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Amirah Amir, Fei Wen Cheong, Jeremy Ryan de Silva, Jonathan Wee Kent Liew, Yee Ling Lau Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Abstract: Originally known to cause simian malaria, Plasmodium knowlesi is now known as the fifth human malaria species. Since the publishing of a report that largely focused on human knowlesi cases in Sarawak in 2004, many more human cases have been reported in nearly all of the countries in Southeast Asia and in travelers returning from these countries. The zoonotic nature of this infection hinders malaria elimination efforts. In order to grasp the current perspective of knowlesi malaria, this literature review explores the different aspects of the disease including risk factors, diagnosis, treatment, and molecular and functional studies. Current studies do not provide sufficient data for an effective control program. Therefore, future direction for knowlesi research is highlighted here with a final aim of controlling, if not eliminating, the parasite. Keywords: zoonosis, epidemiology, diagnosis, treatment, molecular, functional studies