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452 results on '"Liang, Huan"'

5. Prospective prenatal cell-free DNA screening for genetic conditions of heterogenous etiologies

Author

Zhang, Jinglan, Wu, Yanting, Chen, Songchang, Luo, Qiong, Xi, Hui, Li, Jianli, Qin, Xiaomei, Peng, Ying, Ma, Na, Yang, Bingxin, Qiu, Xiang, Lu, Weiliang, Chen, Yuan, Jiang, Ying, Chen, Panpan, Liu, Yifeng, Zhang, Chen, Zhang, Zhiwei, Xiong, Yu, Shen, Jie, Liang, Huan, Ren, Yunyun, Ying, Chunmei, Dong, Minyue, Li, Xiaotian, Xu, Congjian, Wang, Hua, Zhang, Dan, Xu, Chenming, and Huang, Hefeng

Published
2024
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8. A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress

Author

Liang-Huan Wu, Yu-Wen Cheng, Fan-Li Lin, Kai-Cheng Hsu, Mong-Heng Wang, Jing-Lun Yen, Tsung-Jen Wang, Tony Eight Lin, Yi-Chien Liu, Wei-Jan Huang, and George Hsiao

Subjects
Glaucoma, Glutamate, HDAC8 inhibitor, NMDA, Retinal Müller glia, S100B, Therapeutics. Pharmacology, RM1-950
Abstract

Glaucoma is considered a neurodegenerative disease characterized by progressive visual field defects that may lead to blindness. Although controlling intraocular pressure (IOP) is the mainstay of glaucoma treatment, some glaucoma patients have unmet needs due to unclear pathogenic mechanisms. Recently, there has been growing evidence that neuroinflammation is a potential target for the development of novel antiglaucoma agents. In this study, we investigated the protective effects and cellular mechanisms of H7E, a novel small molecule inhibits HDAC8, using in vitro and in vivo glaucoma-like models. Importantly, H7E mitigated extracellular MMP-9 activity and MCP-1 levels in glutamate- or S100B-stimulated reactive Müller glia. In addition, H7E inhibited the upregulation of inflammation- and proliferation-related signaling pathways, particularly the ERK and JNK MAPK pathways. Under conditions of oxidative damage, H7E prevents retinal cell death and reduces extracellular glutamate released from stressed Müller glia. In a mouse model of NMDA-induced retinal degeneration, H7E alleviated functional and structural defects within the inner retina as assessed by electroretinography and optical coherence tomography. Our results demonstrated that the newly identified compound H7E protects against glaucoma damage by specifically targeting HDAC8 activity in the retina. This protective effect is attributed to the inhibition of Müller glial activation and the prevention of retinal cell death caused by oxidative stress.

Published
2024
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15. An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike

Author

Liu, Banghui, Niu, Xuefeng, Deng, Yijun, Zhang, Zhaoyong, Wang, Yanqun, Gao, Xijie, Liang, Huan, Li, Zimu, Wang, Qian, Cheng, Yuanyi, Chen, Qiuluan, Huang, Shuangshuang, Pan, Yingxian, Su, Mengzhen, Lin, Xiancheng, Niu, Chuanying, Chen, Yinglin, Yang, Wenyi, Zhang, Yudi, Yan, Qihong, He, Jun, Zhao, Jincun, Chen, Ling, and Xiong, Xiaoli

Published
2024
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24. Clinical study of CT-guided pulsed radiofrequency combined with platelet-rich plasma in treatment of postherpetic neuralgia

Author

Kang Bowen, Xue Zhaoxia, Liang Huan, Yang Qing, Wang Qiuyun

Subjects
postherpetic neuralgia, pulsed radiofrequency, platelet-rich plasma, infrared thermal imaging, Medicine
Abstract

Objective To observe the clinical efficacy of CT-guided pulsed radiofrequency combined with platelet-rich plasma （PRP） in the treatment of postherpetic neuralgia. Methods Sixty patients with postherpetic neuralgia were divided into the pulsed radiofrequency plusglucocorticoid group （glucocorticoid group） and pulsed radiofrequency plus PRP group （PRP group） using the random number table method， with 30 patients in each group. The pain visual analogue score （VAS）， Pittsburgh sleep quality index （PSQI）， the average temperature difference （∆T） between the skin lesion area and the corresponding healthy skin area of all patients in two groups were observed before treatment， 1 d， 2 weeks， 4 weeks and 3 months after treatment， respectively. The incidence of complications was also recorded. Results The VAS score and PSQI at 1 d， 2 weeks， 4 weeks and 3 months after treatment were significantly improved compared to those before treatment in two groups （all P < 0.05）. In addition， the ∆T at 4 weeks and 3 months after treatment were significantly improved than those before treatment in two groups （all P < 0.05）. At 3 months after treatment， the VAS score and PSQI in the PRP group were significantly lower than those in the glucocorticoid group （both P < 0.05）. At 1 day， 2 weeks， 4 weeks and 3 months after treatment， the ∆T in the PRP group were significantly lower than those in the glucocorticoid group （all P < 0.05）. No severe adverse reactions occurred in two groups. Conclusions CT-guided pulsed radiofrequency combined with PRP can effectively treat postherpetic neuralgia， and the therapeutic effect is better than that of traditional pulsed radiofrequency combined with glucocorticoid therapy.

Published
2023
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44. An Integrated Analysis of Anatomical and Sugar Contents Identifies How Night Temperatures Regulate the Healing Process of Oriental Melon Grafted onto Pumpkin.

Author

Liang, Huan, Liu, Jiangfeng, Shi, Xianfeng, Ge, Mihong, Zhu, Juhong, Wang, Dehuan, and Zhou, Mobing

Subjects
TREHALOSE, SUGAR analysis, HIGH temperatures, LOW temperatures, MELONS, INOSITOL, PUMPKINS
Abstract

Graft healing is a complex process affected by environmental factors, with temperature being one of the most important influencing factors. Here, oriental melon grafted onto pumpkin was used to study changes in graft union formation and sugar contents at the graft interface under night temperatures of 18 °C and 28 °C. Histological analysis suggested that callus formation occurred 3 days after grafting with a night temperature of 28 °C, which was one day earlier than with a night temperature of 18 °C. Vascular reconnection with a night temperature of 28 °C was established 2 days earlier than with a night temperature of 18 °C. Additionally, nine sugars were significantly enriched in the graft union, with the contents of sucrose, trehalose, raffinose, D–glucose, D–fructose, D–galactose, and inositol initially increasing but then decreasing. Furthermore, we also found that exogenous glucose and fructose application promotes vascular reconnection. However, exogenous sucrose application did not promote vascular reconnection. Taken together, our results reveal that elevated temperatures improve the process of graft union formation through increasing the contents of sugars. This study provides information to develop strategies for improving grafting efficiency under low temperatures. [ABSTRACT FROM AUTHOR]

Published
2024
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