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1. Genome‐wide meta‐analysis and fine‐mapping prioritize potential causal variants and genes related to leprosy

Author

Wang, Zhenzhen, primary, Liu, Tingting, additional, Li, Wenchao, additional, Yu, Gongqi, additional, Mi, Zihao, additional, Wang, Chuan, additional, Liao, Xiaojie, additional, Huai, Pengcheng, additional, Chu, Tongsheng, additional, Liu, Dianchang, additional, Sun, Lele, additional, Fu, Xi'an, additional, Sun, Yonghu, additional, Wang, Honglei, additional, Wang, Na, additional, Liu, Jianjun, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2023
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5. Prevalence, risk factors, and medical costs of Chlamydia trachomatis infections in Shandong Province, China: a population-based, cross-sectional study

Author

Huai, Pengcheng, Li, Furong, Li, Zhen, Sun, Lele, Fu, Xi’an, Pan, Qing, Yu, Gongqi, Chai, Zemin, Chu, Tongsheng, Mi, Zihao, Bao, Fangfang, Wang, Honglei, Zhou, Bingni, Wang, Chuan, Sun, Yonghu, Niu, Guiye, Zhang, Yuan, Fu, Fanghui, Lang, Xiaoqiao, Wang, Xiaoling, Zhao, Hui, Liu, Daina, Liu, Hong, Liu, Dianchang, Liu, Jian, Xu, Aiqiang, and Zhang, Furen

Published
2018
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9. The role of an active surveillance strategy of targeting household and neighborhood contacts related to leprosy cases released from treatment in a low-endemic area of China

Author

Wang, Na, primary, Chu, Tongsheng, additional, Li, Furong, additional, Wang, Zhenzhen, additional, Liu, Dianchang, additional, Chen, Mingfei, additional, Wang, Honglei, additional, Niu, Guiye, additional, Liu, Dan, additional, Zhang, Mingkai, additional, Xu, Yuanyuan, additional, Zhang, Yan, additional, Li, Jinghui, additional, Li, Zhen, additional, You, Jiabao, additional, Mao, Liguo, additional, Li, Huaizhang, additional, Chen, Yongjin, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2020
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14. Gender difference in the characteristics of and high-risk behaviours among non-injecting heterosexual methamphetamine users in Qingdao, Shandong Province, China

Author

Liu Dianchang, Wang Zhenhong, Chu Tongsheng, and Chen Shumin

Subjects
Methamphetamines, Heterosexual, High-risk behaviour, Gender, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Despite the increasing risk of HIV infections, few studies concerning the characteristics of non-injecting heterosexual methamphetamine (MA) users and related risk behaviours have been conducted in China. Methods Gender differences in socio-demographic characteristics, perception of MA and STD/HIV, MA use practices, and sexual behaviours related to MA use were examined among 398 non-injecting heterosexual MA users (288 males, 110 females). Results Male MA users were more likely to be married, local, and self-employed; female MA users were more likely to be young, single, engaged in commercial service or unemployed. Female MA users usually start MA use at an earlier age than males (24.3 vs. 31.3 years old), with shorter abuse durations (2.6 vs. 2.9 years), higher frequency of MA use (3.6 vs. 2.4 times per week), and higher likelihood of using MA with heterosexual partners (100% vs. 78.1%). More male MA users have had multiple sex partners (96.9% vs. 77.3%) and sex exchanges (72.9% vs. 46.4%). Among 277 males who had had sex with commercial sex workers (CSW), 69.4% never used condoms, and among 77 males who had had sex with multiple partners who are commercial sex workers and always or usually used condoms, 87.0% never changed condoms when changing partners. Conclusion There may be gender difference in the characteristics of high-risk behaviours among non-injecting heterosexual MA users. The findings suggest the integration of specific risk reduction strategies into intervention programs for non-injecting heterosexual MA user populations may significantly improve program goals.

Published
2013
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15. Seroprevalence and associated factors of HSV-2 infection among general population in Shandong Province, China

Author

Huai, Pengcheng, primary, Li, Furong, additional, Li, Zhen, additional, Sun, Lele, additional, Fu, Xi’an, additional, Pan, Qing, additional, Yu, Gongqi, additional, Chai, Zemin, additional, Chu, Tongsheng, additional, Mi, Zihao, additional, Bao, Fangfang, additional, Wang, Honglei, additional, Zhou, Bingni, additional, Wang, Chuan, additional, Sun, Yonghu, additional, Niu, Guiye, additional, Zhang, Yuan, additional, Fu, Fanghui, additional, Lang, Xiaoqiao, additional, Wang, Xiaoling, additional, Zhao, Hui, additional, Liu, Daina, additional, Liu, Hong, additional, Liu, Dianchang, additional, Liu, Jian, additional, Xu, Aiqiang, additional, and Zhang, Furen, additional

Published
2019
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17. Prediction of leprosy in the Chinese population based on a weighted genetic risk score

Author

Wang, Na, primary, Wang, Zhenzhen, additional, Wang, Chuan, additional, Fu, Xi'an, additional, Yu, Gongqi, additional, Yue, Zhenhua, additional, Liu, Tingting, additional, Zhang, Huimin, additional, Li, Lulu, additional, Chen, Mingfei, additional, Wang, Honglei, additional, Niu, Guiye, additional, Liu, Dan, additional, Zhang, Mingkai, additional, Xu, Yuanyuan, additional, Zhang, Yan, additional, Li, Jinghui, additional, Li, Zhen, additional, You, Jiabao, additional, Chu, Tongsheng, additional, Li, Furong, additional, Liu, Dianchang, additional, Liu, Hong, additional, and Zhang, Furen, additional

Published
2018
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18. Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population

Author

Chu Tongsheng, Zhang Lin, Zhu Chuanfu, Wang Changyuan, Chen Shumin, Liu Hong, Zhang Furen, Liu Dianchang, Yan Xiaoxiao, and Liu Jianjun

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to Mycobacterium leprae. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population. Methods The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals. Results The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease. Conclusion HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.

Published
2009
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19. Evaluation of ProspectiveHLA-B*13:01Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy

Author

Liu, Hong, Wang, Zhenzhen, Bao, Fangfang, Wang, Chuan, Sun, Lele, Zhang, Huimin, Yu, Gongqi, Mi, Zihao, Li, Jianke, Li, Lulu, Zhao, Qing, Yue, Zhenhua, Zhao, Wei, Yu, Wenjun, Cao, Jing, Xiong, Fei, Wang, Yaru, Chai, Zemin, Cheng, Xiujun, Zhang, Yuan, Fu, Fanghui, Lang, Xiaoqiao, Wang, Xiaoling, Irwanto, Astrid, Krismawati, Hana, Fu, Xi’an, Sun, Yonghu, You, Jiabao, Liu, Jian, Pan, Qing, Chu, Tongsheng, Liu, Dianchang, Chen, Shumin, Shen, Jianping, Yan, Liangbin, Zhang, Guocheng, Liu, Jianjun, Zhang, Furen, Xiong, Li, Yang, Jun, Li, Jinlan, Ke, Wei, Li, Ming, Ning, Yong, Xiong, Junhao, Xiong, Mingzhou, Yang, Bin, Duan, Qizhi, Wang, Hong, Li, Wei, Kuang, Yanfei, Li, Junhua, Wang, Lamei, Cao, Qiuyang, Xiao, Peng, Xiao, Bangzhong, Zhang, Lianhua, Lin, Zhaoxing, Wang, Yaofei, Shen, Yunliang, Yan, Liying, Wu, Wenbin, Zheng, Hu, Zhan, Xianfa, Li, Wanghua, Shang, Xiujian, Xu, Yujun, and Liu, Qiao

Subjects
medicine.medical_specialty, business.industry, Standard treatment, Incidence (epidemiology), Dermatology, Dapsone, medicine.disease, Clofazimine, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, Leprosy, Prospective cohort study, Adverse effect, business, Rifampicin, Original Investigation, medicine.drug
Abstract

IMPORTANCE: Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine. Although the HLA-B*13:01 polymorphism has been identified as the genetic determinant of DHS in the Chinese population, no studies to date have been done to evaluate whether prospective HLA-B*13:01 screening could prevent DHS by identifying patients who should not receive dapsone. OBJECTIVE: To evaluate the clinical use of prospective HLA-B*13:01 screening for reduction of the incidence of DHS by excluding dapsone from the treatment for patients with HLA-B*13:01–positive leprosy. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted from February 15, 2015, to April 30, 2018, in 21 provinces throughout China. A total of 1539 patients with newly diagnosed leprosy were enrolled who had not received dapsone previously. After excluding patients who had a history of allergy to sulfones or glucose-6-phosphate dehydrogenase deficiency, 1512 individuals underwent HLA-B*13:01 genotyping. All of the patients were followed up weekly for the first 8 weeks after treatment to monitor for adverse events. EXPOSURES: Patients who were HLA-B*13:01 carriers were instructed to eliminate dapsone from their treatment regimens, and noncarrier patients received standard MDT. MAIN OUTCOMES AND MEASURES: The primary outcome was the incidence of DHS. The historical incidence rate of DHS (1.0%) was used as a control. RESULTS: Among 1512 patients (1026 [67.9%] men, 486 [32.1%] women; mean [SD] age, 43.1 [16.2] years), 261 (17.3%) were identified as carriers of the HLA-B*13:01 allele. A total of 714 adverse events in 384 patients were observed during the follow-up period. Dapsone hypersensitivity syndrome did not develop in any of the 1251 patients who were HLA-B*13:01–negative who received dapsone, while approximately 13 patients would be expected to experience DHS, based on the historical incidence rate of 1.0% per year (P = 2.05 × 10(−5)). No significant correlation was found between other adverse events, including dermatologic or other events, and HLA-B*13:01 status. CONCLUSIONS AND RELEVANCE: Prospective HLA-B*13:01 screening and subsequent elimination of dapsone from MDT for patients with HLA-B*13:01–positive leprosy may significantly reduce the incidence of DHS in the Chinese population.

Published
2019

20. The syphilis epidemic in Shandong province, China: An analysis based on surveillance data from 2004 to 2011

Author

Liu, Dianchang, Chu, Tongsheng, and Chen, Shumin

Subjects
Epidemics -- Analysis -- Usage -- China, Syphilis -- Analysis -- Diagnosis -- Distribution -- Research, Company distribution practices, Health
Abstract

Byline: Dianchang. Liu, Tongsheng. Chu, Shumin. Chen Sir, Since syphilis re-emerged in China in the 1970s, the disease has been spreading widely over the country, with an accelerating speed. [sup][1] [...]

Published
2013

22. Preliminary study of tetracycline resistance genes in Treponema pallidum

Author

Xiao, Hailu, primary, Li, Zhen, additional, Li, Furong, additional, Wen, Jing, additional, Liu, Danxuan, additional, Du, Wenli, additional, Hou, Jianling, additional, Li, Zhongwei, additional, Zheng, Rongtao, additional, Liu, Dianchang, additional, Chu, Tongsheng, additional, Du, Donghong, additional, and Tian, Hongqing, additional

Published
2017
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24. Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy

Author

Liu, Hong, Wang, Zhenzhen, Bao, Fangfang, Wang, Chuan, Sun, Lele, Zhang, Huimin, Yu, Gongqi, Mi, Zihao, Li, Jianke, Li, Lulu, Zhao, Qing, Yue, Zhenhua, Zhao, Wei, Yu, Wenjun, Cao, Jing, Xiong, Fei, Wang, Yaru, Chai, Zemin, Cheng, Xiujun, Zhang, Yuan, Fu, Fanghui, Lang, Xiaoqiao, Wang, Xiaoling, Irwanto, Astrid, Krismawati, Hana, Fu, Xi’an, Sun, Yonghu, You, Jiabao, Liu, Jian, Pan, Qing, Chu, Tongsheng, Liu, Dianchang, Chen, Shumin, Shen, Jianping, Yan, Liangbin, Zhang, Guocheng, Liu, Jianjun, Zhang, Furen, Xiong, Li, Yang, Jun, Li, Jinlan, Ke, Wei, Li, Ming, Ning, Yong, Xiong, Junhao, Li, Ming, Xiong, Mingzhou, Yang, Bin, Duan, Qizhi, Wang, Hong, Li, Wei, Kuang, Yanfei, Li, Junhua, Wang, Lamei, Cao, Qiuyang, Xiao, Peng, Xiao, Bangzhong, Zhang, Lianhua, Lin, Zhaoxing, Wang, Yaofei, Shen, Yunliang, Yan, Liying, Wu, Wenbin, Zheng, Hu, Zhan, Xianfa, Li, Wanghua, Shang, Xiujian, Xu, Yujun, and Liu, Qiao

Abstract

IMPORTANCE: Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine. Although the HLA-B*13:01 polymorphism has been identified as the genetic determinant of DHS in the Chinese population, no studies to date have been done to evaluate whether prospective HLA-B*13:01 screening could prevent DHS by identifying patients who should not receive dapsone. OBJECTIVE: To evaluate the clinical use of prospective HLA-B*13:01 screening for reduction of the incidence of DHS by excluding dapsone from the treatment for patients with HLA-B*13:01–positive leprosy. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted from February 15, 2015, to April 30, 2018, in 21 provinces throughout China. A total of 1539 patients with newly diagnosed leprosy were enrolled who had not received dapsone previously. After excluding patients who had a history of allergy to sulfones or glucose-6-phosphate dehydrogenase deficiency, 1512 individuals underwent HLA-B*13:01 genotyping. All of the patients were followed up weekly for the first 8 weeks after treatment to monitor for adverse events. EXPOSURES: Patients who were HLA-B*13:01 carriers were instructed to eliminate dapsone from their treatment regimens, and noncarrier patients received standard MDT. MAIN OUTCOMES AND MEASURES: The primary outcome was the incidence of DHS. The historical incidence rate of DHS (1.0%) was used as a control. RESULTS: Among 1512 patients (1026 [67.9%] men, 486 [32.1%] women; mean [SD] age, 43.1 [16.2] years), 261 (17.3%) were identified as carriers of the HLA-B*13:01 allele. A total of 714 adverse events in 384 patients were observed during the follow-up period. Dapsone hypersensitivity syndrome did not develop in any of the 1251 patients who were HLA-B*13:01–negative who received dapsone, while approximately 13 patients would be expected to experience DHS, based on the historical incidence rate of 1.0% per year (P = 2.05 × 10−5). No significant correlation was found between other adverse events, including dermatologic or other events, and HLA-B*13:01 status. CONCLUSIONS AND RELEVANCE: Prospective HLA-B*13:01 screening and subsequent elimination of dapsone from MDT for patients with HLA-B*13:01–positive leprosy may significantly reduce the incidence of DHS in the Chinese population.

Published
2019
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25. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy

Author

Liu, Hong, primary, Irwanto, Astrid, additional, Fu, Xi'an, additional, Yu, Gongqi, additional, Yu, Yongxiang, additional, Sun, Yonghu, additional, Wang, Chuan, additional, Wang, Zhenzhen, additional, Okada, Yukinori, additional, Low, Huiqi, additional, Li, Yi, additional, Liany, Herty, additional, Chen, Mingfei, additional, Bao, Fangfang, additional, Li, Jinghui, additional, You, Jiabao, additional, Zhang, Qilin, additional, Liu, Jian, additional, Chu, Tongsheng, additional, Andiappan, Anand Kumar, additional, Wang, Na, additional, Niu, Guiye, additional, Liu, Dianchang, additional, Yu, Xiulu, additional, Zhang, Lin, additional, Tian, Hongqing, additional, Zhou, Guizhi, additional, Rotzschke, Olaf, additional, Chen, Shumin, additional, Zhang, Xuejun, additional, Liu, Jianjun, additional, and Zhang, Furen, additional

Published
2015
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29. Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases

Author

Liu, Hong, primary, Irwanto, Astrid, additional, Tian, Hongqing, additional, Fu, Xi'an, additional, Yu, Yongxiang, additional, Yu, Gongqi, additional, Low, Huiqi, additional, Chu, Tongsheng, additional, Li, Yi, additional, Shi, Benqing, additional, Chen, Mingfei, additional, Sun, Yonghu, additional, Yuan, Chunying, additional, Lu, Nan, additional, You, Jiabao, additional, Bao, Fangfang, additional, Li, Jinghui, additional, Liu, Jian, additional, Liu, Huaxu, additional, Liu, Dianchang, additional, Yu, Xiulu, additional, Zhang, Lin, additional, Yang, Qing, additional, Wang, Na, additional, Niu, Guiye, additional, Ma, Shanshan, additional, Zhou, Yan, additional, Wang, Chuan, additional, Chen, Shumin, additional, Zhang, Xuejun, additional, Liu, Jianjun, additional, and Zhang, Furen, additional

Published
2012
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30. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy

Author

Zhang, Furen, primary, Liu, Hong, additional, Chen, Shumin, additional, Low, Huiqi, additional, Sun, Liangdan, additional, Cui, Yong, additional, Chu, Tongsheng, additional, Li, Yi, additional, Fu, Xi'an, additional, Yu, Yongxiang, additional, Yu, Gongqi, additional, Shi, Benqing, additional, Tian, Hongqing, additional, Liu, Dianchang, additional, Yu, Xiulu, additional, Li, Jinghui, additional, Lu, Nan, additional, Bao, Fangfang, additional, Yuan, Chunying, additional, Liu, Jian, additional, Liu, Huaxu, additional, Zhang, Lin, additional, Sun, Yonghu, additional, Chen, Mingfei, additional, Yang, Qing, additional, Yang, Haitao, additional, Yang, Rongde, additional, Zhang, Lianhua, additional, Wang, Qiang, additional, Zuo, Fuguang, additional, Zhang, Haizhen, additional, Khor, Chiea Chuen, additional, Hibberd, Martin L, additional, Yang, Sen, additional, Liu, Jianjun, additional, and Zhang, Xuejun, additional

Published
2011
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32. A Survey of Men Who Have Sex with Men: Mainland China.

Author

Zhang Beichuan, Liu Dianchang, Li Xiufang, and Hu Tiezhong

Subjects
*SURVEYS, *CHINESE people, *SEXUAL intercourse, *HOMOSEXUALITY, *MEN'S sexual behavior, *SEXUALLY transmitted diseases
Abstract

The article presents a survey of Chinese men who have sex with men. Of the 88.7% of respondents whose first sex occurred with men, 93.4% engaged in orogenital intercourse, 63.6% engaged in anogenital intercourse, 15.5% always engaged in insertive anal intercourse, and 7.8% always engaged in receptive anal intercourse. In regard to female partners, 11.3% of respondents reported that their first sex had occurred with women, and overall 48.4% had engaged in sexual intercourse with women. Of the 302 respondents who gave information on sexually transmitted diseases (STD), 25.5% reported that they had contracted an STD.

Published
2000
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34. Disparity in Availability of Laboratory Testing for Syphilis Among Different Hospitals in Shandong Province, Eastern China.

Author

Chen X, Mi X, Gan Y, Chang D, and Liu D

Subjects
China epidemiology, Hospitals, Humans, Syphilis Serodiagnosis, Syphilis diagnosis, Syphilis epidemiology
Abstract

The aim of this study was to understand the availability of laboratory testing for syphilis among hospitals in Shandong province. Basic information on hospitals that provide clinical health service for sexually transmitted infections (STIs) and the type of laboratory tests for syphilis provided was collected and analyzed using the chi-square test. A total of 410 and 456 hospitals that provided clinical services for STI were surveyed in 2012 and 2018. Significant differences in the availability of nontreponemal tests were observed among different levels (χ 2 = 6.624) and types (χ 2 = 17.752) of hospitals in 2012, but not in 2018. A significant difference in the availability of treponemal tests was observed among different levels of hospitals in 2012 (χ 2 = 9.937) but not in 2018. Significant differences in the availability of nontreponemal tests, titer of nontreponemal tests, and treponemal tests were observed among hospitals with different affiliations in 2018 ( P = 0.000; χ 2 = 15.274, P < .001; P = .021) but not in 2012. The availability of nontreponemal and treponemal tests for syphilis among hospitals in 2018 was higher than that in 2012 (90.13% vs. 57.56%, χ 2 = 121.219). The availability of laboratory testing has been much improved. Further efforts are needed to reduce the disparity in the availability among different hospitals.

Published
2022
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35. Comparison of Doxycycline and Benzathine Penicillin G for the Treatment of Early Syphilis.

Author

Xiao H, Liu D, Li Z, Zheng R, Li Z, Hou J, Zhang S, Chu T, Tian H, and Zhang F

Subjects
Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Anti-Bacterial Agents therapeutic use, Doxycycline therapeutic use, Penicillin G Benzathine therapeutic use, Syphilis drug therapy
Abstract

Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis. The aim of our study was to assess the serological response to the treatment for early syphilis with doxycycline compared with benzathine penicillin G and evaluate whether doxycycline is still an effective agent for the treatment of early syphilis. A record-based retrospective study was conducted. Patients were diagnosed with early syphilis in an sexually transmitted disease (STD) clinic from January 1, 2008 to December 31, 2014. They were treated with a single dose of benzathine penicillin G 2.4MU or oral doxycycline 100 mg twice daily for 14 days. Pearson's chi-squared test was used for data analysis. 601 cases were included in the final study sample: 105 (17.5%) patients received a 14-day course of doxycycline (doxycycline group), and 496 (82.5%) patients received single-dose benzathine penicillin G (BPG group). The serological responses at 6 months and 12 months after treatment were compared. No statistically significant differences were found between the two groups at 6 months (69.52% vs. 75.00%, P=0.245), and at 12 months (92.38% vs. 96.17%, P=0.115). Doxycycline is still an effective agent for the treatment of early syphilis.

Published
2017

36. TRENDS IN THE PREVALENCE OF SYPHILIS AMONG OLDER ADULTS IN SHANDONG, CHINA.

Author

Liu D, Yang Y, Xiu C, Li Z, Chu T, and Tian H

Subjects
Age Distribution, Aged, Aged, 80 and over, China epidemiology, Female, Humans, Male, Middle Aged, Population Surveillance, Prevalence, Retrospective Studies, Sex Distribution, Syphilis epidemiology
Abstract

The epidemiology of syphilis among older adults in China has not been well studied. We studied changes over time in the prevalence of syphilis among older adults in Shandong, China to inform a syphilis intervention program in order to develop management strategies. We retrospectively reviewed passive surveillance data of syphilis among older adults in Shandong, China during 2008-2013, reported by clinicians in medical facilities. The data included the stage of syphilis, age of patient and gender by year. The prevalences for first, second, latent and overall syphilis by age among adults aged ≥60 years in Shandong were 0.92, 0.70, 2.37 and 3.92 cases per 100,000 population in 2008 and 2.66, 1.99, 9.11 and 13.95 cases per 100,000 population in 2013; giving average yearly increases of 23.66%, 23.24%, 30.90% and 28.90%, respectively. The reported overall prevalence of syphilis among those aged ≥80 years was greater than the general population (8.25 vs 4.38 cases per 100,000 population in 2008; 21.99 vs 13.95 cases per 100,000 population in 2013). The prevalence of syphilis is increasing in the study population. Age appropriate interventions are needed to reduce the prevalence of syphilis in the study population.

Published
2016

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