1. Effects of high molecular weight poly-γ-glutamic acid on PIGS with porcine preproductive and respiratory syndrome virus (PRRSV) infection
- Author
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Seo Byoung-Joo, Lee Jee-Hoon, Kang Ick-Jae, Shabir Nadeem, Khatun Amina, Yang Myeon-Sik, Park Chul, Kim Bumseok, and Kim Won-Il
- Subjects
antiviral activity ,immune stimulation ,neutralizing antibody ,poly-γ-glutamic acid ,prrsv ,Veterinary medicine ,SF600-1100 - Abstract
Bacillus subtilis sups. chungkookjang produces a higher molecular mass poly-γ-glutamic acid (γ-PGA). Recently, previous studies have demonstrated immune stimulation and an antitumor effect of the high molecular mass γ-PGA using various mouse models although these effects have not been shown in other species of animals. Therefore, the current study was conducted to determine the effect of γ-PGA in pigs with and without PRRSV infection. PRRS-negative pigs were intramuscularly injected with 1, 3, or 5 ml of 20 mg/mll γ-PGA, and one group of pigs served as a non-treatment (NT) group. All groups treated with γ-PGA had significantly higher weight gains, and pigs treated with 5 ml of γ-PGA exhibited higher tumor necrosis factor (TNF)-α, interferon (IFN)-α and IFN-β expression levels compared with the NT group. According to the preliminary results, an animal challenge study was conducted with a highly virulent PRRSV strain, MN184, along with γ-PGA treatment at different time points. Pigs treated with γ-PGA had lower levels of viral loads in the sera and in lungs and gained significantly more weight (p
- Published
- 2017
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