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10. Ro/SSA and La/SSB specific IgA autoantibodies in serum of patients with Sjögren's syndrome and systemic lupus erythematosus.

Author

Pourmand, N, Wahren-Herlenius, M, Gunnarsson, I, Svenungsson, E, Löfström, B, Ioannou, Y, Isenberg, D A, and Magnusson, C G

Subjects
AUTOANTIBODIES, COMPARATIVE studies, IMMUNOBLOTTING, IMMUNOGLOBULINS, RESEARCH methodology, MEDICAL cooperation, RESEARCH, SJOGREN'S syndrome, SYSTEMIC lupus erythematosus, EVALUATION research, CASE-control method
Abstract

Objective: To investigate the occurrence of IgA autoantibodies to Ro 52 kDa, Ro 60 kDa and La antigen in serum of patients with primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE).Methods: Recombinant Ro 52 kDa, Ro 60 kDa and La antigens were used to analyse autoantibodies in serum from 25 patients with pSS, 30 patients with SLE and 20 controls using a semiquantitative immunoblotting approach.Results: Among the patients with pSS, 21 (84%) had detectable IgA autoantibodies to Ro 52 kDa, 13 (52%) to Ro 60 kDa and 20 (80%) to La antigen. The corresponding results for the patients with SLE were 22 (73%), 14 (47%) and 20 (67%), respectively. No IgA autoantibodies against the three antigens were detected in 20 normal controls. A comparison of several clinical features with the titres of IgA antibodies to Ro 52 kDa, Ro 60 kDa and La, revealed a significant relation between IgA anti-Ro 52 and IgA anti-La to sicca (p< 0.05). Semiquantitative data suggest that IgG is the dominating antibody to the three antigens followed by IgM > IgA in both SLE and pSS patients. Specificity studies of IgA autoantibodies with different subfragments of Ro 52 kDa and Ro 60 kDa antigens showed that IgA antibodies did not differ from IgG and IgM in their recognition pattern.Conclusion: These results suggest that besides IgM and IgG, IgA autoantibodies are also detected at high frequency in patients with pSS and SLE. Further studies are necessary to evaluate the contribution of these IgA autoantibodies to inflammation as well as their diagnostic value. [ABSTRACT FROM AUTHOR]

Published
1999
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20. BILATERAL ULNAR NERVE BLOCKS FOR THE EVALUATION OF LOCAL ANAESTHETIC AGENTS*

Author

Albért J and Löfström B

Subjects
medicine.medical_specialty, Lidocaine, Tetracaine, medicine.drug_class, Mepivacaine, Pain sensation, Prilocaine, Humans, Medicine, Pain perception, Anesthetics, Local, Ulnar nerve, Ulnar Nerve, Anesthetics, Local anaesthetic, Local anesthetic, business.industry, Nerve Block, General Medicine, Surgery, Anesthesiology and Pain Medicine, Epinephrine, Anesthesia, business, Anesthesia, Local, medicine.drug
Abstract

SUMMARY Bilateral ulnar-nerve blocks were performed with a double-blind technique on volunteers for the evaluation of the blocking effect of 1% mepivacaine, 1% mepivacaine with epinephrine 1:200,000, 0.25% LAC-43 (l-butyl-DL-2-piperidincarbon-2,6-dimethylanilide hydrochloride) with epinephrine 1:200,000, and 0.25% tetracaine with epinephrine 1:200,000. 1 It was found that bilateral ulnar-nerve blocks in this series gave the same results in different tests as in previous studies. 2 It was found that the duration of action of LAC-43 was 2-3 times that of mepivacaine with epinephrine, tetracaine with epinephrine and mepivacaine without epinephrine, i.e., LAC-43 blocks lasted for about 8 hours. The effect of mepivacaine with epinephrine was about 75% longer than that of mepivacaine without epinephrine. 3 The regression time, i.e. in this study the time from reappearance of pain perception to complete recovery of pain sensation, seems to be a quality characteristic of the action of a local anaesthetic solution. ZUSAMMENFASSUNG In einem Doppelblindversuch an Freiwilligen wurden zur Beurteilung der blockierenden Wirkung von 1% Mepivacain, 1% Mepivacain mit Adrenalin 1:200.000, 0,25% LAC-43 (l-Butyl-DL-2-piperidincarbon-2, 6-dimethylanilidhydrochlorid) mit Adrenalin 1:200.000 und 0,25% Tetracain mit Adrenalin 1:200.000 doppelseitige Blockadendes N. ulnaris ausgefuhrt. Folgende Ergebnisse wurden gewonnen: 1 Doppelseitige Blockaden des N. ulnaris gaben in dieser Untersuchungsreihe die selben Resultate wie bei fruheren Priifungen. 2 Die Wirkungsdauer von LAC-43 liegt 2-3 mal hoher als die von Mepivacain mit Adrenalin, Tetracain mit Adrenalin und Mepivacain ohne Adrenalin, das heisst, LAC-43-Blockaden halten ungefahr 8 Stunden an. Mepivacain mit Adrenalin ubertrifft Mepivacain ohne Adrenalinzusatz um ca. 75%. 3 Die Regressionszeit (darunter wird in dieser Untersuchung die Zeit vom Wiederauftreten erster Schmerzperception bis zur volligen Restitution der Schmerzempfindung verstanden) scheint ein qualitatives Testmerkmal der Wirkung eines Lokalanaesthetikums darzustellen.

Published
1961
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