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Glioma is a serious disease burden globally, with high mortality and recurrence rates. CDGSH iron sulfur domain 2 (CISD2) is an evolutionarily conserved protein that is involved in several cancers. However, its role in the prognosis and immune infiltration in glioma remains unclear. In our research, RNA-seq matrix and clinicopathological relevant data for CISD2 were downloaded from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. Human Protein Atlas was used to verify the CISD2 protein level in glioma, and STRING was used to establish relative coexpression gene network. The Kaplan-Meier plotter was adopted to analyze the effect of CISD2 on prognosis. The connection between CISD2 expression and immune infiltration was analyzed using single-sample GSEA (ssGSEA), TIMER, and GEPIA. In contrast to normal tissues, CISD2 expression was significantly higher in glioma tissues, and CISD2 presented a certain diagnostic value in distinguishing glioma tissues from normal tissues. Furthermore, the CISD2 level was correlated with age, histologic grade, histological type, isocitrate dehydrogenase (IDH) status, 1p/19q codeletion status, and primary therapy outcome of glioma, while high CISD2 mRNA expression was correlated with grave overall survival. Multivariate analysis demonstrated that CISD2 was an independent risk factor for patients with glioma. Functional enrichment analysis indicated that CISD2 could regulate proliferation, immune reaction, and mitochondrial function. The results from the ssGSEA and TIMER databases confirmed that CISD2 acts a prominent role in immune cell infiltration in the tumor microenvironment, especially in low-grade glioma (LGG). Furthermore, CISD2 expression was observably correlated to M2 polarization in macrophages with glioma progression. This is the first research to investigate the immune role of CISD2 in glioma. CISD2 may be an innovative prognostic biomarker and can act as a potential target for future therapy for glioma. [ABSTRACT FROM AUTHOR]

Chromite is one of the main indicator minerals in kimberlite diamond deposit. Accurate content analysis of the chemical compositions such as FeO, MgO, Cr2O3, Al2O3 and TiO2 in chromite is the key for the naming of chromite, and significant indication for kimberlite diamond deposit prospecting as well. The electron probe spectroscopy is used to analyze the major chemical elements in chromite, and the micro-area chemical analysis of measured samples to infer the mineral name. The analysis results of 25 single mineral samples show that the contents of major chemical components are 15.666%-29.971% of FeO, 7.286%-11.477% of MgO and 56.421%-71.111% of Cr2O3, with minor chemical components MnO 0.012%-0.382%, Al2O3 0.871%-8.993% and TiO2 0.074%-3.375%. The total mineral chemical composition is 99.117%-100.877%. The chemical composition of single mineral is equivalent to that of chromite. According to the mineral characteristics by artificial heavy mineral identification and positions of ion groups A and B, it can be determined that the measured sample is magnochromite. [ABSTRACT FROM AUTHOR]

The 3.5 nm-sized polyanion [H4Te IV48 W VI78 O372]80−, exhibiting an exceptionally high Te : W ratio, expands the structural role of TeIV ions from classical heterogroups within polyoxotungstate subunits to addenda ions. Investigations on the self-assembly conditions, proceeding in a simple one-pot reaction, point to the pH as one critical factor for circumventing this limitation. [ABSTRACT FROM AUTHOR]

Four rectangular molecular architectures have been successfully constructed using {Ti5O7} clusters as inorganic vertical edges and bridging aromatic carboxylates as horizontal edges. The introduced organic ligands show a strong influence on the light absorption behaviors of the obtained hybrid complexes. [ABSTRACT FROM AUTHOR]

Three tetrahedral tetrazolate frameworks (TTFs) with SOD, srs and ctn topologies (TTF-4, -5 and -6) are obtained by using the anion and solvent as structure-directing agents. The resulting SOD-type TTF-4 shows high chemical stability as well as high CO2 uptake capacity. [ABSTRACT FROM AUTHOR]

Through the labile coordination sites of a robust phosphonate-stabilized titanium-oxo cluster, 14 O-donor ligands have been successfully introduced without changing the cluster core. The increasing electron-withdrawing effect of the organic species allows the gradual reduction of the bandgaps of the {Ti6} complexes. Transition-metal ions are then incorporated by the use of bifunctional O/N-donor ligands, organizing these {Ti6} clusters into polymeric structures. The coordination environments of the applied metal ions show significant influence on their visible-light adsorption. Both the above structural functionalizations also tune the photocatalytic H2 production activities of these clusters. This work provides a systematic bandgap engineering study of titanium-oxo clusters, which is important not only for their future photocatalytic applications, also for the better understanding of the structure-property relationships. [ABSTRACT FROM AUTHOR]

A novel Cd(II)-ion-imprinted silica-supportedhybrid sorbent functionalizedwith tetradentate Schiff bases ligands derived from 2-thiophenecarboxaldehydeand 3-[2-(2-aminoethylamino)ethylamino]propyltrimethoxysilane forthe selective removal of Cd(II) ions from aqueous media had been synthesizedby a surface-imprinting technique in conjunction with a sol–gelprocess and characterized by scanning electron microscopy, Fouriertransform infrared spectroscopy, N2adsorption–desorptionisotherms, and thermogravimetric analysis. The results revealed thatthe static adsorption capacity of Cd(II) was 29.1 mg·g–1. The imprinted hybrid sorbent exhibited a fast equilibrium timewith 30 min, had a stable binding capacity in the range of pH 3.5–9.5,and showed the selective adsorption for Cd(II) in binary ions systemsof Cd(II)/Zn(II), Cd(II)/Ni(II), Cd(II)/Cu(II), and Cd(II)/Pb(II).The adsorption/desorption cycles of the imprinted hybrid sorbent couldbe up to nine times. Langmuir, Freundlich, and Dubinin–Radushkevichisotherm models were applied to analyze the experimental data, andthe best interpretation for the experimental data was given by theLangmuir isotherm equation. The adsorption kinetics could be fittedby pseudo-second-order rate equation wonderfully compared with pseudo-first-order,Elovich, and intraparticle diffusion models. Negative values of ΔG° indicated the spontaneous adsorption, and the degreeof the spontaneity increased with increasing temperature. The thermodynamicparameters of ΔH° and ΔS° were 11.77 kJ·mol–1and 74.98 J·K–1·mol–1, respectively. Thus,this novel imprinted hybrid sorbent was a favorable, useful, and promisinggood candidate material for the selective removal of Cd(II) ions fromaqueous media. [ABSTRACT FROM AUTHOR]

Highlights: [•] We develop a new DGT device for measuring the labile Cu2+, Cd2+ and Pb2+ in waters. [•] A water-soluble polymer-bound Schiff base was used as the binding agents of DGT device. [•] 98.7–103.7% of the total concentrations of metals were obtained with uptake experiment of DGT technique. [•] Fewer percentages of labile metals were measured by the DGT device with higher lever of ligands. [•] The different labile fractions of metals were dependent on the binding strengths of binding agents. [Copyright &y& Elsevier]

A new Cd-doped titanium–oxo cluster (TOC) stabilized by tert-butylacetic acid ligands has been prepared through an easily handled solvothermal reaction; photocatalytic studies indicate that it displays good H2 evolution ability (3.15 μmol h−1), and moreover preserves high catalytic stability. [ABSTRACT FROM AUTHOR]

Phytolacacinoside A (1), a novel triterpenoid saponin, together with the seven known compounds, was isolated from 75% ethanol extract of the root of Phytolacca acinosa Roxb (Phytolaccaceae). Their structures were elucidated on the basis of analysis of spectroscopic data and physicochemical properties as 3-O-β-[(β-d-glucopyranosyl-(1 → 4)-O-β-d-xylopyranosyl)]-11β-methoxy-jaligonic acid 30-methyl ester 28-O-β-d-glucopyranoside (1), 3-O-β-[(β-d-glucopyranosyl-(1 → 4)-O-β-d-xylopyranosyl)]-jaligonic acid 30-methyl ester 28-O-β-d-glucopyranoside (2, esculentoside G), 3-O-β-[(β-d-glucopyranosyl-(1 → 4)-O-β-d-xylopyranosyl)]-jaligonic acid 30-methyl ester (3, phytolaccoside E), 3-O-β-d-xylopyranosyl-jaligonic acid 30-methyl ester (4, phytolaccoside B), hypaphorine (5), palmitic acid monoglyceride (6), β-sitosterol (7), and daucosterol (8). [ABSTRACT FROM AUTHOR]

Clusterchemie In ihrer Zuschrift auf S. 5246 ff. zeigen L. Zhang, J. Zhang et al., dass die labilen Koordinationsstellen eines {Ti6}‐Clusters genutzt werden können, um dessen Oberfläche zu funktionalisieren. [ABSTRACT FROM AUTHOR]