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3. Additional file 2: of Enrichment of bacteria samples by centrifugation improves the diagnosis of orthopaedics-related infections via real-time PCR amplification of the bacterial methicillin-resistance gene

Author

Tsuru, Arisa, Setoguchi, Takao, Kawabata, Naoya, Hirotsu, Masataka, Yamamoto, Takuya, Nagano, Satoshi, Yokouchi, Masahiro, Kakoi, Hironori, Kawamura, Hideki, Ishidou, Yasuhiro, Akihide Tanimoto, and Setsuro Komiya

Abstract

Table S2. Summary of the clinical results.

Published
2015
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4. Additional file 1: of Enrichment of bacteria samples by centrifugation improves the diagnosis of orthopaedics-related infections via real-time PCR amplification of the bacterial methicillin-resistance gene

Author

Tsuru, Arisa, Setoguchi, Takao, Kawabata, Naoya, Hirotsu, Masataka, Yamamoto, Takuya, Nagano, Satoshi, Yokouchi, Masahiro, Kakoi, Hironori, Kawamura, Hideki, Ishidou, Yasuhiro, Akihide Tanimoto, and Setsuro Komiya

Subjects
mental disorders, psychological phenomena and processes
Abstract

Table S1. Clinicopathological data of the patients. Grey lines show the positive findings for infection.

Published
2015
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5. Enrichment of bacteria samples by centrifugation improves the diagnosis of orthopaedics-related infections via real-time PCR amplification of the bacterial methicillin-resistance gene

Author

Tsuru, Arisa, primary, Setoguchi, Takao, additional, Kawabata, Naoya, additional, Hirotsu, Masataka, additional, Yamamoto, Takuya, additional, Nagano, Satoshi, additional, Yokouchi, Masahiro, additional, Kakoi, Hironori, additional, Kawamura, Hideki, additional, Ishidou, Yasuhiro, additional, Tanimoto, Akihide, additional, and Komiya, Setsuro, additional

Published
2015
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6. Risk Factors for Venous Thromboembolism After Spine Surgery

Author

Tominaga, Hiroyuki, primary, Setoguchi, Takao, additional, Tanabe, Fumito, additional, Kawamura, Ichiro, additional, Tsuneyoshi, Yasuhiro, additional, Kawabata, Naoya, additional, Nagano, Satoshi, additional, Abematsu, Masahiko, additional, Yamamoto, Takuya, additional, Yone, Kazunori, additional, and Komiya, Setsuro, additional

Published
2015
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7. RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy

Author

Nagao, Hiroko, primary, Setoguchi, Takao, additional, Kitamoto, Sho, additional, Ishidou, Yasuhiro, additional, Nagano, Satoshi, additional, Yokouchi, Masahiro, additional, Abematsu, Masahiko, additional, Kawabata, Naoya, additional, Maeda, Shingo, additional, Yonezawa, Suguru, additional, and Komiya, Setsuro, additional

Published
2012
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14. A Case Report of Dizygotic Twins with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

Author

Matsunaga, Shunji, primary, Koga, Hiroaki, additional, Kawabata, Naoya, additional, Yuasa, Shinya, additional, Imakiire, Takanori, additional, Nagano, Yoshiyuki, additional, Yamamoto, Takuya, additional, Nagatomo, Yoshimi, additional, Miyaguchi, Fumihiro, additional, Ijiri, Kosei, additional, Yone, Kazunori, additional, and Komiya, Setsuro, additional

Published
2007
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18. Treatment of Femoral Fracture with MRSA Myelitis

Author

Imamura, Katsuyuki, primary, Hayashi, Kyoji, additional, Matsunaga, Shunji, additional, Taketomi, Eiji, additional, Komiya, Setsuro, additional, Sunahara, Nobuhiko, additional, Nakamura, Kazushi, additional, and Kawabata, Naoya, additional

Published
2004
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22. Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth

Abstract

The Hedgehog pathway functions as an organizer in embryonic development. Recent studies have shown that mutation of the PTCH1 gene involved in the Hedgehog path-way affects rhabdomyosarcoma development. However, the expression of Hedgehog pathway molecules in human rhabdomyosarcoma cells has not been well clarified. In addition, the effect of pharmacological inhibition of the Hedgehog pathway is not known. We investigated the expression of the genes involved in the Hedgehog pathway using human rhabdomyosarcoma cell lines and biopsy specimens. Further, we evaluated the effect of pharmacological inhibition of the Hedgehog pathway using cyclopamine or GANT61 by WST assay, cell proliferation assay and cell death detection assay. Real-time PCR revealed that human rhabdomyosarcoma cell lines and biopsy specimens overexpressed the following genes: Sonic hedgehog, Indian hedgehog, Desert hedgehog, PTCH1, SMO, GLI1, GLI2 and ULK3. Immunohistochemistry revealed that rhabdomyosarcoma cell lines and biopsy specimens expressed SMO and GLI2. Inhibition of SMO by cyclopamine slowed the growth of human rhabdomyosarcoma cell lines. Similarly, inhibition of GLI by GANT61 slowed the growth of human rhabdomyosarcoma cell lines. Inhibition of cell proliferation and apoptotic cell death together prevented the growth of rhabdomyosarcoma cells by cyclopamine and GANT61 treatment. Our findings suggest that pharmacological inhibition of the Hedgehog pathway may be a useful approach for treating rhabdomyosarcoma patients.

Published
2016

23. Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma

Abstract

GOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer. However, the mechanism through which GOLPH3 is involved in the pathogenesis of rhabdomyosarcoma remains unidentified. In order to explore the function of GOLPH3 and its isoform, GOLPH3L, in the pathogenesis of rhabdomyosarcoma, we investigated the expression and knockdown effects of GOLPH3 and GOLPH3L in human rhabdomyosarcoma. Western blot analysis and real-time PCR revealed that human rhabdomyosarcoma cell lines and biopsy specimens exhibited an increased expression of GOLPH3 and GOLPH3L. GOLPH3 and GOLPH3L knockdown by siRNA prevented the proliferation of human rhabdomyosarcoma cell lines. In addition, double-knockdown of GOLPH3 and GOLPH3L also prevented the proliferation of rhabdomyosarcoma cell lines. Our findings improve the understanding of rhabdomyosarcoma pathogenesis and suggest that the knockdown of GOLPH3 or GOLPH3L may be an effective treatment for rhabdomyosarcoma.

Published
2016

24. RBPJ Is a Novel Target for Rhabdomyosarcoma Therapy

Abstract

The Notch pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. In addition, the Notch pathway plays an important role in controlling tumorigenesis. However, the role of RBPJ, a transcription factor in the Notch pathway, in the development of tumors is largely unknown. In this study, we focused on the role of RBPJ in the pathogenesis of rhabdomyosarcoma (RMS). Our data showed that Notch pathway genes were upregulated and activated in human RMS cell lines and patient samples. Inhibition of the Notch pathway by a csecretase inhibitor (GSI) decreased the in vitro proliferation of RMS cells. Knockdown of RBPJ expression by RNAi inhibited the anchorage-independent growth of RMS cells and the growth of xenografts in vivo. Additionally, overexpression of RBPJ promoted the anchorage-independent growth of RMS cells. Further, we revealed that RBPJ regulated the cell cycle in RMS xenograft tumors and decreased proliferation. Our findings suggest that RBPJ regulates the RMS growth, and that the inhibition of RBPJ may be an effective therapeutic approach for patients with RMS.

Published
2016

25. Patent Issued for Apparatus Suppressing Acoustic Echo Signals From A Near-End Input Signal By Estimated-Echo Signals And A Method Therefor (USPTO 10,090,882)

Subjects
Oki Electric Industry Company Ltd. -- Intellectual property, Telecommunications equipment industry -- Intellectual property -- Acoustic properties -- Methods, Patents -- Acoustic properties -- Methods, Patent/copyright issue, Telecommunications equipment industry, Computers, News, opinion and commentary
Abstract

2018 OCT 17 (VerticalNews) -- By a News Reporter-Staff News Editor at Computer Weekly News -- A patent by the inventor Kawabata, Naoya (Tokyo, JP), filed on December 18, 2014, [...]

Published
2018

26. 'Echo Suppressor Using past Echo Path Characteristics for Updating' in Patent Application Approval Process

Subjects
Oki Electric Industry Company Ltd. -- Intellectual property, Telecommunications equipment industry -- Intellectual property, Patents, Patent/copyright issue, Telecommunications equipment industry, Government, Political science
Abstract

By a News Reporter-Staff News Editor at Politics & Government Week -- A patent application by the inventor KAWABATA, Naoya (Tokyo, JP), filed on July 18, 2014, was made available [...]

Published
2015

27. Researchers Submit Patent Application, 'Howling Suppression Device and Adaptive Notch Filter', for Approval

Subjects
Oki Electric Industry Company Ltd. -- Intellectual property, Telecommunications equipment industry -- Intellectual property, Electric filters, Patents, Patent/copyright issue, Telecommunications equipment industry, Government, Political science
Abstract

By a News Reporter-Staff News Editor at Politics & Government Week -- From Washington, D.C., VerticalNews journalists report that a patent application by the inventor KAWABATA, Naoya (Tokyo, JP), filed [...]

Published
2014

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