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Abstract Proficiency testing (PT) is an impartial laboratory performance-evaluating system using an independent body. It is a mandatory accreditation requirement and means for improving the laboratory’s performance. The study aimed to evaluate the performance of PT, with a focus on identifying and discussing determinants that influence PT performance at comprehensive specialized hospitals in northwest Ethiopia. A retrospective cross-sectional study was carried out from 2020 to 2022. Using a convenient sampling technique, laboratory tests with recorded PT results in each hospital laboratory were included. A data collection template and customized checklists were used to collect the data. Epi Data Version 3.1 for data entry and STATA Version 14.1 for cleaning and analysis were used. Binary logistic regression analyses were used. Variables with p

Abstract Background Health facilities can provide diagnostic, curative, and prognostic services for the community. While providing services, healthcare workers can be exposed to needlestick injuries that can transmit pathogenic organisms through body fluids. Objective The aim was to establish the pooled prevalence of needlestick injuries among healthcare workers in Ethiopia. Methods This systematic review and meta-analysis was conducted according to PRISMA guidelines. Articles were searched from Google Scholar, PubMed, Science Direct, and Scopus databases using a combination of keywords and Boolean functions. All the searched articles were imported into the EndNote X9 software, and then, duplicate data files were removed. Article screening and data extraction were done independently by two authors. Data manipulation and analyses were done using STATA version 15.1 software. Results The analysis of 23 full-text articles showed that the prevalence of the 12-month and lifetime needlestick injuries among the primary studies ranged from 13.2 to 55.1% and 18.6 to 63.6%, respectively. The pooled prevalence of needlestick injuries among the Ethiopian healthcare workers was 28.8% (95% CI 23.0–34.5) and 43.6% (95% CI 35.3–52.0) for the 12 months and lifetime, respectively. Conclusions The pooled prevalence of needlestick injuries among Ethiopian healthcare workers was high. Therefore, efforts should be implemented to reduce the occurrence of injuries. Adequate protective equipment and safety-engineered devices should be supplied for the healthcare workers. It could be more effective to reduce the factors contributing to increased exposures through the allocation of adequate numbers of the healthcare workforce and implementing in-service training.

Abstract Objective Parasitic infections are the commonest infections affecting 3.5 billion people leading 450 million illnesses. Parasites are major public health problems in developing countries. This study was aimed to assess the prevalence and associated factors of parasitic infections among patients. A cross sectional study was conducted on 364 patients, attending Shahura Health Center, Northwest Ethiopia. Stool specimens were collected and examined using formol-ether concentration technique. Socio-demographic data collected using questionnaire. Binary and multivariable logistic regression analyses were conducted to calculate the strength of association between variables. Result The overall prevalence of intestinal parasitosis was 56.9%. The most prevalent parasite was Entamoeba histolytica/dispar 32.4% followed by Hookworm species 11.8% and Giardia lamblia 7.4% singly or mixed with other parasites. Furthermore, double and triple parasitic infections were observed in 3% and 1.4% patients respectively. Being male in gender (P = 0.049), age group interval between 1 and 20 years of old (P = 0.012), having stomach pain (P = 0.032) and having diarrhea (P = 0.007) were found to be significantly associated with parasitic infection. In conclusion, prevalence of parasitic infection in the area is high. Therefore, ensuring provision of clean potable water and minimizing the contamination of vegetables are recommended.

Abstract Objective During the healthcare delivery process, hazardous wastes can be generated from the health facilities. Improper healthcare waste management is responsible for the transmission of more than 30 dangerous bloodborne pathogens. The aim of this systematic review was to evaluate the healthcare waste management practice and potential challenges in Ethiopia. Results Electronic databases and direct Google search yielded 1742 articles from which 17 studies met the inclusion criteria. The proportion of hazardous waste generated in Ethiopian healthcare facilities was unacceptably high which ranged from 21 to 70%. Most studies indicated the absence of proper waste segregation practice at the source of generation. Treatment of the healthcare waste using low combustion incinerator and/or open burning and open disposal of the incinerator ash were very common. Lack of awareness from the healthcare staff, appropriate waste management utilities and enforcement from the regulatory bodies were mainly identified as a common factor shared by most of the studies. The healthcare waste management practice in Ethiopian healthcare facilities was unsatisfactory. There should be close supervision of the waste disposal process by the regulatory bodies or other stakeholders.

Abstract Objective Medical waste is a total waste stream which is generated from the healthcare facilities during the healthcare delivery process. It can contain potentially hazardous substances for the human being and the environment. Waste handlers play a significant role for its proper management and they need to have adequate knowledge, attitude, and practices. The study aimed to evaluate the knowledge, attitude, and practices of waste handlers regarding medical waste management in Debre Markos town healthcare facilities, northwest Ethiopia. Results A total of 55 medical waste handlers were studied from 12 healthcare facilities. Among this, 25 (45.4%) were diploma and certificate holders. The majority (69.1%) of the study participants were not provided with proper training. There was a lack of personal protective devices and waste management equipment supply. Regarding knowledge, attitude, and practices, 25 (45.5%), 43 (78.2%), and 44 (80%) of the study participants had adequate knowledge, favorable attitude, and adequate practice scores, respectively. There was high (30.9%) prevalence of needlestick and sharps injuries. Healthcare facilities should provide periodic training and adequate supplies for the waste handlers. Further study should be conducted on a large scale by including different levels of health facilities and regions of the country.

Breast cancer (BC) is the second most common cause of deaths reported in women worldwide, and therefore there is a need to identify BC patients at an early stage as timely diagnosis would help in effective management and appropriate monitoring of patients. This will allow for proper patient monitoring and effective care. However, the absence of a particular biomarker for BC early diagnosis and surveillance makes it difficult to accomplish these objectives. miRNAs have been identified as master regulators of the molecular pathways that are emphasized in various tumors and that lead to the advancement of malignancies. Small, non-coding RNA molecules known as miRNAs target particular mRNAs to control the expression of genes. miRNAs dysregulation has been linked to the start and development of a number of human malignancies, including BC, since there is compelling evidence that miRNAs can function as tumor suppressor genes or oncogenes. The current level of knowledge on the role of miRNAs in BC diagnosis, prognosis, and treatment is presented in this review. miRNAs can regulate the tumorigenesis of BC through targeting PI3K pathway and can be used as prognostic or diagnostic biomarkers for BC therapy. Some miRNAs, like miR-9, miR-10b, and miR-17-5p, are becoming known as biomarkers of BC for diagnosis, prognosis, and therapeutic outcome prediction. Other miRNAs, like miR-30c, miR-187, and miR-339-5p, play significant roles in the regulation of hallmark functions of BC, including invasion, metastasis, proliferation, resting death, apoptosis, and genomic instability. Other miRNAs, such as miR-155 and miR-210, are circulating in bodily fluids and are therefore of interest as novel, conveniently accessible, reasonably priced, non-invasive methods for the customized care of patients with BC.

Objectives To assess the implementation of proficiency testing in the northwest Ethiopian government comprehensive specialized hospital laboratories, with a focus on identifying and understanding the challenges encountered during their participation in the external quality assessment scheme. Methods A cross-sectional study was conducted among 3 comprehensive specialized hospitals in northwest Ethiopia, analyzing 41 documented laboratory test parameters from 2020 to 2022. In addition, face-to-face, in-depth interviews were carried out to identify the major challenges the participating institutions faced. Results The study covered a total of 41 tests across 9 cycles. Overall, proper implementation of proficiency testing was observed in 59.3% of the tests, with 61.8% maintaining consistent implementation status over 3 consecutive years. In addition, the overall performance of the laboratory was 54.3%, with a 68.7% participation rate. The predominantly identified challenges included the lack of participation, insufficient reagents and supplies, inadequacy of suitable proficiency testing materials, equipment malfunction and downtime, lack of management support, insufficient budget, and inadequate training and awareness. Conclusions The results of this study highlight the ineffective implementation of proficiency testing. Contributing factors include personnel issues, equipment and supplies challenges, managerial shortcomings, difficulties with proficiency testing providers, budgetary constraints, and a lack of training and motivation. [ABSTRACT FROM AUTHOR]

Skin wound management is a very difficult undertaking in the medical field. There is no information available concerning the wound beneath the bandages. Electrospun nanofibrous wound dressings stand out for their resemblance to extracellular matrix (ECM), increased surface-to-volume ratio, porousness, and capacity to encapsulate or load medications, among other distinctive qualities. Traditional antibacterial loaded electrospun nanofibrous wound dressings do not indicate the state of the wound and constantly release antibacterial chemicals even when there are no bacteria in the wound area. As a result, dressings that can track the condition of the wound and dispense medications as needed are crucial. Self-responsive wound dressings can release medications based on bacterial, oxygen spectra, pH, or infection responsiveness, reducing the need for antibacterial agents. Self-responsive mats, which are wound dressings that can release medications based on response to bacteria, oxygen species, and pH or infections, are required to reduce the overuse of antibacterial agents. Self-responsive electrospun nanofibrous mats can be used to monitor the condition of a wound by altering its color in response to an infection or a change in the pH of the wound. Electrospun nanofibrous wound dressings that are stimulus-responsive (self-responsive) are discussed in this review paper. Self-responsive electrospun nanofibrous wound dressings that are triggered by pH, temperature, light, bacteria, and oxygen species are discussed in detail after self-responsive smart materials or polymers used for electrospun nanofibrous wound dressings are covered in the first section of the review.

Sustainable and environmentally friendly activated carbon from biomass materials is proposed to produce supercapacitors from banana peels and has the potential to replace the non-sustainable and hazardous process from either graphite or/and fossil fuels. In order to determine the potential of using banana peel for supercapacitor application, raw banana peel, a bio-waste, was activated both mechanically and chemically to observe the real differences. The sample was activated at 700 °C and chemically activated using KOH. Characterization of activated banana peel was performed using FTIR, DLS, TGA and XRD analytical equipment. FTIR analysis revised the presence of hydroxyl, carbonyl and aromatic compounds on a banana peel cellulose-based carbon. The TGA results proved that 700 °C could be sufficient to totally carbonize banana peel. DLS clearly showed a strong difference between the carbonized and KOH-activated material in particle size distribution. Meanwhile, surface area analysis using BET displayed an increase from 553.862 m2/g to 565.024 m2/g BET in surface area (SBET) when carbon was activated using KOH with a nitrogen isotherm at 77.350 K. Specific capacitance was increased from 0.3997 Fg−1 to 0.821 Fg−1, suggesting more than a 100% increase in the specific capacity due to KOH activation, as proved by the cyclic voltammetry (CV) curve. The X-ray diffraction results revealed the patterns of activated carbon. The findings demonstrated the feasibility of using banana peel waste as a low-cost and sustainable material for the preparation of flexible supercapacitor batteries.

The rapid growth of textile industries in Ethiopia plays an important role in economic development. However, the sludge from these wastewater treatment plants, which is not an integral part of the treatment process, is often considered hazardous as it is contaminated with heavy metals of dyestuffs and chemicals. The customary transfer routines such as landfilling and incineration may not be suitable because the leachate from the landfilling destinations and the buildups from the incinerators lead to optional contamination. Moreover, such transfer choices are not financially practical. Therefore, there is a growing need to look for various applications of sludge handling for sustainable development. This study attempts to find out an environmentally friendly solution for the management of the textile sludge by incinerating the sludge and using it for partial replacement of cement in concrete production. Concrete is a composite material formed by the combination of cement, sand, coarse aggregate, and water in a particular proportion so that concrete produced meets the needs regarding its workability, strength, durability, and economy. Typical textile sludge was having high heavy metal contents as per the United States Environmental Protection Agency (USEPA) guideline and should be properly disposed of. The sludge upon incineration at 625°C for four hours gives 78.1% moisture content, 61.2% volatile organic matter, and 59.6% inorganic ash content. The main reactive oxide elements such as SiO2, Fe2O3, CaO, and Al2O3 were found to be 18.51, 3.19, 23.87, and 12.73% by weight in the ash. The calorific value determined from the dried sludge were found to be 1973 cal/gm. Concrete block was manufactured by replacement of cement with 10, 20, 30, 40, and 50% incinerated textile sludge ash, and the manufactured block was evaluated in terms of their compressive strengths, leaching behavior, and water absorption. The replacement cement by the ash increases the hydration time reduced, and up to 20%, sludge ash incorporation in the concrete mix design gives the designed compressive strength. Eventhough water absorption increases with increasing content of the incorporation of the ash, for the 20% replacement of cement, the lethal concentration of heavy metals was obtained to be below the permissible limit set by USEPA. Consequently, the experiment work indicates that the potential use of textile sludge ash for cement concrete gives the possibilities of reduction of heavy metal contamination to surroundings upon sludge disposal, reduces the use of raw materials for producing cement and reduces environmental pollution during cement production.

Flexible supercapacitors are highly demanding due to their wearability, washability, lightweight property and rollability. In this paper, a comprehensive review on flexible supercapacitors based on conductive polymers such as polypyrrole (PPy), polyaniline (PANI) and poly(3,4-ethylenedioxtthiophne)-polystyrene sulfonate (PEDOT:PSS). Methods of enhancing the conductivity of PEDOT:PSS polymer using various composites and chemical solutions have been reviewed in detail. Furthermore, supercapacitors based on carbonized banana peels and methods of activation have been discussed in point. This review covers the up-to-date progress achieved in conductive polymer-based materials for supercapacitor electrodes. The effect of various composites with PEDOT:PSS have been discussed. The review result indicated that flexible, stretchable, lightweight, washable, and disposable wearable electronics based on banana peel and conductive polymers are highly demanding.

The use of hydrogel in tissue engineering is not entirely new. In the last six decades, researchers have used hydrogel to develop artificial organs and tissue for the diagnosis of real-life problems and research purposes. Trial and error dominated the first forty years of tissue generation. Nowadays, biomaterials research is constantly progressing in the direction of new materials with expanded capabilities to better meet the current needs. Knowing the biological phenomenon at the interaction among materials and the human body has promoted the development of smart bio-inert and bio-active polymeric materials or devices as a result of vigorous and consistent research. Hydrogels can be tailored to contain properties such as softness, porosity, adequate strength, biodegradability, and a suitable surface for adhesion; they are ideal for use as a scaffold to provide support for cellular attachment and control tissue shapes. Perhaps electrical conductivity in hydrogel polymers promotes the interaction of electrical signals among artificial neurons and simulates the physiological microenvironment of electro-active tissues. This paper presents a review of the current state-of-the-art related to the complete process of conductive hydrogel manufacturing for tissue engineering from cellulosic materials. The essential properties required by hydrogel for electro-active-tissue regeneration are explored after a short overview of hydrogel classification and manufacturing methods. To prepare hydrogel from cellulose, the base material, cellulose, is first synthesized from plant fibers or generated from bacteria, fungi, or animals. The natural chemistry of cellulose and its derivatives in the fabrication of hydrogels is briefly discussed. Thereafter, the current scenario and latest developments of cellulose-based conductive hydrogels for tissue engineering are reviewed with an illustration from the literature. Finally, the pro and cons of conductive hydrogels for tissue engineering are indicated.

Breast cancer (BC) is the second most common cause of deaths reported in women worldwide, and therefore there is a need to identify BC patients at an early stage as timely diagnosis would help in effective management and appropriate monitoring of patients. This will allow for proper patient monitoring and effective care. However, the absence of a particular biomarker for BC early diagnosis and surveillance makes it difficult to accomplish these objectives. miRNAs have been identified as master regulators of the molecular pathways that are emphasized in various tumors and that lead to the advancement of malignancies. Small, non-coding RNA molecules known as miRNAs target particular mRNAs to control the expression of genes. miRNAs dysregulation has been linked to the start and development of a number of human malignancies, including BC, since there is compelling evidence that miRNAs can function as tumor suppressor genes or oncogenes. The current level of knowledge on the role of miRNAs in BC diagnosis, prognosis, and treatment is presented in this review. miRNAs can regulate the tumorigenesis of BC through targeting PI3K pathway and can be used as prognostic or diagnostic biomarkers for BC therapy. Some miRNAs, like miR-9, miR-10b, and miR-17-5p, are becoming known as biomarkers of BC for diagnosis, prognosis, and therapeutic outcome prediction. Other miRNAs, like miR-30c, miR-187, and miR-339-5p, play significant roles in the regulation of hallmark functions of BC, including invasion, metastasis, proliferation, resting death, apoptosis, and genomic instability. Other miRNAs, such as miR-155 and miR-210, are circulating in bodily fluids and are therefore of interest as novel, conveniently accessible, reasonably priced, non-invasive methods for the customized care of patients with BC. [ABSTRACT FROM AUTHOR]

Proficiency testing (PT) is an impartial laboratory performance-evaluating system using an independent body. It is a mandatory accreditation requirement and means for improving the laboratory’s performance. The study aimed to evaluate the performance of PT, with a focus on identifying and discussing determinants that influence PT performance at comprehensive specialized hospitals in northwest Ethiopia. A retrospective cross-sectional study was carried out from 2020 to 2022. Using a convenient sampling technique, laboratory tests with recorded PT results in each hospital laboratory were included. A data collection template and customized checklists were used to collect the data. Epi Data Version 3.1 for data entry and STATA Version 14.1 for cleaning and analysis were used. Binary logistic regression analyses were used. Variables with p < 0.05 in the multivariable logistic regression were considered to be statistically significant. Over nine cycles, 3807 PT challenges were distributed. The total failure rate of the laboratories was 32.4%, with a peak failure rate of 40.3% in 2020, after which the failure rate was decline to 20.6% in 2022. Among the five laboratory sections, molecular biology had the lowest failure rate (22.2%), while microbiology had the highest failure rate (56.5%). Multivariate logistic regression revealed that PT results reported without appropriate unit of measurement (AOR 7.5), lack of corrective action for PT nonconformance (AOR 7.1), and reagent unavailability (AOR 6.1) had significant effects on PT performance (p < 0.001). The results of this study showed that the overall performance of the laboratory was lower. Reporting PT results without appropriate units of measurement and not taking corrective action for PT nonconformance were the major aggravating factors for high failure rates. [ABSTRACT FROM AUTHOR]

External quality assessment is the process of evaluating the performance of a laboratory and the competence of professionals. Participation in EQA and standardizing the quality of laboratory services are a mandatory requirements for accreditation. This review is aimed at identifying and discussing challenges that hinder the effective implementation of an EQA program in countries with resource limited setting. To obtain abundant information, articles were identified by searching the literature publishedin English using the National Library of Medicine, PubMed, Science Direct and AMC digital library databases. The articles identified in the references were manually searched and included. After the article was identified, it was imported to Endnote version 8.1 and exported to Microsoft Word for citation. Based on this review, the major identified challenges that hinder the implementation of an EQA program include the high cost of control materials, malfunction and lack of maintenance for equipment failure and breakdown, a knowledge gap among laboratory professionals, noncommutability of control samples, and difficulty in assigning target values. In addition, failing to participate in EQA and failing to take corrective action are the major challenges identified. As a result, applying to an EQA program in resource-limited counties was highly challenging. To attain high performance in the laboratory and to provide quality laboratory service for patient care, the EQA supplier and the user laboratory must pay attention to these issues and take appropriate corrective actions for ongoing quality improvement and accreditation. [ABSTRACT FROM AUTHOR]

This study aims to assess the relationship between the surface roughness of cotton plain-woven fabric before and after each pretreatment processing stage. According to the findings of this study, the surface roughness values of desized fabric increased in the warp and weft directions. On the other hand, the roughness of plain-woven fabric reduced in both the warp and weft directions during the scouring, bleaching, and mercerization processes. The weft roughness values of greige, scoured, bleached, and mercerized fabrics are higher than the warp roughness values. Mercerized fabrics provide the smoothest fabric surface compared to other treatment stages. The pretreatment stages have statistically significant impacts on the surface roughness in both the warp and weft directions at a 95% confidence interval. The pairwise analysis reveals that pretreatment of the fabrics in the warp and weft directions is statistically significant for grey with desizing, grey with scouring, grey with bleaching, grey with mercerizing, desizing with scouring, desizing with bleaching, desizing with mercerization, scouring with mercerization, and bleaching with mercerization, but not for scouring with bleaching. Mercerized fabric is highly recommended for producing textile products with unique requirements in terms of tactilely sensitive surface properties. [ABSTRACT FROM AUTHOR]

Sustainable and environmentally friendly activated carbon from biomass materials is proposed to produce supercapacitors from banana peels and has the potential to replace the non-sustainable and hazardous process from either graphite or/and fossil fuels. In order to determine the potential of using banana peel for supercapacitor application, raw banana peel, a bio-waste, was activated both mechanically and chemically to observe the real differences. The sample was activated at 700 °C and chemically activated using KOH. Characterization of activated banana peel was performed using FTIR, DLS, TGA and XRD analytical equipment. FTIR analysis revised the presence of hydroxyl, carbonyl and aromatic compounds on a banana peel cellulose-based carbon. The TGA results proved that 700 °C could be sufficient to totally carbonize banana peel. DLS clearly showed a strong difference between the carbonized and KOH-activated material in particle size distribution. Meanwhile, surface area analysis using BET displayed an increase from 553.862 m2/g to 565.024 m2/g BET in surface area (SBET) when carbon was activated using KOH with a nitrogen isotherm at 77.350 K. Specific capacitance was increased from 0.3997 Fg−1 to 0.821 Fg−1, suggesting more than a 100% increase in the specific capacity due to KOH activation, as proved by the cyclic voltammetry (CV) curve. The X-ray diffraction results revealed the patterns of activated carbon. The findings demonstrated the feasibility of using banana peel waste as a low-cost and sustainable material for the preparation of flexible supercapacitor batteries. [ABSTRACT FROM AUTHOR]

Skin wound management is a very difficult undertaking in the medical field. There is no information available concerning the wound beneath the bandages. Electrospun nanofibrous wound dressings stand out for their resemblance to extracellular matrix (ECM), increased surface-to-volume ratio, porousness, and capacity to encapsulate or load medications, among other distinctive qualities. Traditional antibacterial loaded electrospun nanofibrous wound dressings do not indicate the state of the wound and constantly release antibacterial chemicals even when there are no bacteria in the wound area. As a result, dressings that can track the condition of the wound and dispense medications as needed are crucial. Self-responsive wound dressings can release medications based on bacterial, oxygen spectra, pH, or infection responsiveness, reducing the need for antibacterial agents. Self-responsive mats, which are wound dressings that can release medications based on response to bacteria, oxygen species, and pH or infections, are required to reduce the overuse of antibacterial agents. Self-responsive electrospun nanofibrous mats can be used to monitor the condition of a wound by altering its color in response to an infection or a change in the pH of the wound. Electrospun nanofibrous wound dressings that are stimulus-responsive (self-responsive) are discussed in this review paper. Self-responsive electrospun nanofibrous wound dressings that are triggered by pH, temperature, light, bacteria, and oxygen species are discussed in detail after self-responsive smart materials or polymers used for electrospun nanofibrous wound dressings are covered in the first section of the review. [ABSTRACT FROM AUTHOR]

Flexible supercapacitors are highly demanding due to their wearability, washability, lightweight property and rollability. In this paper, a comprehensive review on flexible supercapacitors based on conductive polymers such as polypyrrole (PPy), polyaniline (PANI) and poly(3,4-ethylenedioxtthiophne)-polystyrene sulfonate (PEDOT:PSS). Methods of enhancing the conductivity of PEDOT:PSS polymer using various composites and chemical solutions have been reviewed in detail. Furthermore, supercapacitors based on carbonized banana peels and methods of activation have been discussed in point. This review covers the up-to-date progress achieved in conductive polymer-based materials for supercapacitor electrodes. The effect of various composites with PEDOT:PSS have been discussed. The review result indicated that flexible, stretchable, lightweight, washable, and disposable wearable electronics based on banana peel and conductive polymers are highly demanding. [ABSTRACT FROM AUTHOR]

Background: Severe acute malnutrition (SAM) is defined as a weight-for-height < -3z scores of the median WHO growth standards, or visible severe wasting or the presence of nutritional edema. SAM related mortality rates in under-five children are well documented in Ethiopia but data on their predictors are limited. We aimed to document factors associated with SAM related mortality to inform better inpatient management. Methods: A facility-based retrospective cohort study was conducted among children admitted due to SAM at Pawe General Hospital, Northwest Ethiopia, from the 1st of January 2015 to the 31st of December 2019. Data from the records of SAM children were extracted using a standardized checklist. Epi-Data version 3.2 was used for data entry, and Stata version 14 was used for analysis. Bi-variable and multivariable Cox regression analyses were conducted to identify predictors of mortality. Variables with P<0.05 were considered significant predictors of mortality. Results: Five-hundred sixty-eight SAM cases were identified of mean age was 27.4 (SD± 16.5) months. The crude death rate was 91/568 (16.02%) and the mean time to death was determined as 13 (±8) days. Independent risk factors for death were: (i) vomiting AHR = 5.1 (1.35–21.1, p = 0.026), (ii) diarrhea AHR = 2.79 (1.46–5.4, p = 0.002), (iii) needing nasogastric therapy AHR = 3.22 (1.65–6.26, p = 0.001), (iv) anemia AHR = 1.89 (1.15–3.2, p = 0.012), and (v) being readmitted with SAM AHR = 1.7 (1.12–2.8, p = 0.037). Conclusion: SAM mortality was high in under-five children in our setting. The identified risk factors should inform treatment and prevention strategies. Improved community health education should focus on healthy nutrition and seeking early treatment. Inpatient mortality may be reduced by stricter adherence to treatment guidelines and recognizing early the key risk factors for death. [ABSTRACT FROM AUTHOR]

The rapid growth of textile industries in Ethiopia plays an important role in economic development. However, the sludge from these wastewater treatment plants, which is not an integral part of the treatment process, is often considered hazardous as it is contaminated with heavy metals of dyestuffs and chemicals. The customary transfer routines such as landfilling and incineration may not be suitable because the leachate from the landfilling destinations and the buildups from the incinerators lead to optional contamination. Moreover, such transfer choices are not financially practical. Therefore, there is a growing need to look for various applications of sludge handling for sustainable development. This study attempts to find out an environmentally friendly solution for the management of the textile sludge by incinerating the sludge and using it for partial replacement of cement in concrete production. Concrete is a composite material formed by the combination of cement, sand, coarse aggregate, and water in a particular proportion so that concrete produced meets the needs regarding its workability, strength, durability, and economy. Typical textile sludge was having high heavy metal contents as per the United States Environmental Protection Agency (USEPA) guideline and should be properly disposed of. The sludge upon incineration at 625°C for four hours gives 78.1% moisture content, 61.2% volatile organic matter, and 59.6% inorganic ash content. The main reactive oxide elements such as SiO2, Fe2O3, CaO, and Al2O3 were found to be 18.51, 3.19, 23.87, and 12.73% by weight in the ash. The calorific value determined from the dried sludge were found to be 1973 cal/gm. Concrete block was manufactured by replacement of cement with 10, 20, 30, 40, and 50% incinerated textile sludge ash, and the manufactured block was evaluated in terms of their compressive strengths, leaching behavior, and water absorption. The replacement cement by the ash increases the hydration time reduced, and up to 20%, sludge ash incorporation in the concrete mix design gives the designed compressive strength. Eventhough water absorption increases with increasing content of the incorporation of the ash, for the 20% replacement of cement, the lethal concentration of heavy metals was obtained to be below the permissible limit set by USEPA. Consequently, the experiment work indicates that the potential use of textile sludge ash for cement concrete gives the possibilities of reduction of heavy metal contamination to surroundings upon sludge disposal, reduces the use of raw materials for producing cement and reduces environmental pollution during cement production. [ABSTRACT FROM AUTHOR]

Background: The aim was to produce quality results that clinical laboratories need to implement and maintain continuous quality improvement systems. In recent years, health organizations have increasingly prioritized the quality of laboratory services by implementing quality management systems (QMSs) and building quality improvement activities. Efforts to strengthen laboratory systems in the African region have received increased attention in recent years. Assessing the implementation levels of laboratory quality management system components is important to identify the gaps that need further improvements. Methods: A cross-sectional study design was used between March and May 2017 in selected government hospitals of Ethiopia, and sample size was determined using a finite population formula, and a proportional sampling technique was employed; a sample size of 184 (62%) was calculated from 295 laboratory professionals. Results: All respondents were informed about the laboratory's experience in the quality management system implementation; of those, only 138 (79%) engaged in the implementation process. From the 18 selected laboratory quality management components, 5 were observed to have the list implementation status, which are: (1) Performance of internal quality control for all tests, (2) Development and communication of a quality manual for all tests, (3) Adequacy of storage space for the supplies, (4) Development of an action plan based on internal audit, and (5) monitoring of environmental conditions. Running quality controls for all types of tests became a headache in almost all laboratories. From 12 selected quality indicators studied in this research, the 5 indicators with either poor or very poor performance outcome were: control of documents 136 (77.7%), control of records 123 (70.3%), development of manuals and policies 122 (69.7%), development of process and procedures 120 (68.6%), and internal communication 114 (65.1%). Conclusions: This research indicated the top 3 LQMS components with either poor or very poor implementation status: (1) Performance of internal quality controls for all tests, (2) Development and communication of quality manuals for all tests, (3) Adequacy of storage space for the supplies. Of the quality indicators studied, control of documents was perceived to have poor performance outcome by 136 (77.7%) of study participants. [ABSTRACT FROM AUTHOR]

Objective: Parasitic infections are the commonest infections affecting 3.5 billion people leading 450 million illnesses. Parasites are major public health problems in developing countries. This study was aimed to assess the prevalence and associated factors of parasitic infections among patients. A cross sectional study was conducted on 364 patients, attending Shahura Health Center, Northwest Ethiopia. Stool specimens were collected and examined using formol-ether concentration technique. Socio-demographic data collected using questionnaire. Binary and multivariable logistic regression analyses were conducted to calculate the strength of association between variables. Result: The overall prevalence of intestinal parasitosis was 56.9%. The most prevalent parasite was Entamoeba histolytica/dispar 32.4% followed by Hookworm species 11.8% and Giardia lamblia 7.4% singly or mixed with other parasites. Furthermore, double and triple parasitic infections were observed in 3% and 1.4% patients respectively. Being male in gender (P = 0.049), age group interval between 1 and 20 years of old (P = 0.012), having stomach pain (P = 0.032) and having diarrhea (P = 0.007) were found to be significantly associated with parasitic infection. In conclusion, prevalence of parasitic infection in the area is high. Therefore, ensuring provision of clean potable water and minimizing the contamination of vegetables are recommended. [ABSTRACT FROM AUTHOR]

Background: Implementing accurate data management systems ensure safe and efficient transfer of confidential health care data. However, health care professionals overlooked their important tasks of medical data processing. Hence, using high-quality electronic health record (EHR) applications in health care is important to minimize medical errors. Therefore, this review tries to indicate the roles of EHR in advancing quality health care service provisions. Methods: The keywords identified were EHR, EMR, medical data processing, medical data retention, medical data destruction, health care, and patient care, and a few related terms with different combinations. PubMed (National Library of Medicine), Google Scholar, and Google search engine were used to search for articles from those databases. Searching was done using boolean words "AND", "OR", and "NOT" using all [All fields] and [MeSH Terms] searching strategies. Results: Articles were screened using the title, checked by their abstract, and the remaining related full-text materials were included or excluded by two individuals deciding its eligibility. Finally, 73 materials issued from 2013–2018 were used for qualitatively synthesizing and reconciling the idea to produce this review article. Conclusion: Poor medical data processing systems are the key reasons for medical errors. Employing standardized data management systems reduce errors and associated sufferings. Therefore, using electronic tools in the health care institution ensures safe and efficient data management. Therefore, it is important to establish appropriate medical data management systems for efficient health care delivery. [ABSTRACT FROM AUTHOR]

Background: Healthcare activities restore health and save lives at the same time; however, they can generate hazardous biomedical wastes to a human being or the environment. Generation and disposal of biomedical wastes have become an emerging problem worldwide.Objective: To assess knowledge, attitude, and practice about biomedical waste management and associated factors among healthcare professionals in Debre Markos town healthcare facilities, northwest Ethiopia.Methods: A cross-sectional study was employed, and data were collected through structured self-administered questionnaire and observational checklist. Data were entered into the Epi-data 3.1 software and exported into SPSS version 20 for analysis. Bivariate and multivariate logistic regression analyses were computed. Variables with a P value of <0.05 in the multivariate logistic regression analysis were considered to explain the presence of statistically significant associations.Result: Among 296 healthcare professionals studied, 168 (56.8%), 196 (66.2%), and 229 (77.4%) had adequate knowledge, favorable attitude, and adequate practice score, respectively. Regarding associated factors, MSc and MD+ (AOR: 4, 95% CI: (1.37, 149.52)), BSc holders (AOR: 2.53, 95% CI: (1.47, 4.38)), and availability of color-coded bins (AOR: 7.68, 95% CI: (3.30, 17.89)) were identified more likely to contribute for adequate knowledge, favorable attitude, and adequate practice scores, respectively.Conclusion: The level of knowledge, attitude, and practice scores were not satisfactory. Majority of the healthcare professionals did not access biomedical waste management training. Educational level, use of visual aid, and availability of color-coded bins in the department were identified as a factor for biomedical waste management. Regular training should be given to healthcare professionals. [ABSTRACT FROM AUTHOR]

BACKGROUND: Laboratory services have been described as the major processes contributing to safe patient care in the modern healthcare sector. However, occurrences of errors in the overall testing processes impair the clinical decision-making process. Such errors are supposed to be high in resource-poor countries, like Ethiopia. The objective of this study was to assess errors in the total testing process in the Clinical Chemistry laboratory of the University of Gondar Hospital, Northwest Ethiopia METHODS: A cross-sectional study was conducted at the University of Gondar Hospital from February to March 2016. All the required data were collected using established quality indicators. Data were analyzed using SPSS version 20. Frequencies and cross-tabulations were used to summarize descriptive statistics. RESULTS: A total of 3259 samples and corresponding laboratory request forms were received for analysis. The analysis of the overall distribution of errors revealed that 89.6% were preanalytical errors, 2.6% were analytical, and 7.7% were postanalytical errors. Of the pre-analytical errors, incomplete request form filling was the most frequent error observed, followed by sample rejection rate (3.8%). Analytical errors related to internal and external quality control exceeding the target range, (14.4%) and (51.4%) respectively, were reported. Excessive turnaround time and unreported critical value cases were the major defects in the post-analytical phase of quality assurance. CONCLUSION: The present finding showed relatively high frequency of errors, which alarms the importance of quality indicators to assess errors in the total testing process. The University of Gondar Hospital laboratory should improve the quality of healthcare services based on these findings using laboratory standards. [ABSTRACT FROM AUTHOR]

Background: The rapid and continuous growth of health care cost aggravates the frequently low priority and less attention given in financing laboratory services. The poorest countries have the highest out-of-pocket spending as a percentage of income. Higher charges might provide a greater potential for revenue. If fees raise quality sufficiently, it can enhance usage. Therefore, estimating the revenue generated from laboratory services could help in capacity building and improved quality service provision. Methods: Panel study design was used to determine revenue generated from clinical chemistry and hematology services at Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia. Activity-Based Costing (ABC) model was used to determine the true cost of tests performed from October 2011 to December 2011 in the hospital. The principle of Activity-based Costing is that activities consume resources and activities consumed by services which incur the costs and hence service takes the cost of resources. All resources with costs are aggregated with the established casual relationships. The process maps designed was restructured in consultation with the senior staffs working and/or supervising the laboratory and pretested checklists were used for observation. Moreover, office documents, receipts and service bills were used while collecting data. The amount of revenue collected from services was compared with the cost of each subsequent test and the profitability or return on investment (ROI) of services was calculated. Data were collected, entered, cleaned, and analyzed using Microsoft Excel 2007 software program and Statistical Software Package for Social Sciences version 19 (SPSS). Paired sample t test was used to compare the price and cost of each test. P-value less than 0.05 were considered as statistically significant. Result: A total of 25,654 specimens were analyzed during 3 months of regular working hours. The total numbers of clinical chemistry and hematology tests performed during the study period were 45,959 (66.1 %) and 23,570 (33.9 %), respectively. Only 274, 386 (25.3 %) Ethiopian Birr (ETB) was recovered from the total cost of 1,086,008.09 ETB incurred on clinical chemistry and hematology laboratory tests. The result showed that, about 133,821 (12.32 %) ETB was revenue not collected from out-of-pocket payments that was paid for the services as a result of under pricing. The result showed that 18 out of 20 laboratory tests were under priced. The cost burden related to free Anti Retro-viral Therapy (ART) services was 285,979.82 (26.3 %) ETB. Conclusion: The cost per test estimated was significantly different to the existing price. About 90 % of the tests were under priced. This information could warn the hospital to reconsider resetting prices of these tests profitability ration less than 1. The revenue collected could help to build capacity, upscale quality, and sustainable service delivery. [ABSTRACT FROM AUTHOR]

This research was aimed at exploring asset-based community development (ABCD) practice of the Awramba community in Ethiopia, focusing on seven specific principles. A qualitative research design, including in-depth interviews, focus group discussions, observations, and document analysis, was used. The findings revealed that Awramba was practicing ABCD, albeit with some practical deviations. Genuine respect for human dignity has enabled its members to effectively implement most of the ABCD principles. Community members have high levels of shared meaning, sense of community/commitment, full participation and democratic power distribution, civil engagement, internally-focused development, bonding social capital, and effective access to internal resources. However, there were poor relationships with external communities and organizations (due to prejudices both from the outsiders and the community itself), and the community was inflexible towards external resource utilization. Interrelatedness among the principles of ABCD was also observed. Implications for practice and research are proposed. [ABSTRACT FROM AUTHOR]

Background: In spite of advances in control of infections, wound infections have not completely controlled due to many reasons. The widespread uses of antibiotics, together with the length of time over which they have been available have led to major problems of resistant organisms contributing to morbidity and mortality. This study was aimed to assess bacterial isolates and their drug susceptibility patterns from patients with pus and/or wound discharge. Methods: A retrospective study was conducted at Gondar University Hospital from all individuals who provide pus and/or wound discharge sample from September, 2009 to August, 2012. Socio-demographic and laboratory results were collected from the University Hospital Microbiology Laboratory unit registration books by using a standard data collection format. Data were analyzed using SPSS version 20 software. P-value≥0.05 was considered statistically significant. Result: A total of 628 study subjects were included in the study with bacterial isolation rate of 441 (70.2%). Of all, 344 (54.8%) were males. Two hundred eighty two (63.9%) of the isolates were gram positive and 159 (36.1%) were gram negative. About 331/ 441 (75.0%) of the total isolates were Staphylococcus aureus (32.9%), Coagulase Negative staphylococci (14.7%), Streptococcus spp. (11.6%), Escherichia coli (9.5%), Klebsiella spp. (6.3%). The result showed that 66.2% of the isolates were resistant to tetracycline, followed 59.8% for ampicillin, 59.1% for cotrimoxazole, 51.7% for penicillin; least resistant being 6.3% for gentamycin. Conclusion: High prevalence of bacterial isolates were found; S. aureus being the dominant. Most of the isolates were resistant to many of the antibiotics tested where all isolates of Pseudomonas spp. being resistant to two or more antibiotics. Antibiotic susceptibility test is necessary for effective control of wound infections. [ABSTRACT FROM AUTHOR]

Development of smart textiles is an emerging discipline in the last two decades where a conductive element is integrated into a textile material by some means. The purpose of this research was to develop a conductive textile fabric by coating with charcoal as a conductive element. The charcoal was produced by carbonizing the eucalyptus wood at a temperature of 928 °C for 37 min producing 59.17% w/w of fixed carbon yield and conductivity of 463.34 Sm−1 (Siemens per meter) compared to immeasurable conductivity of the wood. This was followed by characterization of physical and chemical properties of charcoal. Thereafter, a cotton fabric was pad-coated with a dispersion based on the charcoal. The paper herein reports the results of preparing different recipes using different quantities of charcoal particles with other components of the coating mixture, which was tested to obtain the best coating in terms of electrical conductivity. The optimal concentration of the conductive particles of the charcoal was studied. Performance evaluation of the coated fabric was assessed for the durability of fabric towards different fastness agents. The effect of charcoal loading on thermal and sensorial comfort of the fabric in addition to the air and water permeability was studied and a significant change was observed. Finally, a proof of concept was developed to demonstrate if the resulting pieces of information during the process were viable. As observed, the pad-coated cotton fabric using charcoal showed increased electrical conductivity from 1.58 × 10−12 Scm−1 (Siemens per centimeter) for the controlled sample to 124.49 Scm−1 for the coated sample designating that the resulting fabric is in a conductor category. [ABSTRACT FROM AUTHOR]

Background: Health facilities can provide diagnostic, curative, and prognostic services for the community. While providing services, healthcare workers can be exposed to needlestick injuries that can transmit pathogenic organisms through body fluids. Objective: The aim was to establish the pooled prevalence of needlestick injuries among healthcare workers in Ethiopia. Methods: This systematic review and meta-analysis was conducted according to PRISMA guidelines. Articles were searched from Google Scholar, PubMed, Science Direct, and Scopus databases using a combination of keywords and Boolean functions. All the searched articles were imported into the EndNote X9 software, and then, duplicate data files were removed. Article screening and data extraction were done independently by two authors. Data manipulation and analyses were done using STATA version 15.1 software. Results: The analysis of 23 full-text articles showed that the prevalence of the 12-month and lifetime needlestick injuries among the primary studies ranged from 13.2 to 55.1% and 18.6 to 63.6%, respectively. The pooled prevalence of needlestick injuries among the Ethiopian healthcare workers was 28.8% (95% CI 23.0–34.5) and 43.6% (95% CI 35.3–52.0) for the 12 months and lifetime, respectively. Conclusions: The pooled prevalence of needlestick injuries among Ethiopian healthcare workers was high. Therefore, efforts should be implemented to reduce the occurrence of injuries. Adequate protective equipment and safety-engineered devices should be supplied for the healthcare workers. It could be more effective to reduce the factors contributing to increased exposures through the allocation of adequate numbers of the healthcare workforce and implementing in-service training. [ABSTRACT FROM AUTHOR]

Objective: During the healthcare delivery process, hazardous wastes can be generated from the health facilities. Improper healthcare waste management is responsible for the transmission of more than 30 dangerous bloodborne pathogens. The aim of this systematic review was to evaluate the healthcare waste management practice and potential challenges in Ethiopia. Results: Electronic databases and direct Google search yielded 1742 articles from which 17 studies met the inclusion criteria. The proportion of hazardous waste generated in Ethiopian healthcare facilities was unacceptably high which ranged from 21 to 70%. Most studies indicated the absence of proper waste segregation practice at the source of generation. Treatment of the healthcare waste using low combustion incinerator and/or open burning and open disposal of the incinerator ash were very common. Lack of awareness from the healthcare staff, appropriate waste management utilities and enforcement from the regulatory bodies were mainly identified as a common factor shared by most of the studies. The healthcare waste management practice in Ethiopian healthcare facilities was unsatisfactory. There should be close supervision of the waste disposal process by the regulatory bodies or other stakeholders. [ABSTRACT FROM AUTHOR]

Objective: Medical waste is a total waste stream which is generated from the healthcare facilities during the healthcare delivery process. It can contain potentially hazardous substances for the human being and the environment. Waste handlers play a significant role for its proper management and they need to have adequate knowledge, attitude, and practices. The study aimed to evaluate the knowledge, attitude, and practices of waste handlers regarding medical waste management in Debre Markos town healthcare facilities, northwest Ethiopia. Results: A total of 55 medical waste handlers were studied from 12 healthcare facilities. Among this, 25 (45.4%) were diploma and certificate holders. The majority (69.1%) of the study participants were not provided with proper training. There was a lack of personal protective devices and waste management equipment supply. Regarding knowledge, attitude, and practices, 25 (45.5%), 43 (78.2%), and 44 (80%) of the study participants had adequate knowledge, favorable attitude, and adequate practice scores, respectively. There was high (30.9%) prevalence of needlestick and sharps injuries. Healthcare facilities should provide periodic training and adequate supplies for the waste handlers. Further study should be conducted on a large scale by including different levels of health facilities and regions of the country. [ABSTRACT FROM AUTHOR]

BackgroundSevere acute malnutrition (SAM) is defined as a weight-for-height < -3z scores of the median WHO growth standards, or visible severe wasting or the presence of nutritional edema. SAM related mortality rates in under-five children are well documented in Ethiopia but data on their predictors are limited. We aimed to document factors associated with SAM related mortality to inform better inpatient management.MethodsA facility-based retrospective cohort study was conducted among children admitted due to SAM at Pawe General Hospital, Northwest Ethiopia, from the 1st of January 2015 to the 31st of December 2019. Data from the records of SAM children were extracted using a standardized checklist. Epi-Data version 3.2 was used for data entry, and Stata version 14 was used for analysis. Bi-variable and multivariable Cox regression analyses were conducted to identify predictors of mortality. Variables with PResultsFive-hundred sixty-eight SAM cases were identified of mean age was 27.4 (SD± 16.5) months. The crude death rate was 91/568 (16.02%) and the mean time to death was determined as 13 (±8) days. Independent risk factors for death were: (i) vomiting AHR = 5.1 (1.35-21.1, p = 0.026), (ii) diarrhea AHR = 2.79 (1.46-5.4, p = 0.002), (iii) needing nasogastric therapy AHR = 3.22 (1.65-6.26, p = 0.001), (iv) anemia AHR = 1.89 (1.15-3.2, p = 0.012), and (v) being readmitted with SAM AHR = 1.7 (1.12-2.8, p = 0.037).ConclusionSAM mortality was high in under-five children in our setting. The identified risk factors should inform treatment and prevention strategies. Improved community health education should focus on healthy nutrition and seeking early treatment. Inpatient mortality may be reduced by stricter adherence to treatment guidelines and recognizing early the key risk factors for death.

Faba bean new disease (faba bean gall) (Olpidium viciae (Kusano) is the most destructive disease of faba bean ((Vicia faba L.) in Ethiopia, particularly in Amhara, Tigray and some part of Oromia region. This problem needs immediate sound management strategy to maximize faba bean productivity. A field study was carried out in Geregera and Jama during the 2013 and 2014 main crop season and Maybar watershed in 2014 to verify the fungicide to faba bean gall. The objective of this study was evaluating effective fungicides for the management of faba bean new disease. The treatments were baylaton in the form of seed dressing and foliar spray; mancozeb, redomil, chlorotalonin and cruzet in the form of foliar spray and apron star and theram used as a foliar spray and also untreated check used as a comparison. The result showed that significantly differ between treatments (p

Background. Work-related musculoskeletal disorders (WMSDs) are an important public health problem in working environments. WMSDs are the major causes of disability and cause individual suffering and financial burdens to the individual, families, industry or employer, healthcare system, and society at large. This study aims to assess the prevalence and associated factors of work-related musculoskeletal disorders among bankers working in Mekelle city, Tigray, Ethiopia, 2018. This study is based on an institutional-based cross-sectional study design, where 328 bankers are selected randomly from bankers working in Mekelle city from February to June 2018. Data were entered, organized, and analyzed by SPSS version 23. A final logistic model was run to identify factors associated with WMSDs, and the magnitude and direction of association were decided based on the adjusted odds ratio (AOR) and its corresponding 95% confidence interval (95% CI). Result. Out of 307 bankers, the annual prevalence rate of WMSDs was 65.5% (201). Significant predictors were being 30–39 years old [AOR = 5.552; 95% CI = 1.465–21.039] and above 40 years old [AOR = 5.719; 95% CI = 1.422–22.994], low educational level [AOR = 4.256; 95% CI = 1.139–15.895], working > 5 years [AOR = 3.892; 95% CI = 1.841–8.231], not doing physical exercises [AOR = 2.866; 95% CI = 1.303–6.304], stress [AOR = 4.723; 95% CI = 2.421–9.213], poor posture [AOR = 2.692; 95% CI = 1.339–5.411], breaks [AOR = 5.170; 95% CI = 2.070–12.912], and ergonomics [AOR = 3.801; 95% CI = 1.260–11.472]. Conclusion. The prevalence of WMSDs among bankers was high. The significant associated factors responsible for the occurrence of work-related musculoskeletal disorders include longer working experience, being above 30 years old, low educational status, physical exercise, job stress, poor posture, absence of breaks during working hours, and absence of ergonomic training.