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27. Dual-control of incubation effect for efficiently fabricating surface structures in fused silica

Author

Wang Zhi, Xiang Zhikun, Li Xiaowei, Wu Mengnan, Yi Peng, Zhang Chao, Yan Yihao, Li Xibiao, Zhang Xiangyu, Wang Andong, and Huang Lingling

Subjects
femtosecond laser, etching, efficient, incubation effect, surface structure, Physics, QC1-999
Abstract

Fused silica with surface structures has potential applications in microfluidic, aerospace and other fields. To fabricate structures with high dimensional accuracy and surface quality is of paramount importance. However, it is indeed a challenge to strike a balance between accuracy and efficiency at the same time. Here, a temporally shaped femtosecond laser Bessel-beam-assisted etching method with dual-control of incubation effect is proposed to achieve this balance. Instead of layer-by-layer ablation continuously with Gaussian pulses, silica is modified discretely by double pulse Bessel beam with one single layer. During the modification process, incubation effect is dual-controlled in single shot process and spatial scanning process to generate even modified region efficiently. Then, the modified region is etched to form designed structures such as microholes, grooves, etc. The proposed method exhibits high efficiency for fabrication of surface structures in fused silica.

Published
2024
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35. Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models

Author

Li, Yang, Ma, Ke, Dong, Zhujun, Gao, Shijuan, Zhang, Jing, Huang, Shan, Yang, Jie, Fang, Guangming, Li, Yujie, Li, Xiaowei, Welch, Carrie, Griffin, Emily L., Ramaswamy, Prema, Valivullah, Zaheer, Liu, Xiuying, Dong, Jianzeng, Wang, Dao Wen, Du, Jie, Chung, Wendy K., and Li, Yulin

Subjects
Heart diseases -- Models -- Causes of -- Genetic aspects, Organs, Culture of -- Research, Cardiovascular research, Genetic variation -- Research, Mice -- Research, Cardiomyopathy -- Models -- Causes of -- Genetic aspects, Health care industry
Abstract

Research advances over the past 30 years have confirmed a critical role for genetics in the etiology of dilated cardiomyopathies (DCMs). However, full knowledge of the genetic architecture of DCM remains incomplete. We identified candidate DCM causal gene, C10orf71, in a large family with 8 patients with DCM by whole-exome sequencing. Four loss-of-function variants of C10orf71 were subsequently identified in an additional group of492 patients with sporadic DCM from 2 independent cohorts. C10orf71 was found to be an intrinsically disordered protein specifically expressed in cardiomyocytes. C10orf71-KO mice had abnormal heart morphogenesis during embryonic development and cardiac dysfunction as adults with altered expression and splicing of contractile cardiac genes. C10orf71-null cardiomyocytes exhibited impaired contractile function with unaffected sarcomere structure. Cardiomyocytes and heart organoids derived from human induced pluripotent stem cells with C10orf71 frameshift variants also had contractile defects with normal electrophysiological activity. A rescue study using a cardiac myosin activator, omecamtiv mecarbil, restored contractile function in C10orf71-KO mice. These data support C10orf71 as a causal gene for DCM by contributing to the contractile function of cardiomyocytes. Mutation-specific pathophysiology may suggest therapeutic targets and more individualized therapy., Introduction Cardiomyopathies are a heterogeneous group of cardiac disorders with primary abnormalities in the structure and function of the heart (1). These disorders are commonly divided into primary--including hypertrophic, dilated, [...]

Published
2024
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