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This investigation deals with the analytical formulation and experimental validation of a prestressed reinforced concrete seismic isolator with kinematic constraints at both ends. The kinematic isolator was proposed initially as a low-cost solution for seismic protection of low-income people housing usually placed at the periphery of big cities where regular to bad soil conditions are common. So, the isolator is also a pile foundation with a central prestressed cable and two rolling steel surfaces at the top and bottom ends. By varying the shapes of the end rolling surfaces, different force-deformation constitutive relationships for the isolator may be obtained. Energy dissipation is introduced by yielding of passive reinforcement at the rolling interphase. Apart from stating the large-deformation formulation of the element, several relevant aspects of the behaviour of these devices are studied herein, such as the increase in the tension of the central prestressed cable, responsible for the self-centring action of the isolator, the floor uplift that results from the geometry of the isolator, and the vertical stability of the system. Experimental and theoretical results obtained for a group of 9 testing specimens show an excellent agreement in the force-deformation constitutive relationship. Although not the intent of this article, the device proposed may be extended directly as a coupling beam element for shear wall systems. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Copyright of Virchows Archiv für Pathologische Anatomie und Physiologie und für Klinische Medizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Buffalo breeding system has a great economic importance in South - America, principally in marginal or sub -tropical lands. Marbofloxacin is a fluoroquinolone developed exclusively for veterinary use. Fluoroquinolones share several pharmacodynamic and pharmacokinetic characteristics such as a wide spectrum of bactericidal activity, a large volume of dist ribution, low plasma protein-binding and relatively low minimal inhibitory concentrations (MICs) against target microorganisms. The pharmacokinetics of marbofloxacin was studied in eighteen buffalo calves 2-3, 10 and 20 days old after single i.v. dose of 2 mg/kg body weight. Drug concentration in plasma was determined by high-performance liquid ch romatography (HPLC) and the data collected were subjected to a non co mpartmental kinetic analysis. The results show that, AUC8 is s ignificantly g reater in youngest animals. Elimination half-life was 8.39± 2.74 (2-3 days old), 6.22 ± 0.52 h (10 days old) and 6.42 ± 0.52 h (20 days old). Volume of distribution was relatively high in all age groups (Vss 1.75 ± 0.36; 1.65 ± 0.24 L/kg and 2.01 ± 0.22 respectively). Total body clearance (Cl) increased with age from 2.75 ± 1,01 mL/kg/min (2- 3 days old) to 3.34 ± 0,85 mL/kg/min (10 days old) and 3.76 ± 0.17 mL/kg/min. As a consequence of inc reased body clearance, area under the plasma concentration vs. time curve decreased with age (AUC8 830.11 ± 257.3 ug-min/mL in 2-3 days old to 591.8 ± 91 ug-min/mL in 10 days old and 532 ± 24 ug-min/mL in 20 days buffalo calves . Although many anatomical and physiological changes occur in the maturing ruminant, modifications in young animal's pharmacokinetics are most probably related to changes in body c omposition. Considering the drugs pharmacokinetic profile of marbofloxacin would appear to be a good therapeutic tool for the treatment of most of the infections produced by Gramnegative and Gram-positive susceptible bacteria in buffalo calves. Further studies are required to understand the kinetics at different ages. [ABSTRACT FROM AUTHOR]

Copyright of Klinische Wochenschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Gliosarcoma is a rare histopathological subtype of glioblastoma. Metastatic spreading is unusual. In this report, we illustrate a case of gliosarcoma with extensive extracranial metastases with confirmation of histological and molecular concordance between the primary tumor and a metastatic lesion of the lung. Only the autopsy revealed the extent of metastatic spread and the hematogenous pattern of metastatic dissemination. Moreover, the case bared a familial coincidence of malignant glial tumors as the patient's son was diagnosed with a high-grade glioma shortly after the patient's death. By molecular analysis (Sanger and next generation panel sequencing), we could confirm that both patient's tumors carried mutations in the TP53 gene. Interestingly, the detected mutations were located in different exons. Altogether, this case draws attention to the fact that sudden clinical aggravation could be caused by the rare phenomenon of metastatic spread and should therefore be always taken into consideration, even at an early disease stage. Furthermore, the presented case highlights the contemporary value of autoptic pathological examination. [ABSTRACT FROM AUTHOR]