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31. A national survey on how to improve traditional Chinese medicine learning internationally: Perceptions from both teachers and students

Author

Zhu, Yuhang, Wu, Yan, Zhang, Hao, Zhao, Yanfei, Ren, Yule, Hu, Wei, Li, Pan, Wang, Huiyi, Wang, Ying, Zhang, Boda, Wang, Yujie, Yuan, Hongwen, Zhang, Jiping, Li, Wenqiang, Zhao, Yufang, Zhao, Jie, Shi, Yedong, Shu, Yanye, Zhang, Xiao, Sun, Yan, Yu, Sheng, Yang, Ling, Geng, Zhenbo, Chen, Jiali, Lv, Kun, Wang, Weilin, Xue, Wenjuan, Gu, Yinger, Wang, Fangfang, Xu, Xiangrong, and Qu, Fan

Published
2022
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42. Research on behavior of underground pressure in shallow coal seam with three-face goaf working face

Author

Wang Yin, Zhao Bin, Deng Zhigang, Lv Kun, and Wang Hongwei

Subjects
room and pillar mining, microseismic monitoring, underground pressure, three-face goaf, pasat-M detection, General Works
Abstract

During the mining process of coal mines, coal pillars are often formed in the goaf on three sides, and the stress behavior of coal seams has a significant impact on the safety of coal mines. The upper part of panel 3104 of Xinwang Coal Mine is the room-pillar goaf of the 2# coal seam, and the lower part is the goaf of the 7# coal seam. The same coal seam is adjacent to the goaf of panel 3102. Therefore, there are hidden dangers for safe mining in panel 3104 affected by the goaf on three sides. Through FLAC3D numerical simulation, on-site Pasat-M detection, microseismic monitoring, and support resistance measurement, the stress distribution law of surrounding rock in the working face is analyzed. The following conclusions are obtained. There are several high wave velocity stress concentration areas in the coal body of 3104 working face. During the mining of the working face, the mining influence 90m in front of the working face began to spread to the area of the left coal pillar, and the vertical stress at the left coal pillar began to increase. Stress concentration appears in 0–20m strata at the top of 3# coal seams. At the top of a 3# coal seam, the vertical stress concentration coefficient can reach 2 in the range of 4–12m. The influence range of 3104 working face mining advance can reach 200m. Under the influence of mining, a large number of microseismic events occurred at 160m above and 150m below 3# coal seam. This law has reference value for the mining strata behaviors of coal seams under similar conditions.

Published
2022
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49. m6A-Mediated Upregulation of lncRNA CHASERR Promotes the Progression of Glioma by Modulating the miR-6893-3p/TRIM14 Axis.

Author

Wu, Xingwei, Fu, Minjie, Ge, Chang, Zhou, Hanyu, Huang, Haoyu, Zhong, Min, Zhang, Mengying, Xu, Hao, Zhu, Guoping, Hua, Wei, Lv, Kun, and Yang, Hui

Abstract

Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are dysregulated in glioma. However, the functional roles of lncRNAs in glioma remain largely unknown. In this study, we utilized the TCGA (the Cancer Genome Atlas database) and GEPIA2 (Gene Expression Profiling Interactive Analysis 2) databases and observed the overexpression of lncRNA CHASERR in glioma tissues. We subsequently investigated this phenomenon in glioma cell lines. The effects of lncRNA CHASERR on glioma proliferation, migration, and invasion were analyzed using in vitro and in vivo experiments. Additionally, the regulatory mechanisms among PTEN/p-Akt/mTOR and Wnt/β-catenin, lncRNA CHASERR, Micro-RNA-6893-3p(miR-6893-3p), and tripartite motif containing14 (TRIM14) were investigated via bioinformatics analyses, quantitative real-time PCR (qRT-PCR), western blot (WB), RNA immunoprecipitation (RIP), dual luciferase reporter assay, fluorescence in situ hybridization (FISH), and RNA sequencing assays. RIP and RT-qRCR were used to analyze the regulatory effect of N6-methyladenosine(m6A) on the aberrantly expressed lncRNA CHASERR. High lncRNA CHASERR expression was observed in glioma tissues and was associated with unfavorable prognosis in glioma patients. Further functional assays showed that lncRNA CHASERR regulates glioma growth and metastasis in vitro and in vivo. Mechanistically, lncRNA CHASERR sponged miR-6893-3p to upregulate TRIM14 expression, thereby facilitating glioma progression. Additionally, the activation of PTEN/p-Akt/mTOR and Wnt/β-catenin pathways by lncRNA CHASERR, miR-6893-3p, and TRIM14 was found to regulate glioma progression. Moreover, the upregulation of lncRNA CHASERR was observed in response to N6-methyladenosine modification, which was facilitated by METTL3/YTHDF1-mediated RNA transcripts. This study elucidates the m6A/lncRNACHASERR/miR-6893-3p/TRIM14 pathway that contributes to glioma progression and underscores the potential of lncRNA CHASERR as a novel prognostic indicator and therapeutic target for glioma. [ABSTRACT FROM AUTHOR]

Published
2024
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