysis of this post hoc, pre-specified study used results from centralized laboratory IHC and Cox models to assess the predictive value of MS on DFS and BCFI, adjusting for traditional risk factors of local treatment, age, ER, PR, Ki67, tumor size and grade. Results: Subgroups of MS (low, 169 samples (30%) and high, 399 samples (70%)) were identified. MS by treatment interaction was significant for DFS and BCFI (each p ≤ 0.004). Among patients with low MS, CMF -> T improved DFS (HR 0.19, 95% CI 0.06-0.59) and BCFI (HR 0.19, 95% CI 0.05-0.72) vs T; 7y DFS was 95% vs 83% with CMF -> T vs T. Among patients with high MS, CMF T did not improve DFS (HR 1.27, 95% CI 0.79-2.05) or BCFI (HR 1.37, 95% CI 0.80-2.33) and 7y DFS of 81% for CMF T and T. Continuous MS was moderately correlated with log Ki67 (r = 0.47) but not correlated with ER or PR. The MS by treatment interaction remained significant with Ki67 in the model. Conclusions: Low MS was associated with differential benefit favoring those women receiving CMF -> T vs T alone for both DFS and BCFI in the first 7 years. The effect was independent of traditional risk factors including Ki67. Hence this study, which is unconfounded by chemotherapy-induced ovarian ablation in younger women, identifies a subset of postmenopausal women with ER+, HER2- tumors that benefit from CMF chemotherapy. This seemingly incongruous observation is consistent with a) the prior observation that only the lowproliferation subgroup by PAM50 11-gene signature benefits from the addition of weekly paclitaxel to adjuvant FEC (GEICAM/9906), b) the ability of MS to identify a subset of women with tumors with disseminated luminal progenitor cells activated through the agonistic activity of tamoxifen, and c) the repetitive dosing of cyclophosphamide and taxol being hypothesized to act via tumor stroma/anti-angiogenesis. The relative contribution of these factors is under investigation. [ABSTRACT FROM AUTHOR]

Published
2012
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